메뉴 건너뛰기




Volumn 136, Issue 6, 2009, Pages 1085-1097

The Ste5 Scaffold Directs Mating Signaling by Catalytically Unlocking the Fus3 MAP Kinase for Activation

Author keywords

CELLBIO; PROTEINS; SIGNALING

Indexed keywords

FUS3 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; SCAFFOLD PROTEIN; STE5 PROTEIN; STE7 PROTEIN; UNCLASSIFIED DRUG;

EID: 62149128986     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2009.01.049     Document Type: Article
Times cited : (156)

References (31)
  • 1
    • 11144352246 scopus 로고    scopus 로고
    • Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast
    • Bao M.Z., Schwartz M.A., Cantin G.T., Yates III J.R., and Madhani H.D. Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell 119 (2004) 991-1000
    • (2004) Cell , vol.119 , pp. 991-1000
    • Bao, M.Z.1    Schwartz, M.A.2    Cantin, G.T.3    Yates III, J.R.4    Madhani, H.D.5
  • 2
    • 0029992810 scopus 로고    scopus 로고
    • Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7
    • Bardwell L., Cook J.G., Chang E.C., Cairns B.R., and Thorner J. Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7. Mol. Cell. Biol. 16 (1996) 3637-3650
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3637-3650
    • Bardwell, L.1    Cook, J.G.2    Chang, E.C.3    Cairns, B.R.4    Thorner, J.5
  • 3
    • 38549141229 scopus 로고    scopus 로고
    • Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre
    • Bennett-Lovsey R.M., Herbert A.D., Sternberg M.J., and Kelley L.A. Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre. Proteins 70 (2008) 611-625
    • (2008) Proteins , vol.70 , pp. 611-625
    • Bennett-Lovsey, R.M.1    Herbert, A.D.2    Sternberg, M.J.3    Kelley, L.A.4
  • 4
    • 32444442870 scopus 로고    scopus 로고
    • The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
    • Bhattacharyya R.P., Remenyi A., Good M.C., Bashor C.J., Falick A.M., and Lim W.A. The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science 311 (2006) 822-826
    • (2006) Science , vol.311 , pp. 822-826
    • Bhattacharyya, R.P.1    Remenyi, A.2    Good, M.C.3    Bashor, C.J.4    Falick, A.M.5    Lim, W.A.6
  • 5
    • 33746363486 scopus 로고    scopus 로고
    • Domains, motifs, and scaffolds: The role of modular interactions in the evolution and wiring of cell signaling circuits
    • Bhattacharyya R.P., Remenyi A., Yeh B.J., and Lim W.A. Domains, motifs, and scaffolds: The role of modular interactions in the evolution and wiring of cell signaling circuits. Annu. Rev. Biochem. 75 (2006) 655-680
    • (2006) Annu. Rev. Biochem. , vol.75 , pp. 655-680
    • Bhattacharyya, R.P.1    Remenyi, A.2    Yeh, B.J.3    Lim, W.A.4
  • 6
    • 0028216851 scopus 로고
    • A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog
    • Brill J.A., Elion E.A., and Fink G.R. A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog. Mol. Biol. Cell 5 (1994) 297-312
    • (1994) Mol. Biol. Cell , vol.5 , pp. 297-312
    • Brill, J.A.1    Elion, E.A.2    Fink, G.R.3
  • 7
    • 0036604986 scopus 로고    scopus 로고
    • Scaffolds, adaptors and linkers of TCR signaling: theory and practice
    • Burack W.R., Cheng A.M., and Shaw A.S. Scaffolds, adaptors and linkers of TCR signaling: theory and practice. Curr. Opin. Immunol. 14 (2002) 312-316
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 312-316
    • Burack, W.R.1    Cheng, A.M.2    Shaw, A.S.3
  • 8
    • 0034009390 scopus 로고    scopus 로고
    • Signal transduction: hanging on a scaffold
    • Burack W.R., and Shaw A.S. Signal transduction: hanging on a scaffold. Curr. Opin. Cell Biol. 12 (2000) 211-216
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 211-216
    • Burack, W.R.1    Shaw, A.S.2
  • 9
    • 0027983908 scopus 로고
    • Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
    • Choi K.Y., Satterberg B., Lyons D.M., and Elion E.A. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78 (1994) 499-512
