Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells

Genes and Development

Volumn 14, Issue 5, 2000, Pages 574-584

  Puri, Pier Lorenzo ^a,c   Wu, Zhenguo ^a   Zhang, Peilin ^a   Wood, Lauren D ^a   Bhakta, Kunjan S ^a   Han, Jiahuai ^b   Feramisco, James R ^a   Karin, Michael ^a   Wang, Jean Y J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Differentiation; Muscle regulatory factors; p38 MAPK, MKK6; RMS

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; REGULATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME INDUCTION; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHABDOMYOSARCOMA; STRESS;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; ENZYME ACTIVATION; ENZYME INDUCTION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 6; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLES; MYOD PROTEIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECOMBINANT PROTEINS; RHABDOMYOSARCOMA; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034162714     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Alemà, S. and F. Tatò. 1994. Oncogenes and muscle differentiation: Multiple mechanism of interference. Semin. Cancer Biol. 5: 147-156.
2. Arndt, C.A.S. and W.M. Crist. 1999. Medical progress: Common musculoskeletal tumors of childhood and adolescence. N. Engl. J. Med. 341: 342-353.
3. Arnold, H.-H. and B. Winter. 1998. Muscle differentiation: More complexity to the network of myogenic regulators. Curr. Opin. Genet. Dev. 8: 539-544.
4. Bengal, E., L. Ransone, R. Scharfmann, V.J. Dwarki, S.J. Tapscott, H. Weintraub, and I.M. Verma. 1992. Functional antagonism between cJun and MyoD proteins: a direct physical association. Cell 68: 507-519.
5. Black, B.L., J.D. Molkentin, and E. Olson. 1998. Multiples roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with Mef2. Mol. Cell. Biol. 18: 69-77.
6. Bouchè, M., F. Zappelli, M. Polimenu, S. Adamo, W.C. Wetsel, M.I. Senni, and M. Molinaro. 1992. Rapid activation and downregulation of protein kinase C in 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells. Cell Growth Differ. 6: 845-852.
7. Crescenzi, M., T.P. Fleming, A.B. Lassar, H. Weintraub, and A.S. Aaronson. 1990. MyoD induces growth arrest independent of differentiation in normal and transformed cells. Proc. Natl. Acad. Sci. 87: 8442-8446.
8. Cuenda, A. and P. Cohen. 1999. Stress activated protein kinase-2 /p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis. J. Biol. Chem. 274: 4341-4346.
9. Dias, P., D.M. Parham, D.N. Shapiro, S.J. Tapscot, and P.J. Houghton. 1992. Monoclonal antibodies to the myogenic regulatory protein MyoD1: Epitope mapping and diagnostic utility. Cancer Res. 52: 6431-6439.
10. Ellinger-Ziegelbauer, H., K. Kelly, and U. Siebenlist. 1999. Cell cycle arrest and reversion of Ras-induced transformation by a conditionaly activated form of mitogen-activated protein kinase kinase kinase 3. Mol. Cell. Biol. 19: 3857-3868.
11. Engelman, J.A., M.P. Lisanti, and P.E. Scherer. 1998. Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis. J. Biol. Chem. 27: 32111-32120.
12. Florini, J.R., D.Z. Ewton, and S.A. Coolican. 1996. Growth hormone and the insulin-like growth factor system in myogenesis. Endocr. Rev. 17: 481-517.
13. Han, J., J.D. Lee, Y. Jiang, Z. Li, L. Feng, and R.J. Ulevitch. 1996. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J. Biol. Chem. 271: 2886-2891
14. Han, J., Y. Jiang, Z. Li, V.V. Kravchenko, and R.J. Ulevitch. 1997. Activation of the transcription factor Mef2c by the MAP kinase p38 in inflammation. Nature 368: 296-299.
15. Hill, C.S and R. Treisman. 1995. Transcriptional regulation by extracellular signals: Mechanism and specificity. Cell 80: 199-211.
16. Huang, S., Y. Jang, Z. Li, E. Nishida, P. Mathias, S. Lin, R.J. Ulevitch, G.R. Nemerow, and J. Han. 1997. Apoptosis signalling pathway in T cells is composed of ICE/CED-3 family proteases and MAP kinase kinase 6b. Immunity 6: 739-749.
