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Using a mouse model of SLE, the authors demonstrate that RAG is reinduced in antigen-activated early memory B cells during an autoimmune response.
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Wang Y.H., and Diamond B. B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice. J Clin Invest 118 (2008) 2896-2907. Using a mouse model of SLE, the authors demonstrate that RAG is reinduced in antigen-activated early memory B cells during an autoimmune response.
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Wang, Y.H.1
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Cooper C.J., Turk G.L., Sun M., Farr A.G., and Fink P.J. Cutting edge: TCR revision occurs in germinal centers. J Immunol 173 (2004) 6532-6536
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IL-6 contributes to the expression of RAGs in human mature B cells
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This paper reports that crosslinking CD40 and BCR of peripheral and tonsillar B cells in vitro induces IL-6 production, which binds to the receptors on the cells and induces RAG expression.
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Hillion S., Dueymes M., Youinou P., and Jamin C. IL-6 contributes to the expression of RAGs in human mature B cells. J Immunol 179 (2007) 6790-6798. This paper reports that crosslinking CD40 and BCR of peripheral and tonsillar B cells in vitro induces IL-6 production, which binds to the receptors on the cells and induces RAG expression.
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Mansson, R.1
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The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system
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0033551866
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Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5′ of RAG2
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Yu W., Misulovin Z., Suh H., Hardy R.R., Jankovic M., Yannoutsos N., and Nussenzweig M.C. Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5′ of RAG2. Science 285 (1999) 1080-1084
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Yu, W.1
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0030981639
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22544478763
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Identification of a third evolutionarily conserved gene within the RAG locus and its RAG1-dependent and -independent regulation
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Cebrat M., Miazek A., and Kisielow P. Identification of a third evolutionarily conserved gene within the RAG locus and its RAG1-dependent and -independent regulation. Eur J Immunol 35 (2005) 2230-2238
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Cebrat, M.1
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28
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NWC, a new gene within RAG locus: could it keep GOD under control?
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The authors propose and discuss the hypothesis that NWC transcription may suppress RAG transcription in nonlymphocytic cells.
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Kisielow P., Miazek A., and Cebrat M. NWC, a new gene within RAG locus: could it keep GOD under control?. Int J Immunogenet 35 (2008) 395-399. The authors propose and discuss the hypothesis that NWC transcription may suppress RAG transcription in nonlymphocytic cells.
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Kisielow, P.1
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34248216554
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Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection
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This paper shows that the activation of PI3K in immature B cells carrying an innocuous receptor results in the accumulation of PIP3, which recruits and activates PLCgamma2 to repress RAG expression.
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Verkoczy L., Duong B., Skog P., Ait-Azzouzene D., Puri K., Vela J.L., and Nemazee D. Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. J Immunol 178 (2007) 6332-6341. This paper shows that the activation of PI3K in immature B cells carrying an innocuous receptor results in the accumulation of PIP3, which recruits and activates PLCgamma2 to repress RAG expression.
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J Immunol
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Verkoczy, L.1
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Vela, J.L.6
Nemazee, D.7
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44449095675
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B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements
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This paper provides evidence that BCR crosslinking in immature B cells causes BCR downregulation, and thus decreases in basal signaling, which induces RAG expression.
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Schram B.R., Tze L.E., Ramsey L.B., Liu J., Najera L., Vegoe A.L., Hardy R.R., Hippen K.L., Farrar M.A., and Behrens T.W. B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements. J Immunol 180 (2008) 4728-4741. This paper provides evidence that BCR crosslinking in immature B cells causes BCR downregulation, and thus decreases in basal signaling, which induces RAG expression.
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J Immunol
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Schram, B.R.1
Tze, L.E.2
Ramsey, L.B.3
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Vegoe, A.L.6
Hardy, R.R.7
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31
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The PI3K p110delta is required for down-regulation of RAG expression in immature B cells
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Further evidence that PI3K signaling suppresses RAG expression.
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Llorian M., Stamataki Z., Hill S., Turner M., and Martensson I.L. The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. J Immunol 178 (2007) 1981-1985. Further evidence that PI3K signaling suppresses RAG expression.
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Llorian, M.1
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32
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44049101651
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SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway
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This paper shows that nuclear accumulation of FoxO3a increases RAG expression through decreased signaling via PI(3)K-Akt pathway and Foxo phosphorylation.
