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Volumn 69, Issue 14, 2009, Pages 5664-5672

Computational identification of a p38 SAPK-regulated transcription factor network required for tumor cell quiescence

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX B3 TRANSCRIPTION FACTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN C JUN; PROTEIN FOXM1; PROTEIN P53; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BHLHB3 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXM1 PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRIDINE DERIVATIVE;

EID: 67651003108     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-3820     Document Type: Article
Times cited : (138)

References (40)
  • 1
    • 7644223136 scopus 로고    scopus 로고
    • p38 MAP kinase's emerging role as a tumor suppressor
    • Bulavin DV, Fornace AJ, Jr. p38 MAP kinase's emerging role as a tumor suppressor. Adv Cancer Res 2004;92:95-118.
    • (2004) Adv Cancer Res , vol.92 , pp. 95-118
    • Bulavin, D.V.1    Fornace Jr, A.J.2
  • 2
    • 0036613212 scopus 로고    scopus 로고
    • Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
    • Bulavin DV, Demidov ON, Saito S, et al. Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet 2002;31:210-5.
    • (2002) Nat Genet , vol.31 , pp. 210-215
    • Bulavin, D.V.1    Demidov, O.N.2    Saito, S.3
  • 3
    • 1842483852 scopus 로고    scopus 로고
    • Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf ) pathway
    • Bulavin DV, Phillips C, Nannenga B, et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf ) pathway. Nat Genet 2004;36:343-50.
    • (2004) Nat Genet , vol.36 , pp. 343-350
    • Bulavin, D.V.1    Phillips, C.2    Nannenga, B.3
  • 4
    • 34249807348 scopus 로고    scopus 로고
    • p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
    • Ventura JJ, Tenbaum S, Perdiguero E, et al. p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet 2007; 39:750-8.
    • (2007) Nat Genet , vol.39 , pp. 750-758
    • Ventura, J.J.1    Tenbaum, S.2    Perdiguero, E.3
  • 5
    • 34249334506 scopus 로고    scopus 로고
    • p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway
    • Hui L, Bakiri L, Mairhorfer A, et al. p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet 2007;39:741-9.
    • (2007) Nat Genet , vol.39 , pp. 741-749
    • Hui, L.1    Bakiri, L.2    Mairhorfer, A.3
  • 6
    • 34547809513 scopus 로고    scopus 로고
    • p38α and p38δ mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells
    • Junttila MR, Ala-Aho R, Jokilehto T, et al. p38α and p38δ mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells. Oncogene 2007;26:5267-79.
    • (2007) Oncogene , vol.26 , pp. 5267-5279
    • Junttila, M.R.1    Ala-Aho, R.2    Jokilehto, T.3
  • 7
    • 0037379794 scopus 로고    scopus 로고
    • ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)
    • Aguirre-Ghiso JA, Estrada Y, Liu D, Ossowski L. ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). Cancer Res 2003;63:1684-95.
    • (2003) Cancer Res , vol.63 , pp. 1684-1695
    • Aguirre-Ghiso, J.A.1    Estrada, Y.2    Liu, D.3    Ossowski, L.4
  • 8
    • 5644222639 scopus 로고    scopus 로고
    • Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth
    • Aguirre-Ghiso JA, Ossowski L, Rosenbaum SK. Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res 2004;64:7336-45.
    • (2004) Cancer Res , vol.64 , pp. 7336-7345
    • Aguirre-Ghiso, J.A.1    Ossowski, L.2    Rosenbaum, S.K.3
  • 9
    • 0035172910 scopus 로고    scopus 로고
    • Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo
    • Aguirre-Ghiso JA, Liu D, Mignatti A, Kovalski K, Ossowski L. Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell 2001;12:863-79.
    • (2001) Mol Biol Cell , vol.12 , pp. 863-879
    • Aguirre-Ghiso, J.A.1    Liu, D.2    Mignatti, A.3    Kovalski, K.4    Ossowski, L.5
  • 10
    • 33644502513 scopus 로고    scopus 로고
    • The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma
    • Hickson JA, Huo D, Vander Griend DJ, et al. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Cancer Res 2006;66: 2264-70.
