Protein mediators of sterol transport across intestinal brush border membrane

Sub-Cellular Biochemistry

Volumn 51, Issue , 2010, Pages 337-380

  Mark Brown, J ^b   Yu, Liqing ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Animal model; ATP binding cassette transporters G5 and G8; Cell model; Ezetimibe; Intestinal cholesterol absorption; Niemann pick C1 Like 1; Scavenger receptor class B type I; Sterol sensing domain

Indexed keywords

ANIMALIA; PYRONIA TITHONUS;

ABC TRANSPORTER; ABCG5 PROTEIN, HUMAN; ABCG8 PROTEIN, HUMAN; AZETIDINE DERIVATIVE; CHOLESTEROL; EZETIMIBE; LIPOPROTEIN; MEMBRANE PROTEIN; NPC1L1 PROTEIN, HUMAN; SCARB1 PROTEIN, HUMAN; SCAVENGER RECEPTOR B; SIGNAL PEPTIDE; SREBP CLEAVAGE ACTIVATING PROTEIN; SREBP CLEAVAGE-ACTIVATING PROTEIN;

ANIMAL; ANIMAL MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTESTINE ABSORPTION; METABOLISM; MICROVILLUS; PHYSIOLOGY; REVIEW;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; AZETIDINES; CHOLESTEROL; GENE EXPRESSION REGULATION; HUMANS; INTESTINAL ABSORPTION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPROTEINS; MEMBRANE PROTEINS; MICROVILLI; MODELS, ANIMAL; SCAVENGER RECEPTORS, CLASS B;

EID: 77952300689     PISSN: 03060225     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-90-481-8622-8_12     Document Type: Article

References (295)

1. 2002, Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106: 3143–3421. (http://circ.ahajournals.org/ cgi/content/full/106/25/3143)
2. Acton, S., Rigotti, A., Landschulz, K.T., Xu, S., Hobbs, H.H., and Krieger, M., 1996, Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271: 518–520.
3. Acton, S.L., Scherer, P.E., Lodish, H.F., and Krieger, M., 1994, Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J. Biol. Chem. 269: 21003–21009.
4. Alrefai, W.A., Annaba, F., Sarwar, Z., Dwivedi, A., Saksena, S., Singla, A., Dudeja, P.K., and Gill, R.K, 2007, Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: role of sterol regulatory element binding protein 2. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G369–376.
5. Altmann, S.W., Davis, H.R., Jr., Yao, X., Laverty, M., Compton, D.S., Zhu, L.J., Crona, J.H., Caplen, M.A., Hoos, L.M., Tetzloff, G., Priestley, T., Burnett, D.A., Strader, C.D., and Graziano, M.P., 2002, The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption. Biochim. Biophys. Acta 1580: 77–93.
6. Altmann, S.W., Davis, H.R., Jr., Zhu, L.J., Yao, X., Hoos, L.M., Tetzloff, G., Iyer, S.P., Maguire, M., Golovko, A., Zeng, M., Wang, L., Murgolo, N., and Graziano, M.P., 2004, Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 303: 1201–1204.
7. Anderson, R.A., Joyce, C., Davis, M., Reagan, J.W., Clark, M., Shelness, G.S., and Rudel, L.L., 1998, Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J. Biol. Chem. 273: 26747–26754.
8. Arai, T., Wang, N., Bezouevski, M., Welch, C., and Tall, A.R., 1999, Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene. J. Biol. Chem. 274: 2366–2371.
9. Ashkenas, J., Penman, M., Vasile, E., Acton, S., Freeman, M., and Krieger, M., 1993, Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. J. Lipid Res. 34: 983–1000.
10. Assanasen, C., Mineo, C., Seetharam, D., Yuhanna, I.S., Marcel, Y.L., Connelly, M.A., Williams, D.L., dela Llera-Moya, M., Shaul, P.W., and Silver, D.L., 2005, Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling. J. Clin. Invest. 115: 969–977.
11. Assy, N., Grozovski, M., Bersudsky, I., Szvalb, S., and Hussein, O., 2006, Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease. World J. Gastroenterol. 12: 4369–4376.
12. Azhar, S., Nomoto, A., Leers-Sucheta, S., and Reaven, E., 1998, Simultaneous induction of an HDL receptor protein (SR-BI) and the selective uptake of HDL-cholesteryl esters in a physiologically relevant steroidogenic cell model. J. Lipid Res. 39: 1616–1628.
13. Babitt, J., Trigatti, B., Rigotti, A., Smart, E.J., Anderson, R.G., Xu, S., and Krieger, M., 1997, Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae. J. Biol. Chem. 272: 13242–13249.
14. Bao, L., Li, Y., Deng, S.X., Landry, D., and Tabas, I., 2006, Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages. J. Biol. Chem. 281: 33635–33649.
15. Basso, F., Freeman, L.A., Ko, C., Joyce, C., Amar, M.J., Shamburek, R.D., Tansey, T., Thomas, F., Wu, J., Paigen, B., Remaley, A.T., Santamarina-Fojo, S., and Brewer, H.B., Jr., 2007, Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J. Lipid Res. 48: 114–126.
16. Berge, K.E., Tian, H., Graf, G.A., Yu, L., Grishin, N.V., Schultz, J., Kwiterovich, P., Shan, B., Barnes, R., and Hobbs, H.H., 2000, Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290: 1771–1775.
17. Bhattacharyya, A.K., and Connor, W.E., 1974, Beta-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters. J. Clin. Invest. 53: 1033–1043.
18. Bhattacharyya, A.K., Connor, W.E., Lin, D.S., McMurry, M.M., and Shulman, R.S., 1991, Sluggish sitosterol turnover and hepatic failure to excrete sitosterol into bile cause expansion of body pool of sitosterol in patients with sitosterolemia and xanthomatosis. Arterioscler. Thromb. 11: 1287–1294.
19. Biddinger, S.B., Haas, J.T., Yu, B.B., Bezy, O., Jing, E., Zhang, W., Unterman, T.G., Carey, M.C., and Kahn, C.R., 2008, Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat. Med. 14: 778–782.
20. Bietrix, F., Yan, D., Nauze, M., Rolland, C., Bertrand-Michel, J., Comera, C., Schaak, S., Barbaras, R., Groen, A.K., Perret, B., Terce, F., and Collet, X., 2006, Accelerated lipid absorption in mice overexpressing intestinal SR-BI. J. Biol. Chem. 281: 7214–7219.
21. Bjorkhem, I., Boberg, K., and Leitersdorf, E., 2001, The Metabolic and Molecular Basis of Inherited Diseases. McGraw-Hill, New York.
22. Borgstrom, B., 1968, Quantitative aspects of the intestinal absorption and metabolism of cholesterol and beta-sitosterol in the rat. J. Lipid Res. 9: 473–481.
23. Bosner, M.S., Lange, L.G., Stenson, W.F., and Ostlund, R.E., Jr., 1999, Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry. J. Lipid Res. 40: 302–308.
24. Braun, A., Trigatti, B.L., Post, M.J., Sato, K., Simons, M., Edelberg, J.M., Rosenberg, R.D., Schrenzel, M., and Krieger, M., 2002, Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Circ. Res. 90: 270–276.
25. Brown, J.M., Bell, T.A., 3rd, Alger, H.M., Sawyer, J.K., Smith, T.L., Kelley, K., Shah, R., Wilson, M.D., Davis, M.A., Lee, R.G., Graham, M.J., Crooke, R.M., and Rudel, L.L., 2008, Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss. J. Biol. Chem. 283: 10522–10534.
26. Brown, J.M., Rudel, L.L., and Yu, L., 2007, NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells. Biochem. J. 406: 273–283.
27. Brown, M.S., and Goldstein, J.L., 1999, A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 96: 11041–11048.
28. Brunham, L.R., Kruit, J.K., Iqbal, J., Fievet, C., Timmins, J.M., Pape, T.D., Coburn, B.A., Bissada, N., Staels, B., Groen, A.K., Hussain, M.M., Parks, J.S., Kuipers, F., and Hayden, M.R., 2006, Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J. Clin. Invest. 116: 1052–1062.
29. Buhman, K.K., Accad, M., Novak, S., Choi, R.S., Wong, J.S., Hamilton, R.L., Turley, S., and Farese, R.V., Jr., 2000, Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nat. Med. 6: 1341–1347.
30. Bultel-Brienne, S., Lestavel, S., Pilon, A., Laffont, I., Tailleux, A., Fruchart, J.C., Siest, G., and Clavey, V., 2002, Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteins. J. Biol. Chem. 277: 36092–36099.
31. Burgos, P.V., Klattenhoff, C., de la Fuente, E., Rigotti, A., and Gonzalez, A., 2004, Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells. Proc. Natl. Acad. Sci. USA 101: 3845–3850.
