ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion

Journal of Biological Chemistry

Volumn 278, Issue 48, 2003, Pages 48275-48282

  Graf, Gregory A ^a   Yu, Liqing ^a   Li, Wei Ping ^b   Gerard, Robert ^a   Tuma, Pamela L ^c   Cohen, Jonathan C ^a   Hobbs, Helen H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c CATHOLIC UNIVERSITY OF AMERICA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOLOGICAL MEMBRANES; BIOLOGICAL ORGANS; CELL CULTURE; CHOLESTEROL; FLUORESCENCE; IMMUNOLOGY; MICROSCOPIC EXAMINATION; PRECIPITATION (CHEMICAL);

PHENOTYPES;

PROTEINS;

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; PROTEIN ABCG1; PROTEIN ABCG4; PROTEIN ABCG5; PROTEIN ABCG8; STEROL; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; CHOLESTEROL METABOLISM; ENDOPLASMIC RETICULUM; HUMAN; IMMUNOFLUORESCENCE MICROSCOPY; INTESTINE ABSORPTION; INTESTINE CELL; LIVER CELL; MEMBRANE TRANSPORT; MOUSE; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; STEROL EXCRETION;

ADENOSINE TRIPHOSPHATE; ADENOVIRIDAE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTILIPEMIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BILE DUCTS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CHO CELLS; CHOLESTEROL; CLONING, MOLECULAR; CRICETINAE; DIMERIZATION; DNA, COMPLEMENTARY; ENDOPLASMIC RETICULUM; ENTEROCYTES; EPITOPES; EVOLUTION, MOLECULAR; HEPATOCYTES; HUMANS; LIPOPROTEINS; LIVER; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PHYLOGENY; PHYTOSTEROLS; PRECIPITIN TESTS; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SITOSTEROLS; TRANSFECTION;

ADENOVIRIDAE; ANIMALIA;

EID: 0348111456     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310223200     Document Type: Article

References (44)

