-
1
-
-
0034213138
-
p38 MAP kinases: Beyond the stress response
-
Nebreda, A. R. and Porras, A. (2000) p38 MAP kinases: beyond the stress response. Trends Biochem. Sci. 25, 257-260
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 257-260
-
-
Nebreda, A.R.1
Porras, A.2
-
2
-
-
0033965158
-
The p38 signal transduction pathway Activation and function
-
DOI 10.1016/S0898-6568(99)00071-6, PII S0898656899000716
-
Ono, K. and Han, J. (2000) The p38 signal transduction pathway: activation and function. Cell. Signalling 12, 1-13 (Pubitemid 30017963)
-
(2000)
Cellular Signalling
, vol.12
, Issue.1
, pp. 1-13
-
-
Ono, K.1
Han, J.2
-
3
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
Kyriakis, J. M. and Avruch, J. (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81, 807-869
-
(2001)
Physiol. Rev.
, vol.81
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
4
-
-
34547154349
-
p38 MAP-kinases pathway regulation, function and role in human diseases
-
Cuenda, A. and Rousseau, S. (2007) p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim. Biophys. Acta 1773, 1358-1375
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 1358-1375
-
-
Cuenda, A.1
Rousseau, S.2
-
5
-
-
0027936755
-
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
-
Han, J., Lee, J.-D., Bibbs, L. and Ulevitch, R. J. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808-811
-
(1994)
Science
, vol.265
, pp. 808-811
-
-
Han, J.1
Lee, J.-D.2
Bibbs, L.3
Ulevitch, R.J.4
-
6
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Heys, J. R., Landvatter, S. W. et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739-746
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
-
7
-
-
0028022750
-
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
-
Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T. and Nebreda, A. R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027-1037
-
(1994)
Cell
, vol.78
, pp. 1027-1037
-
-
Rouse, J.1
Cohen, P.2
Trigon, S.3
Morange, M.4
Alonso-Llamazares, A.5
Zamanillo, D.6
Hunt, T.7
Nebreda, A.R.8
-
8
-
-
0028015872
-
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
-
DOI 10.1016/0092-8674(94)90278-X
-
Freshney, N. W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J. and Saklatvala, J. (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78, 1039-1049 (Pubitemid 24292331)
-
(1994)
Cell
, vol.78
, Issue.6
, pp. 1039-1049
-
-
Freshney, N.W.1
Rawlinson, L.2
Guesdon, F.3
Jones, E.4
Cowley, S.5
Hsuan, J.6
Saklatvala, J.7
-
9
-
-
0029982565
-
Characterization of the structure and function of a new mitogen-activated protein kinase (p38β)
-
Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J. A., Lin, S. and Han, J. (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J. Biol. Chem. 271, 17920-17926
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17920-17926
-
-
Jiang, Y.1
Chen, C.2
Li, Z.3
Guo, W.4
Gegner, J.A.5
Lin, S.6
Han, J.7
-
10
-
-
0029911710
-
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation
-
Lechner, C., Zahalka, M. A., Giot, J.-F., Moller, N. P. H. and Ullrich, A. (1996) ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proc. Natl. Acad. Sci. U.S.A. 93, 4355-4359
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 4355-4359
-
-
Lechner, C.1
Zahalka, M.A.2
Giot, J.-F.3
Moller, N.P.H.4
Ullrich, A.5
-
11
-
-
0029913458
-
SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
-
DOI 10.1016/0014-5793(96)00255-4
-
Mertens, S., Craxton, M. and Goedert, M. (1996) SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. FEBS Lett. 383, 273-276 (Pubitemid 26104075)
-
(1996)
FEBS Letters
, vol.383
, Issue.3
, pp. 273-276
-
-
Mertens, S.1
Craxton, M.2
Goedert, M.3
-
12
-
-
0030927106
-
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6): Comparison of its substrate specificity with that of other SAP kinases
-
Goedert, M., Cuenda, A., Craxton, M., Jakes, R. and Cohen, P. (1997) Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6): comparison of its substrate specificity with that of other SAP kinases. EMBO J. 16, 3563-3571
-
(1997)
EMBO J.
, vol.16
, pp. 3563-3571
-
-
Goedert, M.1
Cuenda, A.2
Craxton, M.3
Jakes, R.4
Cohen, P.5
-
13
-
-
0030828701
-
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38δ
-
Jiang, Y., Gram, H., Zhao, M., New, L., Gu, J., Feng, L., Di Padova, F., Ulevitch, R. J. and Han, J. (1997) Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38δ. J. Biol. Chem. 272, 30122-30128
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30122-30128
-
-
Jiang, Y.1
Gram, H.2
Zhao, M.3
New, L.4
Gu, J.5
Feng, L.6
Di Padova, F.7
Ulevitch, R.J.8
Han, J.9
-
14
-
-
0031916832
-
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
-
Enslen, H., Raingeaud, J. and Davis, R. J. (1998) Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J. Biol. Chem. 273, 1741-1748
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1741-1748
-
-
Enslen, H.1
Raingeaud, J.2
Davis, R.J.3
-
15
-
-
20244365497
-
P38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
-
DOI 10.1038/sj.emboj.7600578
-
Sabio, G., Arthur, J. S., Kuma, Y., Peggie, M., Carr, J., Murray-Tait, V., Centeno, F., Goedert, M., Morrice, N. A. and Cuenda, A. (2005) p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J. 24, 1134-1145 (Pubitemid 40516597)
-
(2005)
EMBO Journal
, vol.24
, Issue.6
, pp. 1134-1145
-
-
Sabio, G.1
Arthur, J.S.C.2
Kuma, Y.3
Peggie, M.4
Carr, J.5
Murray-Tait, V.6
Centeno, F.7
Goedert, M.8
Morrice, N.A.9
Cuenda, A.10
-
16
-
-
33846981476
-
Mxi2 promotes stimulus-independent ERK nuclear translocation
-
Casar, B., Sanz-Moreno, V., Yazicioglu, M. N., Rodriguez, J., Berciano, M. T., Lafarga, M., Cobb, M. H. and Crespo, P. (2007) Mxi2 promotes stimulus-independent ERK nuclear translocation. EMBO J. 26, 635-646
-
(2007)
EMBO J.
, vol.26
, pp. 635-646
-
-
Casar, B.1
Sanz-Moreno, V.2
Yazicioglu, M.N.3
Rodriguez, J.4
Berciano, M.T.5
Lafarga, M.6
Cobb, M.H.7
Crespo, P.8
-
17
-
-
4544324500
-
Exip, a splicing variant of p38α, participates in interleukin-1 receptor proximal complex and downregulates NF-κB pathway
-
Yagasaki, Y., Sudo, T. and Osada, H. (2004) Exip, a splicing variant of p38α, participates in interleukin-1 receptor proximal complex and downregulates NF-κB pathway. FEBS Lett. 575, 136-140
-
(2004)
FEBS Lett.
, vol.575
, pp. 136-140
-
-
Yagasaki, Y.1
Sudo, T.2
Osada, H.3
-
18
-
-
27744602322
-
Structural comparison of p38 inhibitor-protein complexes: A review of recent p38 inhibitors having unique binding interactions
-
Wrobleski, S. T. and Doweyko, A. M. (2005) Structural comparison of p38 inhibitor-protein complexes: a review of recent p38 inhibitors having unique binding interactions. Curr. Top. Med. Chem. 5, 1005-1016
-
(2005)
Curr. Top. Med. Chem.
, vol.5
, pp. 1005-1016
-
-
Wrobleski, S.T.1
Doweyko, A.M.2
-
19
-
-
34248200476
-
Crystal structure of the p38α-MAPKAP kinase 2 heterodimer
-
ter Haar, E., Prabhakar, P., Liu, X. and Lepre, C. (2007) Crystal structure of the p38α-MAPKAP kinase 2 heterodimer. J. Biol. Chem. 282, 9733-9739
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9733-9739
-
-
Ter Haar, E.1
Prabhakar, P.2
Liu, X.3
Lepre, C.4
-
20
-
-
34447295963
-
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
-
White, A., Pargellis, C. A., Studts, J. M., Werneburg, B. G. and Farmer, 2nd, B. T. (2007) Molecular basis of MAPK-activated protein kinase 2:p38 assembly. Proc. Natl. Acad. Sci. U.S.A. 104, 6353-6358
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 6353-6358
-
-
White, A.1
Pargellis, C.A.2
Studts, J.M.3
Werneburg, B.G.4
Farmer II, B.T.5
-
21
-
-
68349154213
-
The three-dimensional structure of MAP kinase p38β: Different features of the ATP-binding site in p38β compared with p38α
-
Patel, S. B., Cameron, P. M., O'Keefe, S. J., Frantz-Wattley, B., Thompson, J., O'Neill, E. A., Tennis, T., Liu, L., Becker, J. W. and Scapin, G. (2009) The three-dimensional structure of MAP kinase p38β: different features of the ATP-binding site in p38β compared with p38α. Acta Crystallogr. Sect. D Biol. Crystallogr. 65, 777-785
-
(2009)
Acta Crystallogr. Sect. D Biol. Crystallogr.
, vol.65
, pp. 777-785
-
-
Patel, S.B.1
Cameron, P.M.2
O'Keefe, S.J.3
Frantz-Wattley, B.4
Thompson, J.5
O'Neill, E.A.6
Tennis, T.7
Liu, L.8
Becker, J.W.9
Scapin, G.10
-
22
-
-
0033567706
-
The structure of phosphorylated p38γ is monomeric and reveals a conserved activation-loop conformation
-
Bellon, S., Fitzgibbon, M. J., Fox, T., Hsiao, H. M. and Wilson, K. P. (1999) The structure of phosphorylated p38γ is monomeric and reveals a conserved activation-loop conformation. Structure 7, 1057-1065
-
(1999)
Structure
, vol.7
, pp. 1057-1065
-
-
Bellon, S.1
Fitzgibbon, M.J.2
Fox, T.3
Hsiao, H.M.4
Wilson, K.P.5
-
23
-
-
0034704178
-
Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength
-
Alonso, G., Ambrosino, C., Jones, M. and Nebreda, A. R. (2000) Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength. J. Biol. Chem. 275, 40641-40648
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40641-40648
-
-
Alonso, G.1
Ambrosino, C.2
Jones, M.3
Nebreda, A.R.4
-
24
-
-
0028969480
-
Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells
-
Doza, N. Y., Cuenda, A., Thomas, G. M., Cohen, P. and Nebreda, A. R. (1995) Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells. FEBS Lett. 364, 223-228
-
(1995)
FEBS Lett.
, vol.364
, pp. 223-228
-
-
Doza, N.Y.1
Cuenda, A.2
Thomas, G.M.3
Cohen, P.4
Nebreda, A.R.5
-
25
-
-
0041660960
-
Mechanism of p38 MAP kinase activation in vivo
-
DOI 10.1101/gad.1107303
-
Brancho, D., Tanaka, N., Jaeschke, A., Ventura, J. J., Kelkar, N., Tanaka, Y., Kyuuma, M., Takeshita, T., Flavell, R. A. and Davis, R. J. (2003) Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 17, 1969-1978 (Pubitemid 36999324)
-
(2003)
Genes and Development
, vol.17
, Issue.16
, pp. 1969-1978
-
-
Brancho, D.1
Tanaka, N.2
Jaeschke, A.3
Ventura, J.-J.4
Kelkar, N.5
Tanaka, Y.6
Kyuuma, M.7
Takeshita, T.8
Flavell, R.A.9
Davis, R.J.10
-
26
-
-
34249331264
-
Novel strategies for inhibition of the p38 MAPK pathway
-
Zhang, J., Shen, B. and Lin, A. (2007) Novel strategies for inhibition of the p38 MAPK pathway. Trends Pharmacol. Sci. 28, 286-295
-
(2007)
Trends Pharmacol. Sci.
, vol.28
, pp. 286-295
-
-
Zhang, J.1
Shen, B.2
Lin, A.3
-
27
-
-
74449083698
-
MAPK isoforms by MKK6 and MKK3
-
MAPK isoforms by MKK6 and MKK3. Cell. Signalling 22, 660-667
-
(2010)
Cell. Signalling
, vol.22
, pp. 660-667
-
-
Remy, G.1
Risco, A.M.2
Iñesta-Vaquera, F.A.3
González-Terán, B.4
Sabio, G.5
Davis, R.J.6
Cuenda, A.7
-
28
-
-
58149201051
-
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
-
Min, X., Akella, R., He, H., Humphreys, J. M., Tsutakawa, S. E., Lee, S. J., Tainer, J. A., Cobb, M. H. and Goldsmith, E. J. (2009) The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure 17, 96-104
-
(2009)
Structure
, vol.17
, pp. 96-104
-
-
Min, X.1
Akella, R.2
He, H.3
Humphreys, J.M.4
Tsutakawa, S.E.5
Lee, S.J.6
Tainer, J.A.7
Cobb, M.H.8
Goldsmith, E.J.9
-
29
-
-
34248563299
-
Role of mitogen-activated protein kinase kinase kinases in signal integration
-
Cuevas, B. D., Abell, A. N. and Johnson, G. L. (2007) Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene 26, 3159-3171
-
(2007)
Oncogene
, vol.26
, pp. 3159-3171
-
-
Cuevas, B.D.1
Abell, A.N.2
Johnson, G.L.3
-
30
-
-
29144535648
-
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli
-
Zhuang, Z. H., Zhou, Y., Yu, M. C., Silverman, N. and Ge, B. X. (2006) Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Cell. Signalling 18, 441-448
-
(2006)
Cell. Signalling
, vol.18
, pp. 441-448
-
-
Zhuang, Z.H.1
Zhou, Y.2
Yu, M.C.3
Silverman, N.4
Ge, B.X.5
-
31
-
-
33846811520
-
p38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis
-
Dolado, I., Swat, A., Ajenjo, N., De Vita, G., Cuadrado, A. and Nebreda, A. R. (2007) p38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell 11, 191-205
-
(2007)
Cancer Cell
, vol.11
, pp. 191-205
-
-
Dolado, I.1
Swat, A.2
Ajenjo, N.3
De Vita, G.4
Cuadrado, A.5
Nebreda, A.R.6
-
32
-
-
9144253936
-
The ASK1-MAP kinase cascades in mammalian stress response
-
Tokyo
-
Matsukawa, J., Matsuzawa, A., Takeda, K. and Ichijo, H. (2004) The ASK1-MAP kinase cascades in mammalian stress response. J. Biochem. (Tokyo) 136, 261-265
-
(2004)
J. Biochem.
, vol.136
, pp. 261-265
-
-
Matsukawa, J.1
Matsuzawa, A.2
Takeda, K.3
Ichijo, H.4
-
33
-
-
53349164136
-
The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
-
Sorrentino, A., Thakur, N., Grimsby, S., Marcusson, A., von Bulow, V., Schuster, N., Zhang, S., Heldin, C. H. and Landstrom, M. (2008) The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat. Cell Biol. 10, 1199-1207
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 1199-1207
-
-
Sorrentino, A.1
Thakur, N.2
Grimsby, S.3
Marcusson, A.4
Von Bulow, V.5
Schuster, N.6
Zhang, S.7
Heldin, C.H.8
Landstrom, M.9
-
34
-
-
52049111663
-
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β
-
Yamashita, M., Fatyol, K., Jin, C., Wang, X., Liu, Z. and Zhang, Y. E. (2008) TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β. Mol. Cell 31, 918-924
-
(2008)
Mol. Cell
, vol.31
, pp. 918-924
-
-
Yamashita, M.1
Fatyol, K.2
Jin, C.3
Wang, X.4
Liu, Z.5
Zhang, Y.E.6
-
35
-
-
48749090228
-
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex
-
Matsuzawa, A., Tseng, P. H., Vallabhapurapu, S., Luo, J. L., Zhang, W., Wang, H., Vignali, D. A., Gallagher, E. and Karin, M. (2008) Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 321, 663-668
-
(2008)
Science
, vol.321
, pp. 663-668
-
-
Matsuzawa, A.1
Tseng, P.H.2
Vallabhapurapu, S.3
Luo, J.L.4
Zhang, W.5
Wang, H.6
Vignali, D.A.7
Gallagher, E.8
Karin, M.9
-
36
-
-
16844367955
-
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases
-
Salvador, J. M., Mittelstadt, P. R., Guszczynski, T., Copeland, T. D., Yamaguchi, H., Appella, E., Fornace, Jr, A. J. and Ashwell, J. D. (2005) Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat. Immunol. 6, 390-395
-
(2005)
Nat. Immunol.
, vol.6
, pp. 390-395
-
-
Salvador, J.M.1
Mittelstadt, P.R.2
Guszczynski, T.3
Copeland, T.D.4
Yamaguchi, H.5
Appella, E.6
Fornace Jr., A.J.7
Ashwell, J.D.8
-
37
-
-
16844366591
-
The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway
-
Salvador, J. M., Mittelstadt, P. R., Belova, G. I., Fornace, Jr, A. J. and Ashwell, J. D. (2005) The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway. Nat. Immunol. 6, 396-402
-
(2005)
Nat. Immunol.
, vol.6
, pp. 396-402
-
-
Salvador, J.M.1
Mittelstadt, P.R.2
Belova, G.I.3
Fornace Jr., A.J.4
Ashwell, J.D.5
-
39
-
-
0037083375
-
MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α
-
Ge, B., Gram, H., Di Padova, F., Huang, B., New, L., Ulevitch, R. J., Luo, Y. and Han, J. (2002) MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α. Science 295, 1291-1294
-
(2002)
Science
, vol.295
, pp. 1291-1294
-
-
Ge, B.1
Gram, H.2
Di Padova, F.3
Huang, B.4
New, L.5
Ulevitch, R.J.6
Luo, Y.7
Han, J.8
-
40
-
-
33646576174
-
Determinants that control the specific interactions between TAB1 and p38α
-
Zhou, H., Zheng, M., Chen, J., Xie, C., Kolatkar, A. R., Zarubin, T., Ye, Z., Akella, R., Lin, S., Goldsmith, E. J. and Han, J. (2006) Determinants that control the specific interactions between TAB1 and p38α. Mol. Cell. Biol. 26, 3824-3834
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3824-3834
-
-
Zhou, H.1
Zheng, M.2
Chen, J.3
Xie, C.4
Kolatkar, A.R.5
Zarubin, T.6
Ye, Z.7
Akella, R.8
Lin, S.9
Goldsmith, E.J.10
Han, J.11
-
41
-
-
0242473165
-
Feedback control of the protein kinase TAK1 by SAPK2a/p38α
-
Cheung, P. C., Campbell, D. G., Nebreda, A. R. and Cohen, P. (2003) Feedback control of the protein kinase TAK1 by SAPK2a/p38α. EMBO J. 22, 5793-5805
-
(2003)
EMBO J.
, vol.22
, pp. 5793-5805
-
-
Cheung, P.C.1
Campbell, D.G.2
Nebreda, A.R.3
Cohen, P.4
-
42
-
-
0042525992
-
Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: Evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia
-
Tanno, M., Bassi, R., Gorog, D. A., Saurin, A. T., Jiang, J., Heads, R. J., Martin, J. L., Davis, R. J., Flavell, R. A. and Marber, M. S. (2003) Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. Circ. Res. 93, 254-261
-
(2003)
Circ. Res.
, vol.93
, pp. 254-261
-
-
Tanno, M.1
Bassi, R.2
Gorog, D.A.3
Saurin, A.T.4
Jiang, J.5
Heads, R.J.6
Martin, J.L.7
Davis, R.J.8
Flavell, R.A.9
Marber, M.S.10
-
43
-
-
27644477357
-
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart
-
Li, J., Miller, E. J., Ninomiya-Tsuji, J., Russell, 3rd, R. R. and Young, L. H. (2005) AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ. Res. 97, 872-879
-
(2005)
Circ. Res.
