Nuclear localization of p38 MAPK in response to DNA damage

International Journal of Biological Sciences

Volumn 5, Issue 5, 2009, Pages 428-437

  Wood, C David ^a   Thornton, Tina M ^a   Sabio, Guadalupe ^b   Davis, Roger A ^b   Rincon, Mercedes ^a  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Cell cycle checkpoint; Dna damage; Dna repair; P38 map kinase

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL NUCLEUS; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETIC RECOMBINATION; HUMAN; METABOLISM; MOUSE; MOUSE MUTANT; PHOSPHORYLATION; X RAY;

ANIMALS; CATALYTIC DOMAIN; CELL CYCLE; CELL NUCLEUS; CELLS, CULTURED; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; HUMANS; MICE; MICE, KNOCKOUT; MICE, SCID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RECOMBINATION, GENETIC; X-RAYS;

EID: 70249090092     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.5.428     Document Type: Article

References (47)

1. Adams R.H., Porras A., Alonso G., Jones M., Vintersten K., Panelli S., Valladares A., Perez L., Klein R., and Nebreda A.R. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 2000;6: 109-116.
2. Allen M., Svensson L., Roach M., Hambor J., McNeish J., and Gabel C.A. Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzymedeficient embryonic stem cells. J Exp Med 2000;191: 859-870.
3. Mudgett J.S., Ding J., Guh-Siesel L., Chartrain N.A., Yang L., Gopal S., and Shen M.M. Essential role for p38alpha mitogenactivated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A 2000;97: 10454-10459.
4. Tamura K., Sudo T., Senftleben U., Dadak A.M., Johnson R., and Karin M. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 2000;102: 221-231.
5. Beardmore V.A., Hinton H.J., Eftychi C., Apostolaki M., Armaka M., Darragh J., McIlrath J., Carr J.M., Armit L.J., Clacher C., et al. Generation and characterization of p38beta (MAPK11) genetargeted mice. Mol Cell Biol 2005;25: 10454-10464.
6. Derijard B., Raingeaud J., Barrett T., Wu I.H., Han J., Ulevitch R.J., and Davis R.J. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 1995;267: 682-685.
7. Han J., Lee J.D., Jiang Y., Li Z., Feng L., and Ulevitch R.J. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem 1996;271: 2886-2891.
8. Brancho D., Tanaka N., Jaeschke A., Ventura J.J., Kelkar N., Tanaka Y., Kyuuma M., Takeshita T., Flavell R.A., and Davis R.J. Mechanism of p38 MAP kinase activation in vivo. Genes Dev 2003;17: 1969-1978.
9. Zarubin T., and Han J. Activation and signaling of the p38 MAP kinase pathway. Cell research 2005;15: 11-18.
10. She Q.B., Chen N., and Dong Z. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J Biol Chem 2000;275: 20444-20449.
11. She Q.B., Bode A.M., Ma W.Y., Chen N.Y., and Dong Z. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res 2001;61: 1604-1610.
12. Bulavin D.V., Higashimoto Y., Popoff I.J., Gaarde W.A., Basrur V., Potapova O., Appella E., and Fornace AJJr. Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 2001;411: 102-107.
13. Mikhailov A., Shinohara M., and Rieder C.L. The p38-mediated stress-activated checkpoint. A rapid response system for delaying progression through antephase and entry into mitosis. Cell Cycle 2005;4: 57-62.
14. Kurosu T., Takahashi Y., Fukuda T., Koyama T., Miki T., and Miura O. p38 MAP kinase plays a role in G2 checkpoint activation and inhibits apoptosis of human B cell lymphoma cells treated with etoposide. Apoptosis 2005;10: 1111-1120.
15. Thornton T.M., and Rincon M. Non-classical p38 map kinase functions: cell cycle checkpoints and survival. Int J Biol Sci 2009;5: 44-51.
16. Raingeaud J., Gupta S., Rogers J.S., Dickens M., Han J., Ulevitch R.J., and Davis R.J. Proinflammatory cytokines and environmental stress cause p38 mitogenactivated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 1995;270: 7420-7426.
17. Ben-Levy R., Hooper S., Wilson R., Paterson H.F., and Marshall C.J. Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol 1998;8: 1049-1057.
18. Cuenda A., Cohen P., Buee-Scherrer V., and Goedert M. Activation of stressactivated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J 1997;16: 295-305.
19. Waskiewicz A.J., Flynn A., Proud C.G., and Cooper J.A. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J 1997;16: 1909-1920.
20. Zhao M., New L., Kravchenko V.V., Kato Y., Gram H., di Padova F., Olson E.N., Ulevitch R.J., and Han J. Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol 1999;19: 21-30.
21. Alvarado-Kristensson M., Melander F., Leandersson K., Ronnstrand L., Wernstedt C., and Andersson T. p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils. J Exp Med 2004;199: 449-458.
