Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

Nature Structural Biology

Volumn 9, Issue 4, 2002, Pages 268-272

  Pargellis, Christopher ^a   Tong, Liang ^a,b   Churchill, Laurie ^a   Cirillo, Pier F ^a   Gilmore, Thomas ^a   Graham, Anne G ^a   Grob, Peter M ^a   Hickey, Eugene R ^a   Moss, Neil ^a   Pav, Susan ^a   Regan, John ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; ADENOSINE TRIPHOSPHATE; DORAMAPIMOD; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG CONFORMATION; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

ALLOSTERIC SITE; AMINO ACID MOTIFS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; NAPHTHALENES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; PROTEIN CONFORMATION; PYRAZOLES; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 18344395134     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb770     Document Type: Article

References (29)