, vol.97
, pp. 872-879
-
-
Li, J.1
Miller, E.J.2
Ninomiya-Tsuji, J.3
Russell III, R.R.4
Young, L.H.5
-
44
-
-
0141955108
-
Activation of discoidin domain receptor 1 facilitates the maturation of human monocyte-derived dendritic cells through the TNF receptor associated factor 6/TGF-β-activated protein kinase 1 binding protein 1β/p38α mitogen-activated protein kinase signaling cascade
-
Matsuyama, W., Faure, M. and Yoshimura, T. (2003) Activation of discoidin domain receptor 1 facilitates the maturation of human monocyte-derived dendritic cells through the TNF receptor associated factor 6/TGF-β- activated protein kinase 1 binding protein 1β/p38α mitogen-activated protein kinase signaling cascade. J. Immunol. 171, 3520-3532
-
(2003)
J. Immunol.
, vol.171
, pp. 3520-3532
-
-
Matsuyama, W.1
Faure, M.2
Yoshimura, T.3
-
45
-
-
15444367812
-
p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection
-
Kim, L., Del Rio, L., Butcher, B. A., Mogensen, T. H., Paludan, S. R., Flavell, R. A. and Denkers, E. Y. (2005) p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection. J. Immunol. 174, 4178-4184
-
(2005)
J. Immunol.
, vol.174
, pp. 4178-4184
-
-
Kim, L.1
Del Rio, L.2
Butcher, B.A.3
Mogensen, T.H.4
Paludan, S.R.5
Flavell, R.A.6
Denkers, E.Y.7
-
46
-
-
54449087508
-
ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7
-
Im, J. S. and Lee, J. K. (2008) ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7. J. Biol. Chem. 283, 25171-25177
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 25171-25177
-
-
Im, J.S.1
Lee, J.K.2
-
47
-
-
55549104054
-
Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38α in different phosphorylation states
-
Zhang, Y. Y., Mei, Z. Q., Wu, J. W. and Wang, Z. X. (2008) Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38α in different phosphorylation states. J. Biol. Chem. 283, 26591-26601
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 26591-26601
-
-
Zhang, Y.Y.1
Mei, Z.Q.2
Wu, J.W.3
Wang, Z.X.4
-
49
-
-
70350335541
-
2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression
-
2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. EMBO J. 28, 3196-3206
-
(2009)
EMBO J.
, vol.28
, pp. 3196-3206
-
-
Lindqvist, A.1
De Bruijn, M.2
Macurek, L.3
Bras, A.4
Mensinga, A.5
Bruinsma, W.6
Voets, O.7
Kranenburg, O.8
Medema, R.H.9
-
50
-
-
75949097839
-
WIP1 phosphatase at the crossroads of cancer and aging
-
Le Guezennec, X. and Bulavin, D. V. (2010) WIP1 phosphatase at the crossroads of cancer and aging. Trends Biochem. Sci. 35, 109-114
-
(2010)
Trends Biochem. Sci.
, vol.35
, pp. 109-114
-
-
Le Guezennec, X.1
Bulavin, D.V.2
-
51
-
-
59249095812
-
2- adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes
-
2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes. Mol. Cell. Biol. 29, 675-686
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 675-686
-
-
McAlees, J.W.1
Sanders, V.M.2
-
52
-
-
36749011295
-
Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase
-
Zhu, Y., Li, H., Long, C., Hu, L., Xu, H., Liu, L., Chen, S., Wang, D. C. and Shao, F. (2007) Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase. Mol. Cell 28, 899-913
-
(2007)
Mol. Cell
, vol.28
, pp. 899-913
-
-
Zhu, Y.1
Li, H.2
Long, C.3
Hu, L.4
Xu, H.5
Liu, L.6
Chen, S.7
Wang, D.C.8
Shao, F.9
-
53
-
-
34248595035
-
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
-
Owens, D. M. and Keyse, S. M. (2007) Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 26, 3203-3213
-
(2007)
Oncogene
, vol.26
, pp. 3203-3213
-
-
Owens, D.M.1
Keyse, S.M.2
-
54
-
-
67649235659
-
Glutamine protects mice from lethal endotoxic shock via a rapid induction of MAPK phosphatase-1
-
Ko, H. M., Oh, S. H., Bang, H. S., Kang, N. I., Cho, B. H., Im, S. Y. and Lee, H. K. (2009) Glutamine protects mice from lethal endotoxic shock via a rapid induction of MAPK phosphatase-1. J. Immunol. 182, 7957-7962
-
(2009)
J. Immunol.
, vol.182
, pp. 7957-7962
-
-
Ko, H.M.1
Oh, S.H.2
Bang, H.S.3
Kang, N.I.4
Cho, B.H.5
Im, S.Y.6
Lee, H.K.7
-
55
-
-
74249111387
-
Induction of MAPK phosphatase-1 by hypothermia inhibits TNF-α-induced endothelial barrier dysfunction and apoptosis
-
Yang, D., Xie, P., Guo, S. and Li, H. (2010) Induction of MAPK phosphatase-1 by hypothermia inhibits TNF-α-induced endothelial barrier dysfunction and apoptosis. Cardiovasc. Res. 85, 520-529
-
(2010)
Cardiovasc. Res.
, vol.85
, pp. 520-529
-
-
Yang, D.1
Xie, P.2
Guo, S.3
Li, H.4
-
56
-
-
66349134442
-
Suppression of GATA-3 nuclear import and phosphorylation: A novel mechanism of corticosteroid action in allergic disease
-
Maneechotesuwan, K., Yao, X., Ito, K., Jazrawi, E., Usmani, O. S., Adcock, I. M. and Barnes, P. J. (2009) Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease. PLoS Med. 6, e1000076
-
(2009)
PLoS Med.
, vol.6
-
-
Maneechotesuwan, K.1
Yao, X.2
Ito, K.3
Jazrawi, E.4
Usmani, O.S.5
Adcock, I.M.6
Barnes, P.J.7
-
57
-
-
0038498118
-
ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway
-
Lin, Y. W., Chuang, S. M. and Yang, J. L. (2003) ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway. J. Biol. Chem. 278, 21534-21541
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 21534-21541
-
-
Lin, Y.W.1
Chuang, S.M.2
Yang, J.L.3
-
58
-
-
45149132474
-
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling
-
Cao, W., Bao, C., Padalko, E. and Lowenstein, C. J. (2008) Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J. Exp. Med. 205, 1491-1503
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1491-1503
-
-
Cao, W.1
Bao, C.2
Padalko, E.3
Lowenstein, C.J.4
-
59
-
-
70350573933
-
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury
-
Qian, F., Deng, J., Cheng, N., Welch, E. J., Zhang, Y., Malik, A. B., Flavell, R. A., Dong, C. and Ye, R. D. (2009) A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J. 28, 2896-2907
-
(2009)
EMBO J.
, vol.28
, pp. 2896-2907
-
-
Qian, F.1
Deng, J.2
Cheng, N.3
Welch, E.J.4
Zhang, Y.5
Malik, A.B.6
Flavell, R.A.7
Dong, C.8
Ye, R.D.9
-
60
-
-
62149128986
-
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
-
Good, M., Tang, G., Singleton, J., Remenyi, A. and Lim, W. A. (2009) The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell 136, 1085-1097
-
(2009)
Cell
, vol.136
, pp. 1085-1097
-
-
Good, M.1
Tang, G.2
Singleton, J.3
Remenyi, A.4
Lim, W.A.5
-
61
-
-
0344668554
-
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock
-
Uhlik, M. T., Abell, A. N., Johnson, N. L., Sun, W., Cuevas, B. D., Lobel-Rice, K. E., Horne, E. A., Dell'Acqua, M. L. and Johnson, G. L. (2003) Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat. Cell Biol. 5, 1104-1110
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 1104-1110
-
-
Uhlik, M.T.1
Abell, A.N.2
Johnson, N.L.3
Sun, W.4
Cuevas, B.D.5
Lobel-Rice, K.E.6
Horne, E.A.7
Dell'Acqua, M.L.8
Johnson, G.L.9
-
62
-
-
0344393408
-
Regulation of MAP kinase signaling modules by scaffold proteins in mammals
-
Morrison, D. K. and Davis, R. J. (2003) Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell Dev. Biol. 19, 91-118
-
(2003)
Annu. Rev. Cell Dev. Biol.
, vol.19
, pp. 91-118
-
-
Morrison, D.K.1
Davis, R.J.2
-
63
-
-
15044357454
-
Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways
-
Kelkar, N., Standen, C. L. and Davis, R. J. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol. Cell. Biol. 25, 2733-2743
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 2733-2743
-
-
Kelkar, N.1
Standen, C.L.2
Davis, R.J.3
-
64
-
-
49749125994
-
A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38α/β MAPK activity and myogenic differentiation
-
Kang, J. S., Bae, G. U., Yi, M. J., Yang, Y. J., Oh, J. E., Takaesu, G., Zhou, Y. T., Low, B. C. and Krauss, R. S. (2008) A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38α/β MAPK activity and myogenic differentiation. J. Cell Biol. 182, 497-507
-
(2008)
J. Cell Biol.
, vol.182
, pp. 497-507
-
-
Kang, J.S.1
Bae, G.U.2
Yi, M.J.3
Yang, Y.J.4
Oh, J.E.5
Takaesu, G.6
Zhou, Y.T.7
Low, B.C.8
Krauss, R.S.9
-
65
-
-
68549115535
-
Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway
-
Oh, J. E., Bae, G. U., Yang, Y. J., Yi, M. J., Lee, H. J., Kim, B. G., Krauss, R. S. and Kang, J. S. (2009) Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. FASEB J. 23, 2088-2099
-
(2009)
FASEB J.
, vol.23
, pp. 2088-2099
-
-
Oh, J.E.1
Bae, G.U.2
Yang, Y.J.3
Yi, M.J.4
Lee, H.J.5
Kim, B.G.6
Krauss, R.S.7
Kang, J.S.8
-
66
-
-
0033548233
-
Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis
-
Cuenda, A. and Cohen, P. (1999) Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis. J. Biol. Chem. 274, 4341-4346
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 4341-4346
-
-
Cuenda, A.1
Cohen, P.2
-
67
-
-
0036687249
-
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis
-
Tanaka, N., Kamanaka, M., Enslen, H., Dong, C., Wysk, M., Davis, R. J. and Flavell, R. A. (2002) Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep. 3, 785-791
-
(2002)
EMBO Rep.
, vol.3
, pp. 785-791
-
-
Tanaka, N.1
Kamanaka, M.2
Enslen, H.3
Dong, C.4
Wysk, M.5
Davis, R.J.6
Flavell, R.A.7
-
68
-
-
36849004500
-
c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy
-
Galan-Moya, E. M., Hernandez-Losa, J., Aceves Luquero, C. I., de la Cruz-Morcillo, M. A., Ramírez-Castillejo, C., Callejas-Valera, J. L., Arriaga, A., Aranburo, A. F., Ramón y Cajal, S., Gutkind, J. S. and Sánchez-Prieto, R. (2008) c-Abl activates p38 MAPK independently of its tyrosine kinase activity: implications in cisplatin-based therapy. Int. J. Cancer 122, 289-297
-
(2008)
Int. J. Cancer
, vol.122
, pp. 289-297
-
-
Galan-Moya, E.M.1
Hernandez-Losa, J.2
Aceves Luquero, C.I.3
De La Cruz-Morcillo, M.A.4
Ramírez-Castillejo, C.5
Callejas-Valera, J.L.6
Arriaga, A.7
Aranburo, A.F.8
Ramón Y Cajal, S.9
Gutkind, J.S.10
Sánchez-Prieto, R.11
-
69
-
-
74049111298
-
Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs
-
Marasa, B. S., Srikantan, S., Masuda, K., Abdelmohsen, K., Kuwano, Y., Yang, X., Martindale, J. L., Rinker-Schaeffer, C. W. and Gorospe, M. (2009) Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs. Sci. Signaling 2, ra69
-
(2009)
Sci. Signaling
, vol.2
-
-
Marasa, B.S.1
Srikantan, S.2
Masuda, K.3
Abdelmohsen, K.4
Kuwano, Y.5
Yang, X.6
Martindale, J.L.7
Rinker-Schaeffer, C.W.8
Gorospe, M.9
-
70
-
-
70350353084
-
MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch
-
Ahn, Y. H. and Kurie, J. M. (2009) MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch. J. Biol. Chem. 284, 29399-29404
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 29399-29404
-
-
Ahn, Y.H.1
Kurie, J.M.2
-
71
-
-
33845807361
-
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK
-
Ronkina, N., Kotlyarov, A., Dittrich-Breiholz, O., Kracht, M., Hitti, E., Milarski, K., Askew, R., Marusic, S., Lin, L. L., Gaestel, M. and Telliez, J. B. (2007) The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol. Cell. Biol. 27, 170-181
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 170-181
-
-
Ronkina, N.1
Kotlyarov, A.2
Dittrich-Breiholz, O.3
Kracht, M.4
Hitti, E.5
Milarski, K.6
Askew, R.7
Marusic, S.8
Lin, L.L.9
Gaestel, M.10
Telliez, J.B.11
-
72
-
-
26444578205
-
p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression
-
Sudo, T., Kawai, K., Matsuzaki, H. and Osada, H. (2005) p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression. Biochem. Biophys. Res. Commun. 337, 415-421
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.337
, pp. 415-421
-
-
Sudo, T.1
Kawai, K.2
Matsuzaki, H.3
Osada, H.4
-
73
-
-
33750218229
-
MAPK
-
MAPK. Curr. Biol. 16, 2042-2047
-
(2006)
Curr. Biol.
, vol.16
, pp. 2042-2047
-
-
Peregrin, S.1
Jurado-Pueyo, M.2
Campos, P.M.3
Sanz-Moreno, V.4
Ruiz-Gomez, A.5
Crespo Jr., P.6
Mayor, F.7
Murga, C.8
-
74
-
-
0038322024
-
Anthrax lethal factor proteolysis and inactivation of MAPK kinase
-
Chopra, A. P., Boone, S. A., Liang, X. and Duesbery, N. S. (2003) Anthrax lethal factor proteolysis and inactivation of MAPK kinase. J. Biol. Chem. 278, 9402-9406
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9402-9406
-
-
Chopra, A.P.1
Boone, S.A.2
Liang, X.3
Duesbery, N.S.4
-
75
-
-
33744457909
-
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation
-
Mukherjee, S., Keitany, G., Li, Y., Wang, Y., Ball, H. L., Goldsmith, E. J. and Orth, K. (2006) Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science 312, 1211-1214
-
(2006)
Science
, vol.312
, pp. 1211-1214
-
-
Mukherjee, S.1
Keitany, G.2
Li, Y.3
Wang, Y.4
Ball, H.L.5
Goldsmith, E.J.6
Orth, K.7
-
76
-
-
0028935270
-
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
-
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J. and Davis, R. J. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270, 7420-7426
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7420-7426
-
-
Raingeaud, J.1
Gupta, S.2
Rogers, J.S.3
Dickens, M.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
77
-
-
0032563807
-
Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
-
Ben-Levy, R., Hooper, S., Wilson, R., Paterson, H. F. and Marshall, C. J. (1998) Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr. Biol. 8, 1049-1057
-
(1998)
Curr. Biol.
, vol.8
, pp. 1049-1057
-
-
Ben-Levy, R.1
Hooper, S.2
Wilson, R.3
Paterson, H.F.4
Marshall, C.J.5
-
78
-
-
70249090092
-
Nuclear localization of p38 MAPK in response to DNA damage
-
Wood, C. D., Thornton, T. M., Sabio, G., Davis, R. A. and Rincon, M. (2009) Nuclear localization of p38 MAPK in response to DNA damage. Int. J. Biol. Sci. 5, 428-437
-
(2009)
Int. J. Biol. Sci.
, vol.5
, pp. 428-437
-
-
Wood, C.D.1
Thornton, T.M.2
Sabio, G.3
Davis, R.A.4
Rincon, M.5
-
79
-
-
0032526988
-
Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation
-
DOI 10.1093/emboj/17.12.3363
-
Engel, K., Kotlyarov, A. and Gaestel, M. (1998) Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. EMBO J. 17, 3363-3371 (Pubitemid 28279510)
-
(1998)
EMBO Journal
, vol.17
, Issue.12
, pp. 3363-3371
-
-
Engel, K.1
Kotlyarov, A.2
Gaestel, M.3
-
80
-
-
33646829136
-
TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling
-
Lu, G., Kang, Y. J., Han, J., Herschman, H. R., Stefani, E. and Wang, Y. (2006) TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J. Biol. Chem. 281, 6087-6095
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6087-6095
-
-
Lu, G.1
Kang, Y.J.2
Han, J.3
Herschman, H.R.4
Stefani, E.5
Wang, Y.6
-
81
-
-
0034067992
-
Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and p38, and glycogen synthase kinase-3β
-
Reynolds, C. H., Betts, J. C., Blackstock, W. P., Nebreda, A. R. and Anderton, B. H. (2000) Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and p38, and glycogen synthase kinase-3β. J. Neurochem. 74, 1587-1595
-
(2000)
J. Neurochem.
, vol.74
, pp. 1587-1595
-
-
Reynolds, C.H.1
Betts, J.C.2
Blackstock, W.P.3
Nebreda, A.R.4
Anderton, B.H.5
-
82
-
-
65849126235
-
Phosphorylation-independent regulation of Atf1-promoted meiotic recombination by stress-activated, p38 kinase Spc1 of fission yeast
-
Gao, J., Davidson, M. K. and Wahls, W. P. (2009) Phosphorylation- independent regulation of Atf1-promoted meiotic recombination by stress-activated, p38 kinase Spc1 of fission yeast. PLoS ONE 4, e5533
-
(2009)
PLoS ONE
, vol.4
-
-
Gao, J.1
Davidson, M.K.2
Wahls, W.P.3
-
83
-
-
0038242285
-
Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II
-
Alepuz, P. M., de Nadal, E., Zapater, M., Ammerer, G. and Posas, F. (2003) Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II. EMBO J. 22, 2433-2442
-
(2003)
EMBO J.
, vol.22
, pp. 2433-2442
-
-
Alepuz, P.M.1
De Nadal, E.2
Zapater, M.3
Ammerer, G.4
Posas, F.5
-
84
-
-
75649108602
-
Multilayered control of gene expression by stress-activated protein kinases
-
de Nadal, E. and Posas, F. (2010) Multilayered control of gene expression by stress-activated protein kinases. EMBO J. 29, 4-13
-
(2010)
EMBO J.
, vol.29
, pp. 4-13
-
-
De Nadal, E.1
Posas, F.2
-
85
-
-
39049190957
-
A novel role of p38α MAPK in mitotic progression independent of its kinase activity
-
Fan, L., Yang, X., Du, J., Marshall, M., Blanchard, K. and Ye, X. (2005) A novel role of p38α MAPK in mitotic progression independent of its kinase activity. Cell Cycle 4, 1616-1624
-
(2005)
Cell Cycle
, vol.4
, pp. 1616-1624
-
-
Fan, L.1
Yang, X.2
Du, J.3
Marshall, M.4
Blanchard, K.5
Ye, X.6
-
86
-
-
45149095784
-
AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation
-
Cheung, W. D. and Hart, G. W. (2008) AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation. J. Biol. Chem. 283, 13009-13020
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 13009-13020
-
-
Cheung, W.D.1
Hart, G.W.2
-
87
-
-
21244490119
-
Essential role of p38γ in K-Ras transformation independent of phosphorylation
-
Tang, J., Qi, X., Mercola, D., Han, J. and Chen, G. (2005) Essential role of p38γ in K-Ras transformation independent of phosphorylation. J. Biol. Chem. 280, 23910-23917
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23910-23917
-
-
Tang, J.1
Qi, X.2
Mercola, D.3
Han, J.4
Chen, G.5
-
88
-
-
0033788484
-
A conserved docking motif in MAP kinases common to substrates, activators and regulators
-
Tanoue, T., Adachi, M., Moriguchi, T. and Nishida, E. (2000) A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell Biol. 2, 110-116
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 110-116
-
-
Tanoue, T.1
Adachi, M.2
Moriguchi, T.3
Nishida, E.4
-
89
-
-
0034759115
-
Regulation of MAP kinases by docking domains
-
DOI 10.1016/S0248-4900(01)01156-X
-
Enslen, H. and Davis, R. J. (2001) Regulation of MAP kinases by docking domains. Biol. Cell 93, 5-14 (Pubitemid 33040855)
-
(2001)
Biology of the Cell
, vol.93
, Issue.1-2
, pp. 5-14
-
-
Enslen, H.1
Davis, R.J.2
-
90
-
-
0037954572
-
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
-
Biondi, R. M. and Nebreda, A. R. (2003) Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem. J. 372, 1-13
-
(2003)
Biochem. J.
