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Volumn 29, Issue 20, 2009, Pages 5552-5563

Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G 1 and resection-mediated inhibition of NHEJ in G2

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; HISTONE H2AX; MRE11 PROTEIN; NIBRIN; RAD50 PROTEIN; TELOMERIC REPEAT BINDING FACTOR 2;

EID: 70350441980     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00476-09     Document Type: Article
Times cited : (94)

References (57)
  • 1
    • 0347990555 scopus 로고    scopus 로고
    • Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM
    • Bai, Y., and J. P. Murnane. 2003. Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM. Mol. Cancer Res. 1:1058-1069.
    • (2003) Mol. Cancer Res. , vol.1 , pp. 1058-1069
    • Bai, Y.1    Murnane, J.P.2
  • 2
    • 0035964864 scopus 로고    scopus 로고
    • Strand-specific postreplicative processing of mammalian telomeres
    • Bailey, S. M., M. N. Cornforth, A. Kurimasa, D. J. Chen, and E. H. Goodwin. 2001. Strand-specific postreplicative processing of mammalian telomeres. Science 293:2462-2465.
    • (2001) Science , vol.293 , pp. 2462-2465
    • Bailey, S.M.1    Cornforth, M.N.2    Kurimasa, A.3    Chen, D.J.4    Goodwin, E.H.5
  • 3
    • 4344605708 scopus 로고    scopus 로고
    • Strand-specific fluorescence in situ hybridization: The CO-FISH family
    • Bailey, S. M., E. H. Goodwin, and M. N. Cornforth. 2004. Strand-specific fluorescence in situ hybridization: the CO-FISH family. Cytogenet. Genome Res. 107:14-17.
    • (2004) Cytogenet. Genome Res. , vol.107 , pp. 14-17
    • Bailey, S.M.1    Goodwin, E.H.2    Cornforth, M.N.3
  • 6
  • 7
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma, S., B. P. Chen, M. Murphy, A. Kurimasa, and D. J. Chen. 2001. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276:42462-42467.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 10
    • 22144490491 scopus 로고    scopus 로고
    • DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
    • Celli, G., and T. de Lange. 2005. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell Biol. 7:712-718.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 712-718
    • Celli, G.1    De Lange, T.2
  • 11
    • 33746644257 scopus 로고    scopus 로고
    • Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination
    • Celli, G. B., E. Lazzerini Denchi, and T. de Lange. 2006. Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nat. Cell Biol. 8:885-890.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 885-890
    • Celli, G.B.1    Lazzerini Denchi, E.2    De Lange, T.3
  • 12
    • 33645800789 scopus 로고    scopus 로고
    • The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres
    • Chai, W., A. J. Sfeir, H. Hoshiyama, J. W. Shay, and W. E. Wright. 2006. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep. 7:225-230.
    • (2006) EMBO Rep. , vol.7 , pp. 225-230
    • Chai, W.1    Sfeir, A.J.2    Hoshiyama, H.3    Shay, J.W.4    Wright, W.E.5
  • 13
    • 0035869155 scopus 로고    scopus 로고
    • DNA-binding and strand-annealing activities of human Mre11: Implications for its roles in DNA double-strand break repair pathways
    • de Jager, M., M. L. Dronkert, M. Modesti, C. E. Beerens, R. Kanaar, and D. C. van Gent. 2001. DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways. Nucleic Acids Res. 29:1317-1325.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 1317-1325
    • De Jager, M.1    Dronkert, M.L.2    Modesti, M.3    Beerens, C.E.4    Kanaar, R.5    Van Gent, D.C.6
  • 15
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange, T. 2005. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19:2100-2110.
    • (2005) Genes Dev. , vol.19 , pp. 2100-2110
    • De Lange, T.1
  • 16
    • 0034437666 scopus 로고    scopus 로고
    • A new connection at human telomeres: Association of the Mre11 complex with TRF2
    • de Lange, T., and J. Petrini. 2000. A new connection at human telomeres: association of the Mre11 complex with TRF2. Cold Spring Harbor Symp. Quant. Biol. LXV:265-273.
    • (2000) Cold Spring Harbor Symp. Quant. Biol. , vol.65 , pp. 265-273
    • De Lange, T.1    Petrini, J.2
  • 18
    • 57049132043 scopus 로고    scopus 로고
    • 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
    • DOI 10.1038/nature07433, PII NATURE07433
    • Dimitrova, N., Y. C. Chen, D. L. Spector, and T. de Lange. 2008. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature 456:524-528. (Pubitemid 50304845)
    • (2008) Nature , vol.456 , Issue.7221 , pp. 524-528
    • Dimitrova, N.1    Chen, Y.-C.M.2    Spector, D.L.3    De Lange, T.4
  • 19
    • 33845419422 scopus 로고    scopus 로고
    • MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres
    • DOI 10.1101/gad.1496606
    • Dimitrova, N., and T. de Lange. 2006. MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev. 20:3238-3243. (Pubitemid 44904845)
    • (2006) Genes and Development , vol.20 , Issue.23 , pp. 3238-3243
    • Dimitrova, N.1    De Lange, T.2
  • 23
    • 33745685066 scopus 로고    scopus 로고
    • Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
    • Hockemeyer, D., J. P. Daniels, H. Takai, and T. de Lange. 2006. Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126:63-77.
    • (2006) Cell , vol.126 , pp. 63-77
    • Hockemeyer, D.1    Daniels, J.P.2    Takai, H.3    De Lange, T.4
  • 25
    • 43249105463 scopus 로고    scopus 로고
    • Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2
    • DOI 10.1101/gad.1634008
    • Konishi, A., and T. de Lange. 2008. Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev. 22:1221-1230. (Pubitemid 351656580)
    • (2008) Genes and Development , vol.22 , Issue.9 , pp. 1221-1230
    • Konishi, A.1    De Lange, T.2
  • 26
    • 34548317418 scopus 로고    scopus 로고
    • Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    • Lazzerini Denchi, E., and T. de Lange. 2007. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448:1068-1071.
    • (2007) Nature , vol.448 , pp. 1068-1071
    • Lazzerini Denchi, E.1    De Lange, T.2
  • 27
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • DOI 10.1126/science.1108297
    • Lee, J. H., and T. T. Paull. 2005. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308:551-554. (Pubitemid 40570585)
    • (2005) Science , vol.308 , Issue.5721 , pp. 551-554
    • Lee, J.-H.1    Paull, T.T.2
  • 28
    • 0035862948 scopus 로고    scopus 로고
    • Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe
    • Manolis, K. G., E. R. Nimmo, E. Hartsuiker, A. M. Carr, P. A. Jeggo, and R. C. Allshire. 2001. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. EMBO J. 20:210-221.
    • (2001) EMBO J. , vol.20 , pp. 210-221
    • Manolis, K.G.1    Nimmo, E.R.2    Hartsuiker, E.3    Carr, A.M.4    Jeggo, P.A.5    Allshire, R.C.6
  • 29
    • 0034749425 scopus 로고    scopus 로고
    • DNA damage-dependent nuclear dynamics of the Mre11 complex
    • Mirzoeva, O. K., and J. H. Petrini. 2001. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell. Biol. 21:281-288.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 281-288
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 30
    • 0029976325 scopus 로고    scopus 로고
    • Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae
    • Moore, J. K., and J. E. Haber. 1996. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:2164-2173.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2164-2173
    • Moore, J.K.1    Haber, J.E.2
  • 31
    • 29144450333 scopus 로고    scopus 로고
    • S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor
    • DOI 10.1101/gad.1373705
    • Morales, M., J. W. Theunissen, C. F. Kim, R. Kitagawa, M. B. Kastan, and J. H. Petrini. 2005. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev. 19:3043-3054. (Pubitemid 41798119)
    • (2005) Genes and Development , vol.19 , Issue.24 , pp. 3043-3054
    • Morales, M.1    Theunissen, J.-W.F.2    Bender Kim, C.F.3    Kitagawa, R.4    Kastan, M.B.5    Petrini, J.H.J.6
  • 32
    • 46249125488 scopus 로고    scopus 로고
    • How shelterin protects mammalian telomeres
    • Palm, W., and T. de Lange. 2008. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42:301-334.
    • (2008) Annu. Rev. Genet. , vol.42 , pp. 301-334
    • Palm, W.1    De Lange, T.2
  • 33
    • 63049101044 scopus 로고    scopus 로고
    • Regulatory ubiquitylation in response to DNA double-strand breaks
    • Amsterdam
    • Panier, S., and D. Durocher. 2009. Regulatory ubiquitylation in response to DNA double-strand breaks. DNA Repair (Amsterdam) 8:436-443.