    • (2006) Cancer Res , vol.66 , pp. 2264-2270
    • Hickson, J.A.1    Huo, D.2    Vander Griend, D.J.3
  • 11
    • 22844451843 scopus 로고    scopus 로고
    • A subtle change in p38 MAPK activity is sufficient to suppress in vivo tumorigenesis
    • Timofeev O, Lee TY, Bulavin DV. A subtle change in p38 MAPK activity is sufficient to suppress in vivo tumorigenesis. Cell Cycle 2005;4:118-20.
    • (2005) Cell Cycle , vol.4 , pp. 118-120
    • Timofeev, O.1    Lee, T.Y.2    Bulavin, D.V.3
  • 12
    • 0020621220 scopus 로고
    • Changes in malignant phenotype of a human carcinoma conditioned by growth environment
    • Ossowski L, Reich E. Changes in malignant phenotype of a human carcinoma conditioned by growth environment. Cell 1983;33:323-33.
    • (1983) Cell , vol.33 , pp. 323-333
    • Ossowski, L.1    Reich, E.2
  • 13
    • 0036596352 scopus 로고    scopus 로고
    • EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
    • Liu D, Aguirre Ghiso J, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 2002;1:445-57.
    • (2002) Cancer Cell , vol.1 , pp. 445-457
    • Liu, D.1    Aguirre Ghiso, J.2    Estrada, Y.3    Ossowski, L.4
  • 14
    • 44849124523 scopus 로고    scopus 로고
    • Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival
    • Ranganathan AC, Ojha S, Kourtidis A, Conklin DS, Aguirre-Ghiso JA. Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival. Cancer Res 2008;68:3260-8.
    • (2008) Cancer Res , vol.68 , pp. 3260-3268
    • Ranganathan, A.C.1    Ojha, S.2    Kourtidis, A.3    Conklin, D.S.4    Aguirre-Ghiso, J.A.5
  • 15
    • 4544341015 scopus 로고    scopus 로고
    • Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004;3: Article3.
    • Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004;3: Article3.
  • 16
    • 33745656175 scopus 로고    scopus 로고
    • Characterizing disease states from topological properties of transcriptional regulatory networks
    • Tuck DP, Kluger HM, Kluger Y. Characterizing disease states from topological properties of transcriptional regulatory networks. BMC Bioinformatics 2006;7:236.
    • (2006) BMC Bioinformatics , vol.7 , pp. 236
    • Tuck, D.P.1    Kluger, H.M.2    Kluger, Y.3
  • 17
    • 2442573864 scopus 로고    scopus 로고
    • Chicken ovalbumin upstream promoter-transcription factor I represses the transcriptional activity of the human muscle glycogen phosphorylase promoter in C2C12 cells
    • Ferrer-Martinez A, Marotta M, Baldan A, Haro D, Gomez-Foix AM. Chicken ovalbumin upstream promoter-transcription factor I represses the transcriptional activity of the human muscle glycogen phosphorylase promoter in C2C12 cells. Biochim Biophys Acta 2004;1678:157-62.
    • (2004) Biochim Biophys Acta , vol.1678 , pp. 157-162
    • Ferrer-Martinez, A.1    Marotta, M.2    Baldan, A.3    Haro, D.4    Gomez-Foix, A.M.5
  • 18
    • 10644223331 scopus 로고    scopus 로고
    • Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors
    • Azmi S, Ozog A, Taneja R. Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors. J Biol Chem 2004;279: 52643-52.
    • (2004) J Biol Chem , vol.279 , pp. 52643-52652
    • Azmi, S.1    Ozog, A.2    Taneja, R.3
  • 19
    • 33750682662 scopus 로고    scopus 로고
    • Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes
    • Kawamoto T, Noshiro M, Furukawa M, et al. Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes. J Biochem (Tokyo) 2006;140:401-8.
