Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks

DNA Repair

Volumn 8, Issue 10, 2009, Pages 1235-1241

  Zhang, Yu ^a   Shim, Eun Yong ^a   Davis, Melody ^a   Lee, Sang Eun ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Cell cycle; Double strand break; End joining; Repair choice

Indexed keywords

CYCLIN DEPENDENT KINASE 1; DNA LIGASE 4; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN LIF1; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL SURVIVAL; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CDC2 PROTEIN KINASE; CELL CYCLE; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA LIGASES; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 70149088145     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2009.07.007     Document Type: Article

References (45)

1. Kolodner R.D., Putnam C.D., and Myung K. Maintenance of genome stability in Saccharomyces cerevisiae. Science 297 (2002) 552-557
2. Wyman C., and Kanaar R. DNA double-strand break repair: all's well that ends well. Annu. Rev. Genet. 40 (2006) 363-383
3. Shrivastav M., De Haro L.P., and Nickoloff J.A. Regulation of DNA double-strand break repair pathway choice. Cell. Res. 18 (2008) 134-147
4. Daley J.M., Palmbos P.L., Wu D., and Wilson T.E. Nonhomologous end joining in yeast. Annu. Rev. Genet. 39 (2005) 431-451
5. Lieber M.R., Ma Y., Pannicke U., and Schwarz K. The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Rep. (Amst.) 3 (2004) 817-826
6. Gu J., and Lieber M.R. Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining. Genes Dev. 22 (2008) 411-415
7. Haber J.E. Transpositions and translocations induced by site-specific double-strand breaks in budding yeast. DNA Rep. (Amst) 5 (2006) 998-1009
8. Franco S., Alt F.W., and Manis J.P. Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. DNA Rep. (Amst.) 5 (2006) 1030-1041
9. Lee G.S., Neiditch M.B., Salus S.S., and Roth D.B. RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination. Cell 117 (2004) 171-184
10. Keeney S. Mechanism and control of meiotic recombination initiation. Curr. Top. Dev. Biol. 52 (2001) 1-53
11. Ira G., Pellicioli A., Balijja A., Wang X., Fiorani S., Carotenuto W., Liberi G., Bressan D., Wan L., Hollingsworth N.M., Haber J.E., and Foiani M. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431 (2004) 1011-1017
12. Aylon Y., Liefshitz B., and Kupiec M. The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J. 23 (2004) 4868-4875
13. Lee S.E., Mitchell R.A., Cheng A., and Hendrickson E.A. Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle. Mol. Cell. Biol. 17 (1997) 1425-1433
14. Takata M., Sasaki M.S., Sonoda E., Morrison C., Hashimoto M., Utsumi H., Yamaguchi-Iwai Y., Shinohara A., and Takeda S. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J 17 (1998) 5497-5508
15. Bressan D.A., Baxter B.K., and Petrini J.H. The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol. Cell. Biol. 19 (1999) 7681-7687
16. Ferreira M.G., and Cooper J.P. Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle. Genes Dev. 18 (2004) 2249-2254
17. Sonoda E., Hochegger H., Saberi A., Taniguchi Y., and Takeda S. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Rep. (Amst.) 5 (2006) 1021-1029
18. Paques F., and Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63 (1999) 349-404
19. Huertas P., Cortes-Ledesma F., Sartori A.A., Aguilera A., and Jackson S.P. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455 (2008) 689-692
20. Yun M.H., and Hiom K. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 459 (2009) 460-463
21. Chen F., Nastasi A., Shen Z., Brenneman M., Crissman H., and Chen D.J. Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52. Mutat. Res. 384 (1997) 205-211
22. Limbo O., Chahwan C., Yamada Y., de Bruin R.A., Wittenberg C., and Russell P. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol. Cell. 28 (2007) 134-146
