Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor β locus

Immunity

Volumn 7, Issue 5, 1997, Pages 601-607

  Aifantis, Iannis ^a   Buer, Jan ^a   Von Boehmer, Harald ^a   Azogui, Orly ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE RECEPTOR;

ALLELE; ANIMAL CELL; ARTICLE; GENE REARRANGEMENT; GENE SEQUENCE; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0031433563     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80381-7     Document Type: Article

References (34)

1. Alt, F., Rosenberg, N., Lewis, S., Thomas, E., and Baltimore, D. (1981). Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell 27, 381-390.
2. Arden, B., Clark, S.P., Kabelitz, D., and Mak, T.W. (1995). Mouse T-cell receptor variable gene segment families. Immunogenetics 42, 501-530.
3. Borgulya, P., Kishi, H., Uematsu, Y., and von Boehmer, H. (1992). Exclusion and inclusion of α and β T cell receptor alleles. Cell 69, 529-537.
4. Brouns, G.S., de Vries, E., van Noesel, C.J., Mason, D.Y., van Lier, R.A., and Borst, J. (1993). The structure of the mu/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction. Eur. J. Immunol. 23, 1088-1097.
5. Buer, J., Aifantis, I., DiSanto, J.P., Fehling, H.J., and von Boehmer, H. (1997). Role of different T cell receptors in the development of pre-T cells. J. Exp. Med. 185, 1541-1547.
6. Casanova, J.L., Romero, P., Widman, C., Kourilsky, P., and Maryanski, J.L. (1991). T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174, 1371-1383.
7. Clark, S.P., Yoshikai, Y., Taylor, S., Siu, G., Hood, L., and Mak, T.W. (1984). Identification of a diversity segment of human T-cell receptor beta-chain, and comparison with the analogous murine element. Nature 311, 387-389.
8. Davis, M.M., and Bjorkman, P.J. (1988). T-cell antigen receptor genes and T-cell recognition. Nature 334, 395-402.
9. Fehling, H.J., Krotkova, A., Saint-Ruf, C., and von Boehmer, H. (1995). Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta cells. Nature 375, 795-798.
10. Gascoigne, N.R., Chien, Y., Becker, D.M., Kavaler, J., and Davis, M.M. (1984). Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes. Nature 310, 387-391.
11. Godfrey, D.I., Kennedy, J., Suda, T., and Zlotnik, A. (1993). A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8-triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150, 4244-4252.
12. Groettrup, M., and von Boehmer, H. (1993). T cell receptor beta chain dimers on immature thymocytes from normal mice. Eur. J. Immunol. 23, 1393-1396.
13. Groettrup, M., Baron, A., Griffiths, G., Palacios, R., and von Boehmer, H. (1992). T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines. EMBO J. 11, 2735-2745.
14. Groettrup, M., Ungewiss, K., Azogui, O., Palacios, R., Owen, M.J., Hayday, A.C., and von Boehmer, H. (1993). A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kDa glycoprotein. Cell 75, 283-294.
15. Jacobs, H., Vandeputte, D., Tolkamp, L., de Vries, E., Borst, J., and Berns, A. (1994). CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur. J. Immunol. 24, 934-939.
16. pre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77, 133-143.
17. Krotkova, A., von Boehmer, H., and Fehling, H.J. (1997). Allelic exclusion in pTIpha-deficient mice: no evidence for cell surface expression of two T cell receptor beta chains, but less efficient inhibition of endogenous Vbeta-(D)Jbeta rearrangements in the presence of a functional TCRbeta transgene. J. Exp. Med. 186, 767-775.
18. Löffert, D., Ehlich, A., Muller, W., and Rajewsky, K. (1996). Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity 4, 133-144.
19. Malissen, M., Minard, K., Mjolsness, S., Kronenberg, M., Goverman, J., Hunkapiller, T., Prystowsky, M.B., Yoshikai, Y., Fitch, F., and Mak, T.W. (1984). Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the β polypeptide. Cell 37, 1101-1110.
20. Malissen, M., Trucy, J., Jouvin-Marche, E., Cazenave, P.A., Scollay, R., and Malissen, B. (1992). Regulation of TCR alpha and beta gene allelic exclusion during T-cell development. Immunol. Today 13, 315-322.
21. Malissen, M., Gillet, A., Ardouin, L., Bouvier, G., Trucy, J., Ferrier, P., Vivier, E., and Malissen, B. (1995). Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene. EMBO J. 14, 4641-4653.
22. Melchers, F., Haasner, D., Grawunder, U., Kalberer, C., Karasuyama, H., Winkler, T., and Rolink, A.G. (1994). Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu. Rev. Immunol. 12, 209-225.
23. Nomura, J., Matsuo, T., Kubota, E., Kimoto, M., and Sakaguchi, N. (1991). Signal transmission through the B cell-specific MB-1 molecule at the pre-B cell stage. Int. Immunol. 3, 117-126.
24. Petrie, H.T., Livak, F., Burtrum, D., and Mazel, S. (1995). T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production. J. Exp. Med. 182, 121-127.
25. Rocha, B., and von Boehmer, H. (1991). Peripheral selection of the T cell repertoire. Science 251, 1225-1228.
26. Saint-Ruf, C., Ungewiss, K., Groettrup, M., Bruno, L., Fehling, H.J., and von Boehmer, H. (1994). Analysis and expression of a cloned pre-T cell receptor gene. Science 266, 1208-1212.
27. Storb, U., Pinkert, C., Arp, B., Engler, P., Gollahon, K., Manz, J., Brady, W., and Brinster, R.L. (1986). Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies. J. Exp. Med. 164, 627-641.
28. Uematsu, Y., Ryser, S., Dembic, Z., Borgulya, P., Krimpenfort, P., Berns, A., von Boehmer, H., and Steinmetz, M. (1988). In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell 52, 831-841.
29. van Oers, N.S.C., Lowin-Kropf, B., Finlay, D., Conolly, K., and Weiss, A. (1996). αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 5, 429-436.
30. von Boehmer, H., and Fehling, H.J. (1997). Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15, 433-452.
31. von Boehmer, H., Teh, H.S., and Kisielow, P. (1989). The thymus selects the useful, neglects the useless and destroys the harmful. Immunol. Today 10, 57-61.
32. Wallace, V.A., Kawai, K., Levelt, C.N., Kishihara, K., Molina, T., Timms, E., Pircher, H., Penninger, J., Ohashi, P.S., Eichmann, K., et al. (1995). T lymphocyte development in p56lck deficient mice: allelic exclusion of the TCRbeta locus is incomplete but thymocyte development is not restored by TCRbeta or TCRalpha/beta transgenes. Eur. J. Immunol. 25, 1312-1318.
33. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A., and Nagata, S. (1992). Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317.
34. Xu, Y., Davidson, L., Alt, F.W., and Baltimore, D. (1996). Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus. Proc. Natl. Acad. Sci. USA 93, 2169-2173.