Differential Regulation of the Cellular Response to DNA Double-Strand Breaks in G1

Molecular Cell

Volumn 30, Issue 1, 2008, Pages 73-85

  Barlow, Jacqueline H ^a   Lisby, Michael ^a   Rothstein, Rodney ^a  

^a Department of Medicine   (United States)

Author keywords

CELLCYCLE; DNA; SIGNALING

Indexed keywords

CDC28 ENZYME; CYCLIN DEPENDENT KINASE; DDC2 PROTEIN; DNA; DOUBLE STRANDED DNA; ENDONUCLEASE; PROTEIN DERIVATIVE; RFA1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; HOMOLOGOUS RECOMBINATION; IONIZING RADIATION;

CDC28 PROTEIN KINASE, S CEREVISIAE; CELL CYCLE PROTEINS; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; G1 PHASE; GENES, CDC; HUMANS; PHOSPHOPROTEINS; RADIATION, IONIZING; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; S PHASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

EID: 39549114009     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2008.01.016     Document Type: Article

References (52)

1. Aguilera A., and Rothstein R. Molecular Genetics of Recombination Volume 17 (2007), Springer, Berlin
2. Alani E., Thresher R., Griffith J.D., and Kolodner R.D. Characterization of DNA-binding and strand-exchange stimulation properties of y-RPA, a yeast single-strand-DNA-binding protein. J. Mol. Biol. 227 (1992) 54-71
3. Antunez de Mayolo A., Lisby M., Erdeniz N., Thybo T., Mortensen U.H., and Rothstein R. Multiple start codons and phosphorylation result in discrete Rad52 protein species. Nucleic Acids Res. 34 (2006) 2587-2597
4. Aylon Y., Liefshitz B., and Kupiec M. The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J. 23 (2004) 4868-4875
5. Bishop A.C., Ubersax J.A., Petsch D.T., Matheos D.P., Gray N.S., Blethrow J., Shimizu E., Tsien J.Z., Schultz P.G., Rose M.D., et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 (2000) 395-401
6. Chen L., Trujillo K., Ramos W., Sung P., and Tomkinson A.E. Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol. Cell 8 (2001) 1105-1115
7. Corda Y., Lee S.E., Guillot S., Walther A., Sollier J., Arbel-Eden A., Haber J.E., and Geli V. Inactivation of Ku-mediated end joining suppresses mec1Delta lethality by depleting the ribonucleotide reductase inhibitor Sml1 through a pathway controlled by Tel1 kinase and the Mre11 complex. Mol. Cell. Biol. 25 (2005) 10652-10664
8. Critchlow S.E., and Jackson S.P. DNA end-joining: from yeast to man. Trends Biochem. Sci. 23 (1998) 394-398
9. Cundari E., and Averbeck D. Alkaline step elution analysis of gamma-ray induced DNA strand breaks and repair in diploid yeast. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 51 (1987) 519-526
10. de Jager M., van Noort J., van Gent D.C., Dekker C., Kanaar R., and Wyman C. Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol. Cell 8 (2001) 1129-1135
11. Din S., Brill S.J., Fairman M.P., and Stillman B. Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes Dev. 4 (1990) 968-977
12. Feldmann H., and Winnacker E.L. A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. J. Biol. Chem. 268 (1993) 12895-12900
13. Frank C.J., Hyde M., and Greider C.W. Regulation of telomere elongation by the cyclin-dependent kinase CDK1. Mol. Cell 24 (2006) 423-432
14. Frank-Vaillant M., and Marcand S. Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. Mol. Cell 10 (2002) 1189-1199
15. Friedland W., Jacob P., Paretzke H.G., Merzagora M., and Ottolenghi A. Simulation of DNA fragment distributions after irradiation with photons. Radiat. Environ. Biophys. 38 (1999) 39-47
16. Henner W.D., Grunberg S.M., and Haseltine W.A. Sites and structure of gamma radiation-induced DNA strand breaks. J. Biol. Chem. 257 (1982) 11750-11754
17. Hoffman C.S., and Winston F. A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57 (1987) 267-272
18. Ira G., Pellicioli A., Balijja A., Wang X., Fiorani S., Carotenuto W., Liberi G., Bressan D., Wan L., Hollingsworth N.M., et al. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431 (2004) 1011-1017
19. Karathanasis E., and Wilson T.E. Enhancement of Saccharomyces cerevisiae end-joining efficiency by cell growth stage but not by impairment of recombination. Genetics 161 (2002) 1015-1027
20. Kim H.S., and Brill S.J. Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Mol. Cell. Biol. 21 (2001) 3725-3737
21. Kim H.S., and Brill S.J. MEC1-dependent phosphorylation of yeast RPA1 in vitro. DNA Repair (Amst.) 2 (2003) 1321-1335
