Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

Journal of Experimental Medicine

Volumn 207, Issue 1, 2010, Pages 247-261

  Janas, Michelle L ^a   Varano, Gabriele ^a   Gudmundsson, Kristjan ^b   Noda, Mamiko ^c   Nagasawa, Takashi ^c   Turner, Martin ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; G PROTEIN COUPLED RECEPTOR; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE B; PROTEIN P101; PROTEIN P110; PROTEIN P110 DELTA; PROTEIN P110 GAMMA; STROMAL CELL DERIVED FACTOR 1; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVATION; IN VITRO STUDY; MOUSE; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STROMA CELL; THYMOCYTE; THYMUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CATALYTIC DOMAIN; CELL LINE; CHEMOKINE CXCL12; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CXCR4; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 76149086153     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20091430     Document Type: Article

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