Comparison of nonhomologous end joining and homologous recombination in human cells

DNA Repair

Volumn 7, Issue 10, 2008, Pages 1765-1771

  Mao, Zhiyong ^a   Bozzella, Michael ^a   Seluanov, Andrei ^a   Gorbunova, Vera ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

DNA repair; Homologous recombination; Nonhomologous end joining; Normal human fibroblasts

Indexed keywords

ARTICLE; CELL LINE; CHROMOSOME; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENE LOCATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR DYNAMICS; MOLECULAR GENETICS; NONHOMOLOGOUS END JOINING; PRIORITY JOURNAL;

CELL LINE; CHROMOSOMES, HUMAN; DNA BREAKS, DOUBLE-STRANDED; GENES, REPORTER; HUMANS; RECOMBINATION, GENETIC;

EID: 52049098230     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2008.06.018     Document Type: Article

References (22)

1. Haber J.E. Partners and pathways repairing a double-strand break. Trends Genet. 16 (2000) 259-264
2. Lieber M.R. The mechanism of human nonhomologous DNA end joining. J. Biol. Chem. 283 (2008) 1-5
3. Thompson L.H., and Schild D. Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutat. Res. 477 (2001) 131-153
4. Sonoda E., Hochegger H., Saberi A., Taniguchi Y., and Takeda S. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst.) 5 (2006) 1021-1029
5. Shrivastav M., De Haro L.P., and Nickoloff J.A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 18 (2008) 134-147
6. Frank-Vaillant M., and Marcand S. Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. Mol. Cell 10 (2002) 1189-1199
7. Morales C.P., Holt I., Ouellette M., Kaur K.J., Yan Y., Wilson K.S., White M.A., Wright W.E., and Shay J.W. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat. Genet. 21 (1999) 115-118
8. Seluanov A., Mittelman D., Pereira-Smith O.M., Wilson J.H., and Gorbunova V. DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 7624-7629
9. Johnson R.D., and Jasin M. Sister chromatid gene conversion is a prominent double strand break repair in mammalian cells. EMBO J. 19 (2000) 3398-3407
10. Mao Z., Seluanov A., Jiang Y., and Gorbunova V. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 13068-13073
11. Sargent R.G., Branneman M.A., and Wilson J.H. Repair of site-specific double-strand breaks in mammalian chromosome by homologous and illegitimate recombination. Mol. Cell. Biol. 17 (1997) 267-277
12. Puchta H. The repair of double-strand breaks in plants: mechanisms and consequences for genome evolution. J. Exp. Bot. 56 (2005) 1-14
13. Gorbunova V., and Levy A.A. How plants make ends meet: DNA double-strand break repair. Trends Plant Sci. 4 (1999) 263-269
14. Lieber M.R., and Karanjawala Z.E. Ageing, repetitive genomes and DNA damage. Nat. Rev. Mol. Cell. Biol. 5 (2004) 69-75
15. White C.I., and Haber J.E. Intermediates of recombination during mating type switching in Saccharomyces cerevisiae. EMBO J. 9 (1990) 663-673
16. Rudin N., Sugarman E., and Haber J.E. Genetic and physical analysis of double-strand break repair and recombination in Saccharomyces cerevisiae. Genetics 122 (1989) 519-534
17. Metzger L., and Iliakis G. Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells. Int. J. Radiat. Biol. 59 (1991) 1325-1339
18. Iliakis G.E., Cicilioni O., and Metzger L. Measurement of DNA double-strand breaks in CHO cells at various stages of the cell cycle using pulsed field gel electrophoresis: calibration by means of 125I decay. Int. J. Radiat. Biol. 59 (1991) 343-357
19. Kruger I., Rothkamm K., and Lobrich M. Enhanced fidelity for rejoining radiation-induced DNA double-strand breaks in the G2 phase of Chinese hamster ovary cells. Nucleic Acids Res. 32 (2004) 2677-2684
20. Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C., Recio M.J., Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P., Gennery A., Jeggo P.A., and Lobrich M. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol. Cell 16 (2004) 715-724
21. Kim J.S., Krasieva T.B., Kurumizaka H., Chen D.J., Taylor A.M., and Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J. Cell Biol. 170 (2005) 341-347
22. Rapp A., and Greulich K.O. After double-strand break induction by UV-A, homologous recombination and nonhomologous end joining cooperate at the same DSB if both systems are available. J. Cell Sci. 117 (2004) 4935-4945