Analysis of TCR, pTα, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment

Blood

Volumn 101, Issue 7, 2003, Pages 2693-2703

  Asnafi, Vahid ^b   Beldjord, Kheira ^b   Boulanger, Emmanuelle ^b   Comba, Béatrice ^b   Le Tutour, Patricia ^b   Estienne, Marie Hélène ^b   Davi, Frédéric ^b   Landman Parker, Judith ^b   Quartier, Pierre ^b   Buzyn, Agnès ^b   Delabesse, Eric ^b   Valensi, Françoise ^b   Macintyre, Elizabeth ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD33 ANTIGEN; CD34 ANTIGEN; DECAY ACCELERATING FACTOR; DNA NUCLEOTIDYLEXOTRANSFERASE; MICROSOMAL AMINOPEPTIDASE; PROTEIN DERIVATIVE; PROTEIN PT ALPHA; RAG1 PROTEIN; T LYMPHOCYTE RECEPTOR; T6 ANTIGEN; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; MESSENGER RNA; PRE T CELL RECEPTOR ALPHA; PRE-T CELL RECEPTOR ALPHA; RAG 1 PROTEIN; RAG-1 PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CARCINOGENESIS; CELL LINEAGE; CELL MATURATION; CELL POPULATION; CHILD; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN CELL; LYMPHATIC SYSTEM; LYMPHOCYTE DIFFERENTIATION; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STEM CELL; T LYMPHOCYTE; CLASSIFICATION; CYTOLOGY; GENETICS; GENOTYPE; IMMUNOLOGY; IMMUNOPHENOTYPING; MIDDLE AGED; PATHOLOGY; T CELL LEUKEMIA;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD; CELL LINEAGE; CHILD; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, T-CELL, ACUTE; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 0037769822     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-08-2438     Document Type: Article

References (66)

1. dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells. Blood. 1996;87:5196-5206.
2. Godfrey DI, Zlotnik A. Control points in early T-cell development. Immunol Today. 1993;14:547-553.
3. + T cells from a common precursor. Semin Immunol. 1997;9:171-179.
4. Capone M, Hockett RD Jr, Zlotnik A. Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes. Proc Natl Acad Sci U S A. 1998;95:12522-12527.
5. von Boehmer H, Aifantis I, Azogui O, et al. Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment. Immunol Rev. 1998;165:111-119.
6. Spits H, Blom B, Jaleco AC, et al. Early stages in the development of human T, natural killer and thymic dendritic cells. Immunol Rev. 1998;165:75-86.
7. Blom B, Verschuren MC, Heemskerk MH, et al. TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation. Blood. 1999;93:3033-3043.
8. Krangel MS, Hemandez-Munain C, Lauzurica P, McMurry M, Roberts JL, Zhong XP. Developmental regulation of V(D)J recombination at the TCR alpha/delta locus. Immunol Rev. 1998;165:131-147.
9. Khor B, Sleckman BP. Allelic exclusion at the TCRβ locus. Curr Opin Immunol. 2002;14:230-234.
10. Krangel MS, Yssel H, Brocklehurst C, Spits H. A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. J Exp Med. 1990;172:847-859
11. Zhang XM, Tonnelle C, Lefranc MP, Huck S. T cell receptor gamma cDNA in human fetal liver and thymus: variable regions of gamma chains are restricted to V gamma I or V9, due to the absence of splicing of the V10 and V11 leader intron. Eur J Immunol. 1994;24:571-578.
12. Roberts JL, Lauzurica P, Krangel MS. Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer. J Exp Med. 1997;185:131-140.
13. Hayday AC. γδ Cells: a right time and a right place for a conserved third way of protection. Annu Rev Immunol. 2000;18:975-1026.
14. Hayday AC, Barber DF, Douglas N, Hoffman ES. Signals involved in gamma/delta T cell versus alpha/beta T cell lineage commitment. Semin Immunol. 1999;11:239-249.
15. MacDonald HR, Radtke F, Wilson A. T cell fate specification and αβ/γδ lineage commitment. Curr Opin Immunol. 2001;13:219-224.
16. Kruisbeek AM, Haks MC, Carleton M, Michie AM, Zuniga-Pflucker JC, Wiest DL. Branching out to gain control: how the pre-TCR is linked to multiple functions. Immunol Today. 2000;21:637-644.
17. von Boehmer H, Aifantis I, Feinberg J, et al. Pleiotropic changes controlled by the pre-T-cell receptor. Curr Opin Immunol. 1999;11:135-142.
18. Leduc I, Hempel WM, Mathieu N, et al. T cell development in TCR beta enhancer-deleted mice: implications for alpha beta T cell lineage commitment and differentiation. J Immunol. 2000;165:1364-1373.
19. Livak F, Wilson A, MacDonald HR, Schatz DG. Alpha beta lineage-committed thymocytes can be rescued by the gamma delta T cell receptor (TCR) in the absence of TCR beta chain. Eur J Immunol. 1997;27:2948-2958.
20. Breit TM, Wolvers-Tettero IL, van Dongen JJ. Phenotypic and genotypic characteristics of human early T-cell differentiation: the T-cell acute lymphoblastic leukaemia model. Res Immunol. 1994;145:139-143; discussion 155-138.
21. Bene MC, Castoldi G, Knapp W, et al. Proposals for the immunological classification of acute leukemias: European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia. 1995;9:1783-1786.
22. Brumpt C, Delabesse E, Beldjord K, et al. The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype. Blood. 2000;96:2254-2261.
23. Borst J, van Dongen JJ, de Vries E, et al. BMA031, a monoclonal antibody suited to identify the T-cell receptor alpha beta/CD3 complex on viable human T lymphocytes in normal and disease states. Hum Immunol. 1990;29:175-188.
24. Davodeau F, Houde I, Boulot G, et al. Secretion of disulfide-linked human T-cell receptor gamma delta heterodimers. J Biol Chem. 1993;268:15455-15460.
25. Brenner MB, McLean J, Scheft H, Warnke RA, Jones N, Strominger JL. Characterization and expression of the human alpha beta T cell receptor by using a framework monoclonal antibody. J Immunol. 1987;138:1502-1509.
26. Delabesse E, Burtin ML, Millien C, et al. Rapid, multifluorescent TCRG Vγ and Jγ typing: application to T cell acute lymphoblastic leukemia and to the detection of minor clonal populations. Leukemia. 2000;14:1143-1152.
27. van Dongen J, Langerak A, San Miguel J, et al. PCR-based clonality studies for early diagnosis of lymphoproliferative disorders: report of the Biomed-2 Concerted Action [abstract]. Blood. 2001;98:129a.
28. Macintyre EA, Smit L, Ritz J, Kirsch IR, Strominger JL. Disruption of the SCL locus in T-lymphoid malignancies correlates with commitment to the T-cell receptor alpha beta lineage. Blood. 1992;80:1511-1520
29. Barber DF, Passoni L, Wen L, Geng L, Hayday AC. The expression in vivo of a second isoform of pT alpha: implications for the mechanism of pT alpha action. J Immunol. 1998;161:11-16.
30. + acute lymphoblastic leukemias. Nouv Rev Fr Hematol. 1990;32:95-99.
31. + T-cell acute lymphoblastic leukemia. Leukemia. 1999;13:206-214.
32. Res P, Spits H. Developmental stages in the human thymus. Semin Immunol. 1999;11:39-46.
33. Bellavia D, Campese AF, Checquolo S, et al. Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A. 2002;99:3788-3793.
34. Allman D, Karnell FG, Punt JA, et al. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J Exp Med. 2001;194:99-106.
35. Hochstenbach F, Brenner MB. T-cell receptor delta-chain can substitute for alpha to form a beta delta heterodimer. Nature. 1989;340:562-565.
36. Wilson A, Capone M, MacDonald HR. Unexpectedly late expression of intracellular CD3ε and TCR γδ proteins during adult thymus development. Int Immunol. 1999;11:1641-1650.
37. Ramiro AR, Trigueros C, Marquez C, San Millan JL, Toribio ML. Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development. J Exp Med. 1996;184:519-530.
38. Fehling HJ, Krotkova A, Saint-Ruf C, von Boehmer H. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature. 1995;375:795-798.
39. Gounari F, Aifantis I, Martin C, et al. Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene. Nat Immunol. 2002;3:489-496.
40. + cells in the human thymus are defined by expression of CD34: delineation of early events in human thymic development. J Exp Med. 1993;178:391-401.
41. Terstappen LW, Huang S, Picker LJ. Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow. Blood. 1992;79:666-677.
42. Shortman K, Wu L. Early T lymphocyte progenitors. Annu Rev Immunol. 1996;14:29-47.
43. Bene MC, Bernier M, Casasnovas RO, et al. The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias: the European Group for the Immunological Classification of Leukemias (EGIL). Blood. 1998;92:596-599.
44. Blom B, Res PC, Spits H. T cell precursors in man and mice. Crit Rev Immunol. 1998;18:371-388.
45. Spits H, Lanier LL, Phillips JH. Development of human T and natural killer cells. Blood. 1995;85:2654-2670.
46. Lanier LL, Chang C, Spits H, Phillips JH. Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells: implications for the relationship of NK and T lymphocytes. J Immunol. 1992;149:1876-1880.
47. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392:245-252.
48. de Yebenes VG, Carrasco YR, Ramiro AR, Toribio ML. Identification of a myeloid intrathymic pathway of dendritic cell development marked by expression of the granulocyte macrophagecolony-stimulating factor receptor. Blood. 2002;99:2948-2956.
49. Res PC, Couwenberg F, Vyth-Dreese FA, Spits H. Expression of pTα mRNA in a committed dendritic cell precursor in the human thymus. Blood. 1999;94:2647-2657.
50. Chaperot L, Bendriss N, Manches O, et al. Identification of a leukemic counterpart of the plasmacytoid dendritic cells. Blood. 2001;97:3210-3217.
51. Calatayud S, Vivier E, Bernaud J, Merieux Y, Rigal D. Expression of a NK cell-restricted epitope on decidual large granular lymphocytes. Int Immunol. 1996;8:1637-1642.
52. Vivier E, Morin PM, O'Brien C, Schlossman SF, Anderson P. CD2 is functionally linked to the zeta-natural killer receptor complex. Eur J Immunol. 1991;21:1077-1080.
53. Sanchez MJ, Muench MO, Roncarolo MG, Lanier LL, Phillips JH. Identification of a common T/natural killer cell progenitor in human fetal thymus. J Exp Med. 1994;180:569-576.
54. Sanchez MJ, Spits H, Lanier LL, Phillips JH. Human natural killer cell committed thymocytes and their relation to the T cell lineage. J Exp Med. 1993;178:1857-1866.
55. Lee PT, Benlagha K, Teyton L, Bendelac A. Distinct functional lineages of human V(alpha)24 natural killer T cells. J Exp Med. 2002;195:637-641.
56. Galy A, Travis M, Cen D, Chen B. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity. 1995;3:459-473.
57. Katsura Y. Redefinition of lymphoid progenitors. Nat Rev Immunol. 2002;2:127-132.
58. Langerak AW, Wolvers-Tettero IL, van Gastel-Mol EJ, Oud ME, van Dongen JJ. Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells. Blood. 2001;98:2456-2465.
59. Lauzurica P, Krangel MS. Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene. J Exp Med. 1994;179:43-55.
60. Yoneda N, Tatsumi E, Kawano S, Matsuo Y, Minowada J, Yamaguchi N. Human recombination activating gene-1 in leukemia/lymphoma cells: expression depends on stage of lymphoid differentiation defined by phenotype and genotype. Blood. 1993;82:207-216.
61. Boeckx N, Willemse MJ, Szczepanski T, et al. Fusion gene transcripts and Ig/TCR gene rearrangements are complementary but infrequent targets for PCR-based detection of minimal residual disease in acute myeloid leukemia. Leukemia. 2002;16:368-375.
62. Wilson A, Held W, MacDonald HR. Two waves of recombinase gene expression in developing thymocytes. J Exp Med. 1994;179:1355-1360.
63. Herblot S, Steff AM, Hugo P, Aplan PD, Hoang T. SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression. Nat Immunol. 2000;1:138-144.
64. Breit TM, Mol EJ, Wolvers-Tettero IL, Ludwig WD, van Wering ER, van Dongen JJ. Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T-cell receptor α/β lineage: T-cell receptor δ gene deletion mechanism affects multiple genes. J Exp Med. 1993;177:965-977.
65. Ferrando AA, Neuberg DS, Staunton J, et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell. 2002;1:75-87.
66. Lefranc MP. IMGT, the international ImMunoGeneTics database. Nucleic Acids Res. 2001;29:207-209.