-
1
-
-
0029065488
-
Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells
-
Fehling H.J., et al. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 375 (1995) 795-798
-
(1995)
Nature
, vol.375
, pp. 795-798
-
-
Fehling, H.J.1
-
2
-
-
0026485046
-
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
-
Mombaerts P., et al. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360 (1992) 225-231
-
(1992)
Nature
, vol.360
, pp. 225-231
-
-
Mombaerts, P.1
-
3
-
-
0029094319
-
Altered T cell development in mice with a targeted mutation of the CD3ε gene
-
Malissen M., et al. Altered T cell development in mice with a targeted mutation of the CD3ε gene. EMBO J. 14 (1995) 4641-4653
-
(1995)
EMBO J.
, vol.14
, pp. 4641-4653
-
-
Malissen, M.1
-
4
-
-
0030294283
-
Fyn can partially substitute for Lck in T lymphocyte development
-
Groves T., et al. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 5 (1996) 417-428
-
(1996)
Immunity
, vol.5
, pp. 417-428
-
-
Groves, T.1
-
5
-
-
0030886836
-
The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling
-
Cheng A.M., et al. The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 9797-9801
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 9797-9801
-
-
Cheng, A.M.1
-
6
-
-
0033103833
-
Essential role of LAT in T cell development
-
Zhang W., et al. Essential role of LAT in T cell development. Immunity 10 (1999) 323-332
-
(1999)
Immunity
, vol.10
, pp. 323-332
-
-
Zhang, W.1
-
7
-
-
0032540906
-
Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
-
Clements J.L., et al. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281 (1998) 416-419
-
(1998)
Science
, vol.281
, pp. 416-419
-
-
Clements, J.L.1
-
8
-
-
0032563256
-
Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
-
Pivniouk V., et al. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94 (1998) 229-238
-
(1998)
Cell
, vol.94
, pp. 229-238
-
-
Pivniouk, V.1
-
9
-
-
21844440323
-
Unique features of the pre-T-cell receptor α-chain: not just a surrogate
-
von Boehmer H. Unique features of the pre-T-cell receptor α-chain: not just a surrogate. Nat. Rev. Immunol. 5 (2005) 571-577
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 571-577
-
-
von Boehmer, H.1
-
10
-
-
24944444760
-
Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism
-
Ciofani M., and Zuniga-Pflucker J.C. Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism. Nat. Immunol. 6 (2005) 881-888
-
(2005)
Nat. Immunol.
, vol.6
, pp. 881-888
-
-
Ciofani, M.1
Zuniga-Pflucker, J.C.2
-
11
-
-
33745698041
-
A survival guide to early T cell development
-
Ciofani M., and Zuniga-Pflucker J.C. A survival guide to early T cell development. Immunol. Res. 34 (2006) 117-132
-
(2006)
Immunol. Res.
, vol.34
, pp. 117-132
-
-
Ciofani, M.1
Zuniga-Pflucker, J.C.2
-
12
-
-
0029556980
-
Cloning and comparative analysis of the human pre-T-cell receptor α-chain gene
-
Del Porto P., et al. Cloning and comparative analysis of the human pre-T-cell receptor α-chain gene. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 12105-12109
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 12105-12109
-
-
Del Porto, P.1
-
13
-
-
0030065493
-
A role for CD81 in early T cell development
-
Boismenu R., et al. A role for CD81 in early T cell development. Science 271 (1996) 198-200
-
(1996)
Science
, vol.271
, pp. 198-200
-
-
Boismenu, R.1
-
14
-
-
0028954224
-
Immune responses in MHC class II-deficient mice
-
Grusby M.J., and Glimcher L.H. Immune responses in MHC class II-deficient mice. Annu. Rev. Immunol. 13 (1995) 417-435
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 417-435
-
-
Grusby, M.J.1
Glimcher, L.H.2
-
15
-
-
0025313515
-
+ T cells
-
+ T cells. Science 248 (1990) 1227-1230
-
(1990)
Science
, vol.248
, pp. 1227-1230
-
-
Koller, B.H.1
-
16
-
-
84948730697
-
Different initiation of pre-TCR and γδTCR signalling
-
Saint-Ruf C., et al. Different initiation of pre-TCR and γδTCR signalling. Nature 406 (2000) 524-527
-
(2000)
Nature
, vol.406
, pp. 524-527
-
-
Saint-Ruf, C.1
-
17
-
-
0037124330
-
Constitutive endocytosis and degradation of the pre-T cell receptor
-
Panigada M., et al. Constitutive endocytosis and degradation of the pre-T cell receptor. J. Exp. Med. 195 (2002) 1585-1597
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1585-1597
-
-
Panigada, M.1
-
18
-
-
29244457799
-
Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development
-
Yamasaki S., et al. Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat. Immunol. 7 (2006) 67-75
-
(2006)
Nat. Immunol.
