Hepatic insulin resistance directly promotes formation of cholesterol gallstones

Nature Medicine

Volumn 14, Issue 7, 2008, Pages 778-782

  Biddinger, Sudha B ^a,b   Haas, Joel T ^a   Yu, Bian B ^c   Bezy, Olivier ^a   Jing, Enxuan ^a   Zhang, Wenwei ^d   Unterman, Terry G ^d   Carey, Martin C ^c,e   Kahn, C Ronald ^a,c  

^a JOSLIN DIABETES CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF ILLINOIS   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; ABCG5 PROTEIN; ABCG8 PROTEIN; BILE ACID; CARRIER PROTEIN; CYTOCHROME P450; CYTOCHROME P450 7B1; FARNESOID X RECEPTOR; INSULIN RECEPTOR; TRANSCRIPTION FACTOR FKHR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL METABOLISM; CHOLESTEROL STONE; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GALLSTONE FORMATION; INSULIN RESISTANCE; LIPID LIVER LEVEL; METABOLIC SYNDROME X; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; CHOLELITHIASIS; CHOLESTEROL; CHOLESTEROL, DIETARY; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; INSULIN RESISTANCE; LIPOPROTEINS; LIVER; MALE; METABOLIC SYNDROME X; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, ANIMAL; RECEPTOR, INSULIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEROID HYDROXYLASES; TRANSCRIPTION FACTORS;

MUS;

EID: 46749094102     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1785     Document Type: Article

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