1. Dean, M., Rzhetsky, A., and Allikmets, R. (2001) Genome Res. 11, 1156-1166
2. Klein, I., Sarkadi, B., and Varadi, A. (1999) Biochim. Biophys. Acta 1461, 237-262
3. Berge, K. E., Tian, H., Graf, G. A., Yu, L., Grishin, N. V., Schultz, J., Kwiterovich, P., Shan, B., Barnes, R., and Hobbs, H. H. (2000) Science 290, 1771-1775
4. Lee, M. H., Lu, K., Hazard, S., Yu, H., Shulenin, S., Hidaka, H., Kojima, H., Allikmets, R., Sakuma, N., Pegoraro, R., Srivastava, A. K., Salen, G., Dean, M., and Patel, S. B. (2001) Nat. Genet. 27, 79-83
5. Salen, G., Shefer, S., Nguyen, L., Ness, G. C., Tint, G. S., and Shore, V. (1992) J. Lipid Res. 33, 945-955
6. Yu, L., Li-Hawkins, J., Hammer, R. E., Berge, K. E., Horton, J. D., Cohen, J. C., and Hobbs, H. H. (2002) J. Clin. Invest. 110, 671-680
7. Yu, L., Hammer, R. E., Li-Hawkins, J., Von Bergmann, K., Lutjohann, D., Cohen, J. C., and Hobbs, H. H. (2003) Proc. Natl. Acad. Sci. U. S. A. 99, 16237-16242
8. Miettinen, T. A. (1980) Eur. J. Clin. Invest. 10, 27-35
9. Salen, G., Shore, V., Tint, G. S., Forte, T., Shefer, S., Horak, I., Horak, E., Dayal, B., Nguyen, L., Batta, A. K. et al. (1989) J. Lipid Res. 30, 1319-1330
10. Lutjohann, D., Bjorkhem, I., Beil, U. F., and von Bergmann, K. (1995) J. Lipid Res. 36, 1763-1773
11. Graf, G. A., Li, W.-P., Gerard, R. D., Gelissen, I., White, A., Cohen, J. C., and Hobbs, H. H. (2002) J. Clin. Invest. 110, 659-669
12. Lee, M.-H., Lu, K., and Patel, S. B. (2001) Curr. Opin. Lipidol. 12, 141-149
13. Trappe, R., Doenecke, D., and Albig, W. (1999) Biochim. Biophys. Acta 1446, 341-351
14. Ikeda, S., Mochizuki, A., Sarker, A. H., and Seki, S. (2000) Biochem. Biophys. Res. Commun. 273, 1063-1068
15. Repa, J. J., Berge, K. E., Pomajzl, C., Richardson, J. A., Hobbs, H., and Mangelsdorf, D. J. (2002) J. Biol. Chem. 277, 18793-18800
16. Ewart, G. D., and Howells, A. J. (1998) Methods Enzymol. 292, 213-224
17. Ewart, G. D., Cannell, D., Cox, G. B., and Howells, A. J. (1994) J. Biol. Chem. 269, 10370-10377
18. Chen, H., Rossier, C., Lalioti, M. D., Lynn, A., Chakravarti, A., Perrin, G., and Antonarakis, S. E. (1996) Am. J. Hum. Genet. 59, 66-75
19. Mackenzie, S. M., Howells, A. J., Cox, G. B., and Ewart, G. D. (2000) Genetica 108, 239-252
20. Maliepaard, M., Scheffer, G. L., Faneyte, I. F., van Gastelen, M. A., Pijnenborg, A. C., Schinkel, A. H., van De Vijver, M. J., Scheper, R. J., and Schellens, J. H. (2001) Cancer Res. 61, 3458-3464
21. Rocchi, E., Khodjakov, A., Volk, E. L., Yang, C. H., Litman, T., Bates, S. E., and Schneider, E. (2000) Biochem. Biophys. Res. Commun. 271, 42-46
22. Jonker, J. W., Buitelaar, M., Wagenaar, E., Van Der Valk, M. A., Scheffer, G. L., Scheper, R. J., Plosch, T., Kuipers, F., Elferink, R. P., Rosing, H., Beijnen, J. H., and Schinkel, A. H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 15649-15654
23. Ozvegy, C., Litman, T., Szakacs, G., Nagy, Z., Bates, S., Varadi, A., and Sarkadi, B. (2001) Biochem. Biophys. Res. Commun. 285, 111-117
24. Kage, K., Tsukahara, S., Sugiyama, T., Asada, S., Ishikawa, E., Tsuruo, T., and Sugimoto, Y. (2002) Int. J. Cancer 97, 626-630
25. Klucken, J., Buchler, C., Orso, E., Kaminski, W. E., Porsch-Ozcurumez, M., Liebisch, G., Kapinsky, M., Diederich, W., Drobnik, W., Dean, M., Allikmets, R., and Schmitz, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 817-822
26. Kennedy, M. A., Venkateswaran, A., Tarr, P. T., Xenarios, I., Kudoh, J., Shimizu, N., and Edwards, P. A. (2001) J. Biol. Chem. 276, 39438-39447
27. Hoekstra, M., Kruijt, J. K., Van Eck, M., and Van Berkel, T. J. (2003) J. Biol. Chem. 278, 25448-25453
28. Oldfield, S., Lowry, C., Ruddick, J., and Lightman, S. (2002) Biochim. Biophys. Acta. 1591, 175-179
29. Yoshikawa, M., Yabuuchi, H., Kuroiwa, A., Ikegami, Y., Sai, Y., Tamai, I., Tsuji, A., Matsuda, Y., Yoshida, H., and Ishikawa, T. (2002) Gene (Amst.) 26, 67-75
30. Tokiwa, G., Tyers, M., Volpe, T., and Futcher, B. (1994) Nature 371, 342-345
31. Velasco-Miguel, S., Richardson, J. A., Gerlach, V. L., Lai, W. C., Gao, T., Russell, L. D., Hladik, C. L., White, C. L., and Friedberg, E. C. (2003) DNA Repair (Amst.) 2, 91-106
32. Tuma, P. L., and Hubbard, A. L. (1999) Current Protocols in Cell Biology, pp. 3.2.1-3.2.16, John Wiley & Sons, Inc., New York
33. Balda, M. S., and Anderson, J. M. (1993) Am. J. Physiol. 264, C918-C924
34. Sanchez-Fernandez, R., Davies, T. G., Coleman, J. O., and Rea, P. A. (2001) J. Biol. Chem. 276, 30231-30244
35. Moreau, R. A., Whitaker, B. D., and Hicks, K. B. (2002) Prog. Lipid Res. 41, 457-500
36. Annilo, T., Tammur, J., Hutchinson, A., Rzhetsky, A., Dean, M., and Allikmets, R. (2001) Cytogenet. Cell Genet. 94, 196-201
37. Walker, J. E., Saraste, M., Runswick, M. J., and Gay, N. J. (1982) EMBO J. 1, 945-951
38. Locher, K. P., Lee, A. T., and Rees, D. C. (2002) Science 296, 1091-1098
39. Yoshida, M., and Amano, T. (1995) FEBS Lett. 359, 1-5
40. Schneider, E. a. H., S. (1998) FEMS Microbiol. Rev. 22, 1-20
41. Venkateswaran, A., Laffitte, B. A., Joseph, S. B., Mak, P. A., Wilpitz, D. C., Edwards, P. A., and Tontonoz, P. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 12097-12102
42. Engel, T., Lorkowski, S., Lueken, A., Rust, S., Schluter, B., Berger, G., Cullen, P., and Assmann, G. (2001) Biochem. Biophys. Res. Commun. 288, 483-488
43. Ozvegy, C., Varadi, A., and Sarkadi, B. (2002) J. Biol. Chem. 277, 47980-47990
44. Suzuki, M., Suzuki, H., Sugimoto, Y., and Sugiyama, Y. (2003) J. Biol. Chem. 278, 22644-22649