-
2
-
-
0026510805
-
Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates
-
Bustelo, X.R., J.A. Ledbetter, and M. Barbacid. 1992. Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature. 356:68-71.
-
(1992)
Nature
, vol.356
, pp. 68-71
-
-
Bustelo, X.R.1
Ledbetter, J.A.2
Barbacid, M.3
-
3
-
-
0026535589
-
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs
-
Margolis, B., P. Hu, S. Katzav, W. Li, J.M. Oliver, A. Ullnch, A. Weiss, and J. Schlessinger. 1992. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature. 356:71-74.
-
(1992)
Nature
, vol.356
, pp. 71-74
-
-
Margolis, B.1
Hu, P.2
Katzav, S.3
Li, W.4
Oliver, J.M.5
Ullnch, A.6
Weiss, A.7
Schlessinger, J.8
-
4
-
-
0024433697
-
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
-
Katzav, S., D. Martin-Zanca, and M. Barbacid. 1989. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 8:2283-2290.
-
(1989)
EMBO J.
, vol.8
, pp. 2283-2290
-
-
Katzav, S.1
Martin-Zanca, D.2
Barbacid, M.3
-
5
-
-
0029911520
-
The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway
-
Teramoto, H., P. Crespo, O.A. Coso, T. Igishi, N.Z. Xu, and J.S. Gutkind. 1996. The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway. J. Biol.Chem. 271:25731-25734.
-
(1996)
J. Biol.Chem.
, vol.271
, pp. 25731-25734
-
-
Teramoto, H.1
Crespo, P.2
Coso, O.A.3
Igishi, T.4
Xu, N.Z.5
Gutkind, J.S.6
-
6
-
-
0028934827
-
Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway
-
Coso, O.A., M. Chiariello, G. Kalinec, J.M. Kyriakis, J. Woodgett, and J.S. Gutkind. 1995. Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway. J. Biol. Chem. 270:5620-5624.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 5620-5624
-
-
Coso, O.A.1
Chiariello, M.2
Kalinec, G.3
Kyriakis, J.M.4
Woodgett, J.5
Gutkind, J.S.6
-
7
-
-
0031042493
-
Rho, Rac and Cdc42 GT-Pases regulate the organization of the actin cytoskeleton
-
Tapon, N., and A. Hall. 1997. Rho, Rac and Cdc42 GT-Pases regulate the organization of the actin cytoskeleton. Curr. Opin. Cell Biol. 9:86-92.
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 86-92
-
-
Tapon, N.1
Hall, A.2
-
8
-
-
0029070887
-
Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
-
Minden, A., A. Lin, F.X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell. 81:1147-1157.
-
(1995)
Cell
, vol.81
, pp. 1147-1157
-
-
Minden, A.1
Lin, A.2
Claret, F.X.3
Abo, A.4
Karin, M.5
-
9
-
-
0028998794
-
Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors
-
Knaus, U.G., S. Morris, H.J. Dong, J. Chernoff, and G.M. Bokoch. 1995. Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science. 269:221-223.
-
(1995)
Science
, vol.269
, pp. 221-223
-
-
Knaus, U.G.1
Morris, S.2
Dong, H.J.3
Chernoff, J.4
Bokoch, G.M.5
-
10
-
-
0031105660
-
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
-
Sells, M.A., U.G. Knaus, S. Bagrodia, D.M. Ambrose, G.M. Bokoch, and J. Chernoff. 1997. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7:202-210.
-
(1997)
Curr. Biol.
, vol.7
, pp. 202-210
-
-
Sells, M.A.1
Knaus, U.G.2
Bagrodia, S.3
Ambrose, D.M.4
Bokoch, G.M.5
Chernoff, J.6
-
11
-
-
0027976785
-
Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein
-
Gulbins, E., K.M. Coggeshall, C. Langlet, G. Baier, N. Bonnefoyberard, P. Burn, A. Wittinghofer, S. Katzav, and A. Altman. 1994. Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein. Mol. Cell. Biol. 14:906-913.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 906-913
-
-
Gulbins, E.1
Coggeshall, K.M.2
Langlet, C.3
Baier, G.4
Bonnefoyberard, N.5
Burn, P.6
Wittinghofer, A.7
Katzav, S.8
Altman, A.9
-
12
-
-
0027207287
-
Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation
-
Gulbins, E., K.M. Coggeshall, G. Baier, S. Katzav, P. Burn, and A. Altman. 1993. Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science. 260:822-825.