    • (1994) Cell , vol.78 , pp. 499-512
    • Choi, K.Y.1    Satterberg, B.2    Lyons, D.M.3    Elion, E.A.4
  • 10
    • 11144340454 scopus 로고    scopus 로고
    • Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast
    • Chou S., Huang L., and Liu H. Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast. Cell 119 (2004) 981-990
    • (2004) Cell , vol.119 , pp. 981-990
    • Chou, S.1    Huang, L.2    Liu, H.3
  • 12
    • 14044266923 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae
    • Flatauer L.J., Zadeh S.F., and Bardwell L. Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae. Mol. Cell. Biol. 25 (2005) 1793-1803
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 1793-1803
    • Flatauer, L.J.1    Zadeh, S.F.2    Bardwell, L.3
  • 14
    • 0035960710 scopus 로고    scopus 로고
    • Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins
    • Harris K., Lamson R.E., Nelson B., Hughes T.R., Marton M.J., Roberts C.J., Boone C., and Pryciak P.M. Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins. Curr. Biol. 11 (2001) 1815-1824
    • (2001) Curr. Biol. , vol.11 , pp. 1815-1824
    • Harris, K.1    Lamson, R.E.2    Nelson, B.3    Hughes, T.R.4    Marton, M.J.5    Roberts, C.J.6    Boone, C.7    Pryciak, P.M.8
  • 15
    • 0029785147 scopus 로고    scopus 로고
    • Mapping the protein universe
    • Holm L., and Sander C. Mapping the protein universe. Science 273 (1996) 595-603
    • (1996) Science , vol.273 , pp. 595-603
    • Holm, L.1    Sander, C.2
  • 16
    • 0030777328 scopus 로고    scopus 로고
    • Mutational analysis of STE5 in the yeast Saccharomyces cerevisiae: application of a differential interaction trap assay for examining protein-protein interactions
    • Inouye C., Dhillon N., Durfee T., Zambryski P.C., and Thorner J. Mutational analysis of STE5 in the yeast Saccharomyces cerevisiae: application of a differential interaction trap assay for examining protein-protein interactions. Genetics 147 (1997) 479-492
    • (1997) Genetics , vol.147 , pp. 479-492
    • Inouye, C.1    Dhillon, N.2    Durfee, T.3    Zambryski, P.C.4    Thorner, J.5
  • 17
    • 0030815533 scopus 로고    scopus 로고
    • Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling
    • Inouye C., Dhillon N., and Thorner J. Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. Science 278 (1997) 103-106
    • (1997) Science , vol.278 , pp. 103-106
    • Inouye, C.1    Dhillon, N.2    Thorner, J.3
  • 18
    • 14544270984 scopus 로고    scopus 로고
    • Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates
    • Loog M., and Morgan D.O. Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434 (2005) 104-108
    • (2005) Nature , vol.434 , pp. 104-108
    • Loog, M.1    Morgan, D.O.2
  • 19
    • 35748968807 scopus 로고    scopus 로고
    • Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling
    • Maeder C.I., Hink M.A., Kinkhabwala A., Mayr R., Bastiaens P.I., and Knop M. Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling. Nat. Cell Biol. 9 (2007) 1319-1326
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1319-1326
    • Maeder, C.I.1    Hink, M.A.2    Kinkhabwala, A.3    Mayr, R.4    Bastiaens, P.I.5    Knop, M.6
  • 20
    • 4744346430 scopus 로고    scopus 로고
    • Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast
    • Maleri S., Ge Q., Hackett E.A., Wang Y., Dohlman H.G., and Errede B. Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast. Mol. Cell. Biol. 24 (2004) 9221-9238
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 9221-9238
    • Maleri, S.1    Ge, Q.2    Hackett, E.A.3    Wang, Y.4    Dohlman, H.G.5    Errede, B.6
  • 21
    • 0037436155 scopus 로고    scopus 로고
    • Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms
    • Park S.H., Zarrinpar A., and Lim W.A. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299 (2003) 1061-1064
