The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres

Current Biology

Volumn 11, Issue 17, 2001, Pages 1328-1335

  Tsukamoto, Yasumasa ^a   Taggart, Andrew K P ^a   Zakian, Virginia A ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SACCHAROMYCES CEREVISIAE;

EID: 0035806977     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00372-4     Document Type: Article

References (49)

1. TLC1, the template RNA component of the Saccharomyces cerevisiae telomerase
2. Reverse transcriptase motifs in the catalytic subunit of telomerase
3. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
4. An in vitro assay for Saccharomyces telomerase requires EST1
5. The Est3 protein is a subunit of yeast telomerase
6. 1-3 telomeric DNA binding protein in vitro that affects telomere behavior in vivo
7. Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
8. Sir proteins, Rif proteins and Cdc13p bind Saccharomyces telomeres in vivo
9. A mutant with a defect in telomere elongation leads to senescence in yeast
10. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase α and the telomerase-associated Est1 protein
11. Cdc13 delivers separate complexes to the telomere for end protection and replication
12. Est1 and Cdc13 as comediators of telomerase access
13. Protein kinase activity of tel1p and mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase
14. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
15. An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae
16. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
17. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
18. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
19. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae
20. Identification of yeast mutants with altered telomere structure
21. The many interfaces of Mre11
22. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination
23. Complex formation and functional versatility of Mre11 of budding yeast in recombination
24. RAD50 protein of S. cerevisiae exhibits ATP-dependent DNA binding
25. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
26. The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae
27. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae
28. Components of the Ku-dependent nonhomologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
29. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast
30. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
31. Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast
32. The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination
33. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
34. An alternative pathway for yeast telomere maintenance rescues est- senescence
35. A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-Fluoro-orotic acid resistance
36. Characterization of double-strand break-induced recombination: Homology requirements and single-stranded DNA formation
37. 1-3 tails late in S phase
38. ATM-dependent phosphorylation of nibrin in response to radiation exposure
39. Accelerated telomere shortening in ataxia telangiectasia
40. The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells
41. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
42. The Mre11 complex and ATM: Collaborating to navigate S phase
43. The Saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation
44. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
45. Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids
46. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
47. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
48. Evidence for a new step in telomere maintenance
49. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint