Human Rad50/Mre11 is a flexible complex that can tether DNA ends

Molecular Cell

Volumn 8, Issue 5, 2001, Pages 1129-1135

  De Jager, Martijn ^a   Van Noort, John ^b   Van Gent, Dik C ^a   Dekker, Cees ^b   Kanaar, Roland ^a   Wyman, Claire ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; MRE11 PROTEIN; OLIGOMER; PROTEIN; RAD50 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA METABOLISM; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; NONHUMAN; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; SCANNING FORCE MICROSCOPY;

ANIMALIA;

EID: 0035930329     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00381-1     Document Type: Article

References (39)

1. Structure of the Rad50/Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy
2. Conserved domains in DNA repair proteins and evolution of repair systems
3. Role of the human RAD51 protein in homologous recombination and double-stranded-break repair
4. Scanning force microscopy of nucleic acids and nucleoprotein assemblies
5. The hMre/hRad50 protein complex and Nijmegan breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
6. Promotion of Dnl4-catalyzed DNA end joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes
7. The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA
8. Recombinational repair of chromosomal DNA double-strand breaks generated by a restriction endonuclease
9. DNA-binding and strand-annealing activities of human Mre11: Implications for its roles in DNA double-strand break repair pathways
10. Human Rad50 is physically associated with human Mre11: Identification of a conserved multiprotein complex implicated in recombinational DNA repair
11. A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein
12. Bimodal activation of SMC ATPase by intra- and inter-molecular interactions
13. Closing the ring: Links between SMC proteins and chromosome partitioning, condensation, and supercoiling
14. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
15. Structural biochemistry and interaction architecture of the DNA double-strand break repair mre11 nuclease and Rad50-atpase
16. Molecular mechanisms of DNA double strand break repair
17. DNA double strand break repair in mammalian cells
18. Tying up loose ends: Nonhomologous end-joining in Saccaromyces cerevisiae
19. Crystal structure of the SMC head domain: An ABC ATPase with 900 residues antiparallel coiled-coil inserted
20. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
21. The symmetrical structure of structural maintenance of chromosomes (SMC) and MukB proteins: Long, antiparallel coiled coils, folded at a flexible hinge
22. DNA repair: Spot(light)s on chromatin
23. Functions of the yeast meiotic recombination genes, MRE11 and MRE2
24. X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil
25. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
26. The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
27. A mechanistic basis for Mre11-directed DNA joining at microhomologies
28. The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA
29. Polymer chain statistics and conformational analysis of DNA molecules with bends or sections of different flexibility
30. The SMC proteins and the coming of age of the chromosome scaffold hypothesis
31. Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast
32. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
33. Structural maintenance of chromosomes (SMC) proteins: Conserved molecular properties for multiple biological functions
34. Recombination factors of Saccharomyces cerevisiae
35. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
36. Complex formation and functional versatility of Mre11 of budding yeast in recombination
37. Unusual oligomerization required for activity of NtrC, a bacterial enhancer-binding protein
38. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
39. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice