메뉴 건너뛰기




Volumn 119, Issue 2, 2010, Pages 115-135

MRN and the race to the break

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CELL DNA; FUNGAL PROTEIN; GENOMIC DNA; MRE11 PROTEIN; NIBRIN; PROTEIN SAE2; RAD50 PROTEIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

EID: 77953287126     PISSN: 00095915     EISSN: 14320886     Source Type: Journal    
DOI: 10.1007/s00412-009-0242-4     Document Type: Review
Times cited : (71)

References (192)
  • 1
    • 0027476083 scopus 로고
    • Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae
    • Ajimura M, Leem SH, Ogawa H (1993) Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics 133:51-66
    • (1993) Genetics , vol.133 , pp. 51-66
    • Ajimura, M.1    Leem, S.H.2    Ogawa, H.3
  • 3
    • 0025334351 scopus 로고
    • Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination
    • Alani E, Padmore R, Kleckner N (1990) Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell 61:419-436
    • (1990) Cell , vol.61 , pp. 419-436
    • Alani, E.1    Padmore, R.2    Kleckner, N.3
  • 4
    • 11244269445 scopus 로고    scopus 로고
    • The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle
    • Aylon Y, Liefshitz B, Kupiec M. (2004) The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J 23:4868-4875
    • (2004) EMBO J , vol.23 , pp. 4868-4875
    • Aylon, Y.1    Liefshitz, B.2    Kupiec, M.3
  • 5
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM. through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB (2003) DNA damage activates ATM. through intermolecular autophosphorylation and dimer dissociation, Nature 421:499-506
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 6
    • 39549114009 scopus 로고    scopus 로고
    • Differential regulation of the cellular response to DNA double-strand breaks in G1
    • Barlow JH, Lisby M, Rothstein R (2008) Differential regulation of the cellular response to DNA double-strand breaks in G1. Mol Cell 30:73-85
    • (2008) Mol Cell , vol.30 , pp. 73-85
    • Barlow, J.H.1    Lisby, M.2    Rothstein, R.3
  • 7
    • 2942594756 scopus 로고    scopus 로고
    • The functions of budding yeast Sae2 in the DNA damage response require Mecl- And Tel 1-dependent phosphorylation
    • Baroni E, Viscardi V, Cartagena-Lirola H, Lucchini G, Longhese MP (2004) The functions of budding yeast Sae2 in the DNA damage response require Mecl- and Tel 1-dependent phosphorylation. Mol Cell Biol 24:4151-4165
    • (2004) Mol Cell Biol , vol.24 , pp. 4151-4165
    • Baroni, E.1    Viscardi, V.2    Cartagena-Lirola, H.3    Lucchini, G.4    Longhese, M.P.5
  • 8
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • Bartek J, Bartkova J, Lukas J (2007) DNA damage signalling guards against activated oncogenes and tumour progression, Oncogene 26:7773-7779
    • (2007) Oncogene , vol.26 , pp. 7773-7779
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 9
    • 34547673378 scopus 로고    scopus 로고
    • Regulating double-stranded DNA break repair towards crossover or non-crossover during mammalian meiosis
    • Baudat F, de Massy B (2007) Regulating double-stranded DNA break repair towards crossover or non-crossover during mammalian meiosis. Chromosome Res 15:565-577
    • (2007) Chromosome Res , vol.15 , pp. 565-577
    • Baudat, F.1    De Massy, B.2
  • 10
    • 33745600397 scopus 로고    scopus 로고
    • Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response
    • Becker E, Meyer V, Madaoui H, Guerois R (2006) Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response. Bioinformatics 22:1289-1292
    • (2006) Bioinformatics , vol.22 , pp. 1289-1292
    • Becker, E.1    Meyer, V.2    Madaoui, H.3    Guerois, R.4
  • 11
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • Berkovich E, Monnat RJ Jr, Kastan MB (2007) Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 9:683-690
    • (2007) Nat Cell Biol , vol.9 , pp. 683-690
    • Berkovich, E.1    Monnat Jr., R.J.2    Kastan, M.B.3
  • 12
    • 36448975490 scopus 로고    scopus 로고
    • Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
    • Bernardi R, Pandolfi PP (2007) Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol 8:1006-1016
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 1006-1016
    • Bernardi, R.1    Pandolfi, P.P.2
  • 14
    • 15444374342 scopus 로고    scopus 로고
    • Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control
    • Boisvert FM, Dery U, Masson JY, Richard S (2005a) Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes Dev 19:671-676
    • (2005) Genes Dev , vol.19 , pp. 671-676
    • Boisvert, F.M.1    Dery, U.2    Masson, J.Y.3    Richard, S.4
  • 15
    • 25444445033 scopus 로고    scopus 로고
    • Methylation of MRE11 regulates its nuclear compartmentalization
    • Boisvert FM, Hendzel MJ, Masson JY, Richard S (2005b) Methylation of MRE11 regulates its nuclear compartmentalization. Cell Cycle 4:981-989
    • (2005) Cell Cycle , vol.4 , pp. 981-989
    • Boisvert, F.M.1    Hendzel, M.J.2    Masson, J.Y.3    Richard, S.4
  • 16
    • 34547686372 scopus 로고    scopus 로고
    • The multiple roles of the Mre11 complex for meiotic recombination
    • Borde V (2007) The multiple roles of the Mre11 complex for meiotic recombination. Chromosome Res 15:551-563
    • (2007) Chromosome Res , vol.15 , pp. 551-563
    • Borde, V.1
  • 17
    • 60349095315 scopus 로고    scopus 로고
    • Double functions for the Mre11 complex during DNA double-strand break repair and replication
    • Borde V, Cobb J (2009) Double functions for the Mre11 complex during DNA double-strand break repair and replication. Int J Biochem. Cell Biol 41:1249-1253
    • (2009) Int J Biochem. Cell Biol , vol.41 , pp. 1249-1253
    • Borde, V.1    Cobb, J.2
  • 18
    • 0031046294 scopus 로고    scopus 로고
    • A superfamily of conserved domains in DNA damageresponsive cell cycle checkpoint proteins
    • Bork P, Hofmann K, Bucher P, Neuwald AF, Altschul SF, Koonin EV (1997) A superfamily of conserved domains in DNA damageresponsive cell cycle checkpoint proteins. FASEB J 11:68-76
    • (1997) FASEB J , vol.11 , pp. 68-76
    • Bork, P.1    Hofmann, K.2    Bucher, P.3    Neuwald, A.F.4    Altschul, S.F.5    Koonin, E.V.6
  • 19
    • 0032721091 scopus 로고    scopus 로고
    • The Mre11-Rad50-xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae
    • Bressan DA, Baxter BK, Petřini JH (1999) The Mre11-Rad50-xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol Cell Biol 19:7681-7687
    • (1999) Mol Cell Biol , vol.19 , pp. 7681-7687
    • Bressan, D.A.1    Baxter, B.K.2    Petřini, J.H.3
  • 20
    • 0031664401 scopus 로고    scopus 로고
    • Alteration of N- Terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11
    • Bressan DA, Olivares HA, Nelms BE, Petřini JH (1998) Alteration of N- terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11. Genetics 150:591-600
