Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway

FASEB Journal

Volumn 23, Issue 7, 2009, Pages 2088-2099

  Oh, Ji Eun ^a   Bae, Gyu Un ^a,b   Yang, Youn Joo ^a   Yi, Min Jeong ^a   Lee, Hye Jin ^a   Kim, Bok Geon ^a   Krauss, Robert S ^b   Kang, Jong Sun ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Bnip 2; Cdc42; JLP; Myogenic differentiation; Neurogenin1; Tissue specific basic helix loop helix transcription factors

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL SURFACE RECEPTOR; HETERODIMER; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROGENIN 1; PROTEIN BNIP2; PROTEIN CDC42; PROTEIN CDO; PROTEIN JLP; REGULATOR PROTEIN; RETINOIC ACID; SCAFFOLD PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E47; UNCLASSIFIED DRUG; CDO PROTEIN, MOUSE; CELL ADHESION MOLECULE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIMERIZATION; EMBRYO; EMBRYONAL CARCINOMA STEM CELL; ENZYME ACTIVATION; GENE CONTROL; MOLECULAR MECHANICS; MOUSE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REDUCTION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL LINEAGE; CYTOLOGY; METABOLISM; MOUSE MUTANT; NERVE CELL; PHYSIOLOGY;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CDC42 GTP-BINDING PROTEIN; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; ENZYME ACTIVATION; MICE; MICE, KNOCKOUT; NEUROGENESIS; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 68549115535     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-119255     Document Type: Article

References (39)