, vol.372
, pp. 1-13
-
-
Biondi, R.M.1
Nebreda, A.R.2
-
91
-
-
33947312823
-
Interfering with MAP kinase docking interactions: Implications and perspective for the p38 route
-
Mayor, Jr, F., Jurado-Pueyo, M., Campos, P. M. and Murga, C. (2007) Interfering with MAP kinase docking interactions: implications and perspective for the p38 route. Cell Cycle 6, 528-533
-
(2007)
Cell Cycle
, vol.6
, pp. 528-533
-
-
Mayor Jr., F.1
Jurado-Pueyo, M.2
Campos, P.M.3
Murga, C.4
-
92
-
-
0036289349
-
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b
-
DOI 10.1016/S1097-2765(02)00525-7
-
Chang, C. I., Xu, B. E., Akella, R., Cobb, M. H. and Goldsmith, E. J. (2002) Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol. Cell 9, 1241-1249 (Pubitemid 34722303)
-
(2002)
Molecular Cell
, vol.9
, Issue.6
, pp. 1241-1249
-
-
Chang, C.-I.1
Xu, B.-E.2
Akella, R.3
Cobb, M.H.4
Goldsmith, E.J.5
-
93
-
-
2942530310
-
ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
-
Roux, P. P. and Blenis, J. (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68, 320-344
-
(2004)
Microbiol. Mol. Biol. Rev.
, vol.68
, pp. 320-344
-
-
Roux, P.P.1
Blenis, J.2
-
94
-
-
67649710849
-
Selectivity of docking sites in MAPK kinases
-
Bardwell, A. J., Frankson, E. and Bardwell, L. (2009) Selectivity of docking sites in MAPK kinases. J. Biol. Chem. 284, 13165-13173
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13165-13173
-
-
Bardwell, A.J.1
Frankson, E.2
Bardwell, L.3
-
95
-
-
0033617341
-
1-syntrophin: A mechanism for specific substrate recognition
-
1-syntrophin: a mechanism for specific substrate recognition. J. Biol. Chem. 274, 12626-12631
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12626-12631
-
-
Hasegawa, M.1
Cuenda, A.2
Spillantini, M.G.3
Thomas, G.M.4
Buee-Scherrer, V.5
Cohen, P.6
Goedert, M.7
-
96
-
-
4644223114
-
Discovery and characterization of a substrate selective p38α inhibitor
-
Davidson, W., Frego, L., Peet, G. W., Kroe, R. R., Labadia, M. E., Lukas, S. M., Snow, R. J., Jakes, S., Grygon, C. A., Pargellis, C. and Werneburg, B. G. (2004) Discovery and characterization of a substrate selective p38α inhibitor. Biochemistry 43, 11658-11671
-
(2004)
Biochemistry
, vol.43
, pp. 11658-11671
-
-
Davidson, W.1
Frego, L.2
Peet, G.W.3
Kroe, R.R.4
Labadia, M.E.5
Lukas, S.M.6
Snow, R.J.7
Jakes, S.8
Grygon, C.A.9
Pargellis, C.10
Werneburg, B.G.11
-
97
-
-
50049084144
-
MSK activation and physiological roles
-
Arthur, J. S. (2008) MSK activation and physiological roles. Front. Biosci. 13, 5866-5879
-
(2008)
Front. Biosci.
, vol.13
, pp. 5866-5879
-
-
Arthur, J.S.1
-
98
-
-
0038182524
-
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
-
Soloaga, A., Thomson, S., Wiggin, G. R., Rampersaud, N., Dyson, M. H., Hazzalin, C. A., Mahadevan, L. C. and Arthur, J. S. (2003) MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 22, 2788-2797
-
(2003)
EMBO J.
, vol.22
, pp. 2788-2797
-
-
Soloaga, A.1
Thomson, S.2
Wiggin, G.R.3
Rampersaud, N.4
Dyson, M.H.5
Hazzalin, C.A.6
Mahadevan, L.C.7
Arthur, J.S.8
-
99
-
-
73349111284
-
MSK2 inhibits p53 activity in the absence of stress
-
Llanos, S., Cuadrado, A. and Serrano, M. (2009) MSK2 inhibits p53 activity in the absence of stress. Sci. Signaling 2, ra57
-
(2009)
Sci. Signaling
, vol.2
-
-
Llanos, S.1
Cuadrado, A.2
Serrano, M.3
-
100
-
-
0036803602
-
In the cellular garden of forking paths: How p38 MAPKs signal for downstream assistance
-
Shi, Y. and Gaestel, M. (2002) In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance. Biol. Chem. 383, 1519-1536
-
(2002)
Biol. Chem.
, vol.383
, pp. 1519-1536
-
-
Shi, Y.1
Gaestel, M.2
-
101
-
-
0035224873
-
Phosphorylation of mammalian eIF4E by Mnk1 and Mnk2: Tantalizing prospects for a role in translation
-
Mahalingam, M. and Cooper, J. A. (2001) Phosphorylation of mammalian eIF4E by Mnk1 and Mnk2: tantalizing prospects for a role in translation. Prog. Mol. Subcell. Biol. 27, 132-142
-
(2001)
Prog. Mol. Subcell. Biol.
, vol.27
, pp. 132-142
-
-
Mahalingam, M.1
Cooper, J.A.2
-
102
-
-
48249114811
-
Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies
-
Zeng, Y., Sankala, H., Zhang, X. and Graves, P. R. (2008) Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies. Biochem. J. 413, 429-436
-
(2008)
Biochem. J.
, vol.413
, pp. 429-436
-
-
Zeng, Y.1
Sankala, H.2
Zhang, X.3
Graves, P.R.4
-
103
-
-
67651163398
-
S-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis
-
S-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis. Nat. Immunol. 10, 918-926
-
(2009)
Nat. Immunol.
, vol.10
, pp. 918-926
-
-
Kundu, M.1
Pathak, S.K.2
Kumawat, K.3
Basu, S.4
Chatterjee, G.5
Pathak, S.6
Noguchi, T.7
Takeda, K.8
Ichijo, H.9
Thien, C.B.10
-
104
-
-
33845916778
-
Regulation of the ring finger E3 ligase Siah2 by p38 MAPK
-
Khurana, A., Nakayama, K., Williams, S., Davis, R. J., Mustelin, T. and Ronai, Z. (2006) Regulation of the ring finger E3 ligase Siah2 by p38 MAPK. J. Biol. Chem. 281, 35316-35326
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 35316-35326
-
-
Khurana, A.1
Nakayama, K.2
Williams, S.3
Davis, R.J.4
Mustelin, T.5
Ronai, Z.6
-
105
-
-
67649211582
-
Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38α mitogen-activated protein kinase via Sprouty2 downregulation
-
Swat, A., Dolado, I., Rojas, J. M. and Nebreda, A. R. (2009) Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38α mitogen-activated protein kinase via Sprouty2 downregulation. Mol. Cell. Biol. 29, 3332-3343
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 3332-3343
-
-
Swat, A.1
Dolado, I.2
Rojas, J.M.3
Nebreda, A.R.4
-
106
-
-
75649085703
-
Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP
-
Webber, J. L. and Tooze, S. A. (2010) Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP. EMBO J. 29, 27-40
-
(2010)
EMBO J.
, vol.29
, pp. 27-40
-
-
Webber, J.L.1
Tooze, S.A.2
-
107
-
-
0035105295
-
The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex
-
Cavalli, V., Vilbois, F., Corti, M., Marcote, M. J., Tamura, K., Karin, M., Arkinstall, S. and Gruenberg, J. (2001) The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex. Mol. Cell 7, 421-432
-
(2001)
Mol. Cell
, vol.7
, pp. 421-432
-
-
Cavalli, V.1
Vilbois, F.2
Corti, M.3
Marcote, M.J.4
Tamura, K.5
Karin, M.6
Arkinstall, S.7
Gruenberg, J.8
-
108
-
-
25144481466
-
Phosphorylation of EEA1 by p38 MAP kinase regulates μ opioid receptor endocytosis
-
Mace, G., Miaczynska, M., Zerial, M. and Nebreda, A. R. (2005) Phosphorylation of EEA1 by p38 MAP kinase regulates μ opioid receptor endocytosis. EMBO J. 24, 3235-3246
-
(2005)
EMBO J.
