Direct Intestinal Cholesterol Secretion Contributes Significantly to Total Fecal Neutral Sterol Excretion in Mice

Gastroenterology

Volumn 133, Issue 3, 2007, Pages 967-975

  van der Velde, Astrid E ^a   Vrins, Carlos L J ^a   van den Oever, Karin ^a   Kunne, Cindy ^a   Oude Elferink, Ronald P J ^a   Kuipers, Folkert ^b   Groen, Albert K ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FAT; STEROL;

ANIMAL EXPERIMENT; ARTICLE; BILE COMPOSITION; BILE FLOW; BILIARY EXCRETION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FAT INTAKE; INTESTINE CELL; INTESTINE PERFUSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE MUCOSA;

EID: 34548492458     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.06.019     Document Type: Article

References (39)

1. Glomset J.A., and Norum K.R. The metabolic role of lecithin: cholesterol acyltransferase: perspectives form pathology. Adv Lipid Res 11 (1973) 1-65
2. Dietschy J.M., Turley S.D., and Spady D.K. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 34 (1993) 1637-1659
3. Berge K.E., Tian H., Graf G.A., et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290 (2000) 1771-1775
4. Yu L., Hammer R.E., Li-Hawkins J., et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A 99 (2002) 16237-16242
5. Smit J.J., Schinkel A.H., Oude Elferink R.P., et al. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 75 (1993) 451-462
6. Kruit J.K., Plosch T., Havinga R., Boverhof R., Groot P.H., Groen A.K., and Kuipers F. Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. Gastroenterology 46 (2005) 526-534
7. Sperry W.M. Lipid excretion. IV. A study of the relationship of the bile to the fecal lipids with special reference to certain problems of sterol metabolism. J Biol Chem 1 (1927) 351-378
8. Pertsemlidis D., Kirchman E.H., and Ahrens Jr. E.H. Regulation of cholesterol metabolism in the dog. I. Effects of complete bile diversion and of cholesterol feeding on absorption, synthesis, accumulation, and excretion rates measured during life. J Clin Invest 52 (1973) 2353-2367
9. Cheng S.H., and Stanley M.M. Secretion of cholesterol by intestinal mucosa in patients with complete common bile duct obstruction. Proc Soc Exp Biol Med 101 (1959) 223-225
10. Bandsma R.H.J., Stellaard F., Vonk R.J., et al. Contribution of newly synthesized cholesterol to rat plasma and bile determined by mass isotopomer distribution analysis: bile-salt flux promotes secretion of newly synthesized cholesterol into bile. Biochem J 329 (1998) 699-703
11. Klett E.L., Lu K., Kosters A., et al. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med 2 (2004) 5
12. Huang H., Kauan J.W., and Guilbault G.G. Fluorometric enzymatic determination of total cholesterol in serum. Clin Chem 21 (1975) 1605-1608
13. Gurantz D., Laker M.F., and Hofmann A.F. Enzymatic measurement of choline-containing phospholipids in bile. J Lipid Res 22 (1981) 373-376
14. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37 (1959) 911-917
15. Gerhardt K.O., and Gehrke C.W. Gas-liquid chromatography of fecal neutral steroids. J Chromatogr 135 (1977) 341-349
16. Amador E., Dorfman L.E., and Wacker W.E. Serum lactic dehydrogenase activity: an analytical assessment of current assays. Clin Chem 12 (1963) 391-399
17. Miller B.C., Thiele D.L., Hersh L.B., et al. Metionine enkephalin is hydrolysed by aminopeptidase N on CD4+ and CD8+ spleen T cells. Arch Biochem Biophys 311 (1994) 174-179
18. Smith P.K., Krohn R.I., Hermanson G.T., et al. Measurement of protein using bicinchoninic acid. Anal Biochem 150 (1985) 76-85
19. Labarca C., and Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102 (1980) 344-352
20. Keiding R., Horder M., Gerhardt W., et al. Recommended methods for the determination of four enzymes in blood. Scand J Clin Lab Invest 33 (1974) 291-306
21. Wang D.Q., and Carey M.C. Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies. J Lipid Res 44 (2003) 1042-1059
22. Grundy S.M. Absorption and metabolism of dietary cholesterol. Annu Rev Nutr 3 (1983) 71-96
23. Carey M.C., and Small D.M. The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and disolution in man. J Clin Invest 61 (1978) 998-1026
24. DeSchryver-Kecskemeti K., Eliakim R., and Carroll S. Intestinal surfactant-like material. A novel secretory product of the rat enterocyte. J Clin Invest 84 (1989) 1355-1361
25. Mahmood A., Mahmood S., DeSchryver-Kecskemeti K., and Alpers D.H. Characterization of proteins in rat and human intestinal surfactant-like particles. Arch Biochem Biophys 300 (1993) 280-286
26. Kawai K., Fujita M., and Nakao M. Lipid components of two different regions of an intestinal epithelial cell membrane of mouse. Biochem Biophys Acta 369 (1974) 222-233
27. Turