ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism

Genes and Development

Volumn 17, Issue 16, 2003, Pages 1957-1962

  Nakada, Daisuke ^a   Matsumoto, Kunihiro ^a   Sugimoto, Katsunori ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

ATM; Double strand break; Tel1; Xrs2

Indexed keywords

ATM PROTEIN; DOUBLE STRANDED DNA; GENE PRODUCT; PROTEIN TEL1; PROTEIN XRS2; UNCLASSIFIED DRUG;

ARTICLE; BUDDING; CARBOXY TERMINAL SEQUENCE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA DEGRADATION; DNA STRAND BREAKAGE; FUNGAL GENE; FUNGUS GROWTH; GENE SEQUENCE; GENETIC CODE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; YEAST;

CELL CYCLE PROTEINS; CELL SURVIVAL; DNA DAMAGE; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION; TUMOR SUPPRESSOR PROTEINS;

FUNGI; SACCHAROMYCETALES;

EID: 0041660970     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1099003     Document Type: Article

References (39)

1. Bakkenist, C.J. and Kastan, M.B. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421: 499-506.
2. Chan, S.W., Chang, J., Prescott, J., and Blackburn, E.H. 2001. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr. Biol. 11: 1240-1250.
3. Cortez, D., Guntuku, S., Qin, J., and Elledge, S.J. 2001. ATR and ATRIP: Partners in checkpoint signaling. Science 294: 1713-1716.
4. D'Amours, D. and Jackson, S.P. 2001. The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes & Dev. 15: 2238-2249.
5. -. 2002. The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling. Nature Rev. Mol. Cell Biol. 3: 317-327.
6. Edwards, R.J., Bentley, N.J., and Carr, A.M. 1999. A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Nat. Cell Biol. 1: 393-398.
7. Galli, A. and Schiestl, R.H. 1999. Cell division transforms mutagenic lesions into deletion-recombinagenic lesions in yeast cells. Mutat. Res. 429: 13-26.
8. Gilbert, C.S., Green, C.M., and Lowndes, N.F. 2001. Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol. Cell 8: 129-136.
9. Grenon, M., Gilbert, C., and Lowndes, N.F. 2001. Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex. Nat. Cell Biol. 3: 844-847.
10. Ivanov, E.L., Sugawara, N., White, C.I., Fabre, F., and Haber, J.E. 1994. Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 3414-3425.
11. Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K., and Sugimoto, K. 2001, Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294: 867-870.
12. Lee, S.E., Moore, J.K., Holmes, A., Umezu, K., Kolodner, R.D., and Haber, J.E. 1998. Saccharomyces Ku70, Mre11/Rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94: 399-409.
13. Lim, D.S., Kim, S.T., Xu, B., Maser, R.S., Lin, J., Petrini, J.H., and Kastan, M.B. 2000. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404: 613-617.
14. Lobachev, K.S., Gordenin, D.A., and Resnick, M.A. 2002. The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 108: 183-193.
15. Lukas, C., Falck, J., Bartkova, J., Bartek, J., and Lukas, J. 2003. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5: 225-260.
16. Melo, J.A., Cohen, J., and Toczyski, D.P. 2001. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes & Dev. 21: 2809-2821.
17. Mirzoeva, O.K. and Petrini, J.H. 2001. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol. 21: 281-288.
18. Moore, C.W. 1988. Internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast. Cancer Res. 23: 6837-6843.
19. Morrow, D.M., Tagle, D.A., Shiloh, Y., Collins, F.S., and Hieter, P. 1995. TEL1 an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82: 831-840.
20. Nakada, D., Shimomura, T., Matsumoto, K., and Sugimoto, K. 2003. The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res. 31: 1715-1724.
21. Paciotti, V., Clerici, M., Lucchini, G., and Longhese, M.P. 2000. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes & Dev. 14: 2046-2059.
22. Pellicioli, A., Lee, S.E., Lucca, C., Foiani, M., and Haber, J.E. 2001. Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. Mol. Cell 7: 293-300.
23. Perkins, E.J., Nair, A., Cowley, D.O., Dyke, T.V., Chang, Y., and Ramsden, D.A. 2002. Sensing of intermediates in V(D)J recombination by ATM. Genes & Dev. 16: 159-164.
24. Petrini, J.H. 2000. The Mre11 complex and ATM: Collaborating to navigate S phase. Curr. Opin. Cell Biol. 12: 293-296.
25. Rattray, A.J., McGill, C.B., Shafer, B.K., and Strathern, J.N. 2001. Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: A role for SAE2/COM1. Genetics 158: 109-122.
26. Raymond, W.E. and Kleckner, N. 1993. RAD50 protein of S. cerevisiae exhibits ATP-dependent DNA binding. Nucleic Acids Res. 21: 3851-3856.
27. Rouse, J. and Jackson, S.P. 2000. LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J. 19: 5793-5800.
28. -. 2002. Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol. Cell 9: 857-869.
29. Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B., and Elledge, S.J. 1996. Regulation of RAD53 by the ATM-like kinase MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271: 357-360.
30. Schwartz, M.F., Duong, J.K., Sun, Z., Morrow, J.S., Pradhan, D., and Stern, D.F. 2002. Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol. Cell 9: 1055-1065.
31. Sun, Z., Fay, D.S., Marini, F., Foiani, M., and Stern, D.F. 1996. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes & Dev. 10: 395-406.
32. Sweetser, D.B., Hough, H., Whelden, J.F., Arbuckle, M., and Nickoloff, J.A. 1994. Fine-resolution mapping of spontaneous and double-strand break-induced gene conversion tracts in Saccharomyces cerevisiae reveals reversible mitotic conversion polarity. Mol. Cell. Biol. 14: 3863-3875.
33. Usui, T., Ogawa, H., and Petrini, J.H. 2001. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol. Cell 7: 1255-1266.
34. Wakayama, T., Kondo, T., Ando, S., Matsumoto, K., and Sugimoto, K. 2001. Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol. Cell. Biol. 21: 755-764.
35. White, C.I. and Haber, J.E. 1990. Intermediates of recombination during mating type switching in Saccharomyces cerevisiae. EMBO J. 9: 663-673.
36. Wu, X., Ranganathan, V., Weisman, D.S., Heine, W.F., Ciccone, D.N., O'Neill, T.B., Crick, K.E., Pierce, K.A., Lane, W.S., Rathbun, G., et al. 2000. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature 405: 477-482.
37. Zhao, S., Weng, Y.C., Yuan, S.S., Lin, Y.T., Hsu, H.C., Lin, S.C., Gerbino, E., Song, M.H., Zdzienicka, M.Z., Gatti, R.A., et al. 2000. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature 405: 473-477.
38. Zhao, X., Muller, E.G.D., and Rothstein, R. 1998. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pool. Mol. Cell 2: 329-340.
39. Zhou, B.-B.S. and Elledge, S.J. 2000. The DNA damage response: Putting checkpoints in perspective. Nature 408: 433-439.