32. Cai, S.F., Kirby, R.J., Howles, P.N, and Hui, D.Y., 2001, Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine. J. Lipid Res. 42: 902–909.
33. Calpe-Berdiel, L., Rotllan, N., Fievet, C., Roig, R., Blanco-Vaca, F., and Escola-Gil, J.C., 2008, Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8. J. Lipid Res. 49: 1904–1911.
34. Calvo, D., and Vega, M.A., 1993, Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. J. Biol. Chem. 268: 18929–18935.
35. Cao, G., Garcia, C.K., Wyne, K.L., Schultz, R.A., Parker, K.L., and Hobbs, H.H., 1997, Structure and localization of the human gene encoding SR-BI/CLA-1. Evidence for transcriptional control by steroidogenic factor 1. J. Biol. Chem. 272: 33068–33076.
36. Cao, G., Liang, Y., Jiang, X.C., and Eacho, P.I., 2004, Liver X receptors as potential therapeutic targets for multiple diseases. Drug News Perspect. 17: 35–41.
37. Cao, G., Zhao, L., Stangl, H., Hasegawa, T., Richardson, J.A., Parker, K.L., and Hobbs, H.H., 1999, Developmental and hormonal regulation of murine scavenger receptor, class B, type 1. Mol. Endocrinol. 13: 1460–1473.
38. Carstea, E.D., Morris, J.A., Coleman, K.G., Loftus, S.K., Zhang, D., Cummings, C., Gu, J., Rosenfeld, M.A., Pavan, W.J., Krizman, D.B., Nagle, J., Polymeropoulos, M.H., Sturley, S.L., Ioannou, Y.A., Higgins, M.E., Comly, M., Cooney, A., Brown, A., Kaneski, C.R., Blanchette-Mackie, E.J., Dwyer, N.K., Neufeld, E.B., Chang, T.Y., Liscum, L., Tagle, D.A., and et al., 1997, Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.Science 277: 228–231.
39. Chang, T.Y., and Chang, C., 2008, Ezetimibe blocks internalization of the NPC1L1/cholesterol complex. Cell Metab. 7: 469–471.
40. Charrin, S., Manie, S., Thiele, C., Billard, M., Gerlier, D., Boucheix, C., and Rubinstein, E., 2003, A physical and functional link between cholesterol and tetraspanins. Eur. J. Immunol. 33:2479–2489.
41. Chu, B.B., Ge, L., Xie, C., Zhao, Y., Miao, H.H., Wang, J., Li, B.L., and Song, B.L., 2009, Requirement of myosin Vb/Rab11a/Rab11-FIP2 complex in cholesterol-regulated translocation of Niemann-Pick C1 like 1 protein to the cell surface. J. Biol. Chem. 284: 22481–22490.
42. Clader, J.W., 2004, The discovery of ezetimibe: a view from outside the receptor. J. Med. Chem.47: 1–9.
43. Cohen, J.C., Pertsemlidis, A., Fahmi, S., Esmail, S., Vega, G.L., Grundy, S.M., and Hobbs, H.H., 2006, Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. Proc. Natl. Acad. Sci. USA 103: 1810–1815.
44. Connelly, M.A., 2009, SR-BI-mediated HDL cholesteryl ester delivery in the adrenal gland. Mol.Cell Endocrinol. 300: 83–88.
45. Cooper, M.K., Wassif, C.A., Krakowiak, P.A., Taipale, J., Gong, R., Kelley, R.I., Porter, F.D., and Beachy, P.A., 2003, A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat. Genet. 33: 508–513.
46. Davidson, M.H., 2009, Novel nonstatin strategies to lower low-density lipoprotein cholesterol.Curr. Atheroscler. Rep. 11: 67–70.
47. Davies, J.P., Levy, B., and Ioannou, Y.A., 2000a, Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1. Genomics 65: 137–145.
48. Davies, J.P., and Ioannou, Y.A., 2006, The role of the Niemann-Pick C1-like 1 protein in the subcellular transport of multiple lipids and their homeostasis. Curr. Opin. Lipidol. 17:221–226.
49. Davies, J.P., Chen, F.W., and Ioannou, Y.A., 2000b, Transmembrane molecular pump activity ofNiemann-Pick C1 protein. Science 290: 2295–2298.
50. Davies, J.P., Scott, C., Oishi, K., Liapis, A., and Ioannou, Y.A., 2005, Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.J. Biol. Chem. 280: 12710–12720.
51. Davis, H.R., and Veltri, E.P., 2007, Zetia: inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to Reduce Intestinal Cholesterol Absorption and Treat Hyperlipidemia. J. Atheroscler. Thromb. 14: 99–108.
52. Davis, H.R., Jr., Zhu, L.J., Hoos, L.M., Tetzloff, G., Maguire, M., Liu, J., Yao, X., Iyer, S.P., Lam, M.H., Lund, E.G., Detmers, P.A., Graziano, M.P., and Altmann, S.W., 2004, Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. J. Biol. Chem. 279: 33586–33592.
53. Dawson, P.A., and Rudel, L.L., 1999, Intestinal cholesterol absorption. Curr. Opin. Lipidol. 10: 315–320.
54. de Beer, M.C., Durbin, D.M., Cai, L., Jonas, A., de Beer, F.C., and van der Westhuyzen, D.R., 2001, Apolipoprotein A-I conformation markedly influences HDL interaction with scavenger receptor BI. J. Lipid Res. 42: 309–313.
55. dela Llera-Moya, M., Rothblat, G.H., Connelly, M.A., Kellner-Weibel, G., Sakr, S.W., Phillips, M.C., and Williams, D.L., 1999, Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface. J. Lipid Res. 40: 575–580.
56. Deushi, M., Nomura, M., Kawakami, A., Haraguchi, M., Ito, M., Okazaki, M., Ishii, H., and Yoshida, M., 2007, Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome. FEBS Lett. 581: 5664–5670.
57. Dietschy, J.M., and Turley, S.D., 2002, Control of cholesterol turnover in the mouse. J. Biol. Chem. 277: 3801–3804.
58. Duan, L.P., Wang, H.H., Ohashi, A., and Wang, D.Q., 2006, Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G269–276.
59. During, A., Dawson, H.D., and Harrison, E.H., 2005, Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in CaCo-2 cells treated with ezetimibe. J. Nutr. 135: 2305–2312.
60. Duval, C., Touche, V., Tailleux, A., Fruchart, J.C., Fievet, C., Clavey, V., Staels, B., and Lestavel, S., 2006, Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine. Biochem. Biophys. Res. Commun. 340: 1259–1263.
61. Eckhardt, E.R., Cai, L., Shetty, S., Zhao, Z., Szanto, A., Webb, N.R., and Van der Westhuyzen, D.R., 2006, High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif. J. Biol. Chem. 281: 4348–4353.
62. Eckhardt, E.R., Cai, L., Sun, B., Webb, N.R., and van der Westhuyzen, D.R., 2004, High density lipoprotein uptake by scavenger receptor SR-BII. J. Biol. Chem. 279: 14372–14381.
63. Epand, R.M., 2006, Cholesterol and the interaction of proteins with membrane domains. Prog. Lipid Res. 45: 279–294.
64. Fahmi, S., Yang, C., Esmail, S., Hobbs, H.H., and Cohen, J.C., 2008, Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes. Hum. Mol. Genet. 17: 2101–2107.
65. Field, F.J., Watt, K., and Mathur, S.N., 2007, Ezetimibe interferes with cholesterol trafficking from the plasma membrane to the endoplasmic reticulum in CaCo-2 cells. J. Lipid Res. 48: 1735–1745.
66. Fluiter, K., van der Westhuijzen, D.R., and van Berkel, T.J., 1998, In vivo regulation of scavenger receptor BI and the selective uptake of high density lipoprotein cholesteryl esters in rat liver parenchymal and Kupffer cells. J. Biol. Chem. 273: 8434–8438.
67. Franc, N.C., Dimarcq, J.L., Lagueux, M., Hoffmann, J., and Ezekowitz, R.A., 1996, Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity 4: 431–443.
68. Franc, N.C., Heitzler, P., Ezekowitz, R.A., and White, K., 1999, Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila. Science 284: 1991–1994.
69. Freeman, L.A., Kennedy, A., Wu, J., Bark, S., Remaley, A.T., Santamarina-Fojo, S., and Brewer, H.B., Jr., 2004, The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter. J. Lipid Res. 45: 1197–1206.
70. Fukasawa, M., Adachi, H., Hirota, K., Tsujimoto, M., Arai, H., and Inoue, K., 1996, SRB1, a class B scavenger receptor, recognizes both negatively charged liposomes and apoptotic cells. Exp. Cell Res. 222: 246–250.
71. Galman, C., Bonde, Y., Matasconi, M., Angelin, B., and Rudling, M., 2008, Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone. Gastroenterology 134: 1127–1136.
