RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways

Proteomics

Volumn 9, Issue 10, 2009, Pages 2776-2787

  Rao, Prema S ^a   Satelli, Arun ^a   Zhang, Sheng ^b   Srivastava, Sanjay K ^a   Srivenugopal, Kalkunte S ^a   Subrahmanyeswara Rao, U ^a,c  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c Texas Tech School of Pharmacy   (United States)

Author keywords

2 D gel electrophoresis; Cancer; Gene expression; Mass spectra; Protein phosphorylation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATASE; PHOSPHOSERINE; PROTEIN RNF2; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TWO DIMENSIONAL ELECTROPHORESIS; WESTERN BLOTTING;

CELL LINE; DNA-BINDING PROTEINS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOMICS; REPRESSOR PROTEINS; TANDEM MASS SPECTROMETRY; UBIQUITIN-PROTEIN LIGASES;

HEXAPODA;

EID: 66449120247     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200800847     Document Type: Article

References (24)

1. Schwartz, Y. B., Pirrotta, V., Polycomb silencing mechanisms and the management of genomic programmes. Nat. Rev. Genet. 2007, 8, 9-22. (Pubitemid 46006046)
2. Cao, R., Wang, L., Wang, H., Xia, L. et al., Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002, 298, 1039-1043. (Pubitemid 35247314)
3. Shao, Z., Raible, F., Mollaaghababa, R., Guyon, J. R. et al., Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 1999, 98, 37-46. (Pubitemid 29331194)
4. Levine, S. S., Weiss, A., Erdjument-Bromage, H., Shao, Z. et al., The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol. Cell Biol. 2002, 22, 6070-6078.
5. Wiederschain, D., Chen, L., Johnson, B., Bettano, K. et al., Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. Mol. Cell Biol. 2007, 27, 4968-4979. (Pubitemid 47016145)
6. Dimri, G. P., Martinez, J. L., Jacobs, J. J., Keblusek, P. et al., The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res. 2002, 62, 4736-4745.
7. Leung, C., Lingbeek, M., Shakhova, O., Liu, J. et al., Bmi1 is essential for cerebellar development and is over-expressed in human medulloblastomas. Nature 2004, 428, 337-341. (Pubitemid 38418806)
8. Vonlanthen, S., Heighway, J., Altermatt, H. J., Gugger, M. et al., The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br. J. Cancer 2001, 84, 1372-1376. (Pubitemid 32522106)
9. Jacobs, J. J., Scheijen, B., Voncken, J. W., Kieboom, K. et al., Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev. 1999, 13, 2678-2690. (Pubitemid 29508555)
10. Francis, N. J., Saurin, A. J., Shao, Z., Kingston, R. E., Reconstitution of a functional core polycomb repressive complex. Mol. Cell 2001, 8, 545-556. (Pubitemid 32946932)
11. Wang, H., Wang, L., Erdjument-Bromage, H., Vidal, M. et al., Role of histone H2A ubiquitination in Polycomb silencing. Nature 2004, 431, 873-878. (Pubitemid 39434086)
12. Stock, J. K., Giadrossi, S., Casanova, M., Brookes, E. et al., Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat. Cell Biol. 2007, 9, 1428-1435. (Pubitemid 350201756)
13. Cao, R., Tsukada, Y., Zhang, Y., Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 2005, 20, 845-854. (Pubitemid 41814874)
14. Li, Z., Cao, R., Wang, M., Myers, M. P. et al., Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. J. Biol. Chem. 2006, 281, 20643-20649. (Pubitemid 44065835)
15. Rao, P. S., Mallya, K. B., Srivenugopal, K. S., Balaji, K. C., Rao, U. S., RNF2 interacts with the linker region of the human P-glycoprotein. Int. J. Oncol. 2006, 29, 1413-1419.
16. Williamson, B. L., Marchese, J., Morrice, N. A., Automated identification and quantification of protein phosphorylation sites by LC/MS on a hybrid triple quadrupole linear ion trap mass spectrometer. Mol. Cell Proteomics 2006, 5, 337-346. (Pubitemid 43329311)
17. Cuenda, A., Rouse, J., Doza, Y. N., Meier, R. et al., SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 1995, 364, 229-233.
18. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., Saltiel, A. R., A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 1995, 92, 7686-7689.
19. Giglione, C., Boularot, A., Meinnel, T., Protein N-terminal methionine excision. Cell Mol. Life Sci. 2004, 61, 1455-1474. (Pubitemid 38858352)
20. Voncken, J. W., Niessen, H., Neufeld, B., Rennefahrt, U. et al., MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. J. Biol. Chem. 2005, 280, 5178-5187. (Pubitemid 40279988)
21. Gil, J., Peters, G., Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat. Rev. Mol. Cell Biol. 2006, 7, 667-677. (Pubitemid 44268212)
22. Myers, F. A., Chong, W., Evans, D. R., Thorne, A. W., Crane-Robinson, C., Acetylation of histone H2B mirrors that of H4 and H3 at the chicken beta-globin locus but not at housekeeping genes. J. Biol. Chem. 2003, 278, 36315-36322. (Pubitemid 37139957)
23. Tsay, Y. G., Wang, Y. H., Chiu, C. M., Shen, B. J., Lee, S. C., A strategy for identification and quantitation of phosphopeptides by liquid chromatography/tandem mass spectrometry. Anal. Biochem. 2000, 287, 55-64.
24. Britton, D. J., Scott, G. K., Schilling, B., Atsriku, C. et al., A novel serine phosphorylation site detected in the N-terminal domain of estrogen receptor isolated from human breast cancer cells. J. Am. Soc. Mass Spectrom. 2008, 19, 729-740.