Differential involvement of p38 mitogen-activated protein kinases MKK3 and MKK6 in T-cell apoptosis

EMBO Reports

Volumn 3, Issue 8, 2002, Pages 785-791

  Tanaka, Nobuyuki ^a   Kamanaka, Masahito ^a   Enslen, Hervé ^a   Dong, Chen ^a   Wysk, Mark ^a   Davis, Roger J ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CELL SURFACE RECEPTOR; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; DNA; INTERLEUKIN 2; IONOMYCIN; IONOPHORE; MAP2K3 PROTEIN, MOUSE; MAP2K6 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INDUCTION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STIMULUS RESPONSE; STRESS; T LYMPHOCYTE; THYMOCYTE; ALLELE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CD4+ T LYMPHOCYTE; CELL DIVISION; CYTOLOGY; GENETIC RECOMBINATION; IMMUNOBLOTTING; METABOLISM; PATHOLOGY; SERODIAGNOSIS; THYMUS; TRANSGENIC MOUSE; UPREGULATION; WESTERN BLOTTING;

ALLELES; ANIMAL; APOPTOSIS; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CD4-POSITIVE T-LYMPHOCYTES; CELL DEATH; CELL DIVISION; DNA; DOWN-REGULATION; ENZYME ACTIVATION; IMMUNOBLOTTING; INTERLEUKIN-2; IONOMYCIN; IONOPHORES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, GENETIC; PRECIPITIN TESTS; PROTEIN-TYROSINE KINASE; RECOMBINATION, GENETIC; T-LYMPHOCYTES; THYMUS GLAND; UP-REGULATION; ANIMALS; MAP KINASE KINASE 3; MAP KINASE KINASE 6; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-TYROSINE KINASES;

EID: 0036687249     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf153     Document Type: Article

References (18)

1. Signal transduction by the JNK group of MAP kinases
2. Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
3. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
4. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment
5. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
6. + T cells
7. P38 MAP kinases: Beyond the stress response
8. + thymocytes
9. Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
10. Signal transduction by MAP kinases in T lymphocytes
11. NGF withdrawal induces apoptosis in CESS B cell line through p38 MAPK activation and Bcl-2 phosphorylation
12. 2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation
13. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
14. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
15. 2-terminal kinase (Jnk) gene expression during T cell activation
16. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors
17. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression
18. 2-terminal kinase