72. Garcia-Calvo, M., Lisnock, J., Bull, H.G., Hawes, B.E., Burnett, D.A., Braun, M.P., Crona, J.H., Davis, H.R., Jr., Dean, D.C., Detmers, P.A., Graziano, M.P., Hughes, M., Macintyre, D.E., Ogawa, A., O’Neill K.A., Iyer, S.P., Shevell, D.E., Smith, M.M., Tang, Y.S., Makarewicz, A.M., Ujjainwalla, F., Altmann, S.W., Chapman, K.T., and Thornberry, N.A., 2005, The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc. Natl. Acad. Sci. USA 102: 8132–8137.
73. Ge, L., Wang, J., Qi, W., Miao, H.H., Cao, J., Qu, Y.X., Li, B.L., and Song, B.L., 2008, The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metab. 7: 508–519.
74. Gillotte-Taylor, K., Boullier, A., Witztum, J.L., Steinberg, D., and Quehenberger, O., 2001, Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein. J. Lipid Res. 42: 1474–1482.
75. Goldstein, J.L., and Brown, M.S., 1990, Regulation of the mevalonate pathway. Nature 343: 425–430.
76. Gould, R.G., Jones, R.J., LeRoy, G.V., Wissler, R.W., and Taylor, C.B., 1969, Absorbability of beta-sitosterol in humans. Metabolism, 18, 652–662.
77. Graf, G.A., Cohen, J.C. and Hobbs, H.H. (2004) Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking. J. Biol. Chem. 279: 24881–24888.
78. Graf, G.A., Li, W.P., Gerard, R.D., Gelissen, I., White, A., Cohen, J.C., and Hobbs, H.H., 2002, Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J. Clin. Invest. 110: 659–669.
79. Graf, G.A., Yu, L., Li, W.P., Gerard, R., Tuma, P.L., Cohen, J.C., and Hobbs, H.H., 2003, ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J. Biol. Chem. 278: 48275–48282.
80. Greene, D.J., Skeggs, J.W., and Morton, R.E., 2001, Elevated triglyceride content diminishes the capacity of high density lipoprotein to deliver cholesteryl esters via the scavenger receptor class B type I (SR-BI). J. Biol. Chem. 276: 4804–4811.
81. Gregg, R.E., Connor, W.E., Lin, D.S., and Brewer, H.B., Jr., 1986, Abnormal metabolism of shellfish sterols in a patient with sitosterolemia and xanthomatosis. J. Clin. Invest. 77: 1864–1872.
82. Gu, X., Kozarsky, K., and Krieger, M., 2000a, Scavenger receptor class B, type I-mediated [3H]cholesterol efflux to high and low density lipoproteins is dependent on lipoprotein binding to the receptor. J. Biol. Chem. 275: 29993–30001.
83. Gu, X., Lawrence, R., and Krieger, M., 2000b, Dissociation of the high density lipopro-tein and low density lipoprotein binding activities of murine scavenger receptor class B type I (mSR-BI) using retrovirus library-based activity dissection. J. Biol. Chem. 275: 9120–9130.
84. Gylling, H., and Miettinen, T.A., 2002, Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients. Atherosclerosis 160: 477–481.
85. Hamada, T., Egashira, N., Nishizono, S., Tomoyori, H., Nakagiri, H., Imaizumi, K., and Ikeda, I., 2007, Lymphatic absorption and deposition of various plant sterols in stroke-prone spontaneously hypertensive rats, a strain having a mutation in ATP binding cassette transporter G5. Lipids 42: 241–248.
86. Hansen, G.H., Niels-Christiansen, L.L., Immerdal, L., and Danielsen, E.M., 2003, Scavenger receptor class B type I (SR-BI) in pig enterocytes: trafficking from the brush border to lipid droplets during fat absorption. Gut 52: 1424–1431.
87. Hansen, G.H., Niels-Christiansen, L.L., Immerdal, L., Nystrom, B.T., and Danielsen, E.M., 2007, Intestinal alkaline phosphatase: selective endocytosis from the enterocyte brush border during fat absorption. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G1325–1332.
88. Harder, C.J., Meng, A., Rippstein, P., McBride, H.M., and McPherson, R., 2007, SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells. J. Biol. Chem., 282, 1445–1455.
89. Hart, K. and Wilcox, M. (1993) A Drosophila gene encoding an epithelial membrane protein with homology to CD36/LIMP II. J. Mol. Biol. 234: 249–253.
90. Hatzopoulos, A.K., Rigotti, A., Rosenberg, R.D., and Krieger, M., 1998, Temporal and spatial pattern of expression of the HDL receptor SR-BI during murine embryogenesis. J. Lipid Res. 39: 495–508.
91. Hauser, H., Dyer, J.H., Nandy, A., Vega, M.A., Werder, M., Bieliauskaite, E., Weber, F.E., Compassi, S., Gemperli, A., Boffelli, D., Wehrli, E., Schulthess, G., and Phillips, M.C., 1998, Identification of a receptor mediating absorption of dietary cholesterol in the intestine. Biochemistry 37: 17843–17850.
92. Hawes, B.E., O’Neill K.A., Yao, X., Crona, J.H., Davis, H.R., Jr., Graziano, M.P., and Altmann, S.W., 2007, In vivo responsiveness to ezetimibe correlates with Niemann-Pick C1 like-1 (NPC1L1) binding affinity: comparison of multiple species NPC1L1 orthologs. Mol. Pharmacol. 71: 19–29.
93. Hegele, R.A., Guy, J., Ban, M.R., and Wang, J., 2005, NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe. Lipids Health Dis. 4: 16.
94. Hernandez, H.H., Chaikoff, I.L., Dauben, W.G., and Abraham, S., 1954, The absorption of C14-labeled epicholesterol in the rat. J. Biol. Chem. 206: 757–765.
95. Horton, J.D., Goldstein, J.L., and Brown, M.S., 2002a, SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109: 1125–1131.
96. Horton, J.D., Goldstein, J.L., and Brown, M.S., 2002b, SREBPs: transcriptional mediators of lipid homeostasis. Cold Spring Harb. Symp. Quant. Biol. 67: 491–498.
97. Huang, T.C., and Kuksis, A., 1965, Lymphatic absorption of cholesterol in the dog following corn oil and butterfat feeding. Can. J. Physiol. Pharmacol. 43: 299–311.
98. Hui, D.Y., and Howles, P.N., 2005, Molecular mechanisms of cholesterol absorption and transport in the intestine. Semin. Cell Dev. Biol. 16: 183–192.
99. Husemann, J., Loike, J.D., Kodama, T., and Silverstein, S.C., 2001, Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid. J. Neuroimmunol. 114: 142–150.
100. Husemann, J., and Silverstein, S.C., 2001, Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer’s disease brain. Am. J. Pathol. 158: 825–832.
101. Infante, R.E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J.D., Brown, M.S., and Goldstein, J.L., 2008a, Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J. Biol. Chem. 283: 1052–1063.
102. Infante, R.E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L.N., Wang, M.L., Grishin, N.V., Goldstein, J.L., and Brown, M.S., 2008b, Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J. Biol. Chem. 283: 1064–1075.
103. Iqbal, J., and Hussain, M.M., 2009, Intestinal lipid absorption. Am. J. Physiol. Endocrinol. Metab. 296: E1183–1194.
104. Iwayanagi, Y., Takada, T., and Suzuki, H., 2008, HNF4alpha is a crucial modulator of the cholesterol-dependent regulation of NPC1L1. Pharm. Res. 25: 1134–1141.
105. Iyer, S.P., Yao, X., Crona, J.H., Hoos, L.M., Tetzloff, G., Davis, H.R., Jr., Graziano, M.P., and Altmann, S.W., 2005, Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1 (NPC1L1) protein. Biochim. Biophys. Acta 1722: 282–292.
106. Ji, Y., Jian, B., Wang, N., Sun, Y., Moya, M.L., Phillips, M.C., Rothblat, G.H., Swaney, J.B., and Tall, A.R., 1997, Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J. Biol. Chem. 272: 20982–20985.
107. Ji, Y., Wang, N., Ramakrishnan, R., Sehayek, E., Huszar, D., Breslow, J.L., and Tall, A.R., 1999, Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J. Biol. Chem. 274: 33398–33402.
108. Jian, B., dela Llera-Moya, M., Ji, Y., Wang, N., Phillips, M.C., Swaney, J.B., Tall, A.R., and Rothblat, G.H., 1998, Scavenger receptor class B type I as a mediator of cellular cholesterol efflux to lipoproteins and phospholipid acceptors. J. Biol. Chem. 273: 5599–5606.
109. Kajinami, K., Takekoshi, N., Brousseau, M.E., and Schaefer, E.J., 2004, Pharmacogenetics of HMG-CoA reductase inhibitors: exploring the potential for genotype-based individualization of coronary heart disease management. Atherosclerosis 177: 219–234.