-
(1993)
Science
, vol.260
, pp. 822-825
-
-
Gulbins, E.1
Coggeshall, K.M.2
Baier, G.3
Katzav, S.4
Burn, P.5
Altman, A.6
-
13
-
-
0031033292
-
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
-
Crespo, P., K.E. Schuebel, A.A. Ostrom, J.S. Gutkind, and X.R. Bustelo. 1997. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature. 385:169-172.
-
(1997)
Nature
, vol.385
, pp. 169-172
-
-
Crespo, P.1
Schuebel, K.E.2
Ostrom, A.A.3
Gutkind, J.S.4
Bustelo, X.R.5
-
14
-
-
0029836263
-
Rac-1 dependent stimulation of the Jnk/Sapk signaling pathway by Vav
-
Crespo, P., X.R. Bustelo, D.S. Aaronson, O.A. Coso, M. Lopez-Barahona, M. Barbacid, and J.S. Gutkind. 1996. Rac-1 dependent stimulation of the Jnk/Sapk signaling pathway by Vav. Oncogene. 13:455-460.
-
(1996)
Oncogene
, vol.13
, pp. 455-460
-
-
Crespo, P.1
Bustelo, X.R.2
Aaronson, D.S.3
Coso, O.A.4
Lopez-Barahona, M.5
Barbacid, M.6
Gutkind, J.S.7
-
15
-
-
0031034050
-
Lck regulates Vav activation of members of the Rho family of GTPases
-
Han, J.W., B. Das, W. Wei, L. Van Aelst, R.D. Mosteller, R. Khosravi-Far, J.K. Westwick, C.J. Der, and D. Broek. 1997. Lck regulates Vav activation of members of the Rho family of GTPases. Mol. Cell. Biol. 17:1346-1353.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1346-1353
-
-
Han, J.W.1
Das, B.2
Wei, W.3
Van Aelst, L.4
Mosteller, R.D.5
Khosravi-Far, R.6
Westwick, J.K.7
Der, C.J.8
Broek, D.9
-
16
-
-
0028904413
-
Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes
-
Fischer, K.D., A. Zmuldzinas, S. Gardner, M. Barbacid, A. Bernstein, and C. Guidos. 1995. Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Nature. 374:474-477.
-
(1995)
Nature
, vol.374
, pp. 474-477
-
-
Fischer, K.D.1
Zmuldzinas, A.2
Gardner, S.3
Barbacid, M.4
Bernstein, A.5
Guidos, C.6
-
17
-
-
0028956337
-
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
-
Tarakhovsky, A., M. Turner, S. Schaal, P.J. Mee, L.P. Duddy, K. Rajewsky, and V.L. Tybulewicz. 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature. 374:467-470.
-
(1995)
Nature
, vol.374
, pp. 467-470
-
-
Tarakhovsky, A.1
Turner, M.2
Schaal, S.3
Mee, P.J.4
Duddy, L.P.5
Rajewsky, K.6
Tybulewicz, V.L.7
-
18
-
-
0028915948
-
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
-
Zhang, R., F.W. Alt, L. Davidson, S.H. Orkin, and W. Swat. 1995. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature. 374:470-473.
-
(1995)
Nature
, vol.374
, pp. 470-473
-
-
Zhang, R.1
Alt, F.W.2
Davidson, L.3
Orkin, S.H.4
Swat, W.5
-
19
-
-
13144259727
-
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
-
Fischer, K.D., Y.Y. Kong, H. Nishina, K. Tedford, L.E.M. Marengere, I. Kozieradzki, T. Sasaki, M. Starr, G. Chan, S. Gardener, et al. 1998. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol. 8:554-562.
-
(1998)
Curr. Biol.
, vol.8
, pp. 554-562
-
-
Fischer, K.D.1
Kong, Y.Y.2
Nishina, H.3
Tedford, K.4
Marengere, L.E.M.5
Kozieradzki, I.6
Sasaki, T.7
Starr, M.8
Chan, G.9
Gardener, S.10
-
20
-
-
0032493028
-
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
-
Holsinger, L.J., I.A. Graef, W. Swat, T. Chi, D.M. Bautista, L. Davidson, R.S. Lewis, F.W. Alt, and G.R. Crabtree. 1998. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr. Biol. 8:563-572.
-
(1998)
Curr. Biol.
, vol.8
, pp. 563-572
-
-
Holsinger, L.J.1
Graef, I.A.2
Swat, W.3
Chi, T.4
Bautista, D.M.5
Davidson, L.6
Lewis, R.S.7
Alt, F.W.8
Crabtree, G.R.9
-
21
-
-
0030719389
-
A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes
-
Turner, M., P.J. Mee, A.E. Walters, M.E. Quinn, A.L. Mellor, R. Zamoyska, and V.L.J. Tybulewicz. 1997. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity. 7:451-460.
