Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice

Circulation Research

Volumn 90, Issue 3, 2002, Pages 270-276

  Braun, Anne ^a   Trigatti, Bernardo L ^a,c   Post, Mark J ^b,e   Sato, Kaori ^b,f   Simons, Michael ^b,e   Edelberg, Jay M ^a,d   Rosenberg, Robert D ^a   Schrenzel, Mark ^a,g   Krieger, Monty ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^f ST ELIZABETH'S MEDICAL CENTER   (United States)

^g INSTITUTE FOR CONSERVATION RESEARCH   (United States)

Author keywords

Atherosclerosis; Coronary artery disease; Lipoprotein metabolism; Myocardial infarction; SR BI apolipoprotein E knockout mice

Indexed keywords

APOLIPOPROTEIN E; FIBRIN; HIGH DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN SRBI; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA SINUS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLEEDING; BLOOD CLOTTING; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE MODEL; DISEASE SEVERITY; ELECTROCARDIOGRAM; FEMALE; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC ANALYSIS; HEART DEATH; HEART DISEASE; HEART EJECTION FRACTION; HEART INFARCTION; HEART MUSCLE CONTRACTILITY; HOMOZYGOSITY; HYPERCHOLESTEROLEMIA; HYPERLIPOPROTEINEMIA TYPE 3; ISCHEMIC HEART DISEASE; KNOCKOUT MOUSE; LIPID METABOLISM; LIPOPROTEIN METABOLISM; MALE; MOUSE; NONHUMAN; NULL ALLELE; PATHOGENESIS; PHARMACOLOGICAL PROCEDURES; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION;

AGE OF ONSET; ANIMALS; ANTIGENS, CD36; APOLIPOPROTEINS E; CORONARY ANGIOGRAPHY; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; DEATH, SUDDEN, CARDIAC; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ELECTROCARDIOGRAPHY; HEART; HEMODYNAMIC PROCESSES; MAGNETIC RESONANCE IMAGING; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIUM; ORGAN SIZE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS B; SURVIVAL RATE;

EID: 0037155049     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh0302.104462     Document Type: Article

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