110. Kalaany, N.Y., Gauthier, K.C., Zavacki, A.M., Mammen, P.P., Kitazume, T., Peterson, J.A., Horton, J.D., Garry, D.J., Bianco, A.C., and Mangelsdorf, D.J., 2005, LXRs regulate the balance between fat storage and oxidation. Cell Metab., 1: 231–244.
111. Kalaany, N.Y., and Mangelsdorf, D.J., 2006, LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu. Rev. Physiol. 68: 159–191.
112. Kaneko, E., Matsuda, M., Yamada, Y., Tachibana, Y., Shimomura, I., and Makishima, M., 2003, Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. J. Biol. Chem. 278: 36091–36098.
113. Karakesisoglou, I., Janssen, K.P., Eichinger, L., Noegel, A.A., and Schleicher, M., 1999, Identification of a suppressor of the Dictyostelium profilin-minus phenotype as a CD36/LIMP-II homologue. J. Cell Biol. 145: 167–181.
114. Kellner-Weibel, G., deLa Llera-Moya, M., Connelly, M.A., Stoudt, G., Christian, A.E., Haynes, M.P., Williams, D.L., and Rothblat, G.H., 2000, Expression of scavenger receptor BI in COS-7 cells alters cholesterol content and distribution. Biochemistry 39: 221–229.
115. Khovidhunkit, W., Moser, A.H., Shigenaga, J.K., Grunfeld, C., and Feingold, K.R., 2003, Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR. J. Lipid Res. 44: 1728–1736.
116. Kim, H.J., Fan, X., Gabbi, C., Yakimchuk, K., Parini, P., Warner, M., and Gustafsson, J.A., 2008, Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson’s dementia. Proc. Natl. Acad. Sci. USA 105: 2094–2099.
117. Klett, E.L., Lee, M.H., Adams, D.B., Chavin, K.D., and Patel, S.B., 2004a, Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine. BMC Gastroenterol. 4: 21.
118. Klett, E.L., Lu, K., Kosters, A., Vink, E., Lee, M.H., Altenburg, M., Shefer, S., Batta, A.K., Yu, H., Chen, J., Klein, R., Looije, N., Oude-Elferink, R., Groen, A.K., Maeda, N., Salen, G., and Patel, S.B., 2004b, A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med. 2: 5.
119. Knight, B.L., Patel, D.D., Humphreys, S.M., Wiggins, D., and Gibbons, G.F., 2003, Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice. J. Lipid Res. 44: 2049–2058.
120. Knopfel, M., Davies, J.P., Duong, P.T., Kvaerno, L., Carreira, E.M., Phillips, M.C., Ioannou, Y.A., and Hauser, H., 2007, Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane. Biochim. Biophys. Acta 1771: 1140–1147.
121. Kocher, O., Yesilaltay, A., Cirovic, C., Pal, R., Rigotti, A., and Krieger, M., 2003, Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. J. Biol. Chem. 278: 52820–52825.
122. Kolovou, G., Voudris, V., Drogari, E., Palatianos, G., and Cokkinos, D.V., 1996, Coronary bypass grafts in a young girl with sitosterolemia. Eur. Heart J. 17: 965–966.
123. Kozarsky, K.F., Donahee, M.H., Glick, J.M., Krieger, M., and Rader, D.J., 2000, Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 20: 721–727.
124. Kozarsky, K.F., Donahee, M.H., Rigotti, A., Iqbal, S.N., Edelman, E.R., and Krieger, M., 1997, Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature 387: 414–417.
125. Kramer, W., Girbig, F., Corsiero, D., Pfenninger, A., Frick, W., Jahne, G., Rhein, M., Wendler, W., Lottspeich, F., Hochleitner, E.O., Orso, E., and Schmitz, G., 2005, Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane. J. Biol. Chem. 280: 1306–1320.
126. Krieger, M., 1999, Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI. Annu. Rev. Biochem. 68: 523–558.
127. Kruit, J.K., Drayer, A.L., Bloks, V.W., Blom, N., Olthof, S.G., Sauer, P.J., de Haan, G., Kema, I.P., Vellenga, E., and Kuipers, F., 2008, Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia. J. Biol. Chem. 283: 6281–6287.
128. Kruit, J.K., Groen, A.K., van Berkel, T.J., and Kuipers, F., 2006, Emerging roles of the intestine in control of cholesterol metabolism. World J. Gastroenterol. 12: 6429–6439.
129. Kruit, J.K., Plosch, T., Havinga, R., Boverhof, R., Groot, P.H., Groen, A.K., and Kuipers, F., 2005, Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. Gastroenterology 128: 147–156.
130. Kuwabara, P.E., and Labouesse, M., 2002, The sterol-sensing domain: multiple families, a unique role? Trends Genet. 18: 193–201.
131. Labonte, E.D., Camarota, L.M., Rojas, J.C., Jandacek, R.J., Gilham, D.E., Davies, J.P., Ioannou, Y.A., Tso, P., Hui, D.Y., and Howles, P.N., 2008, Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G776–G783.
132. Labonte, E.D., Howles, P.N., Granholm, N.A., Rojas, J.C., Davies, J.P., Ioannou, Y.A., and Hui, D.Y., 2007, Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles. Biochim. Biophys. Acta 1771: 1132–1139.
133. Lally, S., Owens, D., and Tomkin, G.H., 2007a, Genes that affect cholesterol synthesis, cholesterol absorption, and chylomicron assembly: the relationship between the liver and intestine in control and streptozotosin diabetic rats. Metabolism 56: 430–438.
134. Lally, S., Owens, D., and Tomkin, G.H., 2007b, The different effect of pioglitazone as compared to insulin on expression of hepatic and intestinal genes regulating post-prandial lipoproteins in diabetes. Atherosclerosis 193: 343–351.
135. Lally, S., Tan, C.Y., Owens, D., and Tomkin, G.H., 2006, Messenger RNA levels of genes involved in dysregulation of postprandial lipoproteins in type 2 diabetes: the role of Niemann-Pick C1-like 1, ATP-binding cassette, transporters G5 and G8, and of microsomal triglyceride transfer protein. Diabetologia 49: 1008–1016.
136. Lally, S.E., Owens, D., and Tomkin, G.H., 2007, Sitosterol and cholesterol in chylomicrons of type 2 diabetic and non-diabetic subjects: the relationship with ATP binding cassette proteins G5 and G8 and Niemann-Pick C1-like 1 mRNA. Diabetologia 50: 217–219.
137. Landschulz, K.T., Pathak, R.K., Rigotti, A., Krieger, M., and Hobbs, H.H., 1996, Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat. J. Clin. Invest. 98: 984–995.
138. Larkin, J.M., Brown, M.S., Goldstein, J.L., and Anderson, R.G., 1983, Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts. Cell 33: 273–285.
139. Lee, M.H., Lu, K., Hazard, S., Yu, H., Shulenin, S., Hidaka, H., Kojima, H., Allikmets, R., Sakuma, N., Pegoraro, R., Srivastava, A.K., Salen, G., Dean, M., and Patel, S.B., 2001, Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat. Genet. 27: 79–83.
140. Lekstrom-Himes, J., and Xanthopoulos, K.G., 1998, Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J. Biol. Chem. 273: 28545–28548.
141. Levy, E., Spahis, S., Sinnett, D., Peretti, N., Maupas-Schwalm, F., Delvin, E., Lambert, M., and Lavoie, M.A., 2007, Intestinal cholesterol transport proteins: an update and beyond. Curr. Opin. Lipidol. 18: 310–318.
142. Li, H., and Papadopoulos, V., 1998, Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139: 4991–4997.
143. Li, X., Kan, H.Y., Lavrentiadou, S., Krieger, M., and Zannis, V., 2002, Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding. J. Biol. Chem. 277: 21149–21157.
144. Li, X., Peegel, H., and Menon, K.M., 1998, In situ hybridization of high density lipoprotein (scavenger, type 1) receptor messenger ribonucleic acid (mRNA) during folliculogenesis and luteinization: evidence for mRNA expression and induction by human chorionic gonadotropin specifically in cell types that use cholesterol for steroidogenesis. Endocrinology 139: 3043–3049.
145. Li, X., Peegel, H., and Menon, K.M., 2001, Regulation of high density lipoprotein receptor messenger ribonucleic acid expression and cholesterol transport in theca-interstitial cells by insulin and human chorionic gonadotropin. Endocrinology 142: 174–181.
146. Li, Z., Park, T.S., Li, Y., Pan, X., Iqbal, J., Lu, D., Tang, W., Yu, L., Goldberg, I.J., Hussain, M.M., and Jiang, X.C., 2009, Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol. Biochim. Biophys. Acta 1791: 297–306.
147. Liadaki, K.N., Liu, T., Xu, S., Ishida, B.Y., Duchateaux, P.N., Krieger, J.P., Kane, J., Krieger, M., and Zannis, V.I., 2000, Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and APOA-I mutations on receptor binding. J. Biol. Chem. 275: 21262–21271.