-
(1997)
Immunity
, vol.7
, pp. 451-460
-
-
Turner, M.1
Mee, P.J.2
Walters, A.E.3
Quinn, M.E.4
Mellor, A.L.5
Zamoyska, R.6
Tybulewicz, V.L.J.7
-
22
-
-
0023813094
-
Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells
-
Teh, H.S., P. Kisielow, B. Scott, H. Kishi, Y. Uematsu, H. Bluethmann, and H. von Boehmer. 1988. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature. 335:229-233.
-
(1988)
Nature
, vol.335
, pp. 229-233
-
-
Teh, H.S.1
Kisielow, P.2
Scott, B.3
Kishi, H.4
Uematsu, Y.5
Bluethmann, H.6
Von Boehmer, H.7
-
23
-
-
0024438903
-
T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice
-
Pircher, H., T.W. Mak, R. Lang, W. Ballhausen, E. Rueedi, H. Hengartner, R.M. Zinkernagel, and K. Buerki. 1989. T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice. EMBO J. 8:719-727.
-
(1989)
EMBO J.
, vol.8
, pp. 719-727
-
-
Pircher, H.1
Mak, T.W.2
Lang, R.3
Ballhausen, W.4
Rueedi, E.5
Hengartner, H.6
Zinkernagel, R.M.7
Buerki, K.8
-
24
-
-
0024502409
-
The thymus selects the useful, neglects the useless and destroys the harmful
-
von Boehmer, H., H.S. Teh, and P. Kisielow. 1989. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol. Today. 10:57-61.
-
(1989)
Immunol. Today
, vol.10
, pp. 57-61
-
-
Von Boehmer, H.1
Teh, H.S.2
Kisielow, P.3
-
25
-
-
0023683669
-
Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
-
Kisielow, P., H.S. Teh, H. Bluethmann, and H. von Boehmer. 1988. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature. 335:730-733.
-
(1988)
Nature
, vol.335
, pp. 730-733
-
-
Kisielow, P.1
Teh, H.S.2
Bluethmann, H.3
Von Boehmer, H.4
-
26
-
-
0028294682
-
Positive and negative thymocyte selection induced by different concentrations of a single peptide
-
Sebzda, E., V.A. Wallace, J. Mayer, R.S. Yeung, T.W. Mak, and P.S. Ohashi. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science. 263:1615-1618.
-
(1994)
Science
, vol.263
, pp. 1615-1618
-
-
Sebzda, E.1
Wallace, V.A.2
Mayer, J.3
Yeung, R.S.4
Mak, T.W.5
Ohashi, P.S.6
-
27
-
-
0030003476
-
Mature T cell reactivity altered by peptide agonist that induces positive selection
-
Sebzda, E., T.M. Kuendig, C.T. Thomson, K. Aoki, S.Y. Mak, J.P. Mayer, T. Zamborelli, S.G. Nathenson, and P.S. Ohashi. 1996. Mature T cell reactivity altered by peptide agonist that induces positive selection. J. Exp. Med. 183:1093-1104.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1093-1104
-
-
Sebzda, E.1
Kuendig, T.M.2
Thomson, C.T.3
Aoki, K.4
Mak, S.Y.5
Mayer, J.P.6
Zamborelli, T.7
Nathenson, S.G.8
Ohashi, P.S.9
-
29
-
-
0031029214
-
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
-
Nishina, H., K.D. Fischer, L. Radvanyi, A. Shahinian, R. Hakem, E.A. Rubie, A. Bernstein, T.W. Mak, J.R. Woodgett, and J.M. Penninger. 1997. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature. 385:350-353.
-
(1997)
Nature
, vol.385
, pp. 350-353
-
-
Nishina, H.1
Fischer, K.D.2
Radvanyi, L.3
Shahinian, A.4
Hakem, R.5
Rubie, E.A.6
Bernstein, A.7
Mak, T.W.8
Woodgett, J.R.9
Penninger, J.M.10
-
30
-
-
0027450332
-
Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells
-
Pircher, H., K. Brduscha, U. Steinhoff, M. Kasai, T. Mizuochi, R.M. Zinkernagel, H. Hengartner, B. Kyewski, and K.P. Mueller. 1993. Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells. Eur. J. Immunol. 23:669-674.
-
(1993)
Eur. J. Immunol.