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Herzog S., Hug E., Meixlsperger S., Paik J.H., DePinho R.A., Reth M., and Jumaa H. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol 9 (2008) 623-631. This paper shows that nuclear accumulation of FoxO3a increases RAG expression through decreased signaling via PI(3)K-Akt pathway and Foxo phosphorylation.
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Herzog, S.1
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Jumaa, H.7
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44049091757
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Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
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The authors demonstrate that FoxO1 regulates RAG transcription in response to various signals including PI(3)K inactivation and MAP kinase activation.
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Amin R.H., and Schlissel M.S. Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat Immunol 9 (2008) 613-622. The authors demonstrate that FoxO1 regulates RAG transcription in response to various signals including PI(3)K inactivation and MAP kinase activation.
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Amin, R.H.1
Schlissel, M.S.2
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Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
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This paper shows that diminished IL-7R signaling results in increased RAG expression in bone marrow B cells.
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Johnson K., Hashimshony T., Sawai C.M., Pongubala J.M., Skok J.A., Aifantis I., and Singh H. Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity 28 (2008) 335-345. This paper shows that diminished IL-7R signaling results in increased RAG expression in bone marrow B cells.
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Immunity
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Johnson, K.1
Hashimshony, T.2
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Singh, H.7
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T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression
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Roose J.P., Diehn M., Tomlinson M.G., Lin J., Alizadeh A.A., Botstein D., Brown P.O., and Weiss A. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol 1 (2003) E53
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PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation
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This paper show that in T cells Akt activation decreases NFAT activity, a negative regulator of RAG expression and that NFATc1 binds the RAG locus.
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Patra A.K., Drewes T., Engelmann S., Chuvpilo S., Kishi H., Hunig T., Serfling E., and Bommhardt U.H. PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation. J Immunol 177 (2006) 4567-4576. This paper show that in T cells Akt activation decreases NFAT activity, a negative regulator of RAG expression and that NFATc1 binds the RAG locus.
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Patra, A.K.1
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A conserved transcriptional enhancer regulates RAG gene expression in developing B cells
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Hsu L.Y., Lauring J., Liang H.E., Greenbaum S., Cado D., Zhuang Y., and Schlissel M.S. A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity 19 (2003) 105-117
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Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
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The authors show that FoxO1, not FoxO3, regulates RAG expression and binds Erag.
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Dengler H.S., Baracho G.V., Omori S.A., Bruckner S., Arden K.C., Castrillon D.H., Depinho R.A., and Rickert R.C. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol 12 (2008) 1388-1398. The authors show that FoxO1, not FoxO3, regulates RAG expression and binds Erag.
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42
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Foxp1 is an essential transcriptional regulator of B cell development
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Nat Immunol
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A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer
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Yannoutsos N., Barreto V., Misulovin Z., Gazumyan A., Yu W., Rajewsky N., Peixoto B.R., Eisenreich T., and Nussenzweig M.C. A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer. Nat Immunol 5 (2004) 443-450
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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
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Bain G., Maandag E.C., Izon D.J., Amsen D., Kruisbeek A.M., Weintraub B.C., Krop I., Schlissel M.S., Feeney A.J., van Roon M., et al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79 (1994) 885-892
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van Roon, M.10
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45
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Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros
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The authors provide ChIP data that Ikaros binds the RAG locus and that mice deficient in Ikaros do not express RAG.
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Reynaud D., Demarco I.A., Reddy K.L., Schjerven H., Bertolino E., Chen Z., Smale S.T., Winandy S., and Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol 9 (2008) 927-936. The authors provide ChIP data that Ikaros binds the RAG locus and that mice deficient in Ikaros do not express RAG.
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Reynaud, D.1
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Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608
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Zhang F., Thomas L.R., Oltz E.M., and Aune T.M. Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608. Nat Immunol 7 (2006) 1309-1316. This paper shows that mice carrying a mutation that overexpresses Zfp608 express low levels of RAG and is thus a negative regulator of RAG expression.
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Zhang, F.1
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A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes
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This paper provides ChIP data showing that p50, p65, and c-rel NF-κB subunits bind the RAG locus and have a role in regulating RAG in cells undergoing receptor editing.
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Verkoczy L., Ait-Azzouzene D., Skog P., Martensson A., Lang J., Duong B., and Nemazee D. A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. Immunity 22 (2005) 519-531. This paper provides ChIP data showing that p50, p65, and c-rel NF-κB subunits bind the RAG locus and have a role in regulating RAG in cells undergoing receptor editing.
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Verkoczy, L.1
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