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Volumn 1791, Issue 4, 2009, Pages 297-306

Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol

Author keywords

Atherosclerosis; Cholesterol absorption; Dyslipidemia; Myriocin; SPT gene knockout

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G5; CARRIER PROTEIN; CHOLESTEROL; PROTEIN NPC1L1; SERINE PALMITOYLTRANSFERASE; THERMOZYMOCIDIN; UNCLASSIFIED DRUG;

EID: 62249186734     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2009.01.010     Document Type: Article
Times cited : (27)

References (44)
  • 1
    • 0029094151 scopus 로고
    • The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level
    • Gylling H., and Miettinen T.A. The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level. Atherosclerosis 117 (1995) 305-308
    • (1995) Atherosclerosis , vol.117 , pp. 305-308
    • Gylling, H.1    Miettinen, T.A.2
  • 5
    • 0038614979 scopus 로고    scopus 로고
    • Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8
    • Yu L., York J., von Bergmann K., Lutjohann D., Cohen J.C., and Hobbs H.H. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J. Biol. Chem. 278 (2003) 15565-15570
    • (2003) J. Biol. Chem. , vol.278 , pp. 15565-15570
    • Yu, L.1    York, J.2    von Bergmann, K.3    Lutjohann, D.4    Cohen, J.C.5    Hobbs, H.H.6
  • 6
    • 20544456374 scopus 로고    scopus 로고
    • Evidence for multiple complementary pathways for efficient cholesterol absorption in mice
    • Iqbal J., and Hussain M.M. Evidence for multiple complementary pathways for efficient cholesterol absorption in mice. J. Lipid Res. 46 (2005) 1491-1501
    • (2005) J. Lipid Res. , vol.46 , pp. 1491-1501
    • Iqbal, J.1    Hussain, M.M.2
  • 7
    • 0042357173 scopus 로고    scopus 로고
    • Multiple, independently regulated pathways of cholesterol transport across the intestinal epithelial cells
    • Iqbal J., Anwar K., and Hussain M.M. Multiple, independently regulated pathways of cholesterol transport across the intestinal epithelial cells. J. Biol. Chem. 278 (2003) 31610-31620
    • (2003) J. Biol. Chem. , vol.278 , pp. 31610-31620
    • Iqbal, J.1    Anwar, K.2    Hussain, M.M.3
  • 8
    • 0025283928 scopus 로고
    • An update of the enzymology and regulation sphingomyelin metabolism
    • Merrill A.H., and Jones D.D. An update of the enzymology and regulation sphingomyelin metabolism. Biochim. Biophysi. Acta. 1044 (1990) 1-12
    • (1990) Biochim. Biophysi. Acta. , vol.1044 , pp. 1-12
    • Merrill, A.H.1    Jones, D.D.2
  • 9
    • 0030755002 scopus 로고    scopus 로고
    • Human and murine serine-palmitoyl-CoA transferase - cloning, expression and characterization of the key enzyme in sphingolipid synthesis
    • Weiss B., and Stoffel W. Human and murine serine-palmitoyl-CoA transferase - cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur. J. Biochem. 249 (1997) 239-247
    • (1997) Eur. J. Biochem. , vol.249 , pp. 239-247
    • Weiss, B.1    Stoffel, W.2
  • 10
    • 0031450391 scopus 로고    scopus 로고
    • A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis
    • Hanada K., Hara T., Nishijima M., Kuge O., Dickson R.C., and Nagiec M.M. A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. J. Biol. Chem. 272 (1997) 32108-32114
    • (1997) J. Biol. Chem. , vol.272 , pp. 32108-32114
    • Hanada, K.1    Hara, T.2    Nishijima, M.3    Kuge, O.4    Dickson, R.C.5    Nagiec, M.M.6
  • 11
    • 33846021289 scopus 로고    scopus 로고
    • Mammalian serine-palmitoyltransferase - cloning and initial characterisation of a new subunit
    • Hornemann T., Richard S., Rütti M.F., Wei Y., and von Eckardstein A. Mammalian serine-palmitoyltransferase - cloning and initial characterisation of a new subunit. J. Biol. Chem. 281 (2006) 37275-37281
    • (2006) J. Biol. Chem. , vol.281 , pp. 37275-37281
    • Hornemann, T.1    Richard, S.2    Rütti, M.F.3    Wei, Y.4    von Eckardstein, A.5
  • 12
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simons K., and Ikonen E. Functional rafts in cell membranes. Nature 387 (1997) 569-572
    • (1997) Nature , vol.387 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 13
    • 0034529050 scopus 로고    scopus 로고
    • How cells handle cholesterol
    • Simons K., and Ikonen E. How cells handle cholesterol. Science 290 (2000) 1721-1726
    • (2000) Science , vol.290 , pp. 1721-1726
    • Simons, K.1    Ikonen, E.2
  • 15
