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Volumn 271, Issue 5248, 1996, Pages 518-520

Identification of scavenger receptor SR-BI as a high density lipoprotein receptor

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

EID: 0030046797     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5248.518     Document Type: Article
Times cited : (2058)

References (47)
  • 1
    • 0001474759 scopus 로고
    • C. R. Scriver, A. L Beaudet, W S. Sly, D. Vaile, Eds McGraw-Hill, New York
    • J. L. Breslow, in The Metabolic and Molecular Bases of Inherited Disease, C. R. Scriver, A. L Beaudet, W S. Sly, D. Vaile, Eds (McGraw-Hill, New York, 1995), pp. 2031-2052.
    • (1995) The Metabolic and Molecular Bases of Inherited Disease , pp. 2031-2052
    • Breslow, J.L.1
  • 2
    • 0023003692 scopus 로고
    • S. M. Grundy, J Am. Med. Assoc. 256, 2849 (1986); A. R. Tall, J. Clin Invest. 86, 379 (1990).
    • (1986) J Am. Med. Assoc. , vol.256 , pp. 2849
    • Grundy, S.M.1
  • 3
    • 0024996141 scopus 로고
    • S. M. Grundy, J Am. Med. Assoc. 256, 2849 (1986); A. R. Tall, J. Clin Invest. 86, 379 (1990).
    • (1990) J. Clin Invest. , vol.86 , pp. 379
    • Tall, A.R.1
  • 4
    • 4243157326 scopus 로고    scopus 로고
    • J. L Goldstein, H. H. Hobbs, M. S. Brown, in (1), pp 1981-2030
    • J. L Goldstein, H. H. Hobbs, M. S. Brown, in (1), pp 1981-2030
  • 5
    • 0025941724 scopus 로고
    • G. Assman, A. von Eckardstein, H B. Brewer Jr., in (1), pp. 2053-2072
    • G. Assman, A. von Eckardstein, H B. Brewer Jr., in (1), pp. 2053-2072, W. J Johnson, F. H. Mahlberg, G. H. Rothblat, M. C Phillips, Biochim. Biophys. Acta 1085, 273 (1991); M. N. Pieters, D. Schotten, T. J. C. Van Berkel, ibid. 1225, 125 (1994): C. J Fielding and P. E Fielding, J. Lipid Res. 36, 211 (1995).
    • (1991) Biochim. Biophys. Acta , vol.1085 , pp. 273
    • Johnson, W.J.1    Mahlberg, F.H.2    Rothblat, G.H.3    Phillips, M.C.4
  • 6
    • 0028069487 scopus 로고
    • G. Assman, A. von Eckardstein, H B. Brewer Jr., in (1), pp. 2053-2072, W. J Johnson, F. H. Mahlberg, G. H. Rothblat, M. C Phillips, Biochim. Biophys. Acta 1085, 273 (1991); M. N. Pieters, D. Schotten, T. J. C. Van Berkel, ibid. 1225, 125 (1994): C. J Fielding and P. E Fielding, J. Lipid Res. 36, 211 (1995).
    • (1994) Biochim. Biophys. Acta , vol.1225 , pp. 125
    • Pieters, M.N.1    Schotten, D.2    Van Berkel, T.J.C.3
  • 7
    • 0028887870 scopus 로고
    • G. Assman, A. von Eckardstein, H B. Brewer Jr., in (1), pp. 2053-2072, W. J Johnson, F. H. Mahlberg, G. H. Rothblat, M. C Phillips, Biochim. Biophys. Acta 1085, 273 (1991); M. N. Pieters, D. Schotten, T. J. C. Van Berkel, ibid. 1225, 125 (1994): C. J Fielding and P. E Fielding, J. Lipid Res. 36, 211 (1995).
    • (1995) J. Lipid Res. , vol.36 , pp. 211
    • Fielding, C.J.1    Fielding, P.E.2
  • 8
    • 0019451698 scopus 로고
    • J. M. Andersen and J. M. Dietschy, J. Biol. Chem. 256, 7362 (1981); M S. Brown, P T Kovanen, J L Goldstein, Recent Prog. Horm. Res. 35, 215 (1979); J. T. Gwynne and J. F. Strauss III, Endocr. Rev. 3, 299 (1982); B. D. Murphy et al., Endocrinology 116, 1587 (1985).