    • (2003) Science , vol.299 , pp. 1061-1064
    • Park, S.H.1    Zarrinpar, A.2    Lim, W.A.3
  • 22
    • 0033574614 scopus 로고    scopus 로고
    • Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors
    • Pavletich N.P. Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. J. Mol. Biol. 287 (1999) 821-828
    • (1999) J. Mol. Biol. , vol.287 , pp. 821-828
    • Pavletich, N.P.1
  • 23
    • 29144502234 scopus 로고    scopus 로고
    • The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network
    • Remenyi A., Good M.C., Bhattacharyya R.P., and Lim W.A. The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol. Cell 20 (2005) 951-962
    • (2005) Mol. Cell , vol.20 , pp. 951-962
    • Remenyi, A.1    Good, M.C.2    Bhattacharyya, R.P.3    Lim, W.A.4
  • 24
    • 33947256308 scopus 로고    scopus 로고
    • Docking interactions in protein kinase and phosphatase networks
    • Remenyi A., Good M.C., and Lim W.A. Docking interactions in protein kinase and phosphatase networks. Curr. Opin. Struct. Biol. 16 (2006) 676-685
    • (2006) Curr. Opin. Struct. Biol. , vol.16 , pp. 676-685
    • Remenyi, A.1    Good, M.C.2    Lim, W.A.3
  • 25
    • 33646710154 scopus 로고    scopus 로고
    • Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5
    • Schwartz M.A., and Madhani H.D. Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5. Curr. Genet. 49 (2006) 351-363
    • (2006) Curr. Genet. , vol.49 , pp. 351-363
    • Schwartz, M.A.1    Madhani, H.D.2
  • 26
    • 0033739255 scopus 로고    scopus 로고
    • Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein
    • Sette C., Inouye C.J., Stroschein S.L., Iaquinta P.J., and Thorner J. Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein. Mol. Biol. Cell 11 (2000) 4033-4049
    • (2000) Mol. Biol. Cell , vol.11 , pp. 4033-4049
    • Sette, C.1    Inouye, C.J.2    Stroschein, S.L.3    Iaquinta, P.J.4    Thorner, J.5
  • 27
    • 0037154295 scopus 로고    scopus 로고
    • MAP kinase cascades: scaffolding signal specificity
    • van Drogen F., and Peter M. MAP kinase cascades: scaffolding signal specificity. Curr. Biol. 12 (2002) R53-R55
    • (2002) Curr. Biol. , vol.12
    • van Drogen, F.1    Peter, M.2
  • 28
    • 0035203511 scopus 로고    scopus 로고
    • MAP kinase dynamics in response to pheromones in budding yeast
    • van Drogen F., Stucke V.M., Jorritsma G., and Peter M. MAP kinase dynamics in response to pheromones in budding yeast. Nat. Cell Biol. 3 (2001) 1051-1059
    • (2001) Nat. Cell Biol. , vol.3 , pp. 1051-1059
    • van Drogen, F.1    Stucke, V.M.2    Jorritsma, G.3    Peter, M.4
  • 29
    • 0029146796 scopus 로고
    • Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p
    • Whiteway M.S., Wu C., Leeuw T., Clark K., Fourest-Lieuvin A., Thomas D.Y., and Leberer E. Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p. Science 269 (1995) 1572-1575
    • (1995) Science , vol.269 , pp. 1572-1575
    • Whiteway, M.S.1    Wu, C.2    Leeuw, T.3    Clark, K.4    Fourest-Lieuvin, A.5    Thomas, D.Y.6    Leberer, E.7
  • 30
    • 0036796740 scopus 로고    scopus 로고
    • Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere
    • Whittaker C.A., and Hynes R.O. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Mol. Biol. Cell 13 (2002) 3369-3387
    • (2002) Mol. Biol. Cell , vol.13 , pp. 3369-3387
    • Whittaker, C.A.1    Hynes, R.O.2
  • 31
    • 25844442435 scopus 로고    scopus 로고
    • A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response
    • Winters M.J., Lamson R.E., Nakanishi H., Neiman A.M., and Pryciak P.M. A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response. Mol. Cell 20 (2005) 21-32
    • (2005) Mol. Cell , vol.20 , pp. 21-32
    • Winters, M.J.1    Lamson, R.E.2    Nakanishi, H.3    Neiman, A.M.4    Pryciak, P.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.