, vol.24
, pp. 3235-3246
-
-
Mace, G.1
Miaczynska, M.2
Zerial, M.3
Nebreda, A.R.4
-
109
-
-
33748928434
-
P38 MAP kinase mediates stress-induced internalization of EGFR: Implications for cancer chemotherapy
-
DOI 10.1038/sj.emboj.7601297, PII 7601297
-
Zwang, Y. and Yarden, Y. (2006) p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy. EMBO J. 25, 4195-4206 (Pubitemid 44435217)
-
(2006)
EMBO Journal
, vol.25
, Issue.18
, pp. 4195-4206
-
-
Zwang, Y.1
Yarden, Y.2
-
110
-
-
76849107016
-
Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation
-
Pinglong, X. and Derynck, R. (2010) Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol. Cell 37, 551-566
-
(2010)
Mol. Cell
, vol.37
, pp. 551-566
-
-
Pinglong, X.1
Derynck, R.2
-
111
-
-
44949253112
-
777by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
-
777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus. Mol. Cell. Biol. 28, 4129-4141
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4129-4141
-
-
Sorensen, V.1
Zhen, Y.2
Zakrzewska, M.3
Haugsten, E.M.4
Walchli, S.5
Nilsen, T.6
Olsnes, S.7
Wiedlocha, A.8
-
113
-
-
38649132623
-
Transcriptional regulation by the p38 MAPK signalling pathway in mammalian cells
-
Perdiguero, E. and Muñoz-Canoves, P. (2008) Transcriptional regulation by the p38 MAPK signalling pathway in mammalian cells. Top. Curr. Genet. 20, 51-79
-
(2008)
Top. Curr. Genet.
, vol.20
, pp. 51-79
-
-
Perdiguero, E.1
Muñoz-Canoves, P.2
-
114
-
-
70349865008
-
p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPα on serine 21
-
Geest, C. R., Buitenhuis, M., Laarhoven, A. G., Bierings, M. B., Bruin, M. C., Vellenga, E. and Coffer, P. J. (2009) p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPα on serine 21. Stem Cells 27, 2271-2282
-
(2009)
Stem Cells
, vol.27
, pp. 2271-2282
-
-
Geest, C.R.1
Buitenhuis, M.2
Laarhoven, A.G.3
Bierings, M.B.4
Bruin, M.C.5
Vellenga, E.6
Coffer, P.J.7
-
115
-
-
67651003108
-
SAPK-regulated transcription factor network required for tumor cell quiescence
-
SAPK-regulated transcription factor network required for tumor cell quiescence. Cancer Res. 69, 5664-5672
-
(2009)
Cancer Res.
, vol.69
, pp. 5664-5672
-
-
Adam, A.P.1
George, A.2
Schewe, D.3
Bragado, P.4
Iglesias, B.V.5
Ranganathan, A.C.6
Kourtidis, A.7
Conklin, D.S.8
Aguirre-Ghiso, J.A.9
-
116
-
-
67650550793
-
Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation
-
Corre, S., Primot, A., Baron, Y., Le Seyec, J., Goding, C. and Galibert, M. D. (2009) Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation. J. Biol. Chem. 284, 18851-18862
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 18851-18862
-
-
Corre, S.1
Primot, A.2
Baron, Y.3
Le Seyec, J.4
Goding, C.5
Galibert, M.D.6
-
117
-
-
0036143654
-
p38-Dependent marking of inflammatory genes for increased NF-κB recruitment
-
Saccani, S., Pantano, S. and Natoli, G. (2002) p38-Dependent marking of inflammatory genes for increased NF-κB recruitment. Nat. Immunol. 3, 69-75
-
(2002)
Nat. Immunol.
, vol.3
, pp. 69-75
-
-
Saccani, S.1
Pantano, S.2
Natoli, G.3
-
118
-
-
57749099221
-
The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation
-
Zhao, Q., Barakat, B. M., Qin, S., Ray, A., El-Mahdy, M. A., Wani, G., Arafa, E.-S., Mir, S. N., Wang, Q. E. and Wani, A. A. (2008) The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation. J. Biol. Chem. 283, 32553-32561
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 32553-32561
-
-
Zhao, Q.1
Barakat, B.M.2
Qin, S.3
Ray, A.4
El-Mahdy, M.A.5
Wani, G.6
Arafa, E.-S.7
Mir, S.N.8
Wang, Q.E.9
Wani, A.A.10
-
119
-
-
36849043170
-
p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation
-
Rampalli, S., Li, L., Mak, E., Ge, K., Brand, M., Tapscott, S. J. and Dilworth, F. J. (2007) p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation. Nat. Struct. Mol. Biol. 14, 1150-1156
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 1150-1156
-
-
Rampalli, S.1
Li, L.2
Mak, E.3
Ge, K.4
Brand, M.5
Tapscott, S.J.6
Dilworth, F.J.7
-
120
-
-
66449120247
-
RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways
-
Rao, P. S., Satelli, A., Zhang, S., Srivastava, S. K., Srivenugopal, K. S. and Rao, U. S. (2009) RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways. Proteomics 9, 2776-2787
-
(2009)
Proteomics
, vol.9
, pp. 2776-2787
-
-
Rao, P.S.1
Satelli, A.2
Zhang, S.3
Srivastava, S.K.4
Srivenugopal, K.S.5
Rao, U.S.6
-
121
-
-
30444440735
-
Regulation of skeletal muscle gene expression by p38 MAP kinases
-
Lluis, F., Perdiguero, E., Nebreda, A. R. and Muñoz-Canoves, P. (2006) Regulation of skeletal muscle gene expression by p38 MAP kinases. Trends Cell Biol. 16, 36-44
-
(2006)
Trends Cell Biol.
, vol.16
, pp. 36-44
-
-
Lluis, F.1
Perdiguero, E.2
Nebreda, A.R.3
Muñoz-Canoves, P.4
-
122
-
-
34249026300
-
High-resolution profiling of histone methylations in the human genome
-
Barski, A., Cuddapah, S., Cui, K., Roh, T. Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I. and Zhao, K. (2007) High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837
-
(2007)
Cell
, vol.129
, pp. 823-837
-
-
Barski, A.1
Cuddapah, S.2
Cui, K.3
Roh, T.Y.4
Schones, D.E.5
Wang, Z.6
Wei, G.7
Chepelev, I.8
Zhao, K.9
-
123
-
-
58049191558
-
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
-
Cui, K., Zang, C., Roh, T. Y., Schones, D. E., Childs, R. W., Peng, W. and Zhao, K. (2009) Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 4, 80-93
-
(2009)
Cell Stem Cell
, vol.4
, pp. 80-93
-
-
Cui, K.1
Zang, C.2
Roh, T.Y.3
Schones, D.E.4
Childs, R.W.5
Peng, W.6
Zhao, K.7
-
124
-
-
34548813366
-
The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters
-
Wong, M. M., Cox, L. K. and Chrivia, J. C. (2007) The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. J. Biol. Chem. 282, 26132-26139
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26132-26139
-
-
Wong, M.M.1
Cox, L.K.2
Chrivia, J.C.3
-
125
-
-
34247179473
-
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis
-
Cuadrado, A., Lafarga, V., Cheung, P. C., Dolado, I., Llanos, S., Cohen, P. and Nebreda, A. R. (2007) A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. EMBO J. 26, 2115-2126
-
(2007)
EMBO J.
, vol.26
, pp. 2115-2126
-
-
Cuadrado, A.1
Lafarga, V.2
Cheung, P.C.3
Dolado, I.4
Llanos, S.5
Cohen, P.6
Nebreda, A.R.7
-
126
-
-
35848952736
-
Hamlet mediates different p53-dependent responses to DNA-damage inducing agents
-
Hamlet mediates different p53-dependent responses to DNA-damage inducing agents. Cell Cycle 6, 2319-2322
-
(2007)
Cell Cycle
, vol.6
, pp. 2319-2322
-
-
Lafarga, V.1
Cuadrado, A.2
Nebreda, A.R.3
-
128
-
-
41549160315
-
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
-
DOI 10.1096/fj.06-7859rev
-
Junttila, M. R., Li, S. P. and Westermarck, J. (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22, 954-965 (Pubitemid 351519953)
-
(2008)
FASEB Journal
, vol.22
, Issue.4
, pp. 954-965
-
-
Junttila, M.R.1
Li, S.-P.2
Westermarck, J.3
-
129
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner, E. F. and Nebreda, A. R. (2009) Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer 9, 537-549
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
130
-
-
0037451357
-
Transcriptional activation of the NF-κB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
-
Vermeulen, L., De Wilde, G., Van Damme, P., Vanden Berghe, W. and Haegeman, G. (2003) Transcriptional activation of the NF-κB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 22, 1313-1324
-
(2003)
EMBO J.