148. Liu, B., and Krieger, M., 2002, Highly purified scavenger receptor class B, type I reconstituted into phosphatidylcholine/cholesterol liposomes mediates high affinity high density lipoprotein binding and selective lipid uptake. J. Biol. Chem. 277: 34125–34135.
149. Liu, R., Iqbal, J., Yeang, C., Wang, D.Q., Hussain, M.M., and Jiang, X.C., 2007, Phospholipid transfer protein-deficient mice absorb less cholesterol. Arterioscler. Thromb. Vasc. Biol. 27: 2014–2021.
150. Liu, T., Krieger, M., Kan, H.Y., and Zannis, V.I., 2002, The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficient lipid transport. J. Biol. Chem. 277: 21576–21584.
151. Loftus, S.K., Morris, J.A., Carstea, E.D., Gu, J.Z., Cummings, C., Brown, A., Ellison, J., Ohno, K., Rosenfeld, M.A., Tagle, D.A., Pentchev, P.G., and Pavan, W.J., 1997, Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science 277: 232–235.
152. Lopez, D., and McLean, M.P., 1999, Sterol regulatory element-binding protein-1a binds to cis elements in the promoter of the rat high density lipoprotein receptor SR-BI gene. Endocrinology 140: 5669–5681.
153. Lopez, D., Shea-Eaton, W., Sanchez, M.D., and McLean, M.P., 2001, DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1. Endocrinology 142: 5097–5106.
154. Lutjohann, D., Bjorkhem, I., Beil, U.F., and von Bergmann, K., 1995, Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment. J. Lipid Res. 36: 1763–1773.
155. Malerod, L., Juvet, L.K., Hanssen-Bauer, A., Eskild, W., and Berg, T., 2002, Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. Biochem. Biophys. Res. Commun. 299: 916–923.
156. Malerod, L., Sporstol, M., Juvet, L.K., Mousavi, A., Gjoen, T., and Berg, T., 2003, Hepatic scavenger receptor class B, type I is stimulated by peroxisome proliferator-activated receptor gamma and hepatocyte nuclear factor 4alpha. Biochem. Biophys. Res. Commun. 305: 557–565.
157. Mardones, P., Quinones, V., Amigo, L., Moreno, M., Miquel, J.F., Schwarz, M., Miettinen, H.E., Trigatti, B., Krieger, M., VanPatten, S., Cohen, D.E., and Rigotti, A., 2001, Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice. J. Lipid Res. 42: 170–180.
158. Mathur, S.N., Watt, K.R., and Field, F.J., 2007, Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid. J. Lipid Res. 48: 395–404.
159. McConihay, J.A., Horn, P.S., and Woollett, L.A., 2001, Effect of maternal hypercholesterolemia on fetal sterol metabolism in the Golden Syrian hamster. J. Lipid Res. 42: 1111–1119.
160. McLean, M.P., and Sandhoff, T.W., 1998, Expression and hormonal regulation of the high-density lipoprotein (HDL) receptor scavenger receptor class B type I messenger ribonucleic acid in the rat ovary. Endocrine 9: 243–252.
161. McNamara, D.J., Davidson, N.O., Samuel, P., and Ahrens, E.H., Jr., 1980, Cholesterol absorption in man: effect of administration of clofibrate and/or cholestyramine. J. Lipid Res. 21: 1058–1064.
162. Miettinen, T.A., 1980, Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease: a case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis. Eur. J. Clin. Invest. 10: 27–35.
163. Miettinen, T.A., Strandberg, T.E., and Gylling, H., 2000, Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. Arterioscler. Thromb. Vasc. Biol. 20: 1340–1346.
164. Mizutani, T., Sonoda, Y., Minegishi, T., Wakabayashi, K., and Miyamoto, K., 1997, Cloning, characterization, and cellular distribution of rat scavenger receptor class B type I (SRBI) in the ovary. Biochem. Biophys. Res. Commun. 234: 499–505.
165. Mizutani, T., Yamada, K., Minegishi, T., and Miyamoto, K., 2000, Transcriptional regulation of rat scavenger receptor class B type I gene. J. Biol. Chem. 275: 22512–22519.
166. Murao, K., Imachi, H., Yu, X., Cao, W.M., Muraoka, T., Dobashi, H., Hosomi, N., Haba, R., Iwama, H., and Ishida, T., 2008, The transcriptional factor prolactin regulatory element-binding protein mediates the gene transcription of adrenal scavenger receptor class B type I via 3’,5’-cyclic adenosine 5’-monophosphate. Endocrinology 149: 6103–6112.
167. Mymin, D., Wang, J., Frohlich, J., and Hegele, R.A., 2003, Image in cardiovascular medicine. Aortic xanthomatosis with coronary ostial occlusion in a child homozygous for a nonsense mutation in ABCG8. Circulation 107: 791.
168. Nauli, A.M., Nassir, F., Zheng, S., Yang, Q., Lo, C.M., Vonlehmden, S.B., Lee, D., Jandacek, R.J., Abumrad, N.A., and Tso, P., 2006, CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology 131: 1197–1207.
169. Ng, D.S., Francone, O.L., Forte, T.M., Zhang, J., Haghpassand, M., and Rubin, E.M., 1997, Disruption of the murine lecithin:cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I. J. Biol. Chem. 272: 15777–15781.
170. Nguyen, D.V., Drover, V.A., Knopfel, M., Dhanasekaran, P., Hauser, H., and Phillips, M.C., 2009, Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption. J. Lipid Res. 50: 2235–2244.
171. Ohgami, N., Ko, D.C., Thomas, M., Scott, M.P., Chang, C.C., and Chang, T.Y., 2004, Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. Proc. Natl. Acad. Sci. USA 101: 12473–12478.
172. Ohgami, N., Nagai, R., Miyazaki, A., Ikemoto, M., Arai, H., Horiuchi, S., and Nakayama, H., 2001, Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products. J. Biol. Chem. 276: 13348–13355.
173. Okiyoneda, T., Kono, T., Niibori, A., Harada, K., Kusuhara, H., Takada, T., Shuto, T., Suico, M.A., Sugiyama, Y., and Kai, H., 2006, Calreticulin facilitates the cell surface expression of ABCG5/G8. Biochem. Biophys. Res. Commun. 347: 67–75.
174. Oliver, W.R., Jr., Shenk, J.L., Snaith, M.R., Russell, C.S., Plunket, K.D., Bodkin, N.L., Lewis, M.C., Winegar, D.A., Sznaidman, M.L., Lambert, M.H., Xu, H.E., Sternbach, D.D., Kliewer, S.A., Hansen, B.C., and Willson, T.M., 2001, A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc. Natl. Acad. Sci. USA 98: 5306–5311.
175. Paresce, D.M., Ghosh, R.N., and Maxfield, F.R., 1996, Microglial cells internalize aggregates of the Alzheimer’s disease amyloid beta-protein via a scavenger receptor. Neuron 17: 553–565.
176. Parker, K.L., 1998, The roles of steroidogenic factor 1 in endocrine development and function. Mol. Cell Endocrinol. 140: 59–63.
177. Patel, S.B., Salen, G., Hidaka, H., Kwiterovich, P.O., Stalenhoef, A.F., Miettinen, T.A., Grundy, S.M., Lee, M.H., Rubenstein, J.S., Polymeropoulos, M.H., and Brownstein, M.J., 1998, Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21. J. Clin. Invest. 102: 1041–1044.
178. Petersen, N.H., Faergeman, N.J., Yu, L., and Wustner, D., 2008, Kinetic imaging of NPC1L1 and sterol trafficking between plasma membrane and recycling endosomes in hepatoma cells. J. Lipid Res. 49: 2023–2037.
179. Pilon, A., Briand, O., Lestavel, S., Copin, C., Majd, Z., Fruchart, J.C., Castro, G., and Clavey, V., 2000, Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Arterioscler. Thromb. Vasc. Biol. 20: 1074–1081.
180. Plosch, T., Bloks, V.W., Terasawa, Y., Berdy, S., Siegler, K., Van Der Sluijs, F., Kema, I.P., Groen, A.K., Shan, B., Kuipers, F., and Schwarz, M., 2004, Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Gastroenterology 126: 290–300.
181. Plosch, T., Kok, T., Bloks, V.W., Smit, M.J., Havinga, R., Chimini, G., Groen, A.K., and Kuipers, F., 2002, Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J. Biol. Chem. 277: 33870–33877.
182. Plosch, T., Kruit, J.K., Bloks, V.W., Huijkman, N.C., Havinga, R., Duchateau, G.S., Lin, Y., and Kuipers, F., 2006, Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter. J. Nutr. 136: 2135–2140.
183. Ponting, C.P., and Aravind, L., 1999, START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins. Trends Biochem. Sci. 24: 130–132.
