BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Biochemical Journal

Volumn 401, Issue 1, 2007, Pages 29-38

  Sapkota, Gopal P ^a   Cummings, Lorna ^a   Newell, Felicity S ^a   Armstrong, Christopher ^a   Bain, Jennifer ^a   Frodin, Morten ^b   Grauert, Matthias ^c   Hoffmann, Matthias ^c   Schnapp, Gisela ^c   Steegmaier, Martin ^d   Cohen, Philip ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^d BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

Author keywords

BI D1870; Kinase specific inhibitor; Mitogen activated protein kinase (MAPK); p90 ribosomal S6 kinase (RSK); Phosphorylation

Indexed keywords

KINASE SPECIFIC INHIBITORS; MITOGEN-ACTIVATED PROTEIN KINASE (MAPK); PHOSPHORYLATION; RIBOSOMAL S6 KINASE (RSK);

CELLS; ESTERS; GROWTH KINETICS; HORMONES; MOLECULAR BIOLOGY;

ENZYME INHIBITION;

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; BI D1870; EPIDERMAL GROWTH FACTOR; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; P90 RIBOSOMAL S6 KINASE; PHORBOL ESTER; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE LKB1; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; S6 KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; DRUG POTENTIATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CELL LINE; CHROMONES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; ISOENZYMES; KINETICS; MORPHOLINES; PROTEIN KINASE INHIBITORS; PTERIDINES; RATS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA;

RATTUS;

EID: 33846312875     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20061088     Document Type: Article

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