1. Ge, W., He, F., Kim, K. J., Blanchi, B., Coskun, V., Nguyen, L., Wu, X., Zhao, J., Heng, J. I., Martinowich, K., Tao, J., Wu, H., Castro, D., Sobeih, M. M., Corfas, G., Gleeson, J. G., Greenberg, M. E., Guillemot, F., and Sun, Y. E. (2006) Coupling of cell migration with neurogenesis by proneural bHLH factors. Proc. Natl. Acad. Sci. U. S. A. 103, 1319-1324 (Pubitemid 43191163)
2. Turner, D. L., and Weintraub, H. (1994) Expression of achaetescute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev. 8, 1434-1447
3. Farah, M. H., Olson, J. M., Sucic, H. B., Hume, R. I., Tapscott, S. J., and Turner, D. L. (2000) Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127, 693-702
4. Bertrand, N., Castro, D. S., and Guillemot, F. (2002) Proneural genes and the specification of neural cell types. Nat. Rev. Neurosci. 3, 517-530 (Pubitemid 135706662)
5. Tibbles, L. A., and Woodgett, J. R. (1999) The stress-activated protein kinase pathways. Cell. Mol. Life Sci. 55, 1230-1254
6. Jones, N. M., and Bergeron, M. (2004) Hypoxia-induced ischemic tolerance in neonatal rat brain involves enhanced ERK1/2 signaling. J. Neurochem. 89, 157-167
7. Lluís, F., Perdiguero, E., Nebreda, A. R., and Muñoz-Cánoves, P. (2006) Regulation of skeletal muscle gene expression by p38 MAP kinases. Trends Cell Biol. 16, 36-44 (Pubitemid 43077093)
8. Morooka, T., and Nishida, E. (1998) Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells. J. Biol. Chem. 273, 24285-24288 (Pubitemid 28454911)
9. Iwasaki, S., Hattori, A., Sato, M., Tsujimoto, M., and Kohno, M. (1996) Characterization of the bone morphogenetic protein-2 as a neurotrophic factor: induction of neuronal differentiation of PC12 cells in the absence of mitogen-activated protein kinase activation. J. Biol. Chem. 271, 17360-17365 (Pubitemid 26244297)
10. Okamoto, S., Krainc, D., Sherman, K., and Lipton, S. A. (2000) Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proc. Natl. Acad. Sci. U. S. A. 97, 7561-7566 (Pubitemid 30431503)
11. Luo, L. (2002) Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. Annu. Rev. Cell Dev. Biol. 18, 601-635 (Pubitemid 35387363)
12. Aoki, K., Nakamura, T., and Matsuda, M. (2004) Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells. J. Biol. Chem. 279, 713-719 (Pubitemid 38044876)
13. Rosário, M., Franke, R., Bednarski, C., and Birchmeier, W. (2007) The neurite outgrowth multiadaptor RhoGAP, NOMAGAP, regulates neurite extension through SHP2 and Cdc42. J. Cell Biol. 178, 503-516 (Pubitemid 47196157)
14. Garvalov, B. K., Flynn, K. C., Neukirchen, D., Meyn, L., Teusch, N., Wu, X., Brakebusch, C., Bamburg, J. R., and Bradke, F. (2007) Cdc42 regulates cofilin during the establishment of neuronal polarity. J. Neurosci. 27, 13117-13129 (Pubitemid 350220488)
15. Cappello, S., Attardo, A., Wu, X., Iwasato, T., Itohara, S., Wilsch-Bräuninger, M., Eilken, H. M., Rieger, M. A., Schroeder, T. T., Huttner, W. B., Brakebusch, C., and Götz, M. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat. Neurosci. 9, 1099-1107 (Pubitemid 44306302)
16. Jaffe, A. B., and Hall, A. (2005) Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269
17. Low, B. C., Seow, K. T., and Guy, G. R. (2000) The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP. J. Biol. Chem. 275, 37742-37751
18. Mulieri, P. J., Okada, A., Sassoon, D. A., McConnell, S. K., and Krauss, R. S. (2000) Developmental expression pattern of the cdo gene. Dev. Dyn. 219, 40-49 (Pubitemid 30667122)
19. Cole, F., Zhang, W., Geyra, A., Kang, J. S., and Krauss, R. S. (2004) Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO. Dev. Cell 7, 843-854 (Pubitemid 39654729)
20. Zhang, W., Kang, J. S., Cole, F., Yi, M. J., and Krauss, R. S. (2006) Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev. Cell 10, 657-665
21. Zhang, W., Yi, M. J., Chen, X., Cole, F., Krauss, R. S., and Kang, J. S. (2006) Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO. Mol. Cell. Biol. 26, 3764-3772 (Pubitemid 43726394)
22. Kang, J. S., Bae, G. U., Yi, M. J., Yang, Y. J., Oh, J. E., Takaesu, G., Zhou, Y. T., Low, B. C., and Krauss, R. S. (2008) A Cdo/Bnip- 2/Cdc42 signaling pathway regulates p38α/β MAPK activity and myogenic differentiation. J. Cell Biol. 182, 497-507
23. Takaesu, G., Kang, J. S., Bae, G. U., Yi, M. J., Lee, C. M., Reddy, E. P., Krauss, R. S. (2006) Activation of p38α/β MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo. J. Cell Biol. 175, 383-388 (Pubitemid 44708063)
24. Kang, J. S., Mulieri, P. J., Miller, C., Sassoon, D. A., and Krauss, R. S. (1998) CDO, a robo-related cell surface protein that mediates myogenic differentiation. J. Cell Biol. 143, 403-413 (Pubitemid 28487859)
25. Pacherník, J., Bryja, V., Esner, M., Kubala, L., Dvorák, P., and Hampl, A. (2005) Neural differentiation of pluripotent mouse embryonal carcinoma cells by retinoic acid: inhibitory effect of serum. Physiol. Res. 54, 115-122 (Pubitemid 40363661)
26. Low, B. C., Lim, Y. P., Lim, J., Wong, E. S., and Guy, G. R. (1999) Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42. J. Biol. Chem. 274, 33123-33130 (Pubitemid 129535355)
27. Lluís, F., Ballestar, E., Suelves, M., Esteller, M., and Muñoz- Cánoves, P. (2005) E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription. EMBO J. 24, 974-984
28. McBurney, M. W. (1993) P19 embryonal carcinoma cells. Int. J. Dev. Biol. 37, 135-140
29. Bain, G., and Gottlieb, D. I. (1994) Expression of retinoid X receptors in P19 embryonal carcinoma cells and embryonic stem cells. Biochem. Biophys. Res. Commun. 200, 1252-1256 (Pubitemid 24181786)
30. Bixby, J. L., and Zhang, R. (1990) Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth. J. Cell Biol. 110, 1253-1260 (Pubitemid 20136501)
31. Massari, M. E., and Murre, C. (2000) Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20, 429-440
32. Xing, J., Kornhauser, J. M., Xia, Z., Thiele, E. A., and Greenberg, M. E. (1998) CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site. Oncogene 16, 1161-1169
33. Yanagisawa, M., Nakashima, K., Takeda, K., Ochiai, W., Takizawa, T., Ueno, M., Takizawa, M., Shibuya, H., and Taga, T. (2001) Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Genes Cells 6, 1091-1099 (Pubitemid 33133697)
34. Faigle, R., Brederlau, A., Elmi, M., Arvidsson, Y., Hamazaki, T. S., Uramoto, H., and Funa, K. (2004) ASK1 inhibits astroglial development via p38 mitogen-activated protein kinase and promotes neuronal differentiation in adult hippocampus-derived progenitor cells. Mol. Cell. Biol. 24, 280-293 (Pubitemid 38010054)
35. Krauss, R. S., Cole, F., Gaio, U., Takaesu, G., Zhang, W., and Kang, J. S. (2005) Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact. J. Cell Sci. 118, 2355-2362 (Pubitemid 40873075)
36. Kang, J. S., Feinleib, J. L., Knox, S., Ketteringham, M. A., and Krauss, R. S. (2003) Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. Proc. Natl. Acad. Sci. U. S. A. 100, 3989-3994 (Pubitemid 36418144)
37. Kang, J. S., Yi, M. J., Zhang, W., Feinleib, J. L., Cole, F., and Krauss, R. S. (2004) Netrins and neogenin promote myotube formation. J. Cell Biol. 167, 493-504 (Pubitemid 39489057)
38. Gao, X., Bian, W., Yang, J., Tang, K., Kitani, H., Atsumi, T., and Jing, J. (2001) A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells. Biochem. Biophys. Res. Commun. 284, 1098-1103 (Pubitemid 32917951)
39. Redies, C. (2000) Cadherins in the central nervous system. Prog. Neurobiol. 61, 611-648