Increased MKK4 abundance with replicative senescence Is linked to the joint reduction of multiple microRNAs

Science Signaling

Volumn 2, Issue 94, 2009, Pages

  Marasa, Bernard S ^a   Srikantan, Subramanya ^a   Masuda, Kiyoshi ^a   Abdelmohsen, Kotb ^a   Kuwano, Yuki ^a   Yang, Xiaoling ^a   Martindale, Jennifer L ^a   Rinker Schaeffer, Carrie W ^b   Gorospe, Myriam ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; MAP2K4 PROTEIN, HUMAN; PRIMER DNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CELL AGING; CELL DIVISION; CELL PROLIFERATION; ENZYME PHOSPHORYLATION; GENE REPRESSION; HELA CELL; HUMAN; PRIORITY JOURNAL; SENESCENCE; SIGNAL TRANSDUCTION; CELL CULTURE; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; DNA PRIMERS; HUMANS; IMMUNOHISTOCHEMISTRY; MAP KINASE KINASE 4; MICRORNAS; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 74049111298     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000442     Document Type: Article

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28. We thank M. Bernier, B. Damdinsuren, and M. Kaileh for providing reagents and N. N. Hooten for help with the preparation of the manuscript. This research was supported by the National Institute on Aging-Intramural Research Program, NIH.