    • (1998) Genetics , vol.150 , pp. 591-600
    • Bressan, D.A.1    Olivares, H.A.2    Nelms, B.E.3    Petřini, J.H.4
  • 22
    • 34547688971 scopus 로고    scopus 로고
    • Dimerization of the Rad50 protein is independent of the conserved hook domain
    • Cahill D, Carney JP (2007) Dimerization of the Rad50 protein is independent of the conserved hook domain. Mutagenesis 22:269-274
    • (2007) Mutagenesis , vol.22 , pp. 269-274
    • Cahill, D.1    Carney, J.P.2
  • 23
    • 0031031787 scopus 로고    scopus 로고
    • From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair
    • Callebaut I, Momon JP (1.997) From BRCA1 to RAP1 : a widespread BRCT module closely associated with DNA repair. FEBS Lett 400:25-30
    • (1997) FEBS Lett , vol.400 , pp. 25-30
    • Callebaut, I.1    Momon, J.P.2
  • 24
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break, repair to the cellular DNA damage response
    • Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR 3rd, Hays L, Morgan WF, Petřini JH (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break, repair to the cellular DNA damage response. Cell 93:477-486
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates III, J.R.6    Hays, L.7    Morgan, W.F.8    Petřini, J.H.9
  • 26
    • 0034066847 scopus 로고    scopus 로고
    • Retroviral expression of the NBS1gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation
    • Cerosaletti KM, Desai-Mehta A, Yeo TC, Kraakman-Van Der Zwet M, Zdzienicka MZ, Concannon P (2000) Retroviral expression of the NBS1gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation. Mutagenesis 15:281-286
    • (2000) Mutagenesis , vol.15 , pp. 281-286
    • Cerosaletti, K.M.1    Desai-Mehta, A.2    Yeo, T.C.3    Kraakman-Van Der Zwet, M.4    Zdzienicka, M.Z.5    Concannon, P.6
  • 27
    • 48649100438 scopus 로고    scopus 로고
    • Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex, at sites of DNA damage
    • Chapman JR., Jackson SP (2008) Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex, at sites of DNA damage. EMBO Rep 9:795-801
    • (2008) EMBO Rep , vol.9 , pp. 795-801
    • Chapman, J.R.1    Jackson, S.P.2
  • 28
    • 0035930342 scopus 로고    scopus 로고
    • Promotion ofDnl4-catalyzed-joining by the Rad50/ Mre11/Xrs2 and Hdfl/Hdf2 complexes
    • Chen L, Trujillo K, Ramos W, Sung P, Tomkinson AE (2001) Promotion of Dnl4-catalyzed-joining by the Rad50/ Mre11/Xrs2 and Hdfl/Hdf2 complexes. Mol Cell 8:1105-1115
    • (2001) Mol Cell , vol.8 , pp. 1105-1115
    • Chen, L.1    Trujillo, K.2    Ramos, W.3    Sung, P.4    Tomkinson, A.E.5
  • 30
    • 17644375501 scopus 로고    scopus 로고
    • Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency
    • Chen PL, Liu F, Cai S, Lin X, Li A, Chen. Y, Gu B, Lee EY, Lee WH (2005b) Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol 25:3535-3542
    • (2005) Mol Cell Biol , vol.25 , pp. 3535-3542
    • Chen, P.L.1    Liu, F.2    Cai, S.3    Lin, X.4    Li, A.5    Chen, Y.6    Gu, B.7    Lee, E.Y.8    Lee, W.H.9
  • 31
    • 43149118369 scopus 로고    scopus 로고
    • Cell cycle-dependent complex formation of BRCA1 CtIP.MRN is important for DNA double-strand break repair
    • Chen L, Nievera CJ, Lee AY, Wu X (2008a) Cell cycle-dependent complex formation of BRCA1 CtIP.MRN is important for DNA double-strand break repair. J Biol Chem 283:7713-7720
    • (2008) J Biol Chem , vol.283 , pp. 7713-7720
    • Chen, L.1    Nievera, C.J.2    Lee, A.Y.3    Wu, X.4
  • 33
    • 33644691699 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand, break, ends
    • Clerici M, Mantiero D, Lucchini G, Longhese MP (2005) The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand, break, ends. J Biol Chem. 280:38631-38638
    • (2005) J Biol Chem. , vol.280 , pp. 38631-38638
    • Clerici, M.1    Mantiero, D.2    Lucchini, G.3    Longhese, M.P.4
  • 34
    • 33645799075 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling
    • Clerici. M, Mantiero D, Lucchini G, Longhese MP (2006) The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling. EMBO Rep 7:212-218
    • (2006) EMBO Rep , vol.7 , pp. 212-218
    • Clerici, M.1    Mantiero, D.2    Lucchini, G.3    Longhese, M.P.4
  • 35
    • 48649086824 scopus 로고    scopus 로고
    • The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle
    • Clerici M, Mantiero D, Guerini I, Lucchini G, Longhese MP (2008) The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Rep 9:810-818
    • (2008) EMBO Rep , vol.9 , pp. 810-818
    • Clerici, M.1    Mantiero, D.2    Guerini, I.3    Lucchini, G.4    Longhese, M.P.5
  • 37
    • 0035449349 scopus 로고    scopus 로고
    • The yeast Xrs2 complex functions in S phase checkpoint regulation
    • D'Amours D, Jackson SP (2001) The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev 15:2238-2249
    • (2001) Genes Dev , vol.15 , pp. 2238-2249
    • D'Amours, D.1    Jackson, S.P.2
  • 39
    • 0037109113 scopus 로고    scopus 로고
    • DNA endbinding specificity of human Rad50/Mre11 is influenced by ATP
    • de Jager M, Wyman C, van Gent DC, Kanaar R (2002) DNA endbinding specificity of human Rad50/Mre11 is influenced by ATP. Nucleic Acids Res 30:4425-4431
    • (2002) Nucleic Acids Res , vol.30 , pp. 4425-4431
    • De Jager, M.1    Wyman, C.2    Van Gent, D.C.3    Kanaar, R.4
  • 40
    • 68949149732 scopus 로고    scopus 로고
    • Multiple roles for MRE11at uncapped telomeres
    • Deng Y, Guo X, Ferguson DO, Chang S (2009) Multiple roles for MRE11at uncapped telomeres. Nature 460:914-918
    • (2009) Nature , vol.460 , pp. 914-918
    • Deng, Y.1    Guo, X.2    Ferguson, D.O.3    Chang, S.4
  • 41
    • 63649110740 scopus 로고    scopus 로고
    • Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates
    • Deriano L, Stracker TH, Baker A, Petřini JH, Roth DB (2009) Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell 34:13-25
    • (2009) Mol Cell , vol.34 , pp. 13-25
    • Deriano, L.1    Stracker, T.H.2    Baker, A.3    Petřini, J.H.4    Roth, D.B.5
  • 43
    • 0034997651 scopus 로고    scopus 로고
    • Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization
    • Desai-Mehta A, Cerosaletti KM, Concannon P (2001) Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. Mol Cell Biol 21:2184-2191
    • (2001) Mol Cell Biol , vol.21 , pp. 2184-2191
    • Desai-Mehta, A.1    Cerosaletti, K.M.2    Concannon, P.3
  • 44
    • 41149127607 scopus 로고    scopus 로고
    • The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: Molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients
    • di Masi A, Viganotti M, Polticelli F, Ascenzi P, Tanzarella C, Antoccia A (2008) The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients. Biochem Biophys Res Commun 369:835-840
    • (2008) Biochem Biophys Res Commun , vol.369 , pp. 835-840
    • Di Masi, A.1    Viganotti, M.2    Polticelli, F.3    Ascenzi, P.4    Tanzarella, C.5    Antoccia, A.6