184. Rader, D.J., 2007, Liver X receptor and farnesoid X receptor as therapeutic targets. Am. J. Cardiol. 100: n15–n19.
185. Radhakrishnan, A., Sun, L.P., Kwon, H.J., Brown, M.S., and Goldstein, J.L., 2004, Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Mol. Cell 15: 259–268.
186. Reaven, E., Cortez, Y., Leers-Sucheta, S., Nomoto, A., and Azhar, S., 2004, Dimerization of the scavenger receptor class B type I: formation, function, and localization in diverse cells and tissues. J. Lipid Res. 45: 513–528.
187. Reaven, E., Lua, Y., Nomoto, A., Temel, R., Williams, D.L., van der Westhuyzen, D.R., and Azhar, S., 1999, The selective pathway and a high-density lipoprotein receptor (SR-BI) in ovarian granulosa cells of the mouse. Biochim. Biophys. Acta 1436: 565–576.
188. Reaven, E., Nomoto, A., Leers-Sucheta, S., Temel, R., Williams, D.L., and Azhar, S., 1998, Expression and microvillar localization of scavenger receptor, class B, type I (a high density lipoprotein receptor) in luteinized and hormone-desensitized rat ovarian models. Endocrinology 139: 2847–2856.
189. Repa, J.J., Berge, K.E., Pomajzl, C., Richardson, J.A., Hobbs, H., and Mangelsdorf, D.J., 2002, Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J. Biol. Chem. 277: 18793–18800.
190. Repa, J.J., Buhman, K.K., Farese, R.V., Jr., Dietschy, J.M., and Turley, S.D., 2004, ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis. Hepatology 40: 1088–1097.
191. Repa, J.J., and Mangelsdorf, D.J., 2002, The liver X receptor gene team: potential new players in atherosclerosis. Nat. Med. 8: 1243–1248.
192. Repa, J.J., Turley, S.D., Lobaccaro, J.A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R.A., Dietschy, J.M., and Mangelsdorf, D.J., 2000, Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289: 1524–1529.
193. Rhainds, D., Bourgeois, P., Bourret, G., Huard, K., Falstrault, L., and Brissette, L., 2004, Localization and regulation of SR-BI in membrane rafts of HepG2 cells. J. Cell Sci. 117: 3095–3105.
194. Rigotti, A., Acton, S.L., and Krieger, M., 1995, The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids. J. Biol. Chem. 270: 16221–16224.
195. Rigotti, A., Edelman, E.R., Seifert, P., Iqbal, S.N., DeMattos, R.B., Temel, R.E., Krieger, M., and Williams, D.L., 1996, Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland. J. Biol. Chem. 271: 33545–33549.
196. Rigotti, A., Trigatti, B.L., Penman, M., Rayburn, H., Herz, J., and Krieger, M., 1997, A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc. Natl. Acad. Sci. USA 94: 12610–12615.
197. Rosamond, W., Flegal, K., Friday, G., Furie, K., Go, A., Greenlund, K., Haase, N., Ho, M., Howard, V., Kissela, B., Kittner, S., Lloyd-Jones, D., McDermott, M., Meigs, J., Moy, C., Nichol, G., O’Donnell, C.J., Roger, V., Rumsfeld, J., Sorlie, P., Steinberger, J., Thom, T., Wasserthiel-Smoller, S., and Hong, Y., 2007, Heart disease and stroke statistics–2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 115: e69–e171.
198. Sabeva, N.S., Rouse, E.J., and Graf, G.A., 2007, Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. J. Biol. Chem. 282: 22397–22405.
199. Sahoo, D., Darlington, Y.F., Pop, D., Williams, D.L., and Connelly, M.A., 2007a, Scavenger receptor class B Type I (SR-BI) assembles into detergent-sensitive dimers and tetramers. Biochim. Biophys. Acta 1771: 807–817.
200. Sahoo, D., Peng, Y., Smith, J.R., Darlington, Y.F., and Connelly, M.A., 2007b, Scavenger receptor class B, type I (SR-BI) homo-dimerizes via its C-terminal region: fluorescence resonance energy transfer analysis. Biochim. Biophys. Acta 1771: 818–829.
201. Salen, G., Horak, I., Rothkopf, M., Cohen, J.L., Speck, J., Tint, G.S., Shore, V., Dayal, B., Chen, T., and Shefer, S., 1985, Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis. J. Lipid Res. 26: 1126–1133.
202. Salen, G., Shore, V., Tint, G.S., Forte, T., Shefer, S., Horak, I., Horak, E., Dayal, B., Nguyen, L., Batta, A.K., and et al., 1989, Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis. J. Lipid Res. 30: 1319–1330.
203. Salen, G., Starc, T., Sisk, C.M., and Patel, S.B., 2006, Intestinal cholesterol absorption inhibitor ezetimibe added to cholestyramine for sitosterolemia and xanthomatosis. Gastroenterology 130: 1853–1857.
204. Salen, G., Tint, G.S., Shefer, S., Shore, V., and Nguyen, L., 1992, Increased sitosterol absorption is offset by rapid elimination to prevent accumulation in heterozygotes with sitosterolemia. Arterioscler. Thromb. 12: 563–568.
205. Salen, G., von Bergmann, K., Lutjohann, D., Kwiterovich, P., Kane, J., Patel, S.B., Musliner, T., Stein, P., and Musser, B., 2004, Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. Circulation 109: 966–971.
206. Sane, A.T., Sinnett, D., Delvin, E., Bendayan, M., Marcil, V., Menard, D., Beaulieu, J.F., and Levy, E., 2006, Localization and role of NPC1L1 in cholesterol absorption in human intestine. J. Lipid Res. 47: 2112–2120.
207. Schoenheimer, R.,1929, Uber die bedeutung der pflanzensterine fur den tierschen organismus. Hoppe-Seyler’s Fur Physiol. Chem. 180: 1–5.
208. Schoenheimer, R., and Breusch, F., 1933, Synthesis and destruction of cholesterol in the organism. J. Biol. Chem. 103: 439–448.
209. Sehayek, E., Wang, R., Ono, J.G., Zinchuk, V.S., Duncan, E.M., Shefer, S., Vance, D.E., Ananthanarayanan, M., Chait, B.T., and Breslow, J.L., 2003, Localization of the PE methy-lation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol. J. Lipid Res. 44: 1605–1613.
210. Shea-Eaton, W., Lopez, D., and McLean, M.P., 2001, Yin yang 1 protein negatively regulates high-density lipoprotein receptor gene transcription by disrupting binding of sterol regulatory element binding protein to the sterol regulatory element. Endocrinology 142: 49–58.
211. Silver, D.L., 2002, A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver. J. Biol. Chem. 277: 34042–34047.
212. Silver, D.L., Wang, N., Xiao, X., and Tall, A.R., 2001, High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion. J. Biol. Chem. 276: 25287–25293.
213. Simon, J.S., Karnoub, M.C., Devlin, D.J., Arreaza, M.G., Qiu, P., Monks, S.A., Severino, M.E., Deutsch, P., Palmisano, J., Sachs, A.B., Bayne, M.L., Plump, A.S., and Schadt, E.E., 2005, Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment. Genomics 86: 648–656.
214. Smart, E.J., De Rose, R.A., and Farber, S.A., 2004, Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport. Proc. Natl. Acad. Sci. USA 101: 3450–3455.
215. Spady, D.K., Kearney, D.M., and Hobbs, H.H., 1999, Polyunsaturated fatty acids up-regulate hepatic scavenger receptor B1 (SR-BI) expression and HDL cholesteryl ester uptake in the hamster. J. Lipid Res. 40: 1384–1394.
216. Stangl, H., Hyatt, M., and Hobbs, H.H., 1999, Transport of lipids from high and low density lipoproteins via scavenger receptor-BI. J. Biol. Chem. 274: 32692–32698.
217. Su, Y., Wang, Z., Yang, H., Cao, L., Liu, F., Bai, X., and Ruan, C., 2006, Clinical and molecular genetic analysis of a family with sitosterolemia and co-existing erythrocyte and platelet abnormalities. Haematologica 91: 1392–1395.
218. Sudhop, T., Lutjohann, D., Kodal, A., Igel, M., Tribble, D.L., Shah, S., Perevozskaya, I., and von Bergmann, K., 2002, Inhibition of intestinal cholesterol absorption by ezetimibe in humans. Circulation 106: 1943–1948.
219. Sudhop, T., Lutjohann, D., and von Bergmann, K., 2005, Sterol transporters: targets of natural sterols and new lipid lowering drugs. Pharmacol. Ther. 105: 333–341.
220. Sullivan, P.M., Mezdour, H., Quarfordt, S.H., and Maeda, N., 1998, Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe∗2. J. Clin. Invest. 102: 130–135.