, vol.22
, pp. 1313-1324
-
-
Vermeulen, L.1
De Wilde, G.2
Van Damme, P.3
Vanden Berghe, W.4
Haegeman, G.5
-
131
-
-
33751002989
-
ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-κB transactivation during oxidative stress in skeletal myoblasts
-
Kefaloyianni, E., Gaitanaki, C. and Beis, I. (2006) ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-κB transactivation during oxidative stress in skeletal myoblasts. Cell. Signalling 18, 2238-2251
-
(2006)
Cell. Signalling
, vol.18
, pp. 2238-2251
-
-
Kefaloyianni, E.1
Gaitanaki, C.2
Beis, I.3
-
132
-
-
67349245931
-
WIP1 phosphatase is a negative regulator of NF-κB signalling
-
Chew, J., Biswas, S., Shreeram, S., Humaidi, M., Wong, E. T., Dhillion, M. K., Teo, H., Hazra, A., Fang, C. C., Lopez-Collazo, E. et al. (2009) WIP1 phosphatase is a negative regulator of NF-κB signalling. Nat. Cell Biol. 11, 659-666
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 659-666
-
-
Chew, J.1
Biswas, S.2
Shreeram, S.3
Humaidi, M.4
Wong, E.T.5
Dhillion, M.K.6
Teo, H.7
Hazra, A.8
Fang, C.C.9
Lopez-Collazo, E.10
-
133
-
-
43249106330
-
Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation
-
Thornton, T. M., Pedraza-Alva, G., Deng, B., Wood, C. D., Aronshtam, A., Clements, J. L., Sabio, G., Davis, R. J., Matthews, D. E., Doble, B. and Rincon, M. (2008) Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation. Science 320, 667-670
-
(2008)
Science
, vol.320
, pp. 667-670
-
-
Thornton, T.M.1
Pedraza-Alva, G.2
Deng, B.3
Wood, C.D.4
Aronshtam, A.5
Clements, J.L.6
Sabio, G.7
Davis, R.J.8
Matthews, D.E.9
Doble, B.10
Rincon, M.11
-
134
-
-
35649013184
-
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3β
-
Abell, A. N., Granger, D. A. and Johnson, G. L. (2007) MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3β. J. Biol. Chem. 282, 30476-30484
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 30476-30484
-
-
Abell, A.N.1
Granger, D.A.2
Johnson, G.L.3
-
135
-
-
0038342509
-
AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: Implication of AKT2 in chemoresistance
-
Yuan, Z. Q., Feldman, R. I., Sussman, G. E., Coppola, D., Nicosia, S. V. and Cheng, J. Q. (2003) AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J. Biol. Chem. 278, 23432-23440
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 23432-23440
-
-
Yuan, Z.Q.1
Feldman, R.I.2
Sussman, G.E.3
Coppola, D.4
Nicosia, S.V.5
Cheng, J.Q.6
-
136
-
-
62049085852
-
Akt2, but not Akt1, is required for cell survival by inhibiting activation of JNK and p38 after UV irradiation
-
Kim, M. A., Kim, H. J., Jee, H. J., Kim, A. J., Bae, Y. S., Bae, S. S. and Yun, J. (2009) Akt2, but not Akt1, is required for cell survival by inhibiting activation of JNK and p38 after UV irradiation. Oncogene 28, 1241-1247
-
(2009)
Oncogene
, vol.28
, pp. 1241-1247
-
-
Kim, M.A.1
Kim, H.J.2
Jee, H.J.3
Kim, A.J.4
Bae, Y.S.5
Bae, S.S.6
Yun, J.7
-
137
-
-
33845291508
-
Negative regulation of Akt activity by p38α MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1
-
Zuluaga, S., Alvarez-Barrientos, A., Gutierrez-Uzquiza, A., Benito, M., Nebreda, A. R. and Porras, A. (2007) Negative regulation of Akt activity by p38α MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1. Cell. Signalling 19, 62-74
-
(2007)
Cell. Signalling
, vol.19
, pp. 62-74
-
-
Zuluaga, S.1
Alvarez-Barrientos, A.2
Gutierrez-Uzquiza, A.3
Benito, M.4
Nebreda, A.R.5
Porras, A.6
-
138
-
-
65249123061
-
Macrophage deficiency of p38α MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice
-
Seimon, T. A., Wang, Y., Han, S., Senokuchi, T., Schrijvers, D. M., Kuriakose, G., Tall, A. R. and Tabas, I. A. (2009) Macrophage deficiency of p38α MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. J. Clin. Invest. 119, 886-898
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 886-898
-
-
Seimon, T.A.1
Wang, Y.2
Han, S.3
Senokuchi, T.4
Schrijvers, D.M.5
Kuriakose, G.6
Tall, A.R.7
Tabas, I.A.8
-
139
-
-
34547588567
-
Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex
-
Wu, R., Kausar, H., Johnson, P., Montoya-Durango, D. E., Merchant, M. and Rane, M. J. (2007) Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex. J. Biol. Chem. 282, 21598-21608
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 21598-21608
-
-
Wu, R.1
Kausar, H.2
Johnson, P.3
Montoya-Durango, D.E.4
Merchant, M.5
Rane, M.J.6
-
140
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall, C. J. (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
141
-
-
38649106489
-
Regulation of tumorigenesis by p38α MAP kinase
-
Dolado, I. and Nebreda, A. R. (2008) Regulation of tumorigenesis by p38α MAP kinase. Top. Curr. Genet. 20, 99-128
-
(2008)
Top. Curr. Genet.
, vol.20
, pp. 99-128
-
-
Dolado, I.1
Nebreda, A.R.2
-
142
-
-
0036731380
-
Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence
-
Haq, R., Brenton, J. D., Takahashi, M., Finan, D., Finkielsztein, A., Damaraju, S., Rottapel, R. and Zanke, B. (2002) Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res. 62, 5076-5082
-
(2002)
Cancer Res.
, vol.62
, pp. 5076-5082
-
-
Haq, R.1
Brenton, J.D.2
Takahashi, M.3
Finan, D.4
Finkielsztein, A.5
Damaraju, S.6
Rottapel, R.7
Zanke, B.8
-
143
-
-
0034162714
-
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells
-
Puri, P. L., Wu, Z., Zhang, P., Wood, L. D., Bhakta, K. S., Han, J., Feramisco, J. R., Karin, M. and Wang, J. Y. (2000) Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev. 14, 574-584
-
(2000)
Genes Dev.
, vol.14
, pp. 574-584
-
-
Puri, P.L.1
Wu, Z.2
Zhang, P.3
Wood, L.D.4
Bhakta, K.S.5
Han, J.6
Feramisco, J.R.7
Karin, M.8
Wang, J.Y.9
-
144
-
-
0037214362
-
Negative feedback regulation of MKK6 mRNA stability by p38α mitogen-activated protein kinase
-
Ambrosino, C., Mace, G., Galban, S., Fritsch, C., Vintersten, K., Black, E., Gorospe, M. and Nebreda, A. R. (2003) Negative feedback regulation of MKK6 mRNA stability by p38α mitogen-activated protein kinase. Mol. Cell. Biol. 23, 370-381
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 370-381
-
-
Ambrosino, C.1
Mace, G.2
Galban, S.3
Fritsch, C.4
Vintersten, K.5
Black, E.6
Gorospe, M.7
Nebreda, A.R.8
-
145
-
-
0033622470
-
Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development
-
Adams, R. H., Porras, A., Alonso, G., Jones, M., Vintersten, K., Panelli, S., Valladares, A., Perez, L., Klein, R. and Nebreda, A. R. (2000) Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development. Mol. Cell 6, 109-116
-
(2000)
Mol. Cell
, vol.6
, pp. 109-116
-
-
Adams, R.H.1
Porras, A.2
Alonso, G.3
Jones, M.4
Vintersten, K.5
Panelli, S.6
Valladares, A.7
Perez, L.8
Klein, R.9
Nebreda, A.R.10
-
146
-
-
0034641614
-
Essential role for p38α mitogen-activated protein kinase in placental angiogenesis
-
Mudgett, J. S., Ding, J., Guh-Siesel, L., Chartrain, N. A., Yang, L., Gopal, S. and Shen, M. M. (2000) Essential role for p38α mitogen-activated protein kinase in placental angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 97, 10454-10459
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 10454-10459
-
-
Mudgett, J.S.1
Ding, J.2
Guh-Siesel, L.3
Chartrain, N.A.4
Yang, L.5
Gopal, S.6
Shen, M.M.7
-
147
-
-
0034697904
-
Requirement for p38α in erythropoietin expression: A role for stress kinases in erythropoiesis
-
Tamura, K., Sudo, T., Senftleben, U., Dadak, A. M., Johnson, R. and Karin, M. (2000) Requirement for p38α in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102, 221-231
-
(2000)
Cell
, vol.102
, pp. 221-231
-
-
Tamura, K.1
Sudo, T.2
Senftleben, U.3
Dadak, A.M.4
Johnson, R.5
Karin, M.6
-
148
-
-
0033118982
-
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
-
Lu, H. T., Yang, D. D., Wysk, M., Gatti, E., Mellman, I., Davis, R. J. and Flavell, R. A. (1999) Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18, 1845-1857
-
(1999)
EMBO J.
, vol.18
, pp. 1845-1857
-
-
Lu, H.T.1
Yang, D.D.2
Wysk, M.3
Gatti, E.4
Mellman, I.5
Davis, R.J.6
Flavell, R.A.7
-
149
-
-
34249807348
-
p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
-
Ventura, J. J., Tenbaum, S., Perdiguero, E., Huth, M., Guerra, C., Barbacid, M., Pasparakis, M. and Nebreda, A. R. (2007) p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat. Genet. 39, 750-758
-
(2007)
Nat. Genet.
, vol.39
, pp. 750-758
-
-
Ventura, J.J.1
Tenbaum, S.2
Perdiguero, E.3
Huth, M.4
Guerra, C.5
Barbacid, M.6
Pasparakis, M.7
Nebreda, A.R.8
-
150
-
-
34249334506
-
p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway
-
Hui, L., Bakiri, L., Mairhorfer, A., Schweifer, N., Haslinger, C., Kenner, L., Komnenovic, V., Scheuch, H., Beug, H. and Wagner, E. F. (2007) p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat. Genet. 39, 741-749
-
(2007)
Nat. Genet.
, vol.39
, pp. 741-749
-
-
Hui, L.1
Bakiri, L.2
Mairhorfer, A.3
Schweifer, N.4
Haslinger, C.5
Kenner, L.6
Komnenovic, V.7
Scheuch, H.8
Beug, H.9
Wagner, E.F.10
-
151
-
-
18844383961
-
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
-
Engel, F. B., Schebesta, M., Duong, M. T., Lu, G., Ren, S., Madwed, J. B., Jiang, H., Wang, Y. and Keating, M. T. (2005) p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev. 19, 1175-1187
-
(2005)
Genes Dev.