  • 45
    • 28544436537 scopus 로고    scopus 로고
    • Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
    • Di Virgilio M, Gautier J (2005) Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol 171:765-771
    • (2005) J Cell Biol , vol.171 , pp. 765-771
    • Di Virgilio, M.1    Gautier, J.2
  • 46
    • 70350441980 scopus 로고    scopus 로고
    • Cell cycle dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction, of NHEJ in G1 and resection-mediated inhibition, of NHEJ in G2
    • Dimitrova N, de Lange T (2009) Cell cycle dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction, of NHEJ in G1 and resection-mediated inhibition, of NHEJ in G2. Mol. Cell Biol 29(20):5552-5563
    • (2009) Mol. Cell Biol , vol.29 , Issue.20 , pp. 5552-5563
    • Dimitrova, N.1    De Lange, T.2
  • 48
    • 0033538496 scopus 로고    scopus 로고
    • The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage
    • Dong Z, Zhong Q, Chen PL (1999) The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage. J Biol Chem 74:19513-19516
    • (1999) J Biol Chem , vol.74 , pp. 19513-19516
    • Dong, Z.1    Zhong, Q.2    Chen, P.L.3
  • 50
    • 0033197541 scopus 로고    scopus 로고
    • The FHA domain is a modular phosphopeptide recognition motif
    • Durocher D, Henckel J, Fersht AR, Jackson SP (1999) The FHA domain is a modular phosphopeptide recognition motif. Mol Cell 4:387-394
    • (1999) Mol Cell , vol.4 , pp. 387-394
    • Durocher, D.1    Henckel, J.2    Fersht, A.R.3    Jackson, S.P.4
  • 51
    • 50049099559 scopus 로고    scopus 로고
    • The importance of making ends meet: Mutations in genes and altered expression of proteins of the MRN complex, and cancer
    • Dzikiewicz-Krawczyk A (2008) The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex, and cancer. Mutat Res 659:262-273
    • (2008) Mutat Res , vol.659 , pp. 262-273
    • Dzikiewicz-Krawczyk, A.1
  • 52
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and. DNA-PKcs to sites of DNA damage
    • Falck J, Coates J, Jackson. SP (2005) Conserved modes of recruitment of ATM, ATR and. DNA-PKcs to sites of DNA damage. Nature 434:605-611
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 53
    • 4444339506 scopus 로고    scopus 로고
    • Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle
    • Ferreira MG, Cooper JP (2004) Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle. Genes .Dev 18:2249-2254
    • (2004) Genes. Dev , vol.18 , pp. 2249-2254
    • Ferreira, M.G.1    Cooper, J.P.2
  • 54
    • 0036864626 scopus 로고    scopus 로고
    • Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination
    • Frank-Vaillant M, Marcand S (2002) Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. Mol Cell 10:1189-1199
    • (2002) Mol Cell , vol.10 , pp. 1189-1199
    • Frank-Vaillant, M.1    Marcand, S.2
  • 55
    • 0032476658 scopus 로고    scopus 로고
    • Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination
    • Furuse M, Nagase Y, Tsubouchi H, Murakami-Murofushi K, Shibata T, Ohta K (1998) Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J 17:6412-6425
    • (1998) EMBO J , vol.17 , pp. 6412-6425
    • Furuse, M.1    Nagase, Y.2    Tsubouchi, H.3    Murakami-Murofushi, K.4    Shibata, T.5    Ohta, K.6
  • 56
    • 0016274036 scopus 로고
    • A genetic study of x-ray sensitive mutants in yeast
    • Game JC, Mortimer RK (1974) A genetic study of x-ray sensitive mutants in yeast. Mutat Res 24:281-292
    • (1974) Mutat Res , vol.24 , pp. 281-292
    • Game, J.C.1    Mortimer, R.K.2
  • 58
    • 34548396349 scopus 로고    scopus 로고
    • The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex, reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity
    • Ghosal G, Muniyappa K (2007) The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex, reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity. J Mol. Biol 372:864-882
    • (2007) J Mol. Biol , vol.372 , pp. 864-882
    • Ghosal, G.1    Muniyappa, K.2
  • 59
    • 53649090109 scopus 로고    scopus 로고
    • DNA helicases Sgs 1 and BLM promote DNA double-strand break resection
    • Gravel S, Chapman JR, Magill C, Jackson SP (2008) DNA helicases Sgs 1 and BLM promote DNA double-strand break resection. Genes Dev 22:2767-2772
    • (2008) Genes Dev , vol.22 , pp. 2767-2772
    • Gravel, S.1    Chapman, J.R.2    Magill, C.3    Jackson, S.P.4
  • 61
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • Harper JW, Elledge SJ (2007) The DNA damage response: ten years after. Mol Cell 28:739-745
    • (2007) Mol Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 62
    • 58149308077 scopus 로고    scopus 로고
    • Ctp1CtIP and Rad32Mre11 nuclease activity are required for Ree12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions
    • Hartsuiker E, Mizuno K, Molnar M, Kohli J, Ohta K, Carr AM (2009a) Ctp1CtIP and Rad32Mre11 nuclease activity are required for Ree12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions. Mol. Cell Biol 29:1671-1681
    • (2009) Mol. Cell Biol , vol.29 , pp. 1671-1681
    • Hartsuiker, E.1    Mizuno, K.2    Molnar, M.3    Kohli, J.4    Ohta, K.5    Carr, A.M.6
  • 63
    • 58149289464 scopus 로고    scopus 로고
    • Distinct requirements for the.Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal, of covalently bound topoisomerase i and II from DNA
    • Hartsuiker E, Neale MJ, Carr AM (2009b) Distinct requirements for the .Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal, of covalently bound topoisomerase I and II from DNA. Mol Cell. 33:117-123
    • (2009) Mol Cell. , vol.33 , pp. 117-123
    • Hartsuiker, E.1    Neale, M.J.2    Carr, A.M.3
  • 67
    • 0029360452 scopus 로고
    • The FHA domain: A putative nuclear signalling domain found in protein kinases and transcription factors
    • Hofmann K, Bucher P (1995) The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem Sci 20:347-349
    • (1995) Trends Biochem Sci , vol.20 , pp. 347-349
    • Hofmann, K.1    Bucher, P.2
  • 68
    • 0032698874 scopus 로고    scopus 로고
    • ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans
    • Holland IB, Blight MA (1999) ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans. J Mol Biol 293:381-399
    • (1999) J Mol Biol , vol.293 , pp. 381-399
    • Holland, I.B.1    Blight, Ma.2
  • 69
    • 0037398027 scopus 로고    scopus 로고
    • Rad50/SMC proteins and ABC transporters: Unifying concepts from, high-resolution structures
    • Hopfner KP, Tainer JA (2003) Rad50/SMC proteins and ABC transporters: unifying concepts from, high-resolution structures. Curr Opin Struct Biol 13:249-255
    • (2003) Curr Opin Struct Biol , vol.13 , pp. 249-255
    • Hopfner, Kp.1    Tainer, J.A.2
  • 70
    • 0033759543 scopus 로고    scopus 로고
    • Mre11 and Rad50 from Pyrococcus furiosus: Cloning and biochemical characterization, reveal an evolutionarily conserved multiprotein machine