, vol.23
, pp. 669-674
-
-
Pircher, H.1
Brduscha, K.2
Steinhoff, U.3
Kasai, M.4
Mizuochi, T.5
Zinkernagel, R.M.6
Hengartner, H.7
Kyewski, B.8
Mueller, K.P.9
-
31
-
-
0027979892
-
Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry
-
Schmid, I., C.H. Uittenbogaart, and J.V. Giorgi. 1994. Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry. 15: 12-20.
-
(1994)
Cytometry
, vol.15
, pp. 12-20
-
-
Schmid, I.1
Uittenbogaart, C.H.2
Giorgi, J.V.3
-
32
-
-
0029950290
-
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
-
Susin, S.A., N. Zamzami, M. Castedo, T. Hirsch, P. Marchetti, A. Macho, E. Daugas, M. Geuskens, and G. Kroemer. 1996. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J. Exp. Med. 184:1331-1341.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1331-1341
-
-
Susin, S.A.1
Zamzami, N.2
Castedo, M.3
Hirsch, T.4
Marchetti, P.5
Macho, A.6
Daugas, E.7
Geuskens, M.8
Kroemer, G.9
-
33
-
-
0029862706
-
Mitochondrial control of nuclear apoptosis
-
Zamzami, N., S.A. Susin, P. Marchetti, T. Hirsch, M.-I. Gomez, M. Castedo, and K. Guido. 1996. Mitochondrial control of nuclear apoptosis. J. Exp. Med. 183:1533-1544.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1533-1544
-
-
Zamzami, N.1
Susin, S.A.2
Marchetti, P.3
Hirsch, T.4
Gomez, M.-I.5
Castedo, M.6
Guido, K.7
-
34
-
-
0030271387
-
NF-kappa B: Ten years after
-
Baeuerle, P.A., and D. Baltimore. 1996. NF-kappa B: ten years after. Cell. 87:13-20.
-
(1996)
Cell
, vol.87
, pp. 13-20
-
-
Baeuerle, P.A.1
Baltimore, D.2
-
35
-
-
0028961573
-
Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton
-
Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181:577-584.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 577-584
-
-
Valitutti, S.1
Dessing, M.2
Aktories, K.3
Gallati, H.4
Lanzavecchia, A.5
-
36
-
-
0031980222
-
Molecular and cellular mechanisms of T lymphocyte apoptosis
-
Penninger, J.M., and G. Kroemer. 1998. Molecular and cellular mechanisms of T lymphocyte apoptosis. Adv. Immunol. 68:51-144.
-
(1998)
Adv. Immunol.
, vol.68
, pp. 51-144
-
-
Penninger, J.M.1
Kroemer, G.2
-
38
-
-
0029101644
-
Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
-
Zamzami, N., P. Marchetti, M. Castedo, D. Decaudin, A. Macho, T. Hirsch, S.A. Susin, P.X. Petit, B. Mignotte, and G. Kroemer. 1995. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med. 182: 367-377.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 367-377
-
-
Zamzami, N.1
Marchetti, P.2
Castedo, M.3
Decaudin, D.4
Macho, A.5
Hirsch, T.6
Susin, S.A.7
Petit, P.X.8
Mignotte, B.9
Kroemer, G.10
-
39
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
Yang, J., X. Liu, K. Bhalla, C.N. Kim, A.M. Ibrado, J. Cai, T.I. Peng, D.P. Jones, and X. Wang. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 275:1129-1132.
-
(1997)
Science
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
Kim, C.N.4
Ibrado, A.M.5
Cai, J.6
Peng, T.I.7
Jones, D.P.8
Wang, X.9
-
40
-
-
0030581151
-
Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
-
Liu, X., C.N. Kim, J. Yang, R. Jemmerson, and X. Wang. 1996. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86:147-157.
-
(1996)
Cell
, vol.86
, pp. 147-157
-
-
Liu, X.1
Kim, C.N.2
Yang, J.3
Jemmerson, R.4
Wang, X.5
-
41
-
-
0031037897
-
The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
-
Kluck, R.M., W.-E. Bossy, D.R. Green, and D.D. Newmeyer. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 275:1132-1136.
-
(1997)
Science
, vol.275
, pp. 1132-1136
-
-
Kluck, R.M.1
Bossy, W.-E.2
Green, D.R.3
Newmeyer, D.D.4
-
42
-
-
0030698056
-
Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus
-
Alam, A., M.Y. Braun, F. Hartgers, S. Lesage, L. Cohen, P. Hugo, F. Denis, and R.P. Sekaly. 1997. Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus. J. Exp. Med. 186:1503-1512.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1503-1512
-
-
Alam, A.1
Braun, M.Y.2
Hartgers, F.3
Lesage, S.4
Cohen, L.5
Hugo, P.6
Denis, F.7
Sekaly, R.P.8
-
44
-
-
15144353776
-
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
-
Han, J.W., K. Luby-Phelps, B. Das, X.D. Shu, Y. Xia, R.D. Mosteller, U.M. Krishna, J.R. Falck, M.A. White, and D. Broek. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science. 279:558-560.
