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Volumn 69, Issue 5, 2009, Pages 1768-1775

Inactivation of the Nijmegen breakage syndrome gene leads to centrosome duplication via the ATR/BRCA1 pathway

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; BRCA1 PROTEIN; COMPLEMENTARY DNA; GAMMA TUBULIN; NIBRIN; SMALL INTERFERING RNA; ATR PROTEIN, HUMAN; CELL CYCLE PROTEIN; NBN PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; TUBULIN; UBIQUITIN;

EID: 62449332005     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-3016     Document Type: Article
Times cited : (27)

References (48)
  • 1
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998;396:643-9.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 4
    • 33745714521 scopus 로고    scopus 로고
    • Haploinsufficiency of RAD51B causes centrosome fragmentation and aneuploidy in human cells
    • Date O, Katsura M, Ishida M, et al. Haploinsufficiency of RAD51B causes centrosome fragmentation and aneuploidy in human cells. Cancer Res 2006;66:6018-24.
    • (2006) Cancer Res , vol.66 , pp. 6018-6024
    • Date, O.1    Katsura, M.2    Ishida, M.3
  • 6
    • 0034653382 scopus 로고    scopus 로고
    • Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells
    • Sato N, Mizumoto K, Nakamura M, Tanaka M. Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells. Exp Cell Res 2000;255:321-6.
    • (2000) Exp Cell Res , vol.255 , pp. 321-326
    • Sato, N.1    Mizumoto, K.2    Nakamura, M.3    Tanaka, M.4
  • 7
    • 0034597513 scopus 로고    scopus 로고
    • A possible role for centrosome overduplication in radiation-induced cell death
    • Sato N, Mizumoto K, Nakamura M, et al. A possible role for centrosome overduplication in. radiation-induced cell death. Oncogene 2000;19:5281-90.
    • (2000) Oncogene , vol.19 , pp. 5281-5290
    • Sato, N.1    Mizumoto, K.2    Nakamura, M.3
  • 8
    • 34547653660 scopus 로고    scopus 로고
    • DNA damage induces Chkl-dependent centrosome amplification
    • Bourke E, Dodson H, Merdes A, et al. DNA damage induces Chkl-dependent centrosome amplification. EMBO Rep 2007;8:603-9.
    • (2007) EMBO Rep , vol.8 , pp. 603-609
    • Bourke, E.1    Dodson, H.2    Merdes, A.3
  • 9
    • 33644849911 scopus 로고    scopus 로고
    • BRCAl-associated complexes: New targets to overcome breast cancer radiation resistance
    • Chen X, Arciero CA, Godwin AK. BRCAl-associated complexes: new targets to overcome breast cancer radia-tion resistance. Expert Rev Anticancer Ther 2006;6:1.87-96.
    • (2006) Expert Rev Anticancer Ther , vol.6 , pp. 187-96
    • Chen, X.1    Arciero, C.A.2    Godwin, A.K.3
  • 10
    • 33751278712 scopus 로고    scopus 로고
    • Cellular functions of the BRCA tumour-suppressor proteins
    • Boulton SJ. Cellular functions of the BRCA tumour-suppressor proteins. Biochem Soc Trans 2006:34:633-45.
    • (2006) Biochem Soc Trans , vol.34 , pp. 633-645
    • Boulton, S.J.1
  • 11
    • 33646243237 scopus 로고    scopus 로고
    • Identification of domains of BRCAl critical for the ubiquitin-dependent inhibition of centrosome function
    • Sankaran S, Starita LM, Simons AM, Parvin JD. Identification of domains of BRCAl critical for the ubiquitin-dependent inhibition of centrosome function. Cancer Res 2006;66:4100-7.
    • (2006) Cancer Res , vol.66 , pp. 4100-4107
    • Sankaran, S.1    Starita, L.M.2    Simons, A.M.3    Parvin, J.D.4
  • 12
    • 33751168729 scopus 로고    scopus 로고
    • Centrosome function in normal and tumor cells
    • Sankaran S, Parvin JD. Centrosome function in normal and tumor cells. J Cell Biochem. 2006;99:1240-50.
    • (2006) J Cell Biochem , vol.99 , pp. 1240-1250
    • Sankaran, S.1    Parvin, J.D.2
  • 13
    • 33750434275 scopus 로고    scopus 로고
    • The BRCAl/ BARDl heterodimer modulates ran-dependent mitotic spindle assembly
    • Joukov V, Groen AC, Prokhorova T, et al. The BRCAl/ BARDl heterodimer modulates ran-dependent mitotic spindle assembly. Cell 2006;127:539-52.