    • Hopfner KP, Karcher A, Shin D, Fairley C, Tainer JA, Carney JP (2000a) Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization, reveal an evolutionarily conserved multiprotein machine. J Bacteriol 182:6036-6041
    • (2000) J Bacteriol , vol.182 , pp. 6036-6041
    • Hopfner, Kp.1    Karcher, A.2    Shin, D.3    Fairley, C.4    Tainer, J.A.5    Carney, J.P.6
  • 71
    • 0034705293 scopus 로고    scopus 로고
    • Structural biology of Rad50 ATPase: ATPdriven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
    • Hopfner KP, Karcher A, Shin DS, Craig L, Arthur LM, Carney JP, Tainer JA (2000b) Structural biology of Rad50 ATPase: ATPdriven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell 101:789-800
    • (2000) Cell , vol.101 , pp. 789-800
    • Hopfner, Kp.1    Karcher, A.2    Shin, D.S.3    Craig, L.4    Arthur, L.M.5    Carney, J.P.6    Tainer, J.A.7
  • 72
    • 0035906860 scopus 로고    scopus 로고
    • Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50ATPase
    • Hopfner KP, Karcher A1 Craig L, Woo TT, Carney JP, Tainer JA (2001) Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50ATPase. Cell 105:473-485
    • (2001) Cell , vol.105 , pp. 473-485
    • Hopfner, Kp.1    Karcher, A.I.2    Craig, L.3    Woo, T.T.4    Carney, J.P.5    Tainer, J.A.6
  • 74
    • 53549093050 scopus 로고    scopus 로고
    • The p. furiosus mre11/rad50 complex promotes 5′ strand resection at a DNA double-strand break
    • Hopkins BB, Paull TT (2008) the p. furiosus mre11/rad50 complex promotes 5′ strand resection at a DNA double-strand break, Cell 135:250-260
    • (2008) Cell , vol.135 , pp. 250-260
    • Hopkins, B.B.1    Paull, T.T.2
  • 75
    • 2442444916 scopus 로고    scopus 로고
    • Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM. activation after low doses of ionizing radiation
    • Horejsi Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J, Bartek J (2004) Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM. activation after low doses of ionizing radiation. Oncogene 23:3122-3127
    • (2004) Oncogene , vol.23 , pp. 3122-3127
    • Horejsi, Z.1    Falck, J.2    Bakkenist, C.J.3    Kastan, M.B.4    Lukas, J.5    Bartek, J.6
  • 76
    • 68349157361 scopus 로고    scopus 로고
    • SOSS complexes participate in the maintenance of genomic stability
    • Huang J, Gong Z, Ghosal G, Chen J (2009) SOSS complexes participate in the maintenance of genomic stability. Mol Cell 35:384-393
    • (2009) Mol Cell , vol.35 , pp. 384-393
    • Huang, J.1    Gong, Z.2    Ghosal, G.3    Chen, J.4
  • 77
    • 66149114020 scopus 로고    scopus 로고
    • Human CtIP mediates cell-cycle control of DNA- End resection and double-strand-break repair
    • Huertas P, Jackson SP (2009) Human CtIP mediates cell-cycle control of DNA- end resection and double-strand-break repair. J Biol Chem. 284(14):9558-9565
    • (2009) J Biol Chem. , vol.284 , Issue.14 , pp. 9558-9565
    • Huertas, P.1    Jackson, S.P.2
  • 80
    • 52249091114 scopus 로고    scopus 로고
    • Dancing on damaged chromatin: Functions of ATM. and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage
    • Iijima K, Ohara M, Seki R, Tauchi H (2008b) Dancing on damaged chromatin: functions of ATM. and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage. J Radiat Res (Tokyo) 49:451-464
    • (2008) J Radiat Res (Tokyo) , vol.49 , pp. 451-464
    • Iijima, K.1    Ohara, M.2    Seki, R.3    Tauchi, H.4
  • 82
    • 0026759693 scopus 로고
    • XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination
    • Ivanov EL, Korolev VG, Fabre F (1992) XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination. Genetics 132:651-664
    • (1992) Genetics , vol.132 , pp. 651-664
    • Ivanov, E.L.1    Korolev, V.G.2    Fabre, F.3
  • 84
    • 47949121598 scopus 로고    scopus 로고
    • Mre11- Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
    • Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V (2008) Mre11- Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO 127:1953-1962
    • (2008) EMBO , vol.127 , pp. 1953-1962
    • Jazayeri, A.1    Balestrini, A.2    Garner, E.3    Haber, J.E.4    Costanzo, V.5
  • 85
    • 0028914077 scopus 로고
    • Interaction of Mre11 and Rad50: Two proteins required for DNA repair and meiosis-specific doublestrand break formation in Saccharomyces cerevisiae
    • Johzuka K, Ogawa H (1995) Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific doublestrand break formation in Saccharomyces cerevisiae. Genetics 139:1521-1532
    • (1995) Genetics , vol.139 , pp. 1521-1532
    • Johzuka, K.1    Ogawa, H.2
  • 86
    • 39449092872 scopus 로고    scopus 로고
    • Quality control, of DNA break metabolism: In the 'end', it's a good thing
    • Kanaar R, Wyman C, Rothstein R (2008) Quality control, of DNA break metabolism: in the 'end', it's a good thing. EMBO J 27:581-588
    • (2008) EMBO J , vol.27 , pp. 581-588
    • Kanaar, R.1    Wyman, C.2    Rothstein, R.3
  • 88
    • 13844256190 scopus 로고    scopus 로고
    • Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through. FHA/BRCT domain
    • Kobayashi J (2004) Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through. FHA/BRCT domain. J Radiat Res (Tokyo) 45:473-478
    • (2004) J Radiat Res (Tokyo) , vol.45 , pp. 473-478
    • Kobayashi, J.1
  • 91
    • 33645119826 scopus 로고    scopus 로고
    • Mutations in Mre11 phosphoesterase motif i that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity
    • Krogh BO, Llorente B, Lam A, Symington. LS (2005) Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. Genetics 171:1561-1570
    • (2005) Genetics , vol.171 , pp. 1561-1570
    • Krogh, B.O.1    Llorente, B.2    Lam, A.3    Symington, L.S.4
  • 92
    • 1842431822 scopus 로고    scopus 로고
    • Direct activation of the ATM protein, kinase by the Mre11/Rad50/Nbs1 complex
    • Lee JH, Paull TT (2004) Direct activation of the ATM protein, kinase by the Mre11/Rad50/Nbs1 complex. Science 304:93-96
    • (2004) Science , vol.304 , pp. 93-96
    • Lee, J.H.1    Paull, T.T.2
  • 93
    • 17644409069 scopus 로고    scopus 로고
    • ATM. activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • Lee JH, Pauli TT (2005) ATM. activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308:551-554
    • (2005) Science , vol.308 , pp. 551-554
    • Lee, J.H.1    Pauli, T.T.2
  • 94
    • 0032493889 scopus 로고    scopus 로고
    • Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
    • Lee SE, Moore JK, Holmes A, Umezu K, Kolodner RD, Haber JE (1998) Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94:399-409
    • (1998) Cell , vol.94 , pp. 399-409
    • Lee, S.E.1    Moore, J.K.2    Holmes, A.3    Umezu, K.4    Kolodner, R.D.5    Haber, J.E.6
  • 95
    • 0242413320 scopus 로고    scopus 로고
    • Regulation of Mre11/Rad50 by Nbs1: Effects on nucleotide-dependent DNA binding and association with ataxiatelangiectasia-like disorder mutant complexes