17. Knudsen, E.S., C. Pazzagli, T.L. Born, B.L. Bertolaet, K.E. Knudsen, K.C. Arden, R.R. Henry, and J.R. Feramisco. 1998. Elevated cyclins and cyclin dependent kinase activity in rhabdomyosarcoma cell line RD. Cancer Res. 58: 2042-2049.
18. Lassar, A.B., S.X. Skapek, and B. Novich. 1994. Regulatory mechanisms that coordinate skeletal muscle differentiaion and cell cycle withdrawal. Curr. Opin. Cell. Biol. 6: 788-794.
19. Li, L., J.C. Chambard, M. Karin, and E. Olson. 1992. Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. Genes & Dev. 6: 676-689.
20. Marshall, C.J. 1995. Specificity of receptor tyrosine kinase signalling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185.
21. Minden, A. and M. Karin. 1997. Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophys. Acta 1333: F85-F104.
22. Molkentin, J.D., B.L. Black, J.F. Martin, and E.N. Olson. 1995. Cooperative activation of muscle gene expression by Mef2 and myogenic bHLH proteins. Cell 83: 1125-1136.
23. Olson, E.N. 1992. Interplay between proliferation and differentiaiton within the myogenic lineage. Dev. Biol. 154: 261-272.
24. Ornatansky, O.I., D.M. Cox, P. Tangirala, J.J. Andreucci, Z.A. Quinn, J.L. Wrana, R. Prywes, Y.-T. Yu, and J. McDermott. 1999. Posttranscriptional control of the MEF2A transcriptional regulatory protein. Nucleic Acids Res. 21: 2646-2656.
25. Otten, A.D., E.J. Firpo, A.N. Gerber, L.L. Brody, J.M. Roberts, and S.J. Tapscott. 1997. Inactivation of MyoD mediated expression of p21 in tumor cell lines. Cell Growth & Diff. 8: 1151-1160.
26. Puri, P.L., C. Balsano, V.L. Burgio, P. Chirillo, G. Natoli, L. Ricci, E. Mattei, A. Graessmann, and M. Levrero. 1997a. MyoD prevents cyclinA/cdk2 containing E2F complex formation in terminally differentiated myocytes. Oncogens 14: 1171-1184.
27. Puri, P.L., V. Sartorelli, X.-J. Yang, Y. Hamamori, V.V. Ogryzko, B.H. Howard, L. Kedes, J.Y.J. Wang, A. Graessmann, Y. Nakatani, and M. Levrero. 1997b. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol. Cell 1: 35-45,
28. Raingeaud, J., A.J. Whitmarsh, T. Barret, B. Derijard, and R. Davis. 1996. MKK3-and MKK6-regulated gene expression is mediated by the p38 mitogen activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16: 1247-1255.
29. Robinson, M.J. and M.H. Cobb. 1997. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9: 180-186.
30. Sorrentino, V., R. Peppekok, R.L. Davis, W. Ansorge, and L. Philipson. 1990. Cell proliferation inhibited by MyoD independent of differentiation. Nature 345: 813-815.
31. Tapscott, S.J., M.J. Thayer, and H. Weintraub. 1993. Deficiency in Rhabdomyosarcoma of a factor required for MyoD activity and myogenesis. Science 259: 1450-1453.
32. Thulasi, R., P. Dias, P.J. Houghton, and J.A. Houghton. 1996. A2a-Interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: Correlation with down-regulation of the Insulin-like growth factor type I receptor. Cell Growth & Differ. 7: 531-541.
33. Walsh, K. and H. Perlman. 1997. Cell cycle exit upon myogenic differentiation. Curr. Opin. Genet. Dev. 7: 597-602.
34. Wu, Z, J. Wu, E. Jacinto, and M. Karin. 1997. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Mol. Cell. Biol. 17: 7407-7416.
35. Yang, S.H., A. Galanis, and A.D. Sharrocks. 1999. Targeting of p38 mitogen activated protein kinases to MEF2 transcription factors. Mol. Cell. Biol. 19: 4028-4038.
36. Yee, S.P. and P.W. Rigby. 1993. The regulation of the myogenin gene expression during embryonic development of the mouse. Genes & Dev. 7: 1277-1289.
37. Zhao, M., L. New, V.V. Kravchenko, Y. Kato, H. Gram, F. di Padova, E.N. Olson, R.J. Ulevitch, and J. Han. 1999. Regulation of the Mef2 family of transcription factors by p38. Mol. Cell. Biol. 19: 21-30.
38. Zetser, A., E. Gredinger, and E. Bengal. 1999. p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. J. Biol. Chem. 274: 5193-5200.