    • (2009) DNA Repair , vol.8 , pp. 436-443
    • Panier, S.1    Durocher, D.2
  • 34
    • 25144469291 scopus 로고    scopus 로고
    • The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM
    • Paull, T. T., and J. H. Lee. 2005. The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM. Cell Cycle 4:737-740.
    • (2005) Cell Cycle , vol.4 , pp. 737-740
    • Paull, T.T.1    Lee, J.H.2
  • 35
    • 0142011461 scopus 로고    scopus 로고
    • The cellular response to DNA double-strand breaks: Defining the sensors and mediators
    • DOI 10.1016/S0962-8924(03)00170-3
    • Petrini, J., and T. H. Stracker. 2003. The cellular response to DNA double strand breaks: defining the sensors and mediators. Trends Cell Biol. 13:458-462. (Pubitemid 37289395)
    • (2003) Trends in Cell Biology , vol.13 , Issue.9 , pp. 458-462
    • Petrini, J.H.J.1    Stracker, T.H.2
  • 37
    • 13444309097 scopus 로고    scopus 로고
    • Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1
    • Reina-San-Martin, B., M. C. Nussenzweig, A. Nussenzweig, and S. Difilippantonio. 2005. Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc. Natl. Acad. Sci. USA 102:1590-1595.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1590-1595
    • Reina-San-Martin, B.1    Nussenzweig, M.C.2    Nussenzweig, A.3    Difilippantonio, S.4
  • 38
    • 30444445118 scopus 로고    scopus 로고
    • Interplay between human DNA repair proteins at a unique double-strand break in vivo
    • DOI 10.1038/sj.emboj.7600914, PII 7600914
    • Rodrigue, A., M. Lafrance, M. C. Gauthier, D. McDonald, M. Hendzel, S. C. West, M. Jasin, and J. Y. Masson. 2006. Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J. 25:222-231. (Pubitemid 43077310)
    • (2006) EMBO Journal , vol.25 , Issue.1 , pp. 222-231
    • Rodrigue, A.1    Lafrance, M.2    Gauthier, M.-C.3    McDonald, D.4    Hendzel, M.5    West, S.C.6    Jasin, M.7    Masson, J.-Y.8
  • 40
    • 0034888424 scopus 로고    scopus 로고
    • Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity
    • Silver, D. P., and D. M. Livingston. 2001. Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol. Cell 8:233-243.
    • (2001) Mol. Cell , vol.8 , pp. 233-243
    • Silver, D.P.1    Livingston, D.M.2
  • 42
    • 0035476710 scopus 로고    scopus 로고
    • T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang
    • Stansel, R. M., T. de Lange, and J. D. Griffith. 2001. T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J. 20:5532-5540.
    • (2001) EMBO J. , vol.20 , pp. 5532-5540
    • Stansel, R.M.1    De Lange, T.2    Griffith, J.D.3
  • 43
    • 33646106590 scopus 로고    scopus 로고
    • GammaH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
    • Amsterdam
    • Stucki, M., and S. P. Jackson. 2006. gammaH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amsterdam) 10:534-543.
    • (2006) DNA Repair , vol.10 , pp. 534-543
    • Stucki, M.1    Jackson, S.P.2
  • 44
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai, H., A. Smogorzewska, and T. de Lange. 2003. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13:1549-1556.
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    De Lange, T.3
  • 45
    • 35648986560 scopus 로고    scopus 로고
    • Ctp1/CtIP and the MRN Complex Collaborate in the Initial Steps of Homologous Recombination
    • DOI 10.1016/j.molcel.2007.10.016, PII S1097276507006983
    • Takeda, S., K. Nakamura, Y. Taniguchi, and T. T. Paull. 2007. Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol. Cell 28:351-352. (Pubitemid 350030570)
    • (2007) Molecular Cell , vol.28 , Issue.3 , pp. 351-352
    • Takeda, S.1    Nakamura, K.2    Taniguchi, Y.3    Paull, T.T.4
  • 46
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • van Steensel, B., and T. de Lange. 1997. Control of telomere length by the human telomeric protein TRF1. Nature 385:740-743.
    • (1997) Nature , vol.385 , pp. 740-743
    • Van Steensel, B.1    De Lange, T.2
  • 47
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., A. Smogorzewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 48
    • 27944496124 scopus 로고    scopus 로고
    • Functional human telomeres are recognized as DNA damage in G2 of the cell cycle
    • Verdun, R. E., L. Crabbe, C. Haggblom, and J. Karlseder. 2005. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol. Cell 20:551-561.
    • (2005) Mol. Cell , vol.20 , pp. 551-561
    • Verdun, R.E.1    Crabbe, L.2    Haggblom, C.3    Karlseder, J.4
  • 50
    • 24944494068 scopus 로고    scopus 로고
    • A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks
    • Williams, R. S., and J. A. Tainer. 2005. A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks. Mol. Cell 19:724-726.
    • (2005) Mol. Cell , vol.19 , pp. 724-726
    • Williams, R.S.1    Tainer, J.A.2
  • 51
    • 0034730633 scopus 로고    scopus 로고
    • NBS1 and TRF1 colocalize at PML bodies during late S/G2 phases in immortalized telomerase-negative cells: Implication of NBS1 in alternative lengthening of telomeres
    • Wu, G., W. H. Lee, and P. L. Chen. 2000. NBS1 and TRF1 colocalize at PML bodies during late S/G2 phases in immortalized telomerase-negative cells: Implication of NBS1 in alternative lengthening of telomeres. J. Biol. Chem. 275:30618-30622.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30618-30622
    • Wu, G.1    Lee, W.H.2    Chen, P.L.3
  • 52
    • 34548492016 scopus 로고    scopus 로고
    • MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control
    • Wu, Y., S. Xiao, and X. D. Zhu. 2007. MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nat. Struct. Mol. Biol. 14:832-840.
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 832-840
    • Wu, Y.1    Xiao, S.2    Zhu, X.D.3
  • 53
    • 10944219768 scopus 로고    scopus 로고
    • Control of sister chromatid recombination by histone H2AX
    • DOI 10.1016/j.molcel.2004.12.007, PII S1097276504007543
    • Xie, A., N. Puget, I. Shim, S. Odate, I. Jarzyna, C. H. Bassing, F. W. Alt, and R. Scully. 2004. Control of sister chromatid recombination by histone H2AX. Mol. Cell 16:1017-1025. (Pubitemid 40018410)
    • (2004) Molecular Cell , vol.16 , Issue.6 , pp. 1017-1025
    • Xie, A.1    Puget, N.2    Shim, I.3    Odate, S.4    Jarzyna, I.5    Bassing, C.H.6    Alt, F.W.7    Scully, R.8
  • 54
    • 33751583362 scopus 로고    scopus 로고
    • Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks
    • Yang, Y. G., A. Saidi, P. O. Frappart, W. Min, C. Barrucand, V. Dumon-Jones, J. Michelon, Z. Herceg, and Z. Q. Wang. 2006. Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. EMBO J. 25:5527-5538.
    • (2006) EMBO J. , vol.25 , pp. 5527-5538
    • Yang, Y.G.1    Saidi, A.2    Frappart, P.O.3    Min, W.4    Barrucand, C.5    Dumon-Jones, V.6    Michelon, J.7    Herceg, Z.8    Wang, Z.Q.9
  • 55
    • 35748968799 scopus 로고    scopus 로고
    • Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres
    • Zhong, Z. H., W. Q. Jiang, A. J. Cesare, A. A. Neumann, R. Wadhwa, and R. R. Reddel. 2007. Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J. Biol. Chem. 282:29314-29322.
    • (2007) J. Biol. Chem. , vol.282 , pp. 29314-29322
    • Zhong, Z.H.1    Jiang, W.Q.2    Cesare, A.J.3    Neumann, A.A.4    Wadhwa, R.5    Reddel, R.R.6
  • 56
    • 0035936554 scopus 로고    scopus 로고
    • Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
    • Zhu, J., S. Petersen, L. Tessarollo, and A. Nussenzweig. 2001. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr. Biol. 11:105-109.
    • (2001) Curr. Biol. , vol.11 , pp. 105-109
    • Zhu, J.1    Petersen, S.2    Tessarollo, L.3    Nussenzweig, A.4
  • 57
    • 0342561644 scopus 로고    scopus 로고
    • Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
    • Zhu, X. D., B. Kuster, M. Mann, J. H. Petrini, and T. de Lange. 2000. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat. Genet. 25:347-352.
    • (2000) Nat. Genet. , vol.25 , pp. 347-352
    • Zhu, X.D.1    Kuster, B.2    Mann, M.3    Petrini, J.H.4    De Lange, T.5


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