    • (2006) Cell , vol.127 , pp. 539-552
    • Joukov, V.1    Groen, A.C.2    Prokhorova, T.3
  • 14
    • 25444455576 scopus 로고    scopus 로고
    • Centrosomal microtubule nucleation activity is inhibited by BRCAl-dependent ubiquitination
    • Sankaran S, Starita LM, Groen AC, Ko MJ, Parvin JD. Centrosomal microtubule nucleation activity Is inhibited by BRCAl-dependent ubiquitination. Mol Cell Biol 2005;25:8656-68.
    • (2005) Mol Cell Biol , vol.25 , pp. 8656-8668
    • Sankaran, S.1    Starita, L.M.2    Groen, A.C.3    Ko, M.J.4    Parvin, J.D.5
  • 15
    • 0037133211 scopus 로고    scopus 로고
    • Centrosome amplification drives chromosomal instability in breast tumor development
    • Lingle WL, Barrett SL, Negron VC, et al. Centrosome amplification drives chromosomal instability in breast tumor development Proc Natl Acad Sei USA 2002;99: 1978-83.
    • (2002) Proc Natl Acad Sei USA , vol.99 , pp. 1978-1983
    • Lingle, W.L.1    Barrett, S.L.2    Negron, V.C.3
  • 16
    • 0037444168 scopus 로고    scopus 로고
    • Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas
    • Pihan GA, Wallace J, Zhou Y, Doxsey SJ. Centrosome abnormalities and chromosome instability occur to-gether in pre-invasive carcinomas. Cancer Res 2003:63:.1398-404.
    • (2003) Cancer Res , vol.63 , pp. 1398-1404
    • Pihan, G.A.1    Wallace, J.2    Zhou, Y.3    Doxsey, S.J.4
  • 18
    • 38349052915 scopus 로고    scopus 로고
    • Nijmegen Breakage Syndrome mutations and risk of breast cancer
    • Bogdanova N, Feshchenko S, Schurmann P, et al. Nijmegen Breakage Syndrome mutations and risk of breast cancer. Int J Cancer 2008;122:802-6.
    • (2008) Int J Cancer , vol.122 , pp. 802-806
    • Bogdanova, N.1    Feshchenko, S.2    Schurmann, P.3
  • 19
    • 44849105787 scopus 로고    scopus 로고
    • I171V germUne mutation in the NBSl gene significantly increases risk of breast cancer
    • Roznowski K, Januszkiewicz-Lewandowska D, Mosor M, et al. I171V germUne mutation in the NBSl gene significantly increases risk of breast cancer. Breast Cancer Res Treat 2008;110:343-8.
    • (2008) Breast Cancer Res Treat , vol.110 , pp. 343-348
    • Roznowski, K.1    Januszkiewicz-Lewandowska, D.2    Mosor, M.3
  • 20
    • 37049016679 scopus 로고    scopus 로고
    • Novel NBSl germ line mutation causing MREIl-domain loss predisposes to common types of cancer
    • Ebi H, Matsuo K, Sugito N, et al. Novel NBSl germ line mutation causing MREIl-domain loss predisposes to common types of cancer. Cancer Res 2007;67:11158-65.
    • (2007) Cancer Res , vol.67 , pp. 11158-11165
    • Ebi, H.1    Matsuo, K.2    Sugito, N.3
  • 21
    • 0037038362 scopus 로고    scopus 로고
    • Nbsl is for DNA repair by homologous recombination higher vertebrate cells
    • Tauchi H, Kobayashi J, Morishima K, et al. Nbsl is for DNA repair by homologous recombination higher vertebrate cells. Nature 2002;420:93-8.
    • (2002) Nature , vol.420 , pp. 93-98
    • Tauchi, H.1    Kobayashi, J.2    Morishima, K.3
  • 22
    • 34548496891 scopus 로고    scopus 로고
    • Homolorecombination repair is regulated by domains at N-and C-terminus of NBSI and is dissociated with Functions
    • Sakamoto S, Iijima K, Mochizuki D, et al. Homolo-recombination repair is regulated by domains at N-and C-terminus of NBSI and is dissociated with functions. Oncogene 2007;26:6002-9.
    • (2007) Oncogene , vol.26 , pp. 6002-6009
    • Sakamoto, S.1    Iijima, K.2    Mochizuki, D.3
  • 23
    • 4444293274 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome and DNA double strand repair by NBSl complex
    • Matsuura S, Kobayashi J, Tauchi H, Komatsu K. Nijmegen breakage syndrome and DNA double strand repair by NBSl complex. Adv Biophys 2004;38:65-80.