    • Lee JH, Ghirlando R, Bhaskara V, Hoffmeyer MR, Gu J, Pauli TT (2003) Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxiatelangiectasia-like disorder mutant complexes. J Biol Chem. 278:45171-45181
    • (2003) J Biol Chem. , vol.278 , pp. 45171-45181
    • Lee, J.H.1    Ghirlando, R.2    Bhaskara, V.3    Hoffmeyer, M.R.4    Gu, J.5    Pauli, T.T.6
  • 96
    • 36248942617 scopus 로고    scopus 로고
    • Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex
    • Lengsfeld BM, Rattray AJ, Bhaskara V, Ghirlando R, Paull TT (2007) Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex, Mol Cell 28:638-651
    • (2007) Mol Cell , vol.28 , pp. 638-651
    • Lengsfeld, B.M.1    Rattray, A.J.2    Bhaskara, V.3    Ghirlando, R.4    Paull, T.T.5
  • 98
    • 38049173021 scopus 로고    scopus 로고
    • Homologous recombination in DNA repair and DNA damage tolerance
    • Li X, Heyer WD (2008) Homologous recombination in DNA repair and DNA damage tolerance. Cell Res 18:99-113
    • (2008) Cell Res , vol.18 , pp. 99-113
    • Li, X.1    Heyer, W.D.2
  • 99
    • 0034531364 scopus 로고    scopus 로고
    • The FHA domain. mediates phosphoprotein interactions
    • Li J, Lee GI, Van Doren SR, Walker JC (2000) The FHA domain. mediates phosphoprotein interactions. J Cell Sci 113(Pt 23):4143-11449
    • (2000) J Cell Sci , vol.113 , Issue.PART 23 , pp. 4143-11449
    • Li, J.1    Lee, G.I.2    Van Doren, S.R.3    Walker, J.C.4
  • 102
    • 34948872046 scopus 로고    scopus 로고
    • Ctpl is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination
    • Limbo O, Chahwan C, Yamada Y, de Bruin RA, Wittenberg C, Russell P (2007) Ctpl is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol Cell 28:134-146
    • (2007) Mol Cell , vol.28 , pp. 134-146
    • Limbo, O.1    Chahwan, C.2    Yamada, Y.3    De Bruin, R.A.4    Wittenberg, C.5    Russell, P.6
  • 103
    • 4544281398 scopus 로고    scopus 로고
    • Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
    • Lisby M, Barlow JH, Burgess RC, Rothstein R (2004) Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118:699-713
    • (2004) Cell , vol.118 , pp. 699-713
    • Lisby, M.1    Barlow, J.H.2    Burgess, R.C.3    Rothstein, R.4
  • 104
    • 6344254299 scopus 로고    scopus 로고
    • The Mre11 nuclease is not required for 5′ to 3′ resection at multiple HO-induced double-strand breaks
    • Llorente B, Symington LS (2004) The Mre11 nuclease is not required for 5′ to 3′ resection at multiple HO-induced double-strand breaks. Mol Cell Biol. 24:9682-9694
    • (2004) Mol Cell Biol. , vol.24 , pp. 9682-9694
    • Llorente, B.1    Symington, L.S.2
  • 105
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
    • Luo G, Yao MS, Bender CF, Mills M, Bladl AR, Bradley A, Petrini JH (1999) Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad. Sci USA 96:7376-7381
    • (1999) Proc Natl Acad. Sci USA , vol.96 , pp. 7376-7381
    • Luo, G.1    Yao, M.S.2    Bender, C.F.3    Mills, M.4    Bladl, A.R.5    Bradley, A.6    Petrini, J.H.7
  • 107
    • 0035862948 scopus 로고    scopus 로고
    • Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe
    • Manolis KG, Nimmo ER, Hartsuiker E, Carr AM, Jeggo PA, Allshire RC (2001) Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. EMBO J 20:210-221
    • (2001) EMBO J , vol.20 , pp. 210-221
    • Manolis, K.G.1    Nimmo, E.R.2    Hartsuiker, E.3    Carr, A.M.4    Jeggo, P.A.5    Allshire, R.C.6
  • 108
    • 34047102946 scopus 로고    scopus 로고
    • Dual role for Saccharomyces cerevisiae Tell in the checkpoint response to double-strand breaks
    • Mantiero D, Clerici M, Lucchini G, Longhese MP (2007) Dual role for Saccharomyces cerevisiae Tell in the checkpoint response to double-strand breaks. EMBO Rep 8:380-387
    • (2007) EMBO Rep , vol.8 , pp. 380-387
    • Mantiero, D.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 109
    • 0030764691 scopus 로고    scopus 로고
    • HMre11 and hRad50 nuclear foci, are induced during the normal cellular response to DNA double-strand breaks
    • Maser RS, Monsen KJ, Nelms BE, Petrini JH (1997) hMre11 and hRad50 nuclear foci, are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol 17:6087-6096
    • (1997) Mol Cell Biol , vol.17 , pp. 6087-6096
    • Maser, R.S.1    Monsen, K.J.2    Nelms, B.E.3    Petrini, J.H.4
  • 112
    • 52049101409 scopus 로고    scopus 로고
    • Forkhead-associated domain of yeast Xrs2, a homolog of human Nbs1, promotes nonhomologous end joining through interaction with a ligase IV partner protein, Lif1
    • Matsuzaki K, Shinohara A, Shinohara M (2008) Forkhead-associated domain of yeast Xrs2, a homolog of human Nbs1, promotes nonhomologous end joining through interaction with a ligase IV partner protein, Lif1. Genetics 179:213-225
    • (2008) Genetics , vol.179 , pp. 213-225
    • Matsuzaki, K.1    Shinohara, A.2    Shinohara, M.3
  • 113
    • 0029954821 scopus 로고    scopus 로고
    • Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
    • Milne GT, Jin S, Shannon KB, Weaver DT (1996) Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol Cell Biol 16:4189-4198
    • (1996) Mol Cell Biol , vol.16 , pp. 4189-4198
    • Milne, G.T.1    Jin, S.2    Shannon, K.B.3    Weaver, D.T.4
  • 114
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break, processing
    • Mimitou EP, Symington LS (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break, processing. Nature 455:770-774
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 115
    • 0034749425 scopus 로고    scopus 로고
    • DNA damage-dependent nuclear dynamics of the Mre11 complex
    • Mirzoeva OK, Petrini JH (2001) DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell Biol 21:281-288
    • (2001) Mol. Cell Biol , vol.21 , pp. 281-288
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 117
    • 0029976325 scopus 로고    scopus 로고
    • Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of doublestrand breaks in Saccharomyces cerevisiae
    • Moore JK, Haber JE (1996) Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of doublestrand breaks in Saccharomyces cerevisiae. Mol Cell Biol 16:2164-2173
    • (1996) Mol Cell Biol , vol.16 , pp. 2164-2173
    • Moore, J.K.1    Haber, J.E.2
  • 118
    • 0032931844 scopus 로고    scopus 로고
    • The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
    • Moreau S, Ferguson JR, Symington LS (1999) The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell Biol 19:556-566
    • (1999) Mol. Cell Biol , vol.19 , pp. 556-566
    • Moreau, S.1    Ferguson, J.R.2    Symington, L.S.3
  • 119
    • 0035692142 scopus 로고    scopus 로고
    • Overlapping functions of the Saccharomyces cerevisiae Mre11, Exol and Rad27 nucleases in DNA metabolism
