p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

Developmental Cell

Volumn 17, Issue 1, 2009, Pages 142-149

  Wong, Esther Sook Miin ^a   Le Guezennec, Xavier ^a   Demidov, Oleg N ^a   Marshall, Nicolette Theresa ^a   Wang, Siew Tein ^b   Krishnamurthy, Janakiraman ^c   Sharpless, Norman E ^c   Dunn, N Ray ^b   Bulavin, Dmitry V ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

CELLCYCLE; SIGNALING

Indexed keywords

BMI1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATASE; UNCLASSIFIED DRUG; WIP1 PROTEIN;

ANIMAL CELL; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AGING; ANIMALS; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ENZYME ACTIVATION; HUMANS; ISLETS OF LANGERHANS; KIDNEY; LIVER; LUNG; MICE; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASES; REPRESSOR PROTEINS; SPLEEN;

MAMMALIA; MUS;

EID: 67650225264     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2009.05.009     Document Type: Article

References (27)

1. Adams R.H., Porras A., Alonso G., Jones M., Vintersten K., Panelli S., Valladares S., Perez L., Klein R., and Nebreda A.R. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol. Cell 6 (2000) 109-116
2. Brancho D., Tanaka N., Jaeschke A., Ventura J.J., Kelkar N., Tanaka Y., Kyuuma M., Takeshita T., Flavell R.A., and Davis R.J. Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 17 (2003) 1969-1978
3. Bulavin D.V., and Fornace Jr. A.J. p38 MAP kinase's emerging role as a tumor suppressor. In: Klein G., and Vande Woude G.F. (Eds). Advances in Cancer Research Volume 92 (2004), Academic Press, San Diego, CA 95-118
4. Bulavin D.V., Demidov O.N., Saito S., Kauraniemi P., Phillips C., Amundson S.A., Ambrosino C., Sauter G., Nebreda A.R., Anderson C.W., et al. Amplification of the Wip1 phosphatase gene in human tumors abrogates p53 tumor-suppressor activity. Nat. Genet. 31 (2002) 210-215
5. Bulavin D.V., Phillips C., Nannenga B., Timofeev O., Donehower L.A., Anderson C.W., Appella E., and Fornace Jr. A.J. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat. Genet. 36 (2004) 343-350
6. Butler A.E., Janson J., Soeller W.C., and Butler P.C. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52 (2003) 2304-2314
7. Demidov O.N., Timofeev O., Lwin H.N., Kek C., Appella E., and Bulavin D.V. Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine. Cell Stem Cell 1 (2007) 180-190
8. Fiscella M., Zhang H., Fan S., Sakaguchi K., Shen S., Mercer W.E., Vande Woude G.F., O'Connor P.M., and Appella E. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc. Natl. Acad. Sci. USA 94 (1997) 6048-6053
9. Gil J., Bernard D., Martínez D., and Beach D. Polycomb CBX7 has a unifying role in cellular lifespan. Nat. Cell Biol. 6 (2004) 67-72
10. Gonzalez S., Klatt P., Delgado S., Conde E., Lopez-Rios F., Sanchez-Cespedes M., Mendez J., Antequera F., and Serrano M. Oncogenic activity of Cdc6 through repression of the INK4a/ARF locus. Nature 440 (2006) 702-706
11. Jacobs J.J., Kieboom K., Marino S., DePinho R.A., and van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397 (1999) 164-168
12. Jacobs J.J., Keblusek P., Robanus-Manndag E., Kristel P., Lingbeek M., Nederlof P.M., van Welsem T., van de Vijver M.J., Koh E.Y., Daley G.Q., and van Lohuizen M. Senescence bypass screen indentifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. Nat. Genet. 26 (2000) 291-299
13. Janzen V., Forkert R., Fleming H.E., Saito Y., Waring M.T., Dombkowski D.M., Cheng T., DePinho R.A., Sharpless N.E., and Scadden D.T. Stem-cell aging modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443 (2006) 404-405
14. Kranc K.R., Bamforth S.D., Bragança J., Norbury C., van Lohuizen M., and Bhattacharya S. Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Mol. Cell. Biol. 23 (2003) 7658-7666
15. Krishnamurthy J., Torrice C., Ramsey M.R., Kovalev G.I., Al-Regaiey K., Su L., and Sharpless N.E. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 114 (2004) 1299-1307
16. Krishnamurthy J., Ramsey M.R., Ligon K.L., Torrice C., Koh A., Bonner-Weir S., and Sharpless N.E. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443 (2006) 453-457
17. Molofsky A.V., Pardal R., Iwashita T., Park I.K., Clarke M.F., and Morrison S.J. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425 (2003) 962-967
18. Molofsky A.V., Slutsky S.G., Joseph N.M., He S., Pardal R., Krishnamurthy J., Sharpless N.E., and Morrison S.J. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during aging. Nature 443 (2006) 448-452
19. Ohtani N., Zebedee Z., Huot T.Z., Stinson J.A., Sugimoto M., Ohashi Y., Sharrocks A.D., Peters G., and Hara E. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409 (2001) 1067-1070
20. Raingeaud J., Whitmarsh A.J., Barrett T., Dérijard B., and Davis R.J. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16 (1996) 1247-1255
21. Shreeram S., Hee W.K., Demidov O.N., Kek C., Yamaguchi H., Fornace Jr. A.J., Anderson C.W., Appella E., and Bulavin D.V. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J. Exp. Med. 203 (2006) 2793-2799
22. Sherr C.J. The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2 (2001) 731-737
23. Tamura K., Sudo T., Senftleben U., Dadak A.M., Johnson R., and Karin M. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102 (2000) 221-231
24. Teta M., Long S.Y., Wartschow L.M., Rankin M.M., and Kushner J.A. Very slow turnover of beta-cells in aged adult mice. Diabetes 54 (2005) 2557-2567
25. Voncken J.W., Niessen H., Neufeld B., Rennefahrt U., Dahlmans V., Kubben N., Holzer B., Ludwig S., and Rapp U.R. MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. J. Biol. Chem. 280 (2005) 5178-5187
26. Wang W., Chen J.X., Liao R., Deng Q., Zhou J.J., Huang S., and Sun P. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol. Cell. Biol. 22 (2002) 3389-3403
27. Zindy F., Quelle D.E., Roussel M.F., and Sherr C.J. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15 (1997) 203-211