Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle

Genes and Development

Volumn 18, Issue 18, 2004, Pages 2249-2254

  Ferreira, Miguel Godinho ^a   Cooper, Julia Promisel ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Cell cycle; DNA repair; HR; NHEJ; Taz1; Telomere

Indexed keywords

DOUBLE STRANDED DNA; PROTEIN TAZ1; TELOMERE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FUSION GENE; GENE DISRUPTION; HOMOLOGOUS RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; TELOMERE; YEAST;

CELL CYCLE; CELL DIVISION; DNA; DNA REPAIR; G1 PHASE; G2 PHASE; GAMMA RAYS; NITROGEN; RECOMBINATION, GENETIC; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TELOMERE; TELOMERE-BINDING PROTEINS;

ANIMALIA; EUKARYOTA; FUNGI; SCHIZOSACCHAROMYCES POMBE;

EID: 4444339506     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.315804     Document Type: Article

References (35)

1. Bahler, J., Wu, J.Q., Longtine, M.S., Shah, N.G., McKenzie III, A., Steever, A.B., Wach, A., Philippsen, P., and Pringle, J.R. 1998. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14: 943-951.
2. Baumann, P. and Cech, T.R. 2000. Protection of telomeres by the Ku protein in fission yeast. Mol. Biol. Cell. 11: 3265-3275.
3. Boulton, S.J. and Jackson, S.P. 1996. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15: 5093-5103.
4. Caspari, T., Murray, J.M., and Carr, A.M. 2002. Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. Genes & Dev. 16: 1195-1208.
5. Cooper, J.P., Nimmo, E.R., Allshire, R.C., and Cech, T.R. 1997. Regulation of telomere length and function by a Myb-domain protein in fission yeast [see comments]. Nature 385: 744-747.
6. Cooper, J.P., Watanabe, Y., and Nurse, P. 1998. Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination [see comments]. Nature 392: 828-831.
7. Ferreira, M.G. and Cooper, J.P. 2001. The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions. Mol. Cell 7: 55-63.
8. Ferreira, M.G., Miller, K.M., and Cooper, J.P. 2004. Indecent exposure: When telomeres become uncapped. Mol. Cell 13: 7-18.
9. Haering, C.H., Nakamura, T.M., Baumann, P., and Cech, T.R. 2000. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. 97: 6367-6372.
10. Jessberger, R. 2002. The many functions of SMC proteins in chromosome dynamics. Nat. Rev. Mol. Cell. Biol. 3: 767-778.
11. Kadyk, L.C. and Hartwell, L.H. 1992. Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae. Genetics 132: 387-402.
12. Karathanasis, E. and Wilson, T.E. 2002. Enhancement of Saccharomyces cerevisiae end-joining efficiency by cell growth stage but not by impairment of recombination. Genetics 161: 1015-1027.
13. Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., and de Lange, T. 1999. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.
14. Keeney, J.B. and Boeke, J.D. 1994. Efficient targeted integration at leu1-32 and ura4-294 in Schizosaccharomyces pombe. Genetics 136: 849-856.
15. Li, B., Oestreich, S., and de Lange, T. 2000. Identification of human Rap1: Implications for telomere evolution. Cell 101: 471-483.
16. Lisby, M., Rothstein, R., and Mortensen, U.H. 2001. Rad52 forms DNA repair and recombination centers during S phase. Proc. Natl. Acad. Sci. 98: 8276-8282.
17. Manolis, K.G., Nimmo, E.R., Hartsuiker, E., Carr, A.M., Jeggo, P.A., and Allshire, R.C. 2001. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. EMBO J. 20: 210-221.
18. Moynahan, M.E. and Jasin, M. 1997. Loss of heterozygosity induced by a chromosomal double-strand break. Proc. Natl. Acad. Sci. 94: 8988-8993.
19. Muris, D.F.R., Vreeken, K., Schmidt, H., Ostermann, K., Clever, B., Lohman, P.H.M., and Pastink, A. 1997. Homologous recombination in the fission yeast Schizosaccharomyces pombe: Different requirements for the rhp51+, rhp54+ and rad22+ genes. Curr. Genet. 31: 248-254.
20. Naito, T., Matsuura, A., and Ishikawa, F. 1998. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Nat. Genet. 20: 203-206.
21. Nakamura, T.M., Cooper, J.P., and Cech, T.R. 1998. Two modes of survival of fission yeast without telomerase. Science 282: 493-496.
22. Orr-Weaver, T.L., Szostak, J.W., and Rothstein, R.J. 1981. Yeast transformation: A model system for the study of recombination. Proc. Natl. Acad. Sci. 78: 6354-6358.
23. Ostermann, K., Lorentz, A., and Schmidt, H. 1993. The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae. Nucleic Acids Res. 21: 5940-5944.
24. Pierce, A.J., Hu, P., Han, M., Ellis, N., and Jasin, M. 2001a. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes & Dev. 15: 3237-3242.
25. Pierce, A.J., Stark, J.M., Araujo, F.D., Moynahan, M.E., Berwick, M., and Jasin, M. 2001b. Double-strand breaks and tumorigenesis. Trends Cell. Biol. 11: S52-S59.
26. Russell, P. and Nurse, P. 1987. Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell 49: 559-567.
27. Sandell, L.L. and Zakian, V.A. 1993. Loss of a yeast telomere: Arrest, recovery, and chromosome loss. Cell 75: 729-739.
28. Siede, W., Friedl, A.A., Dianova, I., Eckardt-Schupp, F., and Friedberg, E.C. 1996. The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics 142: 91-102.
29. Smogorzewska, A., Karlseder, J., Holtgreve-Grez, H., Jauch, A., and de Lange, T. 2002. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr. Biol. 12: 1635-1644.
30. Stern, B. and Nurse, P. 1998. Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast. Mol. Biol. Cell 9: 1309-1321.
31. Takata, M., Sasaki, M.S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi-Iwai, Y., Shinohara, A., and Takeda, S. 1998. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17: 5497-5508.
32. Tomita, K., Matsuura, A., Caspari, T., Carr, A.M., Akamatsu, Y., Iwasaki, H., Mizuno, K., Ohta, K., Uritani, M., Ushimaru, T., et al. 2003. Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol. Cell. Biol. 23: 5186-5197.
33. van den Bosch, M., Vreeken, K., Zonneveld, J.B., Brandsma, J.A., Lombaerts, M., Murray, J.M., Lohman, P.H., and Pastink, A. 2001. Characterization of RAD52 homologs in the fission yeast Schizosaccharomyces pombe. Mutat. Res. 461: 311-323.
34. van Gent, D.C., Hoeijmakers, J.H., and Kanaar, R. 2001. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2: 196-206.
35. van Steensel, B., Smogorzewska, A., and de Lange, T. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413.