221. Sumi, K., Tanaka, T., Uchida, A., Magoori, K., Urashima, Y., Ohashi, R., Ohguchi, H., Okamura, M., Kudo, H., Daigo, K., Maejima, T., Kojima, N., Sakakibara, I., Jiang, S., Hasegawa, G., Kim, I., Osborne, T.F., Naito, M., Gonzalez, F.J., Hamakubo, T., Kodama, T., and Sakai, J., 2007, Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Mol. Cell Biol. 27: 4248–4260.
222. Sun, Y., Wang, N., and Tall, A.R., 1999, Regulation of adrenal scavenger receptor-BI expression by ACTH and cellular cholesterol pools. J. Lipid Res. 40: 1799–1805.
223. Svensson, P.A., Johnson, M.S., Ling, C., Carlsson, L.M., Billig, H., and Carlsson, B., 1999, Scavenger receptor class B type I in the rat ovary: possible role in high density lipoprotein cholesterol uptake and in the recognition of apoptotic granulosa cells. Endocrinology 140: 2494–2500.
224. Tachibana, S., Hirano, M., Hirata, T., Matsuo, M., Ikeda, I., Ueda, K., and Sato, R., 2007, Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters. Biosci. Biotechnol. Biochem. 71: 1886–1895.
225. Tang, W., Ma, Y., Jia, L., Ioannou, Y.A., Davies, J.P., and Yu, L., 2008a, Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8. J. Lipid. Res. 50: 293–300.
226. Tang, W., Ma, Y., Jia, L., Ioannou, Y.A., Davies, J.P., and Yu, L., 2008b, Niemann-Pick C1-Like 1 Is Required for an LXR Agonist to Raise Plasma HDL Cholesterol in Mice. Arterioscler. Thromb. Vasc. Biol. 28: 448–454.
227. Tang, W., Ma, Y., and Yu, L., 2006, Plasma cholesterol is hyperresponsive to statin in ABCG5/ABCG8 transgenic mice. Hepatology 44: 1259–1266.
228. Telford, D.E., Sutherland, B.G., Edwards, J.Y., Andrews, J.D., Barrett, P.H., and Huff, M.W., 2007, The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin. J. Lipid Res. 48: 699–708.
229. Temel, R.E., Brown, J.M., Ma, Y., Tang, W., Rudel, L.L., Ioannou, Y.A., Davies, J.P., and Yu, L., 2009, Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1-dependent. J. Lipid Res. 50: 915–923.
230. Temel, R.E., Lee, R.G., Kelley, K.L., Davis, M.A., Shah, R., Sawyer, J.K., Wilson, M.D., and Rudel, L.L., 2005, Intestinal cholesterol absorption is substantially reduced in mice deficient in both ATP-binding cassette transporter A1 (ABCA1) and Acyl-CoA:Cholesterol O-acyltransferase 2 (ACAT2). J. Lipid Res. 46: 2423–2431.
231. Temel, R.E., Tang, W., Ma, Y., Rudel, L.L., Willingham, M.C., Ioannou, Y.A., Davies, J.P., Nilsson, L.M., and Yu, L., 2007, Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J. Clin. Invest. 117: 1968–1978.
232. Temel, R.E., Trigatti, B., DeMattos, R.B., Azhar, S., Krieger, M., and Williams, D.L., 1997, Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells. Proc. Natl. Acad. Sci. USA 94: 13600–13605.
233. Thiele, C., Hannah, M.J., Fahrenholz, F., and Huttner, W.B., 2000, Cholesterol binds to synapto-physin and is required for biogenesis of synaptic vesicles. Nat. Cell Biol., 2: 42–49.
234. Towns, R., Azhar, S., Peegel, H., and Menon, K.M., 2005, LH/hCG-stimulated andro-gen production and selective HDL-cholesterol transport are inhibited by a dominant-negative CREB construct in primary cultures of rat theca-interstitial cells. Endocrine 27: 269–277.
235. Trigatti, B., Rayburn, H., Vinals, M., Braun, A., Miettinen, H., Penman, M., Hertz, M., Schrenzel, M., Amigo, L., Rigotti, A., and Krieger, M., 1999, Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc. Natl. Acad. Sci. USA 96: 9322–9327.
236. Trigatti, B.L, 2005, Hepatic high-density lipoprotein receptors: roles in lipoprotein metabolism and potential for therapeutic modulation. Curr. Atheroscler. Rep. 7: 344–350.
237. Turley, S.D., and Dietschy, J.M., 2003, Sterol absorption by the small intestine. Curr. Opin. Lipidol. 14: 233–240.
238. Ueda, Y., Gong, E., Royer, L., Cooper, P.N., Francone, O.L., and Rubin, E.M., 2000, Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics. J. Biol. Chem. 275: 20368–20373.
239. Ueda, Y., Royer, L., Gong, E., Zhang, J., Cooper, P.N., Francone, O., and Rubin, E.M., 1999, Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic mice. J. Biol. Chem. 274: 7165–7171.
240. Umeda, Y., Kako, Y., Mizutani, K., Iikura, Y., Kawamura, M., Seishima, M., and Hayashi, H., 2001, Inhibitory action of gemfibrozil on cholesterol absorption in rat intestine. J. Lipid Res. 42: 1214–1219.
241. Urban, S., Zieseniss, S., Werder, M., Hauser, H., Budzinski, R., and Engelmann, B., 2000, Scavenger receptor BI transfers major lipoprotein-associated phospholipids into the cells. J. Biol. Chem. 275: 33409–33415.
242. Valasek, M.A., Clarke, S.L., and Repa, J.J., 2007, Fenofibrate reduces intestinal cholesterol absorption via PPAR{alpha}-dependent modulation of NPC1L1 expression in mouse. J. Lipid Res. 48: 2725–2735.
243. Valasek, M.A., Repa, J.J., Quan, G., Dietschy, J.M., and Turley, S.D., 2008, Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G813–G822.
244. Valasek, M.A., Weng, J., Shaul, P.W., Anderson, R.G., and Repa, J.J., 2005, Caveolin-1 is not required for murine intestinal cholesterol transport. J. Biol. Chem. 280: 28103–28109.
245. van der Veen, J.N., Kruit, J.K., Havinga, R., Baller, J.F., Chimini, G., Lestavel, S., Staels, B., Groot, P.H., Groen, A.K., and Kuipers, F., 2005, Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. J. Lipid Res. 46: 526–534.
246. van der Velde, A.E., Vrins, C.L., van den Oever, K., Kunne, C., Oude Elferink, R.P., Kuipers, F., and Groen, A.K., 2007, Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. Gastroenterology 133: 967–975.
247. van der Velde, A.E., Vrins, C.L., van den Oever, K., Seemann, I., Oude Elferink, R.P., van Eck, M., Kuipers, F., and Groen, A.K., 2008, Regulation of direct transintestinal cholesterol excretion in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G203–G208.
248. van Heek, M., Austin, T.M., Farley, C., Cook, J.A., Tetzloff, G.G., and Davis, H.R., 2001a, Ezetimibe, a potent cholesterol absorption inhibitor, normalizes combined dyslipidemia in obese hyperinsulinemic hamsters. Diabetes 50: 1330–1335.
249. van Heek, M., Farley, C., Compton, D.S., Hoos, L., and Davis, H.R., 2001b, Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function. Br. J. Pharmacol. 134: 409–417.
250. Van Heek, M., France, C.F., Compton, D.S., McLeod, R.L., Yumibe, N.P., Alton, K.B., Sybertz, E.J., and Davis, H.R., Jr., 1997, In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461. J. Pharmacol. Exp. Ther. 283: 157–163.
251. Vanhanen, H.T., and Miettinen, T.A., 1995, Cholesterol absorption and synthesis during pravas-tatin, gemfibrozil and their combination. Atherosclerosis 115: 135–146.
252. Varban, M.L., Rinninger, F., Wang, N., Fairchild-Huntress, V., Dunmore, J.H., Fang, Q., Gosselin, M.L., Dixon, K.L., Deeds, J.D., Acton, S.L., Tall, A.R., and Huszar, D., 1998, Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol. Proc. Natl. Acad. Sci. USA 95: 4619–4624.
253. Vega, M.A., Rodriguez, F., Segui, B., Cales, C., Alcalde, J., and Sandoval, I.V., 1991, Targeting of lysosomal integral membrane protein LIMP II. The tyrosine-lacking carboxyl cytoplasmic tail of LIMP II is sufficient for direct targeting to lysosomes. J. Biol. Chem. 266: 16269– 16272.
254. Voshol, P.J., Schwarz, M., Rigotti, A., Krieger, M., Groen, A.K., and Kuipers, F., 2001, Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine. Biochem. J. 356: 317–325.
255. Vrins, C., Vink, E., Vandenberghe, K.E., Frijters, R., Seppen, J., and Groen, A.K., 2007, The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux. FEBS Lett. 581: 4616–4620.