    • 0019784949 scopus 로고
    • Microvillus membrane vesicles from pig small intestine. Purity and lipid composition
    • Christiansen K., and Carlsen J. Microvillus membrane vesicles from pig small intestine. Purity and lipid composition. Biochim. Biophys. Acta 647 (1981) 188-195
    • (1981) Biochim. Biophys. Acta , vol.647 , pp. 188-195
    • Christiansen, K.1    Carlsen, J.2
  • 16
    • 0026512314 scopus 로고
    • Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
    • Brown D.A., and Rose J.K. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68 (1992) 533-544
    • (1992) Cell , vol.68 , pp. 533-544
    • Brown, D.A.1    Rose, J.K.2
  • 17
    • 0031706594 scopus 로고    scopus 로고
    • Caveolin is present in intestinal cells: role in cholesterol trafficking?
    • Field F.J., Born E., Murthy S., and Mathur S.N. Caveolin is present in intestinal cells: role in cholesterol trafficking?. J. Lipid Res. 39 (1998) 1938-1950
    • (1998) J. Lipid Res. , vol.39 , pp. 1938-1950
    • Field, F.J.1    Born, E.2    Murthy, S.3    Mathur, S.N.4
  • 18
    • 0348111456 scopus 로고    scopus 로고
    • ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion
    • Graf G.A., Yu L., Li W.P., Gerard R., Tuma P.L., Cohen J.C., and Hobbs H.H. ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J. Biol. Chem. 278 (2003) 48275-48282
    • (2003) J. Biol. Chem. , vol.278 , pp. 48275-48282
    • Graf, G.A.1    Yu, L.2    Li, W.P.3    Gerard, R.4    Tuma, P.L.5    Cohen, J.C.6    Hobbs, H.H.7
  • 21
    • 0041912965 scopus 로고    scopus 로고
    • Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies
    • Wang D.Q., and Carey M.C. Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies. J. Lipid Res. 44 (2003) 1042-1059
    • (2003) J. Lipid Res. , vol.44 , pp. 1042-1059
    • Wang, D.Q.1    Carey, M.C.2
  • 22
    • 0027405261 scopus 로고
    • Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts
    • Carr T.P., Andresen C.J., and Rudel L.L. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin. Biochem. 26 (1993) 39-42
    • (1993) Clin. Biochem. , vol.26 , pp. 39-42
    • Carr, T.P.1    Andresen, C.J.2    Rudel, L.L.3
  • 23
    • 33644777552 scopus 로고    scopus 로고
    • Rapid, specific, and sensitive measurements of plasma sphingomyelin and phosphatidylcholine
    • Hojjati M.R., and Jiang X.C. Rapid, specific, and sensitive measurements of plasma sphingomyelin and phosphatidylcholine. J. Lipid Res. 47 (2006) 673-676
    • (2006) J. Lipid Res. , vol.47 , pp. 673-676
    • Hojjati, M.R.1    Jiang, X.C.2
  • 24
    • 27644537134 scopus 로고    scopus 로고
    • Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice
    • Hojjati M.R., Li Z., and Jiang X.C. Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice. Biochim. Biophys. Acta. 1737 (2005) 44-51
    • (2005) Biochim. Biophys. Acta. , vol.1737 , pp. 44-51
    • Hojjati, M.R.1    Li, Z.2    Jiang, X.C.3
  • 25
    • 21244442348 scopus 로고    scopus 로고
    • Spatial and functional heterogeneity of sphingolipid-rich membrane domains
    • Kiyokawa E., Baba T., Otsuka N., Makino A., Ohno S., and Kobayashi T. Spatial and functional heterogeneity of sphingolipid-rich membrane domains. J. Biol. Chem. 280 (2005) 24072-24084
    • (2005) J. Biol. Chem. , vol.280 , pp. 24072-24084
    • Kiyokawa, E.1    Baba, T.2    Otsuka, N.3    Makino, A.4    Ohno, S.5    Kobayashi, T.6
  • 26
    • 33846959454 scopus 로고    scopus 로고
    • Cholesterol and lipid/protein ratio control the oligomerization of a sphingomyelin-specific toxin, lysenin
    • Ishitsuka R., and Kobayashi T. Cholesterol and lipid/protein ratio control the oligomerization of a sphingomyelin-specific toxin, lysenin. Biochemistry 46 (2007) 1495-1502
    • (2007) Biochemistry , vol.46 , pp. 1495-1502
    • Ishitsuka, R.1    Kobayashi, T.2
  • 27
    • 15444367538 scopus 로고    scopus 로고
    • Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice
    • Hojjati M.R., Li Z., Zhou H., Tang S., Huan C., Ooi E., Lu S., and Jiang X.C. Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. J. Biol. Chem. 280 (2005) 10284-10289
    • (2005) J. Biol. Chem. , vol.280 , pp. 10284-10289
    • Hojjati, M.R.1    Li, Z.2    Zhou, H.3    Tang, S.4    Huan, C.5    Ooi, E.6    Lu, S.7    Jiang, X.C.8
  • 28
    • 33947404866 scopus 로고    scopus 로고
    • Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration
    • Glaros E.N., Kim W.S., Wu B.J., Suarna C., Quinn C.M., Rye K.A., Stocker R., Jessup W., and Garner B. Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration. Biochem. Pharmacol. 73 (2007) 1340-1346
    • (2007) Biochem. Pharmacol. , vol.73 , pp. 1340-1346
    • Glaros, E.N.1    Kim, W.S.2    Wu, B.J.3    Suarna, C.4    Quinn, C.M.5    Rye, K.A.6    Stocker, R.7    Jessup, W.8    Garner, B.9
  • 30
    • 50649104363 scopus 로고    scopus 로고
    • Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice
    • Park T.S., Rosebury W., Kindt E.K., Kowala M.C., and Panek R.L. Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice. Pharmacol. Res. 58 (2008) 45-51
    • (2008) Pharmacol. Res. , vol.58 , pp. 45-51
    • Park, T.S.1    Rosebury, W.2    Kindt, E.K.3    Kowala, M.C.4    Panek, R.L.5
  • 31
    • 13444283308 scopus 로고    scopus 로고
    • Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency
    • Bodary P.F., Shen Y., Vargas F.B., Bi X., Ostenso K.A., Gu S., Shayman J.A., and Eitzman D.T. Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency. Circulation 111 (2005) 629-632
    • (2005) Circulation , vol.111 , pp. 629-632
    • Bodary, P.F.1    Shen, Y.2    Vargas, F.B.3    Bi, X.4    Ostenso, K.A.5    Gu, S.6    Shayman, J.A.7    Eitzman, D.T.8
  • 33
    • 0032520147 scopus 로고    scopus 로고
    • Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase
    • Jeong T.S., Schissel S.L., Tabas I., Pownall H.J., Tall A.R., and Jiang X.C. Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. J. Clin. Invest. 101 (1998) 905-912
    • (1998) J. Clin. Invest. , vol.101 , pp. 905-912
    • Jeong, T.S.1    Schissel, S.L.2    Tabas, I.3    Pownall, H.J.4    Tall, A.R.5    Jiang, X.C.6
  • 35
    • 0026766590 scopus 로고
    • Increased sitosterol absorption is offset by rapid elimination to prevent accumulation in heterozygotes with sitosterolemia
    • Salen G., Tint G.S., Shefer S., Shore V., and Nguyen L. Increased sitosterol absorption is offset by rapid elimination to prevent accumulation in heterozygotes with sitosterolemia. Arterioscler. Thromb. 12 (1992) 563-568
    • (1992) Arterioscler. Thromb. , vol.12 , pp. 563-568
    • Salen, G.1    Tint, G.S.2    Shefer, S.3    Shore, V.4    Nguyen, L.5
  • 36
    • 34247399882 scopus 로고    scopus 로고
    • Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice
    • Wang H.H., Patel S.B., Carey M.C., and Wang D.Q. Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice. Hepatology 45 (2007) 998-1006
    • (2007) Hepatology , vol.45 , pp. 998-1006
    • Wang, H.H.1    Patel, S.B.2    Carey, M.C.3    Wang, D.Q.4
  • 37
    • 0036733630 scopus 로고    scopus 로고
    • Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
    • Yu L., Li-Hawkins J., Hammer R.E., Berge K.E., Horton J.D., Cohen J.C., and Hobbs H.H. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J. Clin. Invest. 110 (2002) 671-680
    • (2002) J. Clin. Invest. , vol.110 , pp. 671-680
    • Yu, L.1    Li-Hawkins, J.2    Hammer, R.E.3    Berge, K.E.4    Horton, J.D.5    Cohen, J.C.6    Hobbs, H.H.7
  • 41
    • 0141891109 scopus 로고    scopus 로고
    • Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1
    • Witting S.R., Maiorano J.N., and Davidson W.S. Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. J. Biol. Chem. 278 (2003) 40121-40127
    • (2003) J. Biol. Chem. , vol.278 , pp. 40121-40127
    • Witting, S.R.1    Maiorano, J.N.2    Davidson, W.S.3
  • 42
    • 33845572483 scopus 로고    scopus 로고
    • Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I
    • Ghering A.B., and Davidson W.S. Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I. J. Lipid Res. 47 (2006) 2781-2788
    • (2006) J. Lipid Res. , vol.47 , pp. 2781-2788
    • Ghering, A.B.1    Davidson, W.S.2
  • 44
    • 29144480539 scopus 로고    scopus 로고
    • Disruption of lipid rafts stimulates phospholipase d activity in human lymphocytes: implication in the regulation of immune function
    • Diaz O., Mébarek-Azzam S., Benzaria A., Dubois M., Lagarde M., Némoz G., and Prigent A.F. Disruption of lipid rafts stimulates phospholipase d activity in human lymphocytes: implication in the regulation of immune function. J. Immunol. 175 (2005) 8077-8086
    • (2005) J. Immunol. , vol.175 , pp. 8077-8086
    • Diaz, O.1    Mébarek-Azzam, S.2    Benzaria, A.3    Dubois, M.4    Lagarde, M.5    Némoz, G.6    Prigent, A.F.7


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