23. Baroni E., Viscardi V., Cartagena-Lirola H., Lucchini G., and Longhese M.P. The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol. Cell. Biol. 24 (2004) 4151-4165
24. Daley J.M., and Wilson T.E. Rejoining of DNA double-strand breaks as a function of overhang length. Mol. Cell. Biol. 25 (2005) 896-906
25. Frank-Vaillant M., and Marcand S. Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. Mol. Cell. 10 (2002) 1189-1199
26. Rothkamm K., Kruger I., Thompson L.H., and Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol. 23 (2003) 5706-5715
27. Hinz J.M., Yamada N.A., Salazar E.P., Tebbs R.S., and Thompson L.H. Influence of double-strand-break repair pathways on radiosensitivity throughout the cell cycle in CHO cells. DNA Rep. (Amst.) 4 (2005) 782-792
28. Zhang Y., Hefferin M.L., Chen L., Shim E.Y., Tseng H.M., Kwon Y., Sung P., Lee S.E., and Tomkinson A.E. Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat. Struct. Mol. Biol. 14 (2007) 639-646
29. Shim E.Y., Ma J.L., Oum J.H., Yanez Y., and Lee S.E. The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks. Mol. Cell. Biol. 25 (2005) 3934-3944
30. Valencia M., Bentele M., Vaze M.B., Herrmann G., Kraus E., Lee S.E., Schar P., and Haber J.E. NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature 414 (2001) 666-669
31. Pierce A.J., Hu P., Han M., Ellis N., and Jasin Ku M. DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15 (2001) 3237-3242
32. Allen C., Kurimasa A., Brenneman M.A., Chen D.J., and Nickoloff J.A. DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc. Natl. Acad. Sci. USA 99 (2002) 3758-3763
33. Clikeman J.A., Khalsa G.J., Barton S.L., and Nickoloff J.A. Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms. Genetics 157 (2001) 579-589
34. Kaplun L., Ivantsiv Y., Kornitzer D., and Raveh D. Functions of the DNA damage response pathway target Ho endonuclease of yeast for degradation via the ubiquitin-26S proteasome system. Proc. Natl. Acad. Sci. USA 97 (2000) 10077-10082
35. Karathanasis E., and Wilson T.E. Enhancement of Saccharomyces cerevisiae end-joining efficiency by cell growth stage but not by impairment of recombination. Genetics 161 (2002) 1015-1027
36. Lisby M., Barlow J.H., Burgess R.C., and Rothstein R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118 (2004) 699-713
37. Walker J.R., Corpina R.A., and Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412 (2001) 607-614
38. Krogh B.O., and Symington L.S. Recombination proteins in yeast. Annu. Rev. Genet. 38 (2004) 233-271
39. Palmbos P.L., Wu D., Daley J.M., and Wilson T.E. Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain. Genetics 180 (2008) 1809-1819
40. Teo S.H., and Jackson S.P. Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks. Curr. Biol. 10 (2000) 165-168
41. Foiani M., Liberi G., Lucchini G., and Plevani P. Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase alpha-primase B subunit. Mol. Cell. Biol. 15 (1995) 883-891
42. Muller-Tidow C., Ji P., Diederichs S., Potratz J., Baumer N., Kohler G., Cauvet T., Choudary C., van der Meer T., Chan W.Y., Nieduszynski C., Colledge W.H., Carrington M., Koeffler H.P., Restle A., Wiesmuller L., Sobczak-Thepot J., Berdel W.E., and Serve H. The cyclin A1-CDK2 complex regulates DNA double-strand break repair. Mol. Cell. Biol. 24 (2004) 8917-8928
43. Zhao X., and Blobel G. A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc. Natl. Acad. Sci. USA 102 (2005) 4777-4782
44. Clerici M., Mantiero D., Guerini I., Lucchini G., and Longhese M.P. The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Rep. 9 (2008) 810-818
45. Patterson E.E., and Fox C.A. The Ku complex in silencing the cryptic mating-type loci of Saccharomyces cerevisiae. Genetics 180 (2008) 771-783