    • (2006) J Biochem (Tokyo) , vol.140 , pp. 401-408
    • Kawamoto, T.1    Noshiro, M.2    Furukawa, M.3
  • 20
    • 33644966507 scopus 로고    scopus 로고
    • Influence of photoperiodic history on clock genes and the circadian pacemaker in the rat retina
    • Rohleder N, Langer C, Maus C, et al. Influence of photoperiodic history on clock genes and the circadian pacemaker in the rat retina. Eur J Neurosci 2006;23: 105-11.
    • (2006) Eur J Neurosci , vol.23 , pp. 105-111
    • Rohleder, N.1    Langer, C.2    Maus, C.3
  • 21
    • 45949084638 scopus 로고    scopus 로고
    • BHLHB3: A candidate tumor suppressor in lung cancer
    • Falvella FS, Colombo F, Spinola M, et al. BHLHB3: a candidate tumor suppressor in lung cancer. Oncogene 2008;27:3761-4.
    • (2008) Oncogene , vol.27 , pp. 3761-3764
    • Falvella, F.S.1    Colombo, F.2    Spinola, M.3
  • 22
    • 4644247108 scopus 로고    scopus 로고
    • Association between gene expression profile and tumor invasion in oral squamous cell carcinoma
    • Toruner GA, Ulger C, Alkan M, et al. Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. Cancer Genet Cytogenet 2004;154:27-35.
    • (2004) Cancer Genet Cytogenet , vol.154 , pp. 27-35
    • Toruner, G.A.1    Ulger, C.2    Alkan, M.3
  • 23
    • 0032849292 scopus 로고    scopus 로고
    • Minimal residual disease in head and neck cancer
    • Gath HJ, Brakenhoff RH. Minimal residual disease in head and neck cancer. Cancer Metastasis Rev 1999;18: 109-26.
    • (1999) Cancer Metastasis Rev , vol.18 , pp. 109-126
    • Gath, H.J.1    Brakenhoff, R.H.2
  • 24
    • 0034702250 scopus 로고    scopus 로고
    • Identification of a tumor-derived p53 mutant with novel transactivating selectivity
    • Pan Y, Haines DS. Identification of a tumor-derived p53 mutant with novel transactivating selectivity. Oncogene 2000;19:3095-100.
    • (2000) Oncogene , vol.19 , pp. 3095-3100
    • Pan, Y.1    Haines, D.S.2
  • 25
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • Aguirre Ghiso JA, Kovalski K, Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 1999;147:89-104.
    • (1999) J Cell Biol , vol.147 , pp. 89-104
    • Aguirre Ghiso, J.A.1    Kovalski, K.2    Ossowski, L.3
  • 26
    • 0026701989 scopus 로고
    • The Jun family members, c-Jun and JunD, transactivate the human c-myb promoter via an Ap1-like element
    • Nicolaides NC, Correa I, Casadevall C, et al. The Jun family members, c-Jun and JunD, transactivate the human c-myb promoter via an Ap1-like element. J Biol Chem 1992;267:19665-72.
    • (1992) J Biol Chem , vol.267 , pp. 19665-19672
    • Nicolaides, N.C.1    Correa, I.2    Casadevall, C.3
  • 27
    • 33747377165 scopus 로고    scopus 로고
    • c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
    • Stepniak E, Ricci R, Eferl R, et al. c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev 2006;20:2306-14.
    • (2006) Genes Dev , vol.20 , pp. 2306-2314
    • Stepniak, E.1    Ricci, R.2    Eferl, R.3
  • 28
    • 0037462454 scopus 로고    scopus 로고
    • Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53
    • Eferl R, Ricci R, Kenner L, et al. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 2003;112:181-92.
    • (2003) Cell , vol.112 , pp. 181-192
    • Eferl, R.1    Ricci, R.2    Kenner, L.3
  • 29
    • 0033104956 scopus 로고    scopus 로고
    • Control of cell cycle progression by c-Jun is p53 dependent
    • Schreiber M, Kolbus A, Piu F, et al. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev 1999;13:607-19.
