Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

Journal of Experimental Medicine

Volumn 198, Issue 10, 2003, Pages 1595-1608

  Fujikawa, Keiko ^a,b,c   Miletic, Ana V ^b   Alt, Frederick W ^a   Faccio, Roberta ^b   Brown, Tracie ^b   Hoog, Jeremy ^b   Fredericks, Jessica ^b   Nishi, Shinzo ^c   Mildiner, Shirly ^b   Moores, Sheri L ^d   Brugge, Joan ^d   Rosen, Fred S ^a   Swat, Wojciech ^a,b,e  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b USA   (United States)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d HARVARD MEDICAL SCHOOL   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen receptor; Ca++; Mitogen activated protein kinase; Signal transduction; Thymocyte

Indexed keywords

B LYMPHOCYTE RECEPTOR; CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VAV PROTEIN; VAV PROTEIN 1; VAV PROTEIN 2; VAV PROTEIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE ACTIVATION; CALCIUM SIGNALING; CELL MATURATION; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME ACTIVATION; EXPERIMENTAL MOUSE; HUMORAL IMMUNITY; IMMUNE RESPONSE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMUS;

ANIMALS; B-LYMPHOCYTES; CALCIUM; CALCIUM SIGNALING; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-VAV; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 10744222965     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030874     Document Type: Article

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