    • (1981) J. Biol. Chem. , vol.256 , pp. 7362
    • Andersen, J.M.1    Dietschy, J.M.2
  • 9
    • 0018652616 scopus 로고
    • J. M. Andersen and J. M. Dietschy, J. Biol. Chem. 256, 7362 (1981); M S. Brown, P T Kovanen, J L Goldstein, Recent Prog. Horm. Res. 35, 215 (1979); J. T. Gwynne and J. F. Strauss III, Endocr. Rev. 3, 299 (1982); B. D. Murphy et al., Endocrinology 116, 1587 (1985).
    • (1979) Recent Prog. Horm. Res. , vol.35 , pp. 215
    • Brown, M.S.1    Kovanen, P.T.2    Goldstein, J.L.3
  • 10
    • 0020150042 scopus 로고
    • J. M. Andersen and J. M. Dietschy, J. Biol. Chem. 256, 7362 (1981); M S. Brown, P T Kovanen, J L Goldstein, Recent Prog. Horm. Res. 35, 215 (1979); J. T. Gwynne and J. F. Strauss III, Endocr. Rev. 3, 299 (1982); B. D. Murphy et al., Endocrinology 116, 1587 (1985).
    • (1982) Endocr. Rev. , vol.3 , pp. 299
    • Gwynne, J.T.1    Strauss III, J.F.2
  • 11
    • 0021858045 scopus 로고
    • J. M. Andersen and J. M. Dietschy, J. Biol. Chem. 256, 7362 (1981); M S. Brown, P T Kovanen, J L Goldstein, Recent Prog. Horm. Res. 35, 215 (1979); J. T. Gwynne and J. F. Strauss III, Endocr. Rev. 3, 299 (1982); B. D. Murphy et al., Endocrinology 116, 1587 (1985).
    • (1985) Endocrinology , vol.116 , pp. 1587
    • Murphy, B.D.1
  • 12
    • 0025337629 scopus 로고
    • R Wishart and M MacKinnon, Biochim. Biophys. Acta 1044, 375 (1990); E. Leitersdorf, A. Israeli, O. Stein, S Eisenberg, Y. Stein, ibid. 878, 320 (1986).
    • (1990) Biochim. Biophys. Acta , vol.1044 , pp. 375
    • Wishart, R.1    MacKinnon, M.2
  • 14
    • 0024554647 scopus 로고
    • T. P. Knecht and R. C. Pittman, Biochim. Biophys. Acta 1002, 365 (1989); F. Rinninger, S. Jaeckle, R. C. Pittman, ibid. 1166, 275 (1993), F Rinninger et al., Hepatology 19, 1100 (1994); C. P Sparrow and R. C. Pittman, Biochim. Biophys. Acta 1043, 203 (1990); J. G. DeLamatre, R. M. Carter, C. A. Homich, J. Cell Physiol. 146, 18 (1991).
    • (1989) Biochim. Biophys. Acta , vol.1002 , pp. 365
    • Knecht, T.P.1    Pittman, R.C.2
  • 15
    • 0027537176 scopus 로고
    • T. P. Knecht and R. C. Pittman, Biochim. Biophys. Acta 1002, 365 (1989); F. Rinninger, S. Jaeckle, R. C. Pittman, ibid. 1166, 275 (1993), F Rinninger et al., Hepatology 19, 1100 (1994); C. P Sparrow and R. C. Pittman, Biochim. Biophys. Acta 1043, 203 (1990); J. G. DeLamatre, R. M. Carter, C. A. Homich, J. Cell Physiol. 146, 18 (1991).
    • (1993) Biochim. Biophys. Acta , vol.1166 , pp. 275
    • Rinninger, F.1    Jaeckle, S.2    Pittman, R.C.3
  • 16
    • 0028215190 scopus 로고
    • T. P. Knecht and R. C. Pittman, Biochim. Biophys. Acta 1002, 365 (1989); F. Rinninger, S. Jaeckle, R. C. Pittman, ibid. 1166, 275 (1993), F Rinninger et al., Hepatology 19, 1100 (1994); C. P Sparrow and R. C. Pittman, Biochim. Biophys. Acta 1043, 203 (1990); J. G. DeLamatre, R. M. Carter, C. A. Homich, J. Cell Physiol. 146, 18 (1991).
    • (1994) Hepatology , vol.19 , pp. 1100
    • Rinninger, F.1
  • 17
    • 0025323370 scopus 로고
    • T. P. Knecht and R. C. Pittman, Biochim. Biophys. Acta 1002, 365 (1989); F. Rinninger, S. Jaeckle, R. C. Pittman, ibid. 1166, 275 (1993), F Rinninger et al., Hepatology 19, 1100 (1994); C. P Sparrow and R. C. Pittman, Biochim. Biophys. Acta 1043, 203 (1990); J. G. DeLamatre, R. M. Carter, C. A. Homich, J. Cell Physiol. 146, 18 (1991).
    • (1990) Biochim. Biophys. Acta , vol.1043 , pp. 203
    • Sparrow, C.P.1    Pittman, R.C.2
  • 18
    • 0025981673 scopus 로고
    • T. P. Knecht and R. C. Pittman, Biochim. Biophys. Acta 1002, 365 (1989); F. Rinninger, S. Jaeckle, R. C. Pittman, ibid. 1166, 275 (1993), F Rinninger et al., Hepatology 19, 1100 (1994); C. P Sparrow and R. C. Pittman, Biochim. Biophys. Acta 1043, 203 (1990); J. G. DeLamatre, R. M. Carter, C. A. Homich, J. Cell Physiol. 146, 18 (1991).
    • (1991) J. Cell Physiol. , vol.146 , pp. 18
    • DeLamatre, J.G.1    Carter, R.M.2    Homich, C.A.3
  • 21
    • 0023066231 scopus 로고
    • C. M. Arbeeny, V. A Rifici, H. A Eder, Biochim. Biophys. Acta 917, 9 (1987); M MacKinnon, J. Savage, R. Wishart, P. Barter, J. Biol. Chem. 261, 2548 (1986), E Reaven, Y. I. Chen, M. Spicher, S Azhar, J. Clin. Invest. 74, 1384 (1984)
    • (1987) Biochim. Biophys. Acta , vol.917 , pp. 9
    • Arbeeny, C.M.1    Rifici, V.A.2    Eder, H.A.3
  • 22
    • 0023025489 scopus 로고
    • C. M. Arbeeny, V. A Rifici, H. A Eder, Biochim. Biophys. Acta 917, 9 (1987); M MacKinnon, J. Savage, R. Wishart, P. Barter, J. Biol. Chem. 261, 2548 (1986), E Reaven, Y. I. Chen, M. Spicher, S Azhar, J. Clin. Invest. 74, 1384 (1984)
    • (1986) J. Biol. Chem. , vol.261 , pp. 2548
    • MacKinnon, M.1    Savage, J.2    Wishart, R.3    Barter, P.4
  • 23
    • 0021722374 scopus 로고
    • C. M. Arbeeny, V. A Rifici, H. A Eder, Biochim. Biophys. Acta 917, 9 (1987); M MacKinnon, J. Savage, R. Wishart, P. Barter, J. Biol. Chem. 261, 2548 (1986), E Reaven, Y. I. Chen, M. Spicher, S Azhar, J. Clin. Invest. 74, 1384 (1984)
    • (1984) J. Clin. Invest. , vol.74 , pp. 1384
    • Reaven, E.1    Chen, Y.I.2    Spicher, M.3    Azhar, S.4
  • 24
    • 0000940687 scopus 로고
    • C. Glass, R C. Pittman, D. B. Weinstein, D. Steinberg, Proc. Natl. Acad. Sci. USA 80, 5435 (1983); C. Glass, R. C. Pittman, M Given, D. Steinberg, J. Biol Chem. 260, 744 (1985), Y Stein, Y Dabach, G. Hollander, G Halperin, O. Stein, Biochim. Biophys Acta 752, 98 (1983).
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 5435
    • Glass, C.1    Pittman, R.C.2    Weinstein, D.B.3    Steinberg, D.4
  • 25
    • 0021991141 scopus 로고
    • C. Glass, R C. Pittman, D. B. Weinstein, D. Steinberg, Proc. Natl. Acad. Sci. USA 80, 5435 (1983); C. Glass, R. C. Pittman, M Given, D. Steinberg, J. Biol Chem. 260, 744 (1985), Y Stein, Y Dabach, G. Hollander, G Halperin, O. Stein, Biochim. Biophys Acta 752, 98 (1983).
    • (1985) J. Biol Chem. , vol.260 , pp. 744
    • Glass, C.1    Pittman, R.C.2    Given, M.3    Steinberg, D.4
  • 26
    • 0021106134 scopus 로고
    • C. Glass, R C. Pittman, D. B. Weinstein, D. Steinberg, Proc. Natl. Acad. Sci. USA 80, 5435 (1983); C. Glass, R. C. Pittman, M Given, D. Steinberg, J. Biol Chem. 260, 744 (1985), Y Stein, Y Dabach, G. Hollander, G Halperin, O. Stein, Biochim. Biophys Acta 752, 98 (1983).