-
(1998)
Science
, vol.279
, pp. 558-560
-
-
Han, J.W.1
Luby-Phelps, K.2
Das, B.3
Shu, X.D.4
Xia, Y.5
Mosteller, R.D.6
Krishna, U.M.7
Falck, J.R.8
White, M.A.9
Broek, D.10
-
45
-
-
0030762437
-
The potential for isoenzyme-selective modulation of protein kinase C
-
Hofmann, J. 1997. The potential for isoenzyme-selective modulation of protein kinase C. FASEB J. 11:649-669.
-
(1997)
FASEB J.
, vol.11
, pp. 649-669
-
-
Hofmann, J.1
-
46
-
-
0031202791
-
Protein kinase C and tumorigenic potential
-
Baron-Delage, S., and G. Cherqui. 1997. Protein kinase C and tumorigenic potential. Bull. Cancer. 84:829-832.
-
(1997)
Bull. Cancer.
, vol.84
, pp. 829-832
-
-
Baron-Delage, S.1
Cherqui, G.2
-
47
-
-
0031964645
-
Anchoring proteins for protein kinase C: A means for isozyme selectivity
-
Mochly-Rosen, D., and A.S. Gordon. 1998. Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J. 12:35-42.
-
(1998)
FASEB J.
, vol.12
, pp. 35-42
-
-
Mochly-Rosen, D.1
Gordon, A.S.2
-
48
-
-
0027936679
-
Expression and biochemical characterization of human protein kinase C-theta
-
Baier, G., B.-G. Baier, N. Meller, K.M. Coggeshall, L. Giampa, D. Telford, N. Isakov, and A. Altman. 1994. Expression and biochemical characterization of human protein kinase C-theta. Eur. J. Biochem. 225:195-203.
-
(1994)
Eur. J. Biochem.
, vol.225
, pp. 195-203
-
-
Baier, G.1
Baier, B.-G.2
Meller, N.3
Coggeshall, K.M.4
Giampa, L.5
Telford, D.6
Isakov, N.7
Altman, A.8
-
49
-
-
0027287657
-
Unique expression pattern of protein kinase C-theta: High mRNA levels in normal mouse testes and in T-lymphocytic cells and neoplasms
-
Mischak, H., J. Goodnight, D.W. Henderson, S. Osada, S. Ohno, and J.F. Mushinski. 1993. Unique expression pattern of protein kinase C-theta: high mRNA levels in normal mouse testes and in T-lymphocytic cells and neoplasms. FEBS Lett. 326:51-55.
-
(1993)
FEBS Lett.
, vol.326
, pp. 51-55
-
-
Mischak, H.1
Goodnight, J.2
Henderson, D.W.3
Osada, S.4
Ohno, S.5
Mushinski, J.F.6
-
50
-
-
0027153592
-
Molecular cloning and expression of a cDNa encoding a novel isoenzyme of protein kinase C (nPKC). a new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets
-
Chang, J.D., Y. Xu, M.K. Raychowdhury, and J.A. Ware. 1993. Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets. J. Biol. Chem. 268:14208-14214.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14208-14214
-
-
Chang, J.D.1
Xu, Y.2
Raychowdhury, M.K.3
Ware, J.A.4
-
51
-
-
0032032140
-
Different protein kinase C isoenzymes regulate IL-2 receptor expression or IL-2 synthesis in human lymphocytes stimulated via the TCR
-
Szamel, M., A. Appel, R. Schwinzer, and K. Resch. 1998. Different protein kinase C isoenzymes regulate IL-2 receptor expression or IL-2 synthesis in human lymphocytes stimulated via the TCR. J. Immunol 160:2207-2214.
-
(1998)
J. Immunol
, vol.160
, pp. 2207-2214
-
-
Szamel, M.1
Appel, A.2
Schwinzer, R.3
Resch, K.4
-
52
-
-
0029670089
-
Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes
-
Baier, B.-G., F. Uberall, B. Bauer, F. Fresser, H. Wachter, H. Grunicke, G. Utermann, A. Altman, and G. Baier. 1996. Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes. Mol. Cell. Biol. 16:1842-1850.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1842-1850
-
-
Baier, B.-G.1
Uberall, F.2
Bauer, B.3
Fresser, F.4
Wachter, H.5
Grunicke, H.6
Utermann, G.7
Altman, A.8
Baier, G.9
-
53
-
-
0032101707
-
Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes
-
Werlen, G., E. Jacinto, Y. Xia, and M. Karin. 1998. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17: 3101-3111.
