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Volumn 25, Issue 24, 2005, Pages 10782-10790

Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining

Author keywords

[No Author keywords available]

Indexed keywords

DN14 PROTEIN; DNA LIGASE IV; DOUBLE STRANDED DNA; FUNGAL PROTEIN; HYBRID PROTEIN; KU ANTIGEN; KU80 PROTEIN; LIF1 PROTEIN; MRE11 PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RAD50 PROTEIN; UNCLASSIFIED DRUG; XRS2 PROTEIN; YKU80 PROTEIN;

EID: 28544447826     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.24.10782-10790.2005     Document Type: Article
Times cited : (62)

References (47)
  • 1
    • 0141868298 scopus 로고    scopus 로고
    • The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini
    • Bertuch, A. A., and V. Lundblad. 2003. The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini. Mol. Cell. Biol. 23:8202-8215.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8202-8215
    • Bertuch, A.A.1    Lundblad, V.2
  • 2
    • 0032536861 scopus 로고    scopus 로고
    • Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
    • Boulton, S. J., and S. P. Jackson. 1998. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17:1819-1828.
    • (1998) EMBO J. , vol.17 , pp. 1819-1828
    • Boulton, S.J.1    Jackson, S.P.2
  • 3
    • 0029843408 scopus 로고    scopus 로고
    • Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance
    • Boulton, S. J., and S. P. Jackson. 1996. Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24:4639-4648.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4639-4648
    • Boulton, S.J.1    Jackson, S.P.2
  • 4
    • 0032579440 scopus 로고    scopus 로고
    • Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
    • Brachmann, C. B., A. Davies, G. J. Cost, E. Caputo, J. Li, P. Hieter, and J. D. Boeke. 1998. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14:115-132.
    • (1998) Yeast , vol.14 , pp. 115-132
    • Brachmann, C.B.1    Davies, A.2    Cost, G.J.3    Caputo, E.4    Li, J.5    Hieter, P.6    Boeke, J.D.7
  • 5
    • 0035930342 scopus 로고    scopus 로고
    • Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes
    • Chen, L., K. Trujillo, W. Ramos, P. Sung, and A. E. Tomkinson. 2001. Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol. Cell 8:1105-1115.
    • (2001) Mol. Cell , vol.8 , pp. 1105-1115
    • Chen, L.1    Trujillo, K.2    Ramos, W.3    Sung, P.4    Tomkinson, A.E.5
  • 6
    • 12844278880 scopus 로고    scopus 로고
    • Rejoining of DNA double-strand breaks as a function of overhang length
    • Daley, J. M., and T. E. Wilson. 2005. Rejoining of DNA double-strand breaks as a function of overhang length. Mol. Cell. Biol. 25:896-906.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 896-906
    • Daley, J.M.1    Wilson, T.E.2
  • 7
    • 0036276388 scopus 로고    scopus 로고
    • The mre11 complex: At the crossroads of DNA repair and checkpoint signalling
    • D'Amours, D., and S. P. Jackson. 2002. The mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 3:317-327.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 8
    • 0037124373 scopus 로고    scopus 로고
    • Synapsis of DNA ends by DNA-dependent protein kinase
    • DeFazio, L. G., R. M. Stansel, J. D. Griffith, and G. Chu. 2002. Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J. 21:3192-3200.
    • (2002) EMBO J. , vol.21 , pp. 3192-3200
    • Defazio, L.G.1    Stansel, R.M.2    Griffith, J.D.3    Chu, G.4
  • 10
    • 0346249708 scopus 로고    scopus 로고
    • Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining
    • Dore, A. S., A. C. Drake, S. C. Brewerton, T. L. Blundell, and A. M. Robert. 2004. Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining. DNA Repair 3:33-41.
    • (2004) DNA Repair , vol.3 , pp. 33-41
    • Dore, A.S.1    Drake, A.C.2    Brewerton, S.C.3    Blundell, T.L.4    Robert, A.M.5
  • 11
    • 7944231563 scopus 로고    scopus 로고
    • Non-homologous end-joining factors of Saccharomyces cerevisiae
    • Dudasova, Z., A. Dudas, and M. Chovanec. 2004. Non-homologous end-joining factors of Saccharomyces cerevisiae. FEMS Microbiol. Rev. 28:581-601.
    • (2004) FEMS Microbiol. Rev. , vol.28 , pp. 581-601
    • Dudasova, Z.1    Dudas, A.2    Chovanec, M.3
  • 12
    • 0033638454 scopus 로고    scopus 로고
    • The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phosphodependent signaling mechanisms
    • Durocher, D., I. A. Taylor, D. Sarbassova, L. F. Haire, S. L. Westcott, S. P. Jackson, S. J. Smerdon, and M. B. Yaffe. 2000. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phosphodependent signaling mechanisms. Mol. Cell 6:1169-1182.
    • (2000) Mol. Cell , vol.6 , pp. 1169-1182