22. Krogh B.O., and Symington L.S. Recombination proteins in yeast. Annu. Rev. Genet. 38 (2004) 233-271
23. Lee S.E., Moore J.K., Holmes A., Umezu K., Kolodner R.D., and Haber J.E. Saccharomyces Ku70, mre11/rad50, and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94 (1998) 399-409
24. Lee G.S., Neiditch M.B., Salus S.S., and Roth D.B. RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination. Cell 117 (2004) 171-184
25. Limbo O., Chahwan C., Yamada Y., de Bruin R.A., Wittenberg C., and Russell P. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol. Cell 28 (2007) 134-146
26. Lisby M., Rothstein R., and Mortensen U.H. Rad52 forms DNA repair and recombination centers during S phase. Proc. Natl. Acad. Sci. USA 98 (2001) 8276-8282
27. Lisby M., Barlow J.H., Burgess R.C., and Rothstein R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118 (2004) 699-713
28. Majka J., and Burgers P.M. Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc. Natl. Acad. Sci. USA 100 (2003) 2249-2254
29. Majka J., Binz S.K., Wold M.S., and Burgers P.M. Replication protein A directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions. J. Biol. Chem. 281 (2006) 27855-27861
30. Maniatis T., Fritsch E.F., and Sambrook J. Molecular Cloning: A Laboratory Manual (1982), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
31. Maringele L., and Lydall D. EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev. 16 (2002) 1919-1933
32. Melo J.A., Cohen J., and Toczyski D.P. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 15 (2001) 2809-2821
33. Mendenhall M.D., and Hodge A.E. Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62 (1998) 1191-1243
34. Moore J.K., and Haber J.E. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol. Cell. Biol. 16 (1996) 2164-2173
35. Moreau S., Ferguson J.R., and Symington L.S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19 (1999) 556-566
36. Ogorek B., and Bryant P.E. Repair of DNA single-strand breaks in X-irradiated yeast. I. Use of the DNA-unwinding method to measure DNA strand breaks. Mutat. Res. 146 (1985) 55-61
37. Ogorek B., and Bryant P.E. Repair of DNA single-strand breaks in X-irradiated yeast. II. Kinetics of repair as measured by the DNA-unwinding method. Mutat. Res. 146 (1985) 63-70
38. Paques F., and Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63 (1999) 349-404
39. Petrini J.H., and Stracker T.H. The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol. 13 (2003) 458-462
40. Sanchez Y., Bachant J., Wang H., Hu F., Liu D., Tetzlaff M., and Elledge S.J. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science 286 (1999) 1166-1171
41. Sartori A.A., Lukas C., Coates J., Mistrik M., Fu S., Bartek J., Baer R., Lukas J., and Jackson S.P. Human CtIP promotes DNA end resection. Nature 450 (2007) 509-514
42. Siede W., Friedl A.A., Dianova I., Eckardt-Schupp F., and Friedberg E.C. The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics 142 (1996) 91-102
43. Takata M., Sasaki M.S., Sonoda E., Morrison C., Hashimoto M., Utsumi H., Yamaguchi-Iwai Y., Shinohara A., and Takeda S. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17 (1998) 5497-5508
44. Tomita K., Matsuura A., Caspari T., Carr A.M., Akamatsu Y., Iwasaki H., Mizuno K., Ohta K., Uritani M., Ushimaru T., et al. Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol. Cell. Biol. 23 (2003) 5186-5197
45. Ubersax J.A., Woodbury E.L., Quang P.N., Paraz M., Blethrow J.D., Shah K., Shokat K.M., and Morgan D.O. Targets of the cyclin-dependent kinase Cdk1. Nature 425 (2003) 859-864
46. Umezu K., Sugawara N., Chen C., Haber J.E., and Kolodner R.D. Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism. Genetics 148 (1998) 989-1005
47. Usui T., Ogawa H., and Petrini J.H. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol. Cell 7 (2001) 1255-1266
48. Vernis L., Piskur J., and Diffley J.F. Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. Nucleic Acids Res. 31 (2003) e120 10.1093/nar/gng121
49. Vodenicharov M.D., and Wellinger R.J. DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase. Mol. Cell 24 (2006) 127-137
50. Zhao X., Chabes A., Domkin V., Thelander L., and Rothstein R. The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. EMBO J. 20 (2001) 3544-3553
51. Zou L., and Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300 (2003) 1542-1548
52. Zou L., Liu D., and Elledge S.J. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. USA 100 (2003) 13827-13832