Genetic Analysis of the DNA-dependent Protein Kinase Reveals an Inhibitory Role of Ku in Late S-G2 Phase DNA Double-strand Break Repair

Journal of Biological Chemistry

Volumn 276, Issue 48, 2001, Pages 44413-44418

  Fukushima, Toru ^a   Takata, Minoru ^a,e   Morrison, Ciaran ^b   Araki, Ryoko ^c   Fujimori, Akira ^a   Abe, Masumi ^c   Tatsumi, Kouichi ^c   Jasin, Maria ^d   Dhar, Pawan Kumar ^a   Sonoda, Eiichiro ^a   Chiba, Tsutomu ^a   Takeda, Shunichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^d Weill Cornell Medical Center   (United States)

^e KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; GENES; PROTEINS;

GENETIC ABLATION;

GENETIC ENGINEERING;

DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; PROTEIN DERIVATIVE; RAD54 PROTEIN; RESTRICTION ENDONUCLEASE; UNCLASSIFIED DRUG; DNA; DNA ACTIVATED PROTEIN KINASE; DNA BINDING PROTEIN; DNA BINDING PROTEINS; DNA-ACTIVATED PROTEIN KINASE; KU PROTEIN, HUMAN; NOCODAZOLE; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASES;

ANIMAL CELL; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CHROMATID; DNA BINDING; DNA STRAND BREAKAGE; GENE; GENE DISRUPTION; GENE LOCUS; GENE TARGETING; GENETIC ANALYSIS; HOMOLOGOUS RECOMBINATION; KU70 GENE; KU80 GENE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; ANIMAL; CELL CYCLE; CELL LINE; CHICKEN; DIMERIZATION; DNA DAMAGE; DNA REPAIR; EXON; GENETIC RECOMBINATION; GENETICS; GENOTYPE; METABOLISM; MOUSE; PHYSIOLOGY; RADIATION RESPONSE; WESTERN BLOTTING;

ANIMALIA; GALLUS GALLUS; VERTEBRATA;

ANIMAL; BLOTTING, WESTERN; CELL CYCLE; CELL LINE; CHICKENS; CHROMATIDS; DIMERIZATION; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, RADIATION; EXONS; G2 PHASE; GENOTYPE; MICE; NOCODAZOLE; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINATION, GENETIC; S PHASE; SUPPORT, NON-U.S. GOV'T;

EID: 0035977007     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106295200     Document Type: Article

References (38)

