Function of the nucleotide exchange activity of vav1 in t cell development and activation

Science Signaling

Volumn 2, Issue 101, 2009, Pages

  Saveliev, Alexander ^a   Vanes, Lesley ^a   Ksionda, Olga ^a   Rapley, Jonathan ^a   Smerdon, Stephen J ^a   Rittinger, Katrin ^a   Tybulewicz, Victor L J ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTEGRIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE D; RAC1 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VAV1 PROTEIN; VAV PROTEIN; VAV1 PROTEIN, MOUSE;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ADHESION; CELL MATURATION; CIRCULAR DICHROISM; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; LYMPHOCYTE PROLIFERATION; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THERMOSTABILITY; THYMOCYTE; WESTERN BLOTTING; ANIMAL; CYTOLOGY; GENETICS; PHYSIOLOGY; T LYMPHOCYTE; TRANSGENIC MOUSE;

MUS;

ANIMALS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MICE, TRANSGENIC; MUTATION; PROTO-ONCOGENE PROTEINS C-VAV; T-LYMPHOCYTES;

EID: 77649214306     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000420     Document Type: Article

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61. We thank D. Kioussis, A. O'Garra, and D. Baltimore for mouse strains; C. Marshall, M. Turner, and D. Cantrell for antibodies; L. Desire (ExonHit Therapeutics) for EHT1864 and EHT 4063; R. Köchl for help with image analysis; J. Janzen and S. Sriskantharajah for technical advice; Biological Services at NIMR for animal husbandry; and S. Ley for critical reading of the manuscript. A.S. was funded by a grant from the Leukaemia Research Fund. L.V., O.K., J.R., S.S., K.R., and V.T. were funded by the Medical Research Council.