, vol.19
, pp. 1175-1187
-
-
Engel, F.B.1
Schebesta, M.2
Duong, M.T.3
Lu, G.4
Ren, S.5
Madwed, J.B.6
Jiang, H.7
Wang, Y.8
Keating, M.T.9
-
152
-
-
44449100233
-
Macrophage deletion of p38α partially impairs lipopolysaccharide- induced cellular activation
-
Kang, Y. J., Chen, J., Otsuka, M., Mols, J., Ren, S., Wang, Y. and Han, J. (2008) Macrophage deletion of p38α partially impairs lipopolysaccharide-induced cellular activation. J. Immunol. 180, 5075-5082
-
(2008)
J. Immunol.
, vol.180
, pp. 5075-5082
-
-
Kang, Y.J.1
Chen, J.2
Otsuka, M.3
Mols, J.4
Ren, S.5
Wang, Y.6
Han, J.7
-
153
-
-
50049122380
-
The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
-
Kim, C., Sano, Y., Todorova, K., Carlson, B. A., Arpa, L., Celada, A.,
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1019-1027
-
-
Kim, C.1
Sano, Y.2
Todorova, K.3
Carlson, B.A.4
Arpa, L.5
Celada, A.6
Lawrence, T.7
Otsu, K.8
Brissette, J.L.9
Arthur, J.S.10
Park, J.M.11
-
154
-
-
48649109203
-
Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
-
Sakurai, T., He, G., Matsuzawa, A., Yu, G. Y., Maeda, S., Hardiman, G. and Karin, M. (2008) Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 14, 156-165
-
(2008)
Cancer Cell
, vol.14
, pp. 156-165
-
-
Sakurai, T.1
He, G.2
Matsuzawa, A.3
Yu, G.Y.4
Maeda, S.5
Hardiman, G.6
Karin, M.7
-
155
-
-
67650225264
-
MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age
-
MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. Dev. Cell 17, 142-149
-
(2009)
Dev. Cell
, vol.17
, pp. 142-149
-
-
Wong, E.S.1
Le Guezennec, X.2
Demidov, O.N.3
Marshall, N.T.4
Wang, S.T.5
Krishnamurthy, J.6
Sharpless, N.E.7
Dunn, N.R.8
Bulavin, D.V.9
-
156
-
-
27944461325
-
Generation and characterization of p38β (MAPK11) gene-targeted mice
-
Beardmore, V. A., Hinton, H. J., Eftychi, C., Apostolaki, M., Armaka, M., Darragh, J., McIlrath, J., Carr, J. M., Armit, L. J., Clacher, C. et al. (2005) Generation and characterization of p38β (MAPK11) gene-targeted mice. Mol. Cell. Biol. 25, 10454-10464
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10454-10464
-
-
Beardmore, V.A.1
Hinton, H.J.2
Eftychi, C.3
Apostolaki, M.4
Armaka, M.5
Darragh, J.6
McIlrath, J.7
Carr, J.M.8
Armit, L.J.9
Clacher, C.10
-
157
-
-
58249087541
-
Regulation of PKD by the MAPK p38δ in insulin secretion and glucose homeostasis
-
Sumara, G., Formentini, I., Collins, S., Sumara, I., Windak, R., Bodenmiller, B., Ramracheya, R., Caille, D., Jiang, H., Platt, K. A. et al. (2009) Regulation of PKD by the MAPK p38δ in insulin secretion and glucose homeostasis. Cell 136, 235-248
-
(2009)
Cell
, vol.136
, pp. 235-248
-
-
Sumara, G.1
Formentini, I.2
Collins, S.3
Sumara, I.4
Windak, R.5
Bodenmiller, B.6
Ramracheya, R.7
Caille, D.8
Jiang, H.9
Platt, K.A.10
-
158
-
-
66349138173
-
p38δ Mitogen-activated protein kinase is essential for skin tumor development in mice
-
Schindler, E. M., Hindes, A., Gribben, E. L., Burns, C. J., Yin, Y., Lin, M. H., Owen, R. J., Longmore, G. D., Kissling, G. E., Arthur, J. S. and Efimova, T. (2009) p38δ Mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res. 69, 4648-4655
-
(2009)
Cancer Res.
, vol.69
, pp. 4648-4655
-
-
Schindler, E.M.1
Hindes, A.2
Gribben, E.L.3
Burns, C.J.4
Yin, Y.5
Lin, M.H.6
Owen, R.J.7
Longmore, G.D.8
Kissling, G.E.9
Arthur, J.S.10
Efimova, T.11
-
159
-
-
76149089145
-
p38γ-dependent gene silencing restricts entry into the myogenic differentiation program
-
Gillespie, M. A., Le Grand, F., Scime, A., Kuang, S., von Maltzahn, J., Seale, V., Cuenda, A., Ranish, J. A. and Rudnicki, M. A. (2009) p38γ-dependent gene silencing restricts entry into the myogenic differentiation program. J. Cell Biol. 187, 991-1005
-
(2009)
J. Cell Biol.
, vol.187
, pp. 991-1005
-
-
Gillespie, M.A.1
Le Grand, F.2
Scime, A.3
Kuang, S.4
Von Maltzahn, J.5
Seale, V.6
Cuenda, A.7
Ranish, J.A.8
Rudnicki, M.A.9
-
160
-
-
0142026209
-
p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
-
Kumar, S., Boehm, J. and Lee, J. C. (2003) p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat. Rev. Drug Discov. 2, 717-726
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 717-726
-
-
Kumar, S.1
Boehm, J.2
Lee, J.C.3
-
162
-
-
0030783156
-
The search for physiological substrates of MAP and SAP kinases in mammalian cells
-
Cohen, P. (1997) The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol. 7, 353-361
-
(1997)
Trends Cell Biol.
, vol.7
, pp. 353-361
-
-
Cohen, P.1
-
163
-
-
0032102902
-
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
-
Eyers, P. A., Craxton, M., Morrice, N., Cohen, P. and Goedert, M. (1998) Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution. Chem. Biol. 5, 321-328
-
(1998)
Chem. Biol.
, vol.5
, pp. 321-328
-
-
Eyers, P.A.1
Craxton, M.2
Morrice, N.3
Cohen, P.4
Goedert, M.5
-
164
-
-
10744227768
-
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
-
Gum, R. J., McLaughlin, M. M., Kumar, S., Wang, Z., Bower, M. J., Lee, J. C., Adams, J. L., Livi, G. P., Goldsmith, E. J. and Young, P. R. (1998) Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket. J. Biol. Chem. 273, 15605-15610
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15605-15610
-
-
Gum, R.J.1
McLaughlin, M.M.2
Kumar, S.3
Wang, Z.4
Bower, M.J.5
Lee, J.C.6
Adams, J.L.7
Livi, G.P.8
Goldsmith, E.J.9
Young, P.R.10
-
165
-
-
9144219693
-
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
-
Godl, K., Wissing, J., Kurtenbach, A., Habenberger, P., Blencke, S., Gutbrod, H., Salassidis, K., Stein-Gerlach, M., Missio, A., Cotten, M. and Daub, H. (2003) An efficient proteomics method to identify the cellular targets of protein kinase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 100, 15434-15439
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 15434-15439
-
-
Godl, K.1
Wissing, J.2
Kurtenbach, A.3
Habenberger, P.4
Blencke, S.5
Gutbrod, H.6
Salassidis, K.7
Stein-Gerlach, M.8
Missio, A.9
Cotten, M.10
Daub, H.11
-
166
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian, M. A., Biggs, 3rd, W. H., Treiber, D. K., Atteridge, C. E., Azimioara, M. D., Benedetti, M. G., Carter, T. A., Ciceri, P., Edeen, P. T., Floyd, M. et al. (2005) A small molecule-kinase interaction map for clinical kinase inhibitors. Nat. Biotechnol. 23, 329-336
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 329-336
-
-
Fabian, M.A.1
Biggs III, W.H.2
Treiber, D.K.3
Atteridge, C.E.4
Azimioara, M.D.5
Benedetti, M.G.6
Carter, T.A.7
Ciceri, P.8
Edeen, P.T.9
Floyd, M.10
-
167
-
-
67650066466
-
Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804
-
Xing, L., Shieh, H. S., Selness, S. R., Devraj, R. V., Walker, J. K., Devadas, B., Hope, H. R., Compton, R. P., Schindler, J. F., Hirsch, J. L. et al. (2009) Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry 48, 6402-6411
-
(2009)
Biochemistry
, vol.48
, pp. 6402-6411
-
-
Xing, L.1
Shieh, H.S.2
Selness, S.R.3
Devraj, R.V.4
Walker, J.K.5
Devadas, B.6
Hope, H.R.7
Compton, R.P.8
Schindler, J.F.9
Hirsch, J.L.10
-
168
-
-
18344395134
-
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
-
Pargellis, C., Tong, L., Churchill, L., Cirillo, P. F., Gilmore, T., Graham, A. G., Grob, P. M., Hickey, E. R., Moss, N., Pav, S. and Regan, J. (2002) Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat. Struct. Biol. 9, 268-272
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 268-272
-
-
Pargellis, C.1
Tong, L.2
Churchill, L.3
Cirillo, P.F.4
Gilmore, T.5
Graham, A.G.6
Grob, P.M.7
Hickey, E.R.8
Moss, N.9
Pav, S.10
Regan, J.11
-
169
-
-
67651083303
-
p38α MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses
-
Perry, J. J., Harris, R. M., Moiani, D., Olson, A. J. and Tainer, J. A. (2009) p38α MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses. J. Mol. Biol. 391, 1-11
-
(2009)
J. Mol. Biol
, vol.391
, pp. 1-11
-
-
Perry, J.J.1
Harris, R.M.2
Moiani, D.3
Olson, A.J.4
Tainer, J.A.5
-
170
-
-
33646473843
-
p38 MAP kinase inhibitors: A future therapy for inflammatory diseases
-
Mayer, R. J. and Callahan, J. F. (2006) p38 MAP kinase inhibitors: a future therapy for inflammatory diseases. Drug Discov. Today 3, 49-54
-
(2006)
Drug Discov. Today
, vol.3
, pp. 49-54
-
-
Mayer, R.J.1
Callahan, J.F.2
-
171
-
-
54949112389
-
Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction
-
Sy, J. C., Seshadri, G., Yang, S. C., Brown, M., Oh, T., Dikalov, S., Murthy, N. and Davis, M. E. (2008) Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction. Nat. Mater. 7, 863-868
-
(2008)
Nat. Mater.
, vol.7
, pp. 863-868
-
-
Sy, J.C.1
Seshadri, G.2
Yang, S.C.3
Brown, M.4
Oh, T.5
Dikalov, S.6
Murthy, N.7
Davis, M.E.8
-
172
-
-
69249115278
-
Peptides as signaling inhibitors for mammalian MAP kinase cascades
-
Gaestel, M. and Kracht, M. (2009) Peptides as signaling inhibitors for mammalian MAP kinase cascades. Curr. Pharm. Des. 15, 2471-2480
-
(2009)
Curr. Pharm. Des.
, vol.15
, pp. 2471-2480
-
-
Gaestel, M.1
Kracht, M.2
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