1. Smith, G. C. M., and Jackson, S. P. (1999) Genes Dev. 13, 916-934
2. Li, Z., Otevrel, T., Gao, Y., Cheng, H. L., Seed, B., Stamato, T. D., Taccioli, G. E., and Alt, F. W. (1995) Cell 83, 1079-1089
3. Critchlow, S. E., Bowater, R. P., and Jackson, S. P. (1997) Curr. Biol. 7, 588-598
4. Grawunder, U., Wilm, M., Wu, X., Kulesza, P., Wilson, T. E., Mann, M., and Lieber, M. R. (1997) Nature 388, 492-495
5. Wilson, T. E., Grawunder, U., and Lieber, M. R. (1997) Nature 388, 495-498
6. Mimori, T., and Hardin, J. A. (1986) J. Biol. Chem. 261, 10375-10379
7. Mimori, T., Ohosone, Y., Hama, N., Suwa, A., Akizuki, M., Homma, M., Griffith, A. J., and Hardin, J. A. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 1777-1781
8. Yaneva, M., kowalewski, T., and Lieber, M. R. (1997) EMBO J. 16, 5098-5112
9. Zakian, V. A. (1995) Cell 82, 685-687
10. Singleton, B. K., Torres-Arzayus, M. I., Rottinghaus, S. T., Taccioli, G. E., and Jeggo, P. A. (1999) Mol. Cell. Biol. 19, 3267-3277
11. Nussenzweig, A., Chen, C., da-Costa-Soares, V., Sanchez, M., Sokol, K., Nussenzweig, M. C., and Li, G. C. (1996) Nature 382, 551-555
12. Zhu, C., Bogue, M. A., Lim, D. S., Hasty, P., and Roth, D. B. (1996) Cell 86, 379-389
13. Gao, Y., Chaudhuri, J., Zhu, C., Davidson, L., Weaver, D. T., and Alt, F. W. (1998) Immunity 9, 367-376
14. Taccioli, G. E., Amatucci, A. G., Beamish, H. J., Gell, D., Xiang, X. H., Torres Arzayus, M. I., Priestley, A., Jackson, S. P., Marshak Rothstein, A., Jeggo, P. A., and Herrera, V. L. (1998) Immunity 9, 355-366
15. Ouyang, H., Nussenzweig, A., Kurimasa, A., da Costa Soares, V., Li, X., Cordon-Cardo, C., Li, W.-H., Cheong, N., Nussenzweig, M., Iliakis, G., Chen, D. J., and Li, G. C. (1997) J. Exp. Med. 186, 921-929
16. Li, G. C., Ouyang, H., Li, X., Nagasawa, H., Little, J. B., Chen, D. J., Ling, C. C., Fuks, Z., and Cordon-Cardo, C. (1998) Mol. Cell 2, 1-8
17. Nussenzweig, A., Sokol, K., Burgman, P., Li, L., and Li, G. C. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 13588-13593
18. Gao, Y., Sun, Y., Frank, K. M., Dikkes, P., Fujiwara, Y., Seidl, K. J., Sekiguchi, J. M., Rathbun, G. A., Swat, W., Wang, J., Bronson, R. T., Malynn, B. A., Bryans, M., Zhu, C., Chaudhuri, J., Davidson, L., Ferrini, R., Stamato, T., Orkin, S. H., Greenberg, M. E., and Alt, F. W. (1998) Cell 95, 891-902
19. Frank, K. M., Sekiguchi, J. M., Seidl, K. J., Swat, W., Rathbun, G. A., Cheng, H. L., Davidson, L., Kangaloo, L., and Alt, F. W. (1998)Nature 396, 173-177
20. Takata, M., Sasaki, M. S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi-Iwai, Y., Shinohara, A., and Takeda, S. (1998) EMBO J. 17, 5497-5508
21. Essers, J., van Steeg, H., de Wit, J., Swagemakers, S. M., Vermeij, M., Hoeijmakers, J. H., and Kanaar, R. (2000) EMBO J. 19, 1703-1710
22. Van Dyck, E., Stasiak, A. Z., Stasiak, A., and West, S. C. (1999) Nature 398, 728-731
23. Fujimori, A., Araki, R., Fukumura, R., Ohhata, T., Takahashi, H., Kawahara, A., Tatsumi, K., and Abe, M. (2000) Immunogenetics 51, 965-973
24. Bezzubova, O. Y., Silbergleit, A., Yamaguchi-Iwai, Y., Takeda, S., and Buerstedde, J. M. (1997) Cell 89, 185-193
25. Sugawara, H., Kurosaki, M., Takata, M., and Kurosaki, T. (1997) EMBO J. 16, 3078-3088
26. Sonoda, E., Sasaki, M. S., Buerstedde, J.-M., Bezzubova, O., Shinohara, A., Ogawa, H., Takata, M., Yamaguchi-Iwai, Y., and Takeda, S. (1998) EMBO J. 17, 598-608
27. Johnson, R. D., Liu, N., and Jasin, M. (1999) Nature 401, 397-399
28. Buerstedde, J. M., Reynaud, C. A., Humphries, E. H., Olson, W., Ewert, D. L., and Weill, J. C. (1990) EMBO J. 9, 921-927
29. Buerstedde, J. M., and Takeda, S. (1991) Cell 67, 179-188
30. Adachi, N., Ishino, T., Ishii, Y., Takeda, S., and Koyama, H. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 12109-12113
31. Lee, S. E., Moore, J. K., Holmes, A., Umezu, K., Kolodner, R. D., and Haber, J. E. (1998) Cell 94, 399-409
32. Liang, F., Han, M., Romanienko, P. J., and Jasin, M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 5172-5177
33. Liang, F., Romanienko, P. J., Weaver, D. T., Jeggo, P. A., and Jasin, M. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 8929-8933
34. Essers, J., Hendriks, R. W., Swagemakers, S. M. A., Troelstra, C., de Wit, J., Bootsma, D., Hoeijmakers, J. H. J., and Kanaar, R. (1997) Cell 89, 195-204
35. Gu, Y., Jin, S., Gao, Y., Weaver, D. T., and Alt, F. W. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 8076-8081
36. Bishop, D. K., Ear, U., Bhattacharyya, A., Calderone, C., Beckett, M., Weichselbaum, R. R., and Shinohara, A. (1998) J. Biol. Chem. 273, 21482-21488
37. Haber, J. E. (2000) Trends Genet. 16, 259-264
38. Richardson, C., Moynahan, M. E., and Jasin, M. (1998) Genes Dev. 12, 3831-3842