-
(1998)
EMBO J.
, vol.17
, pp. 3101-3111
-
-
Werlen, G.1
Jacinto, E.2
Xia, Y.3
Karin, M.4
-
54
-
-
0030906543
-
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2
-
Raab, M., A.J. da Silva, P.R. Findell, and C.E. Rudd. 1997. Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. Immunity. 6:155-164.
-
(1997)
Immunity
, vol.6
, pp. 155-164
-
-
Raab, M.1
Da Silva, A.J.2
Findell, P.R.3
Rudd, C.E.4
-
55
-
-
0029658306
-
p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells
-
Tuosto, L., F. Michel, and O. Acuto. 1996. p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J. Exp. Med. 184:1161-1166.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1161-1166
-
-
Tuosto, L.1
Michel, F.2
Acuto, O.3
-
56
-
-
0001584956
-
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
-
Wu, J., D.G. Motto, G.A. Koretzky, and A. Weiss. 1996. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity. 4:593-602.
-
(1996)
Immunity
, vol.4
, pp. 593-602
-
-
Wu, J.1
Motto, D.G.2
Koretzky, G.A.3
Weiss, A.4
-
57
-
-
0031909355
-
Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes
-
Jacinto, E., G. Werlen, and M. Karin. 1998. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity. 8:31-41.
-
(1998)
Immunity
, vol.8
, pp. 31-41
-
-
Jacinto, E.1
Werlen, G.2
Karin, M.3
-
58
-
-
0029874657
-
T cell antigen receptor signal transduction pathways
-
Cantrell, D. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol 14:259-274.
-
(1996)
Annu. Rev. Immunol
, vol.14
, pp. 259-274
-
-
Cantrell, D.1
-
59
-
-
0032513031
-
The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1
-
Arnould, T., E. Kim, L. Tsiokas, F. Jochimsen, W. Gruning, J.D. Chang, and G. Walz. 1998. The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1. J. Biol. Chem. 273:6013-6018.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 6013-6018
-
-
Arnould, T.1
Kim, E.2
Tsiokas, L.3
Jochimsen, F.4
Gruning, W.5
Chang, J.D.6
Walz, G.7
-
60
-
-
0028075246
-
Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras
-
Khosravi, F.-R., W.-M. Chrzanowska, P.A. Solski, A. Eva, K. Burridge, and C.J. Der. 1994. Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras. Mol. Cell. Biol. 14:6848-6857.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6848-6857
-
-
Khosravi, F.-R.1
Chrzanowska, W.-M.2
Solski, P.A.3
Eva, A.4
Burridge, K.5
Der, C.J.6
-
61
-
-
0030466893
-
Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases
-
Olson, M.F., N.G. Pasteris, J.L. Gorski, and A. Hall. 1996. Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Curr. Biol. 6:1628-1633.
-
(1996)
Curr. Biol.
, vol.6
, pp. 1628-1633
-
-
Olson, M.F.1
Pasteris, N.G.2
Gorski, J.L.3
Hall, A.4
-
62
-
-
0030931125
-
Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes
-
Nishina, H., M. Bachmann, A.J. Oliveira-dos-Santos, I. Kozieradzki, K.D. Fischer, B. Odermatt, A. Wakeham, A. Shahinian, H. Takimoto, A. Bernstein, et al. 1997. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J. Exp. Med. 186:941-953.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 941-953
-
-
Nishina, H.1
Bachmann, M.2
Oliveira-dos-Santos, A.J.3
Kozieradzki, I.4
Fischer, K.D.5
Odermatt, B.6
Wakeham, A.7
Shahinian, A.8
Takimoto, H.9
Bernstein, A.10
-
63
-
-
0030732750
-
+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: Implications for negative selection in the thymus
-
+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus. J. Exp. Med. 186: 1911-1922.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1911-1922
-
-
Punt, J.A.1
Havran, W.2
Abe, R.3
Sarin, A.4
Singer, A.5
-
64
-
-
0030820875
-
Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
-
Kothakota, S., T. Azuma, C. Reinhard, A. Klippel, J. Tang, K.T. Chu, T.J. McGarry, M.W. Kirschner, K. Koths, D.J. Kwiatkowski, and L.T. Williams. 1997. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science. 278:294-298.
-
(1997)
Science
, vol.278
, pp. 294-298
-
-
Kothakota, S.1
Azuma, T.2
Reinhard, C.3
Klippel, A.4
Tang, J.5
Chu, K.T.6
McGarry, T.J.7
Kirschner, M.W.8
Koths, K.9
Kwiatkowski, D.J.10
Williams, L.T.11
-
65
-
-
0030829514
-
Inhibition of apoptosis by the actin-regulatory protein gelsolin
-
Ohtsu, M., N. Sakai, H. Fujita, M. Kashiwagi, S. Gasa, S. Shimizu, Y. Eguchi, Y. Tsujimoto, Y. Sakiyama, K. Kobayashi, and N. Kuzumaki. 1997. Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J. 16:4650-4656.
-
(1997)
EMBO J.
, vol.16
, pp. 4650-4656
-
-
Ohtsu, M.1
Sakai, N.2
Fujita, H.3
Kashiwagi, M.4
Gasa, S.5
Shimizu, S.6
Eguchi, Y.7
Tsujimoto, Y.8
Sakiyama, Y.9
Kobayashi, K.10
Kuzumaki, N.11
-
66
-
-
0030878051
-
Gelsolin activates DNase I in vitro and in cystic fibrosis sputum
-
Davoodian, K., B.W. Ritchings, R. Ramphal, and M.R. Bubb. 1997. Gelsolin activates DNase I in vitro and in cystic fibrosis sputum. Biochemistry. 36:9637-9641.
-
(1997)
Biochemistry
, vol.36
, pp. 9637-9641
-
-
Davoodian, K.1
Ritchings, B.W.2
Ramphal, R.3
Bubb, M.R.4
-
67
-
-
0030707519
-
Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin
-
Brancolini, C., D. Lazarevic, J. Rodriguez, and C. Schneider. 1997. Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin. J. Cell Biol. 139:759-771.
-
(1997)
J. Cell Biol.
, vol.139
, pp. 759-771
-
-
Brancolini, C.1
Lazarevic, D.2
Rodriguez, J.3
Schneider, C.4
-
68
-
-
0030918572
-
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
-
Rudel, T., and G.M. Bokoch. 1997. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science. 276:1571-1574.
-
(1997)
Science
, vol.276
, pp. 1571-1574
-
-
Rudel, T.1
Bokoch, G.M.2
-
69
-
-
0031969695
-
Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis
-
Villa, P.G., W.J. Henzel, M. Sensenbrenner, C.E. Henderson, and B. Pettmann. 1998. Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis. J. Cell Sci. 111:713-722.
-
(1998)
J. Cell Sci.
, vol.111
, pp. 713-722
-
-
Villa, P.G.1
Henzel, W.J.2
Sensenbrenner, M.3
Henderson, C.E.4
Pettmann, B.5
-
70
-
-
0031930313
-
Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease
-
Yang, F.S., X.Y. Sun, W. Beech, B. Teter, S. Wu, J. Sigel, H.V. Vinters, S.A. Frautschy, and G.M. Cole. 1998. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am. J. Pathol. 152:379-389.
-
(1998)
Am. J. Pathol.
, vol.152
, pp. 379-389
-
-
Yang, F.S.1
Sun, X.Y.2
Beech, W.3
Teter, B.4
Wu, S.5
Sigel, J.6
Vinters, H.V.7
Frautschy, S.A.8
Cole, G.M.9
-
71
-
-
0031889132
-
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
-
Sakahira, H., M. Enari, and S. Nagata. 1998. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature. 391:96-99.
-
(1998)
Nature
, vol.391
, pp. 96-99
-
-
Sakahira, H.1
Enari, M.2
Nagata, S.3
-
72
-
-
16944366731
-
Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and Rhoa activities
-
Donovan, F.M., C.J. Pike, C.W. Cotman, and D.D. Cunningham. 1997. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J. Neurosci. 17:5316-5326.
-
(1997)
J. Neurosci.
, vol.17
, pp. 5316-5326
-
-
Donovan, F.M.1
Pike, C.J.2
Cotman, C.W.3
Cunningham, D.D.4
-
73
-
-
0030957458
-
Actin is cleaved during constitutive apoptosis
-
Brown, S.B., K. Bailey, and J. Savill. 1997. Actin is cleaved during constitutive apoptosis. Biochem. J. 323:233-237.
-
(1997)
Biochem. J.
, vol.323
, pp. 233-237
-
-
Brown, S.B.1
Bailey, K.2
Savill, J.3
-
74
-
-
0030888898
-
Actin cleavage by CPP-32/ apopain during the development of apoptosis
-
Mashima, T., M. Naito, K. Noguchi, D.K. Miller, D.W. Nicholson, and T. Tsuruo. 1997. Actin cleavage by CPP-32/ apopain during the development of apoptosis. Oncogene. 14: 1007-1012.
