Cutting edge: T cell development requires the combined activities of the p110γ and p110δ catalytic isoforms of phosphatidylinositol 3-kinase

Journal of Immunology

Volumn 175, Issue 5, 2005, Pages 2783-2787

  Webb, Louise M C ^a   Vigorito, Elena ^a   Wymann, Matthias P ^b   Hirsch, Emilio ^c   Turner, Martin ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN P110; PROTEIN P110 DELTA; PROTEIN P110 GAMMA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CATALYSIS; CELL DEATH; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; THYMOCYTE;

EID: 23844462453     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.5.2783     Document Type: Article

References (26)

1. Michie, A. M., and J. C. Zuniga-Pflucker. 2002. Regulation of thymocyte differentiation: pre-TCR signals and β-selection. Semin. Immunol. 14: 311-323.
2. von Boehmer, H., I. Aifantis, J. Feinberg, O. Lechner, C. Saint-Ruf, U. Walter, J. Buer, and O. Azogui. 1999. Pleictropic changes controlled by the pre-T-cell receptor. Curr. Opin. Immunol. 11: 135-142.
3. Fruman, D. A. 2004. Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling. Curr. Opin. Immunol. 16: 314-320.
4. Okkenhaug, K., A. Bilancio, G. Farjot, H. Priddle, S. Sancho, E. Peskett, W. Pearce, S. E. Meek, A. Salpekar, M. D. Waterfield, A. J. Smith, and B. Vanhaesebroeck. 2002. Impaired B and T cell antigen receptor signaling in p110δ PI3-kinase mutant mice. Science 297: 1031-1034.
5. Sasaki, T., J. Irie-Sasald, R. G. Jones, A. J. Oliveira-dos-Santos, W. L. Stanford, B. Bolon, A. Wakeham, A. Itie, D. Bouchard, I. Kozietadzki, N. Joza, T. W. Mak, P. S. Ohashi, A. Suzuki, and J. M. Penninger. 2000. Function of PI3γ in thymocyte development, T cell activation, and neutrophil migration. Science 287: 1040-1046.
6. Hinton, H. J., D. R. Alessi, and D. A. Cantrell. 2004. The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development. Nat. Immunol. 5: 539-545.
7. Hagenbeek, T. J., M. Naspetti, F. Malergue, F. Garcon, J. A. Nunes, K. B. Cleutjens, J. Trapman, P. Krimpenfort, and H Spits. 2004. The loss of PTEN allows TCRαβ lineage thymocytes to bypass IL-7 and pre-TCR-mediated signaling. J. Exp. Med. 200: 883-894.
8. Clayton, E., G. Bardi, S. E. Bell, D. Chantry, C. P. Downes, A. Gray, L. A. Humphries, D. Rawlings, H. Reynolds, E. Vigorito, and M. Turner, 2002. A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 196: 753-763.
9. + precursors. Proc. Natl. Acad. Sci. USA 86: 7542-7546.
10. Donahue, A. C., and D. A. Fruman. 2003. Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J Immunol. 170: 5851-5860.
11. Aifantis, I., J. Buer, H. von Boehmer, and O. Azogui, 1997. Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor β locus. Immunity 7: 601-607.
12. Haks, M. C., P. Krimpenfort, J. H, van den Brakel, and A. M. Kruisbeek. 1999. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11:91-101.
13. Voll, R. E., E. Jimi, R. J. Phillips, D. F. Barber, M. Rincon, A. C. Hayday, R. A. Flavell, and S. Ghosh. 2000. NF-κB activation by the pte-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity 13: 677-689.
14. Costello, P. S., S. C. Cleverley, R. Galandtini, S. W. Henning, and D. A. Canttell. 2000. The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis. J. Exp. Med. 192: 77-85.
15. Marrack, P., and J. Kappler. 2004. Control of T cell viability. Annu. Rev. Immunol. 22: 765-787.
16. Liston, A., S. Lesage, D. H. Gray, L. A. O'Reilly, A. Strasser, A. M. Fahrer, R. L. Boyd, J. Wilson, A. G. Baxter, E. M. Gallo, G. R. Crabtree, K. Peng, S. R. Wilson, and C. C. Goodnow. 2004. Generalized resistance to thymic deletion in the NOD mouse: a polygenic trait characterized by defective induction of Bim. Immunity 21: 817-830.
17. + thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. Proc. Natl Acad. Sci. USA 101: 7052-7057.
18. Bouillet, P., J. F. Purton, D. I. Godfrey, L. C. Zhang, L. Coultas, H. Puthalakath, M. Pellegrini, S. Cory, J. M. Adams, and A. Strasser. 2002. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415: 922-926.
19. Jones, R. G., M. Parsons, M. Bonnard, V. S. Chan, W. C. Yeh, J. R. Woodgett, and P. S. Ohashi. 2000. Protein kinase B regulates T lymphocyte survival, nuclear factor κB activation, and Bcl-X(L) levels in vivo. J. Exp. Med. 191: 1721-1734.
20. Ma, A., J. C. Pena, B. Chang, E. Margosian, L. Davidson, F. W. Alt, and C. B. Thompson. 1995. Bclx regulates the survival of double-positive thymocytes. Proc. Natl. Acad. Sci. USA 92: 4763-4767.
21. Dijkers, P. F., K. U. Birkenkamp, E. W. Lam, N. S. Thomas, J. W. Lammets, L. Koenderman, and P. J. Coffer. 2002. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156: 531-542.
22. Goldtath, A. W., L. Y. Bogatzki, and M. J. Bevan. 2000. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J. Exp. Med. 192: 557-564.
23. Zamoyska, R., A. Basson, A. Filby, G. Legname, M. Lovatt, and B. Seddon. 2003. The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol. Rev. 191: 107-118.
24. Fujikawa, K., A. V, Miletic, F. W. Alt, R. Faccio, T. Brown, J. Hoog, J. Fredericks, S. Nishi, S. Mildiner, S. L. Moores, J. Brugge, F. S. Rosen, and W. Swat. 2003. Vav1/2/3-null mice define an essential role for Vav family proceins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J. Exp. Med. 198: 1595-1608.
25. Reynolds, L. F., L. A. Smyrh, T. Norton, N. Freshney, J. Downward, D. Kioussis, and V. L. Tybulewicz. 2002. Vav1 transduces T cell receptor signals to the activation of phospholipase C-γ1 via phosphoinositide 3-kinase-dependent and -independent pathways. J. Exp. Med. 195: 1103-1114.
26. 2+ mobilization and activation of NF-κB and NFAT. Nat. Immunol 2: 403-409.