256. Wang, C., Lin, H.J., Chan, T.K., Salen, G., Chan, W.C., and Tse, T.F., 1981, A unique patient with coexisting cerebrotendinous xanthomatosis and beta-sitosterolemia. Am. J. Med. 71: 313–319.
257. Wang, D.Q., 2007a, Regulation of intestinal cholesterol absorption. Annu. Rev. Physio. 69: 221–248.
258. Wang, H.H., Patel, S.B., Carey, M.C., and Wang, D.Q., 2007b, Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice. Hepatology 45: 998–1006.
259. Wang, H.H., Portincasa, P., Mendez-Sanchez, N., Uribe, M., and Wang, D.Q., 2008a, Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones. Gastroenterology 134: 2101–2110.
260. Wang, J., Chu, B.B., Ge, L., Li, B.L., Yan, Y., and Song, B.L., 2009, Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption. J. Lipid Res. [epub ahead of print].
261. Wang, J., Sun, F., Zhang, D.W., Ma, Y., Xu, F., Belani, J.D., Cohen, J.C., Hobbs, H.H., and Xie, X.S., 2006, Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution. J. Biol. Chem. 281: 27894–27904.
262. Wang, J., Williams, C., and Hegele, R., 2005, Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe. Clin. Genet. 67: 175–177.
263. Wang, J., Zhang, D.W., Lei, Y., Xu, F., Cohen, J.C., Hobbs, H.H., and Xie, X.S., 2008b, Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8. Biochemistry 47: 5194–5204.
264. Wang, N., Arai, T., Ji, Y., Rinninger, F., and Tall, A.R., 1998, Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein ApoB, low density lipoprotein ApoB, and high density lipoprotein in transgenic mice. J. Biol. Chem. 273: 32920–32926.
265. Wang, N., Weng, W., Breslow, J.L., and Tall, A.R., 1996, Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores. In vivo evidence that SR-BI is a functional high density lipoprotein receptor under feedback control. J. Biol. Chem. 271: 21001–21004.
266. Wang, X., Collins, H.L., Ranalletta, M., Fuki, I.V., Billheimer, J.T., Rothblat, G.H., Tall, A.R., and Rader, D.J., 2007c, Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J. Clin. Invest. 117: 2216–2224.
267. Webb, N.R., Connell, P.M., Graf, G.A., Smart, E.J., de Villiers, W.J., de Beer, F.C., and van der Westhuyzen, D.R., 1998, SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells. J. Biol. Chem. 273: 15241–15248.
268. Weinglass, A.B., Kohler, M., Schulte, U., Liu, J., Nketiah, E.O., Thomas, A., Schmalhofer, W., Williams, B., Bildl, W., McMasters, D.R., Dai, K., Beers, L., McCann, M.E., Kaczorowski, G.J., and Garcia, M.L., 2008, Extracellular loop C of NPC1L1 is important for binding to ezetimibe. Proc. Natl. Acad. Sci. USA 105: 11140–11145.
269. Williams, D.L., Connelly, M.A., Temel, R.E., Swarnakar, S., Phillips, M.C., dela Llera-Moya, M., and Rothblat, G.H., 1999, Scavenger receptor BI and cholesterol trafficking. Curr. Opin. Lipidol. 10: 329–339.
270. Williams, D.L., deLa Llera-Moya, M., Thuahnai, S.T., Lund-Katz, S., Connelly, M.A., Azhar, S., Anantharamaiah, G.M., and Phillips, M.C., 2000, Binding and cross-linking studies show that scavenger receptor BI interacts with multiple sites in apolipoprotein A-I and identify the class A amphipathic alpha-helix as a recognition motif. J. Biol. Chem. 275: 18897–18904.
271. Wilson, M.D., and Rudel, L.L., 1994, Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. J. Lipid Res. 35: 943–955.
272. Wilund, K.R., Yu, L., Xu, F., Hobbs, H.H., and Cohen, J.C., 2004a, High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr-/- mice. J. Lipid Res. 45: 1429–1436.
273. Wilund, K.R., Yu, L., Xu, F., Vega, G.L., Grundy, S.M., Cohen, J.C., and Hobbs, H.H., 2004b, No association between plasma levels of plant sterols and atherosclerosis in mice and men. Arterioscler. Thromb. Vasc. Biol. 24: 2326–2332.
274. Wu, J.E., Basso, F., Shamburek, R.D., Amar, M.J., Vaisman, B., Szakacs, G., Joyce, C., Tansey, T., Freeman, L., Paigen, B.J., Thomas, F., Brewer, H.B., Jr., and Santamarina-Fojo, S., 2004, Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice. J. Biol. Chem. 279: 22913–22925.
275. Wustner, D., Mondal, M., Huang, A., and Maxfield, F.R., 2004, Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells. J. Lipid Res. 45: 427–437.
276. Xu, S., Laccotripe, M., Huang, X., Rigotti, A., Zannis, V.I., and Krieger, M., 1997, Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake. J. Lipid Res. 38: 1289–1298.
277. Yamamoto, T., 1982, Ultrastructural basis of intestinal absorption. Arch. Histol. Jpn. 45: 1–22.
278. Yamanashi, Y., Takada, T., and Suzuki, H., 2007, Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells. J. Pharmacol. Exp. Ther. 320: 559–564.
279. Yancey, P.G., dela Llera-Moya, M., Swarnakar, S., Monzo, P., Klein, S.M., Connelly, M.A., Johnson, W.J., Williams, D.L., and Rothblat, G.H., 2000, High density lipoprotein phospho-lipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI. J. Biol. Chem. 275: 36596–36604.
280. Yang, C., Yu, L., Li, W., Xu, F., Cohen, J.C., and Hobbs, H.H., 2004, Disruption of cholesterol homeostasis by plant sterols. J. Clin. Invest. 114: 813–822.
281. Yesilaltay, A., Kocher, O., Pal, R., Leiva, A., Quinones, V., Rigotti, A., and Krieger, M., 2006, PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function. J. Biol. Chem. 281: 28975–28980.
282. Yu, L., 2007, Dual action of the ezetimibe target Niemann-Pick C1-Like 1. Future Lipidol. 2: 379–382.
283. Yu, L., 2008, The structure and function of Niemann-Pick C1-like 1 protein. Curr. Opin. Lipidol. 19: 263–269.
284. Yu, L., Bharadwaj, S., Brown, J.M., Ma, Y., Du, W., Davis, M.A., Michaely, P., Liu, P., Willingham, M.C., and Rudel, L.L., 2006, Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake. J. Biol. Chem. 281: 6616–6624.
285. Yu, L., von Bergmann, K., Lutjohann, D., Hobbs, H.H., and Cohen, J.C., 2004a, Selective sterol accumulation in ABCG5/ABCG8-deficient mice. J. Lipid Res. 45: 301–307.
286. Yu, L., Hammer, R.E., Li-Hawkins, J., Von Bergmann, K., Lutjohann, D., Cohen, J.C., and Hobbs, H.H., 2002a, Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc. Natl. Acad. Sci. USA 99: 16237–16242.
287. Yu, L., Li-Hawkins, J., Hammer, R.E., Berge, K.E., Horton, J.D., Cohen, J.C., and Hobbs, H.H., 2002b, Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J. Clin. Invest. 110: 671–680.
288. Yu, L., Cao, G., Repa, J., and Stangl, H., 2004b, Sterol regulation of scavenger receptor class B type I in macrophages. J. Lipid Res. 45: 889–899.
289. Yu, L., von Bergmann, K., Lutjohann, D., Hobbs, H.H., and Cohen, J.C., 2005, Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. J. Lipid Res 46: 1739–1744.
290. Yu, L., York, J., von Bergmann, K., Lutjohann, D., Cohen, J.C., and Hobbs, H.H., 2003, Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J. Biol. Chem. 278: 15565–15570.
291. Yvan-Charvet, L., Pagler, T.A., Wang, N., Senokuchi, T., Brundert, M., Li, H., Rinninger, F., and Tall, A.R., 2008, SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL. J. Lipid Res. 49: 107–114.
292. Zhang, Y., Da Silva, J.R., Reilly, M., Billheimer, J.T., Rothblat, G.H., and Rader, D.J., 2005a, Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J. Clin. Invest. 115: 2870–2874.
293. Zhang, S., Picard, M.H., Vasile, E., Zhu, Y., Raffai, R.L., Weisgraber, K.H., and Krieger, M., 2005b, Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation 111: 3457–3464.
294. Zheng, S., Hoos, L., Cook, J., Tetzloff, G., Davis, H., Jr., van Heek, M., and Hwa, J.J., 2008, Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice. Eur. J. Pharmacol. 584: 118–124.
295. Zuniga, S., Molina, H., Azocar, L., Amigo, L., Nervi, F., Pimentel, F., Jarufe, N., Arrese, M., Lammert, F, and Miquel, J.F., 2008, Ezetimibe prevents cholesterol gallstone formation in mice. Liver Int. 28: 935–947.