-
(1997)
Oncogene
, vol.14
, pp. 1007-1012
-
-
Mashima, T.1
Naito, M.2
Noguchi, K.3
Miller, D.K.4
Nicholson, D.W.5
Tsuruo, T.6
-
75
-
-
0029876247
-
Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition
-
Kayalar, C., T. Ord, M.P. Testa, L.T. Zhong, and D.E. Bredesen. 1996. Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition. Proc. Natl. Acad. Sci. USA. 93:2234-2238.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2234-2238
-
-
Kayalar, C.1
Ord, T.2
Testa, M.P.3
Zhong, L.T.4
Bredesen, D.E.5
-
76
-
-
0028788309
-
Microfilament reorganization during apoptosis: The role of Gas2, a possible substrate for ICE-like proteases
-
Brancolini, C., M. Benedetti, and C. Schneider. 1995. Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases. EMBO J. 14: 5179-5190.
-
(1995)
EMBO J.
, vol.14
, pp. 5179-5190
-
-
Brancolini, C.1
Benedetti, M.2
Schneider, C.3
-
77
-
-
0028934919
-
Proteolysis of fodrin (non-erythroid spectrin) during apoptosis
-
Martin, S.J., G.A. O'Brien, W.K. Nishioka, A.J. McGahon, A. Mahboubi, T.C. Saido, and D.R. Green. 1995. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J. Biol. Chem. 270:6425-6428.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 6425-6428
-
-
Martin, S.J.1
O'Brien, G.A.2
Nishioka, W.K.3
McGahon, A.J.4
Mahboubi, A.5
Saido, T.C.6
Green, D.R.7
-
78
-
-
0031012266
-
Selective modulation of protein kinase C-theta during T-cell activation
-
Monks, C.R., H. Kupfer, I. Tamir, A. Barlow, and A. Kupfer. 1997. Selective modulation of protein kinase C-theta during T-cell activation. Nature. 385:83-86.
-
(1997)
Nature
, vol.385
, pp. 83-86
-
-
Monks, C.R.1
Kupfer, H.2
Tamir, I.3
Barlow, A.4
Kupfer, A.5
-
79
-
-
0028409106
-
Intracellular signals that mediate thymic negative selection
-
Vasquez, N.J., L.P. Kane, and S.M. Hedrick. 1994. Intracellular signals that mediate thymic negative selection. Immunity. 1:45-56.
-
(1994)
Immunity
, vol.1
, pp. 45-56
-
-
Vasquez, N.J.1
Kane, L.P.2
Hedrick, S.M.3
-
80
-
-
0026763544
-
In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands
-
Nakayama, T., Y. Ueda, H. Yamada, E.W. Shores, A. Singer, and C.H. June. 1992. In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands. Science. 257:96-99.
-
(1992)
Science
, vol.257
, pp. 96-99
-
-
Nakayama, T.1
Ueda, Y.2
Yamada, H.3
Shores, E.W.4
Singer, A.5
June, C.H.6
-
81
-
-
0029824312
-
Lymphocyte apoptosis: Mediation by increased type 3 mositol 1,4,5-trisphosphate receptor
-
Khan, A.A., M.J. Soloski, A.H. Sharp, G. Schilling, D.M. Sabatini, S.H. Li, C.A. Ross, and S.H. Snyder. 1996. Lymphocyte apoptosis: mediation by increased type 3 mositol 1,4,5-trisphosphate receptor. Science. 273:503-507.
-
(1996)
Science
, vol.273
, pp. 503-507
-
-
Khan, A.A.1
Soloski, M.J.2
Sharp, A.H.3
Schilling, G.4
Sabatini, D.M.5
Li, S.H.6
Ross, C.A.7
Snyder, S.H.8
-
82
-
-
0030973158
-
Cells deficient in the inositol 1,4,5-trisphosphate receptor are resistant to apoptosis
-
Jayaraman, T., and A.R. Marks. 1997. Cells deficient in the inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Mol. Cell. Biol. 17:3005-3012.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 3005-3012
-
-
Jayaraman, T.1
Marks, A.R.2
-
83
-
-
0024468088
-
Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex
-
McConkey, D.J., P. Hartzell, P.-J.F. Amador S. Orrenius, and M. Jondal. 1989. Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex. J. Immunol 143:1801-1806.
-
(1989)
J. Immunol
, vol.143
, pp. 1801-1806
-
-
McConkey, D.J.1
Hartzell, P.2
Amador, P.-J.F.3
Orrenius, S.4
Jondal, M.5
|