    • Moreau S, Morgan EA, Symington LS (2001) Overlapping functions of the Saccharomyces cerevisiae Mre11, Exol and Rad27 nucleases in DNA metabolism. Genetics 159:1423-1433
    • (2001) Genetics , vol.159 , pp. 1423-1433
    • Moreau, S.1    Morgan, E.A.2    Symington, L.S.3
  • 120
    • 24944540931 scopus 로고    scopus 로고
    • Mesoscale conformational changes in the DNArepair complex Rad50/Mre11/Nbs1 upon binding DNA
    • Moreno-Herrero F, de Jager M, Dekker NH, Kanaar R, Wyman C, Dekker C (2005) Mesoscale conformational changes in the DNArepair complex Rad50/Mre11/Nbs1 upon binding DNA. Nature 437:440-443
    • (2005) Nature , vol.437 , pp. 440-443
    • Moreno-Herrero, F.1    De Jager, M.2    Dekker, N.H.3    Kanaar, R.4    Wyman, C.5    Dekker, C.6
  • 121
    • 34547107878 scopus 로고    scopus 로고
    • A proteomic analysis of ataxia telangiectasiamutated (ATM)/ATM-Rad3- related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints
    • Mu JJ, Wang Y, Luo H, Leng M, Zhang J, Yang T, Besusso D, Jung SY, Qin J (2007) A proteomic analysis of ataxia telangiectasiamutated (ATM)/ATM-Rad3- related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem 282:17330-17334
    • (2007) J Biol Chem , vol.282 , pp. 17330-17334
    • Mu, J.J.1    Wang, Y.2    Luo, H.3    Leng, M.4    Zhang, J.5    Yang, T.6    Besusso, D.7    Jung, S.Y.8    Qin, J.9
  • 122
    • 0030885998 scopus 로고    scopus 로고
    • Mre11S-A yeast mutation that blocks double-strand- Break processing and permits nonhomologous synapsis in meiosis
    • Nairz K, Klein. F (1.997) mre11S-a yeast mutation that blocks double-strand- break processing and permits nonhomologous synapsis in meiosis. Genes Dev 11:2272-2290
    • (1997) Genes Dev , vol.11 , pp. 2272-2290
    • Nairz, K.1    Klein, F.2
  • 123
    • 0041660970 scopus 로고    scopus 로고
    • ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism
    • Nakada D, Matsumoto K, Sugimoto K (2003) ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. Genes Dev 17:1957-1962
    • (2003) Genes Dev , vol.17 , pp. 1957-1962
    • Nakada, D.1    Matsumoto, K.2    Sugimoto, K.3
  • 124
    • 7644232348 scopus 로고    scopus 로고
    • Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway
    • Nakada D, Hirano Y, Sugimoto K (2004) Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Mol Cell Biol 24:10016-10025
    • (2004) Mol Cell Biol , vol.24 , pp. 10016-10025
    • Nakada, D.1    Hirano, Y.2    Sugimoto, K.3
  • 125
    • 68349152467 scopus 로고    scopus 로고
    • SOSS1/2: Sensors of single-stranded DNA at a break
    • Nam EA, Cortez D (2009) SOSS1/2: sensors of single-stranded DNA at a break. Mol Cell 35:258-259
    • (2009) Mol Cell , vol.35 , pp. 258-259
    • Nam, E.A.1    Cortez, D.2
  • 127
    • 67649635451 scopus 로고    scopus 로고
    • Multiplicity of DNA end resection machineries in chromosome break repair
    • Niu H, Raynard S, Sung P (2009) Multiplicity of DNA end resection machineries in chromosome break repair. Genes Dev 23:1481-1486
    • (2009) Genes Dev , vol.23 , pp. 1481-1486
    • Niu, H.1    Raynard, S.2    Sung, P.3
  • 128
    • 34547950170 scopus 로고    scopus 로고
    • The Mre11-Rad50-Nbs1 complex, acts both upstream, and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment
    • Olson E, Nievera CJ, Lee AY, Chen L, Wu X (2007) The Mre11-Rad50-Nbs1 complex, acts both upstream, and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem. 282:22939-22952
    • (2007) J Biol Chem. , vol.282 , pp. 22939-22952
    • Olson, E.1    Nievera, C.J.2    Lee, A.Y.3    Chen, L.4    Wu, X.5
  • 129
    • 28544447826 scopus 로고    scopus 로고
    • Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining
    • Palmbos PL, Daley JM, Wilson. TE (2005) Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining. Mol Cell Biol 25:10782-10790
    • (2005) Mol Cell Biol , vol.25 , pp. 10782-10790
    • Palmbos, P.L.1    Daley, J.M.2    Wilson, T.E.3
  • 130
    • 61849109768 scopus 로고    scopus 로고
    • Recruitment of Saccharomyces cerevisiae Dn14-Lifl complex, to a double-strand break, requires interactions with Yku80 and the Xrs2 FHA domain
    • Palmbos PL, Wu D, Daley JM, Wilson. TE (2008) Recruitment of Saccharomyces cerevisiae Dn14-Lifl complex, to a double-strand break, requires interactions with Yku80 and the Xrs2 FHA domain. Genetics 180:1809-1819
    • (2008) Genetics , vol.180 , pp. 1809-1819
    • Palmbos, P.L.1    Wu, D.2    Daley, J.M.3    Wilson, T.E.4
  • 131
    • 0032085295 scopus 로고    scopus 로고
    • The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
    • Paull TT, Gellert M (1.998) The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell 1:969-979
    • (1998) Mol Cell , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 132
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • Paull TT, Gellert M (1999) Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev 13:1276-1288
    • (1999) Genes Dev , vol.13 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 133
    • 37149043618 scopus 로고    scopus 로고
    • A conserved function, for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination
    • Penkner A, Portik-Dobos Z, Tang L, Schnabel R, Novatchkova M, Jantsch V, Loidl J (2007) A conserved function, for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination. EMBO J 26:5071-5082
    • (2007) EMBO J , vol.26 , pp. 5071-5082
    • Penkner, A.1    Portik-Dobos, Z.2    Tang, L.3    Schnabel, R.4    Novatchkova, M.5    Jantsch, V.6    Loidl, J.7
  • 135
    • 0027325759 scopus 로고
    • RAD50 protein of S.cerevisiae exhibits ATP- Dependent DNA binding
    • Raymond WE, Kleckner N (1993) RAD50 protein of S.cerevisiae exhibits ATP- dependent DNA binding. Nucleic Acids Res 21:3851-3856
    • (1993) Nucleic Acids Res , vol.21 , pp. 3851-3856
    • Raymond, W.E.1    Kleckner, N.2
  • 137
    • 52049096814 scopus 로고    scopus 로고
    • BRCT domains: Phosphopeptide binding and signaling modules
    • Rodriguez MC, Songyang Z (2008) BRCT domains: phosphopeptide binding and signaling modules. Front Biosci 13:5905-5915
    • (2008) Front Biosci , vol.13 , pp. 5905-5915
    • Rodriguez, M.C.1    Songyang, Z.2
  • 141
    • 20444390159 scopus 로고    scopus 로고
    • Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae
    • Shima H, Suzuki M, Shinohara M (2005) Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae. Genetics 170:71-85
    • (2005) Genetics , vol.170 , pp. 71-85
    • Shima, H.1    Suzuki, M.2    Shinohara, M.3
  • 142
    • 62449332005 scopus 로고    scopus 로고
    • Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway
    • Shimada M, Sagae R, Kobayashi J, Habu T, Komatsu K (2009) Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway. Cancer Res 69:1768-1775
    • (2009) Cancer Res , vol.69 , pp. 1768-1775
    • Shimada, M.1    Sagae, R.2    Kobayashi, J.3    Habu, T.4    Komatsu, K.5
  • 143
    • 61649093808 scopus 로고    scopus 로고