, vol.7
, pp. 67-75
-
-
Yamasaki, S.1
-
19
-
-
0033638003
-
On the dynamics of TCR:CD3 complex cell surface expression and downmodulation
-
Liu H., et al. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 13 (2000) 665-675
-
(2000)
Immunity
, vol.13
, pp. 665-675
-
-
Liu, H.1
-
20
-
-
0037443414
-
Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells
-
Haks M.C., et al. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. J. Immunol. 170 (2003) 2853-2861
-
(2003)
J. Immunol.
, vol.170
, pp. 2853-2861
-
-
Haks, M.C.1
-
21
-
-
1542373531
-
Pre-TCRα and TCRα are not interchangeable partners of TCRβ during T lymphocyte development
-
Borowski C., et al. Pre-TCRα and TCRα are not interchangeable partners of TCRβ during T lymphocyte development. J. Exp. Med. 199 (2004) 607-615
-
(2004)
J. Exp. Med.
, vol.199
, pp. 607-615
-
-
Borowski, C.1
-
22
-
-
3242695397
-
Impact of early expression of TCR α chain on thymocyte development
-
Huang C.Y., and Kanagawa O. Impact of early expression of TCR α chain on thymocyte development. Eur. J. Immunol. 34 (2004) 1532-1541
-
(2004)
Eur. J. Immunol.
, vol.34
, pp. 1532-1541
-
-
Huang, C.Y.1
Kanagawa, O.2
-
23
-
-
0032496362
-
Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains
-
Irving B.A., et al. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 280 (1998) 905-908
-
(1998)
Science
, vol.280
, pp. 905-908
-
-
Irving, B.A.1
-
24
-
-
0035801607
-
The biological activity of natural and mutant pTα alleles
-
Gibbons D., et al. The biological activity of natural and mutant pTα alleles. J. Exp. Med. 194 (2001) 695-703
-
(2001)
J. Exp. Med.
, vol.194
, pp. 695-703
-
-
Gibbons, D.1
-
25
-
-
0037515750
-
A role for the cytoplasmic tail of the pre-T cell receptor (TCR) α chain in promoting constitutive internalization and degradation of the pre-TCR
-
Carrasco Y.R., et al. A role for the cytoplasmic tail of the pre-T cell receptor (TCR) α chain in promoting constitutive internalization and degradation of the pre-TCR. J. Biol. Chem. 278 (2003) 14507-14513
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14507-14513
-
-
Carrasco, Y.R.1
-
26
-
-
0030847208
-
-/- mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or tailless pTα
-
-/- mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or tailless pTα. Immunity 6 (1997) 703-714
-
(1997)
Immunity
, vol.6
, pp. 703-714
-
-
Fehling, H.J.1
-
27
-
-
0036098502
-
A critical role for the cytoplasmic tail of pTα in T lymphocyte development
-
Aifantis I., et al. A critical role for the cytoplasmic tail of pTα in T lymphocyte development. Nat. Immunol. 3 (2002) 483-488
-
(2002)
Nat. Immunol.
, vol.3
, pp. 483-488
-
-
Aifantis, I.1
-
28
-
-
0025633003
-
Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity
-
Yoshimura A., et al. Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity. Nature 348 (1990) 647-649
-
(1990)
Nature
, vol.348
, pp. 647-649
-
-
Yoshimura, A.1
-
29
-
-
0027406812
-
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes
-
Shinkai Y., et al. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 259 (1993) 822-825
-
(1993)
Science
, vol.259
, pp. 822-825
-
-
Shinkai, Y.1
-
30
-
-
0027079356
-
Inhibition of T-cell receptor β-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck
-
Anderson S.J., et al. Inhibition of T-cell receptor β-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. EMBO J. 11 (1992) 4877-4886
-
(1992)
EMBO J.
, vol.11
, pp. 4877-4886
-
-
Anderson, S.J.1
-
31
-
-
0035895211
-
Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes
-
Michie A.M., et al. Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 609-614
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 609-614
-
-
Michie, A.M.1
-
32
-
-
0027489782
-
Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε
-
Levelt C.N., et al. Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 11401-11405
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 11401-11405
-
-
Levelt, C.N.1
-
33
-
-
0028174201
-
-/- mice in the absence of TCR β chain expression
-
-/- mice in the absence of TCR β chain expression. Int. Immunol. 6 (1994) 995-1001
-
(1994)
Int. Immunol.