    • (1983) Biochim. Biophys Acta , vol.752 , pp. 98
    • Stein, Y.1    Dabach, Y.2    Hollander, G.3    Halperin, G.4    Stein, O.5
  • 31
    • 0027217893 scopus 로고
    • A 600-base pair probe from the haSR-BI cDNA (14) was used to isolate an mSR-BI clone from a murine 3T3-L1 adipocyte pcDNA1 library. GenBank accession number U37799; 89% amino acid identity and 96% similarity to haSR-BI (74) and 79% identity and 91% similarity to the human sequence CLA1 [D. Calvo and M A Vega, J. Biol Chem. 268, 18929 (1993)] The corresponding expression vector pmSR-BI-77 was transfected (14) into IdIA cells [D. M Kingsley and M. Krieger, Proc. Natl. Acad. Sci USA 81, 5454 (1984)] The receptor-positive cells, IdlA[mSR-BI] (done 15), were isolated by selection and flow cytometry (14).
    • (1993) J. Biol Chem. , vol.268 , pp. 18929
    • Calvo, D.1    Vega, M.A.2
  • 32
    • 0021126647 scopus 로고
    • A 600-base pair probe from the haSR-BI cDNA (14) was used to isolate an mSR-BI clone from a murine 3T3-L1 adipocyte pcDNA1 library. GenBank accession number U37799; 89% amino acid identity and 96% similarity to haSR-BI (74) and 79% identity and 91% similarity to the human sequence CLA1 [D. Calvo and M A Vega, J. Biol Chem. 268, 18929 (1993)] The corresponding expression vector pmSR-BI-77 was transfected (14) into IdIA cells [D. M Kingsley and M. Krieger, Proc. Natl. Acad. Sci USA 81, 5454 (1984)] The receptor-positive cells, IdlA[mSR-BI] (done 15), were isolated by selection and flow cytometry (14).
    • (1984) Proc. Natl. Acad. Sci USA , vol.81 , pp. 5454
    • Kingsley, D.M.1    Krieger, M.2
  • 33
  • 35
    • 4243125160 scopus 로고    scopus 로고
    • data not shown
    • S. Acton et al , data not shown.
    • Acton, S.1
  • 36
    • 4243059358 scopus 로고    scopus 로고
    • note
    • Cells were plated as in Fig. 1 in medium A (26) with 3% newborn calf lipoprotein-deficient serum. On day 2, cells were incubated with or without unlabeled HDL (20 μg of protein per militer for 5 hours at 37°C in medium B) and washed (Fig. 1), lipids were extracted twice with hexane: isopropanol (3:2; 3 ml for 30 min) Extracts were pooled, back-extracted with 1 ml of water, and dried, and total (free and esterified) cholesterol masses (averages of six replicates) were determined (Sigma Diagnostics, St Louis, MO). The protein contents were estimated from replicate cultures. The values of total cholesterol (micrograms per milligram of cell protein, ± SEM) for cells incubated without HDL were 20.5 ± 0.3 (IdlA) and 23.0 ± 0 4 (IdlA[mSR-BI]).
  • 42
    • 4243113937 scopus 로고    scopus 로고
    • note
    • 495.
  • 43
    • 4243189168 scopus 로고    scopus 로고
    • unpublished results
    • The difference between the predicted mass of mSR-BI (57 kD) and the observed mass (82 kD) is due primarily to glycosylation (J. Babitt, A. Rigotti, M. Krieger, unpublished results).
    • Babitt, J.1    Rigotti, A.2    Krieger, M.3
  • 44
    • 4243100473 scopus 로고    scopus 로고
    • note
    • 3H]cholesteryl oleate was extracted with isopropyl alcohol (30 min at room temperature) and quantified by scintillation counting. Dil was extracted with dimethyl sulfoxide (DMSO) and its fluorescence (550-nm excitation, 565-nm emission) measured with Dil-HDL standards dissolved in DMSO
  • 45
    • 0020534918 scopus 로고
    • M. Krieger, Cell 33, 413 (1983).
    • (1983) Cell , vol.33 , pp. 413
    • Krieger, M.1
  • 47
    • 4243175731 scopus 로고    scopus 로고
    • note
    • We thank M. Chnstiansen and T. Hyatt for technical assistance and G. Baldini, H. Lodish, A Tall, P. Kim, L. Liscum, and members of our laboratones for materials and advice. Supported by NIH grants HL41484, HL52212, HL09047, and HL20948; The Perot Family Fund; and a Howard Hughes Medical Institute postdoctoral fellowship (A R.).


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