    • Durocher, D.1    Taylor, I.A.2    Sarbassova, D.3    Haire, L.F.4    Westcott, S.L.5    Jackson, S.P.6    Smerdon, S.J.7    Yaffe, M.B.8
  • 13
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck, J., J. Coates, and S. P. Jackson. 2005. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434:605-611.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 14
    • 0035889233 scopus 로고    scopus 로고
    • NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway
    • Frank-Vaillant, M., and S. Marcand. 2001. NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway. Genes Dev. 15:3005-3012.
    • (2001) Genes Dev. , vol.15 , pp. 3005-3012
    • Frank-Vaillant, M.1    Marcand, S.2
  • 16
    • 0033198709 scopus 로고    scopus 로고
    • Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
    • Gell, D., and S. P. Jackson. 1999. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res. 27:3494-3502.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 3494-3502
    • Gell, D.1    Jackson, S.P.2
  • 17
    • 28544434686 scopus 로고    scopus 로고
    • Reference deleted
    • Reference deleted.
  • 20
    • 0036261707 scopus 로고    scopus 로고
    • Sensing and repairing DNA double-strand breaks
    • Jackson, S. P. 2002. Sensing and repairing DNA double-strand breaks. Carcinogenesis 23:687-696.
    • (2002) Carcinogenesis , vol.23 , pp. 687-696
    • Jackson, S.P.1
  • 21
    • 0036021357 scopus 로고    scopus 로고
    • Enhancement of Saccharomyces cerevisiae end-joining efficiency by cell growth stage but not by impairment of recombination
    • Karathanasis, E., and T. E. Wilson. 2002. Enhancement of Saccharomyces cerevisiae end-joining efficiency by cell growth stage but not by impairment of recombination. Genetics 161:1015-1027.
    • (2002) Genetics , vol.161 , pp. 1015-1027
    • Karathanasis, E.1    Wilson, T.E.2
  • 24
    • 28544446104 scopus 로고    scopus 로고
    • Damage-induced recombination in the yeast Saccharomyces cerevisiae
    • Kupiec, M. 2000. Damage-induced recombination in the yeast Saccharomyces cerevisiae. Curr. Genet. 38:23-32.
    • (2000) Curr. Genet. , vol.38 , pp. 23-32
    • Kupiec, M.1
  • 25
    • 2442463320 scopus 로고    scopus 로고
    • Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells
    • Lewis, L. K., F. Storici, S. Van Komen, S. Calero, P. Sung, and M. A. Resnick. 2004. Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells. Genetics 166:1701-1713.
    • (2004) Genetics , vol.166 , pp. 1701-1713
    • Lewis, L.K.1    Storici, F.2    Van Komen, S.3    Calero, S.4    Sung, P.5    Resnick, M.A.6
  • 26
    • 0037069381 scopus 로고    scopus 로고
    • Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1
    • Liu, C., J. J. Pouliot, and H. A. Nash. 2002. Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1. Proc. Natl. Acad. Sci. USA 99:14970-14975.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14970-14975
    • Liu, C.1    Pouliot, J.J.2    Nash, H.A.3
  • 27
    • 0242468933 scopus 로고    scopus 로고
    • Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences
    • Ma, J. L., E. M. Kim, J. E. Haber, and S. E. Lee. 2003. Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol. Cell. Biol. 23:8820-8828.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8820-8828
    • Ma, J.L.1    Kim, E.M.2    Haber, J.E.3    Lee, S.E.4
  • 28
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • Ma, Y., U. Pannicke, K. Schwarz, and M. R. Lieber. 2002. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108:781-794.
    • (2002) Cell , vol.108 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 29
    • 3242875642 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase: The director at the end
    • Meek, K., S. Gupta, D. A. Ramsden, and S. P. Lees-Miller. 2004. The DNA-dependent protein kinase: the director at the end. Immunol. Rev. 200:132-141.
    • (2004) Immunol. Rev. , vol.200 , pp. 132-141
    • Meek, K.1    Gupta, S.2    Ramsden, D.A.3    Lees-Miller, S.P.4
  • 31
    • 0032474732 scopus 로고    scopus 로고
    • The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities
    • Polotnianka, R. M., J. Li, and A. J. Lustig. 1998. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr. Biol. 8:831-834.
    • (1998) Curr. Biol. , vol.8 , pp. 831-834
    • Polotnianka, R.M.1    Li, J.2    Lustig, A.J.3
  • 32
    • 3242885293 scopus 로고    scopus 로고
    • The PredictProtein server
    • Rost, B. 2004. The PredictProtein server. Nucleic Acids Res. 32:W517-W521.
    • (2004) Nucleic Acids Res. , vol.32
    • Rost, B.1
  • 33
    • 0347683485 scopus 로고    scopus 로고
    • Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing
    • Roy, R., B. Meier, A. D. McAinsh, H. M. Feldmann, and S. P. Jackson. 2004. Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing. J. Biol. Chem. 279:86-94.