, vol.6
, pp. 995-1001
-
-
Shinkai, Y.1
Alt, F.W.2
-
34
-
-
0028986925
-
CD3ε and CD3ζ cytoplasmic domains can independently generate signals for T cell development and function
-
Shinkai Y., et al. CD3ε and CD3ζ cytoplasmic domains can independently generate signals for T cell development and function. Immunity 2 (1995) 401-411
-
(1995)
Immunity
, vol.2
, pp. 401-411
-
-
Shinkai, Y.1
-
35
-
-
21844445331
-
The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire
-
Melchers F. The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire. Nat. Rev. Immunol. 5 (2005) 578-584
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 578-584
-
-
Melchers, F.1
-
36
-
-
0041732283
-
The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling
-
Ohnishi K., and Melchers F. The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling. Nat. Immunol. 4 (2003) 849-856
-
(2003)
Nat. Immunol.
, vol.4
, pp. 849-856
-
-
Ohnishi, K.1
Melchers, F.2
-
37
-
-
0036790940
-
Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering
-
Gauthier L., et al. Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 13014-13019
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 13014-13019
-
-
Gauthier, L.1
-
38
-
-
0042430496
-
Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of λ5 and stroma cell-associated heparan sulfate
-
Bradl H., et al. Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of λ5 and stroma cell-associated heparan sulfate. J. Immunol. 171 (2003) 2338-2348
-
(2003)
J. Immunol.
, vol.171
, pp. 2338-2348
-
-
Bradl, H.1
-
39
-
-
0033919659
-
Pre-B and pre-T-cell receptors: conservation of strategies in regulating early lymphocyte development
-
Muljo S.A., and Schlissel M.S. Pre-B and pre-T-cell receptors: conservation of strategies in regulating early lymphocyte development. Immunol. Rev. 175 (2000) 80-93
-
(2000)
Immunol. Rev.
, vol.175
, pp. 80-93
-
-
Muljo, S.A.1
Schlissel, M.S.2
-
40
-
-
0036097258
-
Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene
-
Gounari F., et al. Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene. Nat. Immunol. 3 (2002) 489-496
-
(2002)
Nat. Immunol.
, vol.3
, pp. 489-496
-
-
Gounari, F.1
-
41
-
-
0035881544
-
E2A and HEB activate the pre-TCR α promoter during immature T cell development
-
Takeuchi A., et al. E2A and HEB activate the pre-TCR α promoter during immature T cell development. J. Immunol. 167 (2001) 2157-2163
-
(2001)
J. Immunol.
, vol.167
, pp. 2157-2163
-
-
Takeuchi, A.1
-
42
-
-
0034670045
-
Competitive displacement of pTα by TCR-α during TCR assembly prevents surface coexpression of pre-TCR and αβ TCR
-
Trop S., et al. Competitive displacement of pTα by TCR-α during TCR assembly prevents surface coexpression of pre-TCR and αβ TCR. J. Immunol. 165 (2000) 5566-5572
-
(2000)
J. Immunol.
, vol.165
, pp. 5566-5572
-
-
Trop, S.1
-
43
-
-
0037769822
-
Analysis of TCR, pTα, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment
-
Asnafi V., et al. Analysis of TCR, pTα, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment. Blood 101 (2003) 2693-2703
-
(2003)
Blood
, vol.101
, pp. 2693-2703
-
-
Asnafi, V.1
-
44
-
-
0034600850
-
Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
-
Bellavia D., et al. Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 19 (2000) 3337-3348
-
(2000)
EMBO J.
, vol.19
, pp. 3337-3348
-
-
Bellavia, D.1
-
45
-
-
0037133497
-
Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
-
Bellavia D., et al. Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 3788-3793
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 3788-3793
-
-
Bellavia, D.1
-
46
-
-
0035796488
-
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
-
Allman D., et al. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J. Exp. Med. 194 (2001) 99-106
-
(2001)
J. Exp. Med.
, vol.194
, pp. 99-106
-
-
Allman, D.1
-
47
-
-
33645281796
-
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling
-
Campese A.F., et al. Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling. Blood 108 (2006) 305-310
-
(2006)
Blood
, vol.108
, pp. 305-310
-
-
Campese, A.F.1
-
48
-
-
0038725685
-
Negative selection - clearing out the bad apples from the T-cell repertoire
-
Palmer E. Negative selection - clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 3 (2003) 383-391
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 383-391
-
-
Palmer, E.1
|