    • (1999) Genes Dev , vol.13 , pp. 607-619
    • Schreiber, M.1    Kolbus, A.2    Piu, F.3
  • 30
    • 48749105093 scopus 로고    scopus 로고
    • ATF6α-RhebmTOR signaling promotes survival of dormant tumor cells in vivo
    • Schewe DM, Aguirre-Ghiso JA. ATF6α-RhebmTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci U S A 2008; 105:10519-24.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10519-10524
    • Schewe, D.M.1    Aguirre-Ghiso, J.A.2
  • 32
    • 1642377561 scopus 로고    scopus 로고
    • ONCOMINE: A cancer microarray database and integrated data-mining platform
    • Rhodes DR, Yu J, Shanker K, et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 2004;6:1-6.
    • (2004) Neoplasia , vol.6 , pp. 1-6
    • Rhodes, D.R.1    Yu, J.2    Shanker, K.3
  • 33
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van 't Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415:530-6.
    • (2002) Nature , vol.415 , pp. 530-536
    • van 't Veer, L.J.1    Dai, H.2    van de Vijver, M.J.3
  • 34
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver MJ, He YD, van't Veer LJ, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002;347:1999-2009.
    • (2002) N Engl J Med , vol.347 , pp. 1999-2009
    • van de Vijver, M.J.1    He, Y.D.2    van't Veer, L.J.3
  • 35
    • 0033485261 scopus 로고    scopus 로고
    • Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    • Bulavin DV, Saito S, Hollander MC, et al. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 1999;18:6845-54.
    • (1999) EMBO J , vol.18 , pp. 6845-6854
    • Bulavin, D.V.1    Saito, S.2    Hollander, M.C.3
  • 36
    • 17944379798 scopus 로고    scopus 로고
    • ASPP proteins specifically stimulate the apoptotic function of p53
    • Samuels-Lev Y, O'Connor DJ, Bergamaschi D, et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 2001;8:781-94.
    • (2001) Mol Cell , vol.8 , pp. 781-794
    • Samuels-Lev, Y.1    O'Connor, D.J.2    Bergamaschi, D.3
  • 37
    • 0027940573 scopus 로고
    • Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2
    • Thukral SK, Blain GC, Chang KK, Fields S. Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2. Mol Cell Biol 1994;14:8315-21.
    • (1994) Mol Cell Biol , vol.14 , pp. 8315-8321
    • Thukral, S.K.1    Blain, G.C.2    Chang, K.K.3    Fields, S.4
  • 38
    • 63049136592 scopus 로고    scopus 로고
    • A Mutant-p53/Smad complex opposes p63 to empower TGFβ-induced metastasis
    • Adorno M, Cordenonsi M, Montagner M, et al. A Mutant-p53/Smad complex opposes p63 to empower TGFβ-induced metastasis. Cell 2009;137:87-98.
    • (2009) Cell , vol.137 , pp. 87-98
    • Adorno, M.1    Cordenonsi, M.2    Montagner, M.3
  • 39
    • 0035947728 scopus 로고    scopus 로고
    • The p38 MAPK pathway is required for cell growth inhibition of human breast cancer cells in response to activin
    • Cocolakis E, Lemay S, Ali S, Lebrun JJ. The p38 MAPK pathway is required for cell growth inhibition of human breast cancer cells in response to activin. J Biol Chem 2001;276:18430-6.
    • (2001) J Biol Chem , vol.276 , pp. 18430-18436
    • Cocolakis, E.1    Lemay, S.2    Ali, S.3    Lebrun, J.J.4
  • 40
    • 39749157093 scopus 로고    scopus 로고
    • Sustained TGF β exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis
    • Gal A, Sjoblom T, Fedorova L, et al. Sustained TGF β exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene 2008;27: 1218-30.
    • (2008) Oncogene , vol.27 , pp. 1218-1230
    • Gal, A.1    Sjoblom, T.2    Fedorova, L.3


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