    • (2004) Adv Biophys , vol.38 , pp. 65-80
    • Matsuura, S.1    Kobayashi, J.2    Tauchi, H.3    Komatsu, K.4
  • 24
    • 0034953719 scopus 로고    scopus 로고
    • Chk2 activation on Nbsl after DNA damage
    • Buscemi G, Savlo C, Zanninl L, et al. Chk2 activation, on Nbsl after DNA damage. Mol Cell Biol;21:5214-22.
    • (2001) Mol Cell Biol , vol.21 , pp. 5214-5222
    • Buscemi, G.1    Savlo, C.2    Zanninl, L.3
  • 26
    • 2942687831 scopus 로고    scopus 로고
    • Phosphorylation of SMCI is a critical downstream, event in ATM-NBSl-I pathway
    • Kitagawa R, Bakkenist CJ, McKinnon PJ, Kaštan MB. Phosphorylation of SMCI is a critical downstream, event in ATM-NBSl-I pathway. Genes Dev 2004;18:1423-38.
    • (2004) Genes Dev , vol.18 , pp. 1423-1438
    • Kitagawa, R.1    Bakkenist, C.J.2    McKinnon, P.J.3    Kaštan, M.B.4
  • 27
    • 0036500690 scopus 로고    scopus 로고
    • SMCl is a downstream effector in the ATM/NBS1 branch of the S-phase checkpoint
    • Yazdi PT, Wang Y, Zhao S, et al. SMCl is a downstream, effector in the ATM/NBS1 branch of the S-phase checkpoint. Genes Dev 2002;16:571-82.
    • (2002) Genes Dev , vol.16 , pp. 571-82
    • Yazdi, P.T.1    Wang, Y.2    Zhao, S.3
  • 28
    • 33646117239 scopus 로고    scopus 로고
    • Spatial of the mammalian genome surveillance in response to DNA strand breaks
    • Bekker-Jensen S, Lukas C, Kitagawa R, et al. Spatial, of the mammalian genome surveillance in response to DNA strand breaks. J Cell Biol;173:195-206.
    • J Cell Biol , vol.173 , pp. 195-206
    • Bekker-Jensen, S.1    Lukas, C.2    Kitagawa, R.3
  • 29
    • 13244287780 scopus 로고    scopus 로고
    • Nbsl is required for dependent phosphorylation events
    • Stiff T, Reis C, Alderton GK, et al. Nbsl. is required for dependent phosphorylation events. EMBO J 2005;24:199-208.
    • (2005) EMBO J , vol.24 , pp. 199-208
    • Stiff, T.1    Reis, C.2    Alderton, G.K.3
  • 30
    • 34547950170 scopus 로고    scopus 로고
    • The Mrell-50-Nbsl complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment
    • Olson E, Nievera CJ, Lee AY, Chen L1 Wu X. The Mrell-50-Nbsl complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem 2007; 282:22939-52.
    • (2007) J Biol Chem , vol.282 , pp. 22939-22952
    • Olson, E.1    Nievera, C.J.2    Lee, A.Y.3    Chen, L.4    Wu, X.5
  • 31
    • 38649092988 scopus 로고    scopus 로고
    • Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
    • Griffith E, Walker S, Martin CA, et al. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet 2008;40:232-6.
    • (2008) Nat Genet , vol.40 , pp. 232-236
    • Griffith, E.1    Walker, S.2    Martin, C.A.3
  • 32
    • 34247875990 scopus 로고    scopus 로고
    • Centrosomal localization of DNA damage checkpoint proteins
    • Zhang S, Hemmerich P, Grosse F. Centrosomal. localization of DNA damage checkpoint proteins. J Cell Biochem 2007;101:451-65.
    • (2007) J Cell Biochem , vol.101 , pp. 451-65
    • Zhang, S.1    Hemmerich, P.2    Grosse, F.3
  • 34
    • 0034730321 scopus 로고    scopus 로고
    • Nucleophos-min/B23 is a target of CDK2/cycUn E in centrosome duplication
    • Okuda M., Horn HF, Tarapore P, et al., Nucleophos-min/B23 is a target of CDK2/cycUn E in centrosome duplication, Cell, 2000, 103, 127-40
    • (2000) Cell , vol.103 , pp. 127-40
    • Okuda, M.1    Horn, H.F.2    Tarapore, P.3
  • 36
    • 36148985345 scopus 로고    scopus 로고
    • The Mrell/RadSO/Nbsl complex plays an important role in the prevention of DNA »replication in mammalian cells
    • Lee AY, Liu E, Wu X. The Mrell/RadSO/Nbsl complex plays an important role in the prevention of DNA »replication in mammalian cells. J Biol. Chem 2007;282:32243-55.
