Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif

Journal of Molecular Medicine

Volumn 86, Issue 4, 2008, Pages 401-412

  Chen, Yen Chung ^a   Chiang, Hsiu Yin ^a   Yang, Muh Hwa ^a,b   Chen, Po Min ^b   Chang, Shyue Yih ^b   Teng, Shu Chun ^c   Vanhaesebroeck, Bart ^d   Wu, Kou Juey ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Activation motif; NBS1; p110 ; PI 3 kinase

Indexed keywords

ADAPTOR PROTEIN; DNA; DOUBLE STRANDED DNA; NIBRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P110ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CANCER PATIENT; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL TRANSFORMATION; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CELL LINE; ENZYME ACTIVATION; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT;

EID: 42449155412     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-008-0302-x     Document Type: Article

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