22. Trouillas M., Saucourt C., Duval D., Gauthereau X., Thibault C., Dembele D., Feraud O., Menager J., Rallu M., Pradier L., et al. Bcl2, a transcriptional target of p38alpha, is critical for neuronal commitment of mouse embryonic stem cells. Cell Death Differ 2008;15: 1450-1459.
23. Jenner T.J., Fulford J., and O'Neill P. Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response. Radiation research 2001;156: 590-593.
24. Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., and Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998;273: 5858-5868.
25. Sedelnikova O.A., Rogakou E.P., Panyutin I.G., and Bonner W.M. Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiation research 2002;158: 486-492.
26. Kumar S., McDonnell P.C., Gum R.J., Hand A.T., Lee J.C., and Young P.R. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun 1997;235: 533-538.
27. Pargellis C., Tong L., Churchill L., Cirillo P.F., Gilmore T., Graham A.G., Grob P.M., Hickey E.R., Moss N., Pav S., et al. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat Struct Biol 2002;9: 268-272.
28. Enslen H., Raingeaud J., and Davis R.J. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem 1998;273: 1741-1748.
29. Sen J., Kapeller R., Fragoso R., Sen R., Zon L.I., and Burakoff S.J. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. J Immunol 1996;156: 4535-4538.
30. Pedraza-Alva G., Koulnis M., Charland C., Thornton T., Clements J.L., Schlissel M.S., and Rincon M. Activation of p38 MAP kinase by DNA doublestrand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint. Embo J 2006;25: 763-773.
31. Carney J.P., Maser R.S., Olivares H., Davis E.M., Le Beau M., Yates JR3rd, Hays L., Morgan W.F., and Petrini J.H. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 1998;93: 477-486.
32. Hollander M.C., Alamo I., Jackman J., Wang M.G., McBride O.W., and Fornace AJJr. Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem 1993;268: 24385-24393.
33. Zhu N., Shao Y., Xu L., Yu L., and Sun L. Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells. Mol Biol Rep. 2008 [Epub ahead of print]
34. Engel K., Kotlyarov A., and Gaestel M. Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. EMBO J 1998;17: 3363-3371.
35. Ge B., Gram H., Di Padova F., Huang B., New L., Ulevitch R.J., Luo Y., and Han J. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science 2002;295: 1291-1294.
36. Lu G., Kang Y.J., Han J., Herschman H.R., Stefani E., and Wang Y. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem 2006;281: 6087-6095.
37. Dmitrieva N.I., Bulavin D.V., Fornace AJJr., and Burg M.B. Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase. Proc Natl Acad Sci U S A 2002;99: 184-189.
38. Chao J.I., and Kuo P.C. Role of p53 and p38 MAP kinase in nitric oxide-induced G2/M arrest and apoptosis in the human lung carcinoma cells. Carcinogenesis 2004;25: 645.
39. Reinhardt H.C., Aslanian A.S., Lees J.A., and Yaffe M.B. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer cell 2007;11: 175-189.
40. Messier T.L., O'Neill J.P., and Finette B.A. V(D)J recombinase mediated interchromosomal HPRT alterations at cryptic recombination signal sequences in peripheral human T cells. Hum Mutat 2006;27: 829.
41. Murray J.M., O'Neill J.P., Messier T., Rivers J., Walker V.E., McGonagle B., Trombley L., Cowell L.G., Kelsoe G., McBlane F., et al. V(D)J recombinase-mediated processing of coding junctions at cryptic recombination signal sequences in peripheral T cells during human development. J Immunol 2006;177: 5393-5404.
42. Chatterji M., Tsai C.L., and Schatz D.G. Mobilization of RAG-generated signal ends by transposition and insertion in vivo. Mol Cell Biol 2006;26: 1558-1568.
43. Reddy Y.V., Perkins E.J., and Ramsden D.A. Genomic instability due to V(D)J recombination-associated transposition. Genes Dev 2006;20: 1575-1582.
44. Vanura K., Montpellier B., Le T., Spicuglia S., Navarro J.M., Cabaud O., Roulland S., Vachez E., Prinz I., Ferrier P., et al. In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability. PLoS biology 2007;5: e43.
45. Curry J.D., Schulz D., Guidos C.J., Danska J.S., Nutter L., Nussenzweig A., and Schlissel M.S. Chromosomal reinsertion of broken RSS ends during T cell development. J Exp Med 2007;204: 2293-2303.
46. Tanaka N., Kamanaka M., Enslen H., Dong C., Wysk M., Davis R.J., and Flavell R.A. Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep 2002;3: 785-791.
47. Hatle K.M., Neveu W., Dienz O., Rymarchyk S., Barrantes R., Hale S., Farley N., Lounsbury K.M., Bond J.P., Taatjes D., et al. Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression. Mol Cell Biol 2007;27: 2952-2966.