    • (2007) J Biol. Chem , vol.282 , pp. 32243-55
    • Lee, A.Y.1    Liu, E.2    Wu, X.3
  • 37
    • 33644979481 scopus 로고    scopus 로고
    • pI6(INK4a) Prevents centrosome dysfunction and genomic instability in primary ceUs
    • McDermott KM, Zhang J, Hoist CR, et al. pI6(INK4a) prevents centrosome dysfunction and genomic instability in primary ceUs. PLoS Biol 2006;4
    • (2006) PLoS Biol , vol.4 , pp. 51
    • McDermott, K.M.1    Zhang, J.2    Hoist, C.R.3
  • 38
    • 2342587462 scopus 로고    scopus 로고
    • Roscovitine, olomoucine, purvalanol: Inducers of apoptosis in maturing cerebellar granule neurons
    • Monaco EA III, Beaman-Hall CM, Mathur A, Vallano ML. Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. Biochem Pharmacol 2004;67:1947-64.
    • (2004) Biochem Pharmacol , vol.67 , pp. 1947-64
    • Monaco III, E.A.1    Beaman-Hall, C.M.2    Mathur, A.3    Vallano, M.L.4
  • 39
    • 0033055061 scopus 로고    scopus 로고
    • Cyclin-dependent kinase control of centrosome duplication
    • Lacey KR, Jackson PK, Steams T. Cyclin-dependent kinase control of centrosome duplication. Proc Natl Acad Sei U S A 1999:96:2817-22.
    • (1999) Proc Natl Acad Sei USA , vol.96 , pp. 2817-22
    • Lacey, K.R.1    Jackson, P.K.2    Steams, T.3
  • 40
    • 36448987217 scopus 로고    scopus 로고
    • Oncogenes and tumour suppressors take on centrosomes
    • Fukasawa K. Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 2007;7:911-24.
    • (2007) Nat Rev Cancer , vol.7 , pp. 911-24
    • Fukasawa, K.1
  • 41
    • 18344395671 scopus 로고    scopus 로고
    • Human MREIl is inactivated in mismatch repair-deficient cancers
    • Giannini G, Ristori E, Cerignoli F, et al. Human MREIl is inactivated in mismatch repair-deficient cancers. EMBO Rep 2002;3:248-54.
    • (2002) EMBO Rep , vol.3 , pp. 248-54
    • Giannini, G.1    Ristori, E.2    Cerignoli, F.3
  • 42
    • 33845715977 scopus 로고    scopus 로고
    • ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
    • Stiff T, Walker SA, Cerosaletti K, et al. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 2006;25:5775-82.
    • (2006) EMBO J , vol.25 , pp. 5775-82
    • Stiff, T.1    Walker, S.A.2    Cerosaletti, K.3
  • 43
  • 44
    • 36549060102 scopus 로고    scopus 로고
    • Human CtIP promotes DNA end resection
    • Sartori AA, Lukas C, Coates J, et al. Human CtIP promotes DNA end resection. Nature 2007:450:509-14.
    • (2007) Nature , vol.450 , pp. 509-514
    • Sartori, A.A.1    Lukas, C.2    Coates, J.3
  • 45
    • 50049099559 scopus 로고    scopus 로고
    • The importance of making ends meet: Mutations in genes and altered expression of proteins of the MRN complex and cancer
    • Dzlkiewicz-Krawczyk A. The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer. Mutat Res 2008;659:262-73.
    • (2008) Mutat Res , vol.659 , pp. 262-73
    • Dzlkiewicz-Krawczyk, A.1
  • 46
    • 0141923141 scopus 로고    scopus 로고
    • Tanière P, Hall J. Altered expression, of DNA double-strand break detection and repair proteins in breast carcinomas
    • Angele S, Treilleux I, Bremond A, Tanière P, Hall J. Altered expression, of DNA double-strand break detection and repair proteins in breast carcinomas. Histopathology 2003;43:347-53.
    • (2003) Histopathology , vol.43 , pp. 347-53
    • Angele, S.1    Treilleux, I.2    Bremond, A.3
  • 47
    • 34249885603 scopus 로고    scopus 로고
    • Deletion of the developmental essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
    • Ruzankina Y, Pinzon-Guzman C, Asare A, et al. Deletion of the developmental essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Ceu 2007;1:113-26.
    • (2007) Cell Stem Ceu , vol.1 , pp. 113-26
    • Ruzankina, Y.1    Pinzon-Guzman, C.2    Asare, A.3
  • 48
    • 17244367849 scopus 로고    scopus 로고
    • DNA. damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova J, Horejsi Z, Koed K, et al. DNA. damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005;434:864-70.
    • (2005) Nature , vol.434 , pp. 864-70
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.