    • (2004) J. Biol. Chem. , vol.279 , pp. 86-94
    • Roy, R.1    Meier, B.2    McAinsh, A.D.3    Feldmann, H.M.4    Jackson, S.P.5
  • 34
    • 0036270928 scopus 로고    scopus 로고
    • LacZ assays in yeast
    • Rupp, S. 2002. LacZ assays in yeast. Methods Enzymol. 350:112-131.
    • (2002) Methods Enzymol. , vol.350 , pp. 112-131
    • Rupp, S.1
  • 35
    • 20444390159 scopus 로고    scopus 로고
    • Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae
    • Shima, H., M. Suzuki, and M. Shinohara. 2005. Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae. Genetics 170:71-85.
    • (2005) Genetics , vol.170 , pp. 71-85
    • Shima, H.1    Suzuki, M.2    Shinohara, M.3
  • 36
    • 28544445017 scopus 로고    scopus 로고
    • Reference deleted
    • Reference deleted.
  • 37
    • 1942503933 scopus 로고    scopus 로고
    • Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins
    • Taddei, A., F. Hediger, F. R. Neumann, C. Bauer, and S. M. Gasser. 2004. Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins. EMBO J. 23:1301-1312.
    • (2004) EMBO J. , vol.23 , pp. 1301-1312
    • Taddei, A.1    Hediger, F.2    Neumann, F.R.3    Bauer, C.4    Gasser, S.M.5
  • 38
    • 0035808385 scopus 로고    scopus 로고
    • The fork-head-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50-hMRE11-NBS1 complex DNA repair activity
    • Tauchi, H., J. Kobayashi, K. Morishima, S. Matsuura, A. Nakamura, T. Shiraishi, E. Ito, D. Masnada, D. Delia, and K. Komatsu. 2001. The fork-head-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50-hMRE11-NBS1 complex DNA repair activity. J. Biol. Chem. 276:12-15.
    • (2001) J. Biol. Chem. , vol.276 , pp. 12-15
    • Tauchi, H.1    Kobayashi, J.2    Morishima, K.3    Matsuura, S.4    Nakamura, A.5    Shiraishi, T.6    Ito, E.7    Masnada, D.8    Delia, D.9    Komatsu, K.10
  • 39
    • 0034628617 scopus 로고    scopus 로고
    • Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks
    • Teo, S. H., and S. P. Jackson. 2000. Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks. Curr. Biol. 10:165-168.
    • (2000) Curr. Biol. , vol.10 , pp. 165-168
    • Teo, S.H.1    Jackson, S.P.2
  • 40
    • 0037160145 scopus 로고    scopus 로고
    • A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining
    • Tseng, H. M., and A. E. Tomkinson. 2002. A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining. J. Biol. Chem. 277:45630-45637.
    • (2002) J. Biol. Chem. , vol.277 , pp. 45630-45637
    • Tseng, H.M.1    Tomkinson, A.E.2
  • 41
    • 12844271048 scopus 로고    scopus 로고
    • Xrs2p regulates mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination
    • Tsukamoto, Y., C. Mitsuoka, M. Terasawa, H. Ogawa, and T. Ogawa. 2005. Xrs2p regulates mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination. Mol. Biol. Cell 16:597-608.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 597-608
    • Tsukamoto, Y.1    Mitsuoka, C.2    Terasawa, M.3    Ogawa, H.4    Ogawa, T.5
  • 42
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker, J. R., R. A. Corpina, and J. Goldberg. 2001. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412:607-614.
    • (2001) Nature , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 43
    • 0036812245 scopus 로고    scopus 로고
    • A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio
    • Wilson, T. E. 2002. A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio. Genetics 162:677-688.
    • (2002) Genetics , vol.162 , pp. 677-688
    • Wilson, T.E.1
  • 44
    • 0030811523 scopus 로고    scopus 로고
    • Yeast DNA ligase IV mediates non-homologous DNA end joining
    • Wilson, T. E., U. Grawunder, and M. R. Lieber. 1997. Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 388:495-498.
    • (1997) Nature , vol.388 , pp. 495-498
    • Wilson, T.E.1    Grawunder, U.2    Lieber, M.R.3
  • 45
    • 0033551662 scopus 로고    scopus 로고
    • Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase β (Pol4)-dependent pathway
    • Wilson, T. E., and M. R. Lieber. 1999. Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase β (Pol4)-dependent pathway. J. Biol. Chem. 274:23599-23609.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23599-23609
    • Wilson, T.E.1    Lieber, M.R.2
  • 47
    • 1542581549 scopus 로고    scopus 로고
    • Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions
    • Zhang, Z., W. Hu, L. Cano, T. D. Lee, D. J. Chen, and Y. Chen. 2004. Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions. Structure (Cambridge) 12:495-502.
    • (2004) Structure (Cambridge) , vol.12 , pp. 495-502
    • Zhang, Z.1    Hu, W.2    Cano, L.3    Lee, T.D.4    Chen, D.J.5    Chen, Y.6


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