    • Single-stranded DNA orchestrates an ATMto-ATR switch at DNA breaks
    • Shiotani B, Zou L (2009) Single-stranded DNA orchestrates an ATMto-ATR switch at DNA breaks. Mol Cell 33:547-558
    • (2009) Mol Cell , vol.33 , pp. 547-558
    • Shiotani, B.1    Zou, L.2
  • 144
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break, repair pathway choice
    • Shrivastav M, De Haro LP, Nickoloff JA (2008) Regulation of DNA double-strand break, repair pathway choice. Cell Res 18:134-147
    • (2008) Cell Res , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 145
    • 67149121060 scopus 로고    scopus 로고
    • AdnAB: A new DSB-resecting motor-nuclease from mycobacteria
    • Sinha KM, Unciuleac MC, Glickman MS, Shuman S (2009) AdnAB: a new DSB-resecting motor-nuclease from mycobacteria. Genes Dev 23:1423-1437
    • (2009) Genes Dev , vol.23 , pp. 1423-1437
    • Sinha, K.M.1    Unciuleac, M.C.2    Glickman, M.S.3    Shuman, S.4
  • 146
    • 33750006616 scopus 로고    scopus 로고
    • The role of DNA damage response proteins at telomeres-an "integrative" model
    • Slijepcevic P (2006) The role of DNA damage response proteins at telomeres-an "integrative" model. DNA Repair (Amst) 5:1299-1306
    • (2006) DNA Repair (Amst) , vol.5 , pp. 1299-1306
    • Slijepcevic, P.1
  • 147
    • 45849117573 scopus 로고    scopus 로고
    • Activation of the cellular DNA damage response in the absence of DNA lesions
    • Soutoglou E, Misteli T (2008) Activation of the cellular DNA damage response in the absence of DNA lesions. Science 320:1507-1510
    • (2008) Science , vol.320 , pp. 1507-1510
    • Soutoglou, E.1    Misteli, T.2
  • 148
    • 33747882071 scopus 로고    scopus 로고
    • Tip60 in DNA damage response and growth control: Many tricks in one HAT
    • Squatrito M, Gorrini C, Amati B (2006) Tip60 in DNA damage response and growth control: many tricks in one HAT. Trends Cell Biol 16:433-442
    • (2006) Trends Cell Biol , vol.16 , pp. 433-442
    • Squatrito, M.1    Gorrini, C.2    Amati, B.3
  • 150
    • 3242891189 scopus 로고    scopus 로고
    • The Mre11 complex and the metabolism of chromosome breaks: The importance of communicating and holding things together
    • Stracker TH, Theunissen JW, Morales M, Petrini JH (2004) The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair (Amst) 3:845-854
    • (2004) DNA Repair (Amst) , vol.3 , pp. 845-854
    • Stracker, T.H.1    Theunissen, J.W.2    Morales, M.3    Petrini, J.H.4
  • 151
    • 37549028411 scopus 로고    scopus 로고
    • DNA damage-induced acetylation of lysine 3016 of ATM. activates ATM. kinase activity
    • Sun Y, Xu Y, Roy K, Price BD (2007) DNA damage-induced acetylation of lysine 3016 of ATM. activates ATM. kinase activity. Mol Cell Biol 27:8502-8509
    • (2007) Mol Cell Biol , vol.27 , pp. 8502-8509
    • Sun, Y.1    Xu, Y.2    Roy, K.3    Price, B.D.4
  • 152
    • 35648986560 scopus 로고    scopus 로고
    • Ctpl/CtIP and the MRN complex collaborate in the initial steps of homologous recombination
    • Takeda S, Nakamura K, Taniguchi Y, Paull TT (2007) Ctpl/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol Cell 28:351-352
    • (2007) Mol Cell , vol.28 , pp. 351-352
    • Takeda, S.1    Nakamura, K.2    Taniguchi, Y.3    Paull, T.T.4
  • 153
    • 0035808385 scopus 로고    scopus 로고
    • The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation, but not essential for hRAD50·hM- RE11-NBS1 complex DNA repair activity
    • Tauchi H, Kobayashi J, Morishima K, Matsuura S, Nakamura A, Shiraishi T, Ito E, Masnada D, Delia D, Komatsu K (2001) The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation, but not essential for hRAD50·hM- RE11-NBS1 complex DNA repair activity. J Biol Chem 276:12-15
    • (2001) J Biol Chem , vol.276 , pp. 12-15
    • Tauchi, H.1    Kobayashi, J.2    Morishima, K.3    Matsuura, S.4    Nakamura, A.5    Shiraishi, T.6    Ito, E.7    Masnada, D.8    Delia, D.9    Komatsu, K.10
  • 155
    • 3242889151 scopus 로고    scopus 로고
    • Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis
    • Taylor AM, Groom A, Byrd PJ (2004) Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis. DNA Repair (Amst) 3:1219-1225
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1219-1225
    • Taylor, A.M.1    Groom, A.2    Byrd, P.J.3
  • 156
    • 0034147549 scopus 로고    scopus 로고
    • The International Nijmegen Breakage Syndrome Study Group The International Nijmegen Breakage Syndrome Study Group Arch. Dis Child
    • The International Nijmegen Breakage Syndrome Study Group (2000) Nijmegen Breakage Syndrome. The International Nijmegen Breakage Syndrome Study Group. Arch. Dis Child 82:400-406
    • (2000) Nijmegen Breakage Syndrome , vol.82 , pp. 400-406
  • 159
    • 0035929667 scopus 로고    scopus 로고
    • DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex
    • Trujillo KM, Sung P (2001) DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J Biol Chem 276:35458-35464
    • (2001) J Biol Chem , vol.276 , pp. 35458-35464
    • Trujillo, K.M.1    Sung, P.2
  • 160
    • 0032555480 scopus 로고    scopus 로고
    • Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
    • Trujillo KM, Yuan SS, Lee EY, Sung P (1998) Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J Biol Chem 273:21447-21450
    • (1998) J Biol Chem , vol.273 , pp. 21447-21450
    • Trujillo, K.M.1    Yuan, S.S.2    Lee, E.Y.3    Sung, P.4
  • 161
    • 0033915812 scopus 로고    scopus 로고
    • Exol roles for repair of DNA doublestrand breaks and meiotic crossing over in Saccharomyces cerevisiae
    • Tsubouchi H, Ogawa H (2000) Exol roles for repair of DNA doublestrand breaks and meiotic crossing over in Saccharomyces cerevisiae. Mol Biol Cell 11:2221-2233
    • (2000) Mol Biol Cell , vol.11 , pp. 2221-2233
    • Tsubouchi, H.1    Ogawa, H.2
  • 162
    • 12844271048 scopus 로고    scopus 로고
    • Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation, and meiotic recombination
    • Tsukamoto Y, Mitsuoka C, Terasawa M, Ogawa H, Ogawa T (2005) Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation, and meiotic recombination. Mol Biol Cell 16:597-608
    • (2005) Mol Biol Cell , vol.16 , pp. 597-608
    • Tsukamoto, Y.1    Mitsuoka, C.2    Terasawa, M.3    Ogawa, H.4    Ogawa, T.5
  • 164
    • 0032567108 scopus 로고    scopus 로고
    • Complex formation and functional versatility of Mre11 of budding yeast in recombination
    • Usui T, Ohta T, Oshiumi H, Tomizawa J, Ogawa H, Ogawa T (1998) Complex formation and functional versatility of Mre11 of budding yeast in recombination, Cell 95:705-716
    • (1998) Cell , vol.95 , pp. 705-716
    • Usui, T.1    Ohta, T.2    Oshiumi, H.3    Tomizawa, J.4    Ogawa, H.5    Ogawa, T.6
  • 165
    • 0034964498 scopus 로고    scopus 로고
    • A DNA damage response pathway controlled by Tel1 and the Mre11 complex
    • Usui T, Ogawa H, Petřini JH (2001) A DNA damage response pathway controlled by Tel1 and the Mre11 complex, Mol Cell 7:1255-1266
    • (2001) Mol Cell , vol.7 , pp. 1255-1266
    • Usui, T.1    Ogawa, H.2    Petřini, J.H.3
  • 167
    • 63249083853 scopus 로고    scopus 로고
    • RAD50 and NBS1 form, a stable complex, functional in DNA binding and tethering
    • van der Linden E, Sanchez H, Kinoshita E, Kanaar R, Wyman C (2009) RAD50 and NBS1 form, a stable complex, functional in DNA binding and tethering. Nucleic Acids Res 37(5):1580-1588
    • (2009) Nucleic Acids Res , vol.37 , Issue.5 , pp. 1580-1588
    • Van Der Linden, E.1    Sanchez, H.2    Kinoshita, E.3    Kanaar, R.4    Wyman, C.5
  • 170
    • 38049125555 scopus 로고    scopus 로고
    • The endless tale of non-homologous end-joining
    • Weterings E, Chen DJ (2008) The endless tale of non-homologous end-joining. Cell Res 18:114-124
    • (2008) Cell Res , vol.18 , pp. 114-124
    • Weterings, E.1    Chen, D.J.2
  • 171
    • 34948899943 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, doublestrand break signaling, and the chromatin template
    • Williams RS, Williams JS, Tainer JA (2007) Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, doublestrand break signaling, and the chromatin template. Biochem Cell Biol 85:509-520
    • (2007) Biochem Cell Biol , vol.85 , pp. 509-520
    • Williams, R.S.1    Williams, J.S.2    Tainer, J.A.3
  • 173
    • 20444468899 scopus 로고    scopus 로고
    • The Rad50 hook domain, is a critical determinant of Mre11 complex functions
    • Wiltzius JJ, Hohl M, Fleming JC, Petřini JH (2005) The Rad50 hook domain, is a critical determinant of Mre11 complex functions. Nat Struct Mol Biol 12:403-407
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 403-407
    • Wiltzius, J.J.1    Hohl, M.2    Fleming, J.C.3    Petřini, J.H.4
  • 174
    • 33747837752 scopus 로고    scopus 로고
    • CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression
    • Wu G, Lee WH (2006) CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression. Cell Cycle 5:1592-1596
    • (2006) Cell Cycle , vol.5 , pp. 1592-1596
    • Wu, G.1    Lee, W.H.2
  • 176
    • 49649089537 scopus 로고    scopus 로고
    • MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
    • Wu L, Luo K, Lou Z, Chen J (2008) MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci USA 105:11200-11205
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11200-11205
    • Wu, L.1    Luo, K.2    Lou, Z.3    Chen, J.4
  • 177
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
    • Xiao Y, Weava DT (1997) Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res 25:2985-2991
    • (1997) Nucleic Acids Res , vol.25 , pp. 2985-2991
    • Xiao, Y.1    Weava, D.T.2
  • 178
    • 68249146431 scopus 로고    scopus 로고
    • Role of mammalian Mre11 in classical and alternative nonhomologous end joining
    • Xie A, Kwok A, Scully R (2009) Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol 16:814-818
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 814-818
    • Xie, A.1    Kwok, A.2    Scully, R.3
  • 182
    • 20744436198 scopus 로고    scopus 로고
    • ATM. activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • You Z, Chahwan C, Bailis J, Hunter T, Russell P (2005) ATM. activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol 25:5363-5379
    • (2005) Mol Cell Biol , vol.25 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5
  • 183
    • 0034674706 scopus 로고    scopus 로고
    • Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor
    • Yu X, Baer R (2000) Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J Biol Chem 275:18541-18549
    • (2000) J Biol Chem , vol.275 , pp. 18541-18549
    • Yu, X.1    Baer, R.2
  • 184
    • 6344264992 scopus 로고    scopus 로고
    • DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains
    • Yu X, Chen J (2004) DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 24:9478-9486
    • (2004) Mol Cell Biol , vol.24 , pp. 9478-9486
    • Yu, X.1    Chen, J.2
  • 185
    • 0142147272 scopus 로고    scopus 로고
    • The BRCT domain is a phospho-protein binding domain
    • Yu X, Chini CC, He M, Mer G, Chen J (2003) The BRCT domain is a phospho-protein binding domain. Science 302:639-642
    • (2003) Science , vol.302 , pp. 639-642
    • Yu, X.1    Chini, C.C.2    He, M.3    Mer, G.4    Chen, J.5
  • 186
    • 33745614048 scopus 로고    scopus 로고
    • BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP
    • Yu X, Fu S, Lai M, Baer R, Chen J (2006) BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev 20:1721-1726
    • (2006) Genes Dev , vol.20 , pp. 1721-1726
    • Yu, X.1    Fu, S.2    Lai, M.3    Baer, R.4    Chen, J.5
  • 187
    • 34250897968 scopus 로고    scopus 로고
    • SIRT1 regulates the function of the Nijmegen breakage syndrome protein
    • Yuan Z, Zhang X, Sengupta N, Lane WS, Seto E (2007) SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell 27:149-162
    • (2007) Mol Cell , vol.27 , pp. 149-162
    • Yuan, Z.1    Zhang, X.2    Sengupta, N.3    Lane, W.S.4    Seto, E.5
  • 188
    • 67349246802 scopus 로고    scopus 로고
    • CtIP-BRCA1 modulates the choice of DNA double-strand-break, repair pathway throughout the cell cycle
    • Yun MH, Hiom K (2009) CtIP-BRCA1 modulates the choice of DNA double-strand-break, repair pathway throughout the cell cycle. Nature 459:460-463
    • (2009) Nature , vol.459 , pp. 460-463
    • Yun, M.H.1    Hiom, K.2
  • 189
    • 68249150701 scopus 로고    scopus 로고
    • Mre11: Roles in DNA repair beyond homologous recombination
    • Zha S, Boboila C, Alt FW (2009) Mre11 : roles in DNA repair beyond homologous recombination. Nat Struct Mol Biol 16:798-800
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 798-800
    • Zha, S.1    Boboila, C.2    Alt, F.W.3
  • 190
    • 31144471460 scopus 로고    scopus 로고
    • The role of NBS1 in DNA double strand break repair, telomae stability, and cell cycle checkpoint control
    • Zhang Y, Zhou. J, Lim CU (2006) The role of NBS1 in DNA double strand break repair, telomae stability, and cell cycle checkpoint control, Cell Res 16:45-54
    • (2006) Cell Res , vol.16 , pp. 45-54
    • Zhang, Y.1    Zhou, J.2    Lim, C.U.3
  • 191
    • 0035936554 scopus 로고    scopus 로고
    • Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
    • Zhu J, Petersen S, Tessarollo L, Nussenzweig A (200.1) Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol 11:105-109
    • (2001) Curr Biol , vol.11 , pp. 105-109
    • Zhu, J.1    Petersen, S.2    Tessarollo, L.3    Nussenzweig, A.4
  • 192
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exol resect DNA double-strand break ends
    • Zhu Z, Chung WH, Shim EY, Lee SE, Ira G (2008) Sgs1 helicase and two nucleases Dna2 and Exol resect DNA double-strand break ends. Cell 134:981-994
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.