Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

Nature

Volumn 436, Issue 7053, 2005, Pages 1053-1057

  Neale, Matthew J ^a   Pan, Jing ^a   Keeney, Scott ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIODIVERSITY; CHEMICAL BONDS; DNA; ENZYMES; YEAST;

CLEAVAGES; MEOTIC RECOMBINATION; OLIGONUCLEOTIDES;

PROTEINS;

DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; OLIGONUCLEOTIDE; SPO11 PROTEIN;

DNA;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COVALENT BOND; DNA PROTEIN COMPLEX; DNA REPAIR; DNA STRAND BREAKAGE; GENETIC REGULATION; IMMUNOPRECIPITATION; MALE; MEIOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TESTIS; YEAST;

ANIMALS; CELL CYCLE PROTEINS; DNA; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; ESTERASES; EXODEOXYRIBONUCLEASES; MALE; MEIOSIS; MICE; NUCLEAR PROTEINS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TESTIS;

SACCHAROMYCETALES;

EID: 23944459784     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03872     Document Type: Article

References (29)

1. Keeney, S., Giroux, C. N. & Kleckner, N. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88, 375-384 (1997).
2. Bergerat, A. et al. An atypical topoisomerase II from Archaea with implications for meiotic recombination. Nature 386, 414-417 (1997).
3. Connelly, J. C. & Leach, D. R. Repair of DNA covalently linked to protein. Mol. Cell 13, 307-316 (2004).
4. Keeney, S. Mechanism and control of meiotic recombination initiation. Curr. Top. Dev. Biol. 52, 1-53 (2001).
5. Alani, E., Padmore, R. & Kleckner, N. Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell 61, 419-436 (1990).
6. Diaz, R. L., Alcid, A. D., Berger, J. M. & Keeney, S. Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Mol. Cell. Biol. 22, 1106-1115 (2002).
7. Liu, J., Wu, T.-C. & Lichten, M. The location and structure of double-strand DNA breaks induced during yeast meiosis: evidence for a covalently linked DNA-protein intermediate. EMBO J. 14, 4599-4608 (1995).
8. Paull, T. T. & Gellert, M. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell 1, 969-979 (1998).
9. Romanienko, P. J. & Camerini-Otero, R. D. Cloning, characterization, and localization of mouse and human SPO11. Genomics 61, 156-169 (1999).
10. Keeney, S. et al. A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p. Genomics 61, 170-182 (1999).
11. Baudat, F., Manova, K., Yuen, J. P., Jasin, M. & Keeney, S. Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. Mol. Cell 6, 989-998 (2000).
12. Romanienko, P. J. & Camerini-Otero, R. D. The mouse Spo11 gene is required for meiotic chromosome synapsis. Mol. Cell 6, 975-987 (2000).
13. Pittman, D. L. et al. Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog. Mol. Cell 1, 697-705 (1998).
14. Barchi, M. et al. Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol. Cell. Biol. (in the press).
15. Walker, J. V. & Nitiss, J. L. DNA topoisomerase II as a target for cancer chemotherapy. Cancer Invest. 20, 570-589 (2002).
16. Fortune, J. M. & Osheroff, N. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Prog. Nucleic Acid Res. Mol. Biol. 64, 221-253 (2000).
17. Pouliot, J. J., Yao, K. C., Robertson, C. A. & Nash, H. A. Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science 286, 552-555 (1999).
18. Stohr, B. A. & Kreuzer, K. N. Repair of topoisomerase-mediated DNA damage in bacteriophage T4. Genetics 158, 19-28 (2001).
19. Connelly, J. C., de Leau, E. S. & Leach, D. R. Nucleolytic processing of a protein-bound DNA end by the F. coli SbcCD (MR) complex. DNA Repair (Amst) 2, 795-807 (2003).
20. Stracker, T. H., Carson, C. T. & Weitzman, M. D. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature 418, 348-352 (2002).
21. Johnson, R. E., Kovvali, G. K., Prakash, L. & Prakash, S. Role of yeast Rth1 nuclease and its homologs in mutation avoidance, DNA repair, and DNA replication. Curr. Genet. 34, 21-29 (1998).
22. Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J. & Stahl, F. W. The double-strand-break repair model for recombination. Cell 33, 25-35 (1983).
23. Paques, F. & Haber, J. E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63, 349-404 (1999).
24. Hunter, N. & Kleckner, N. The single-end invasion: an asymmetric intermediate at the double- strand break to double-holliday junction transition of meiotic recombination. Cell 106, 59-70 (2001).
25. Shinohara, M., Gasior, S. L., Bishop, D. K. & Shinohara, A. Tid1/Rdh54 promotes colocalization of Rad51 and Dmc1 during meiotic recombination. Proc. Natl Acad. Sci. USA 97, 10814-10819 (2000).
26. Schwacha, A. & Kleckner, N. Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis. Cell 76, 51-63 (1994).
27. Henderson, K. A. & Keeney, S. Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks. Proc. Natl Acad. Sci. USA 101, 4519-4524 (2004).
28. Nitiss, J. L. et al. Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II. Cancer Res. 52, 4467-4472 (1992).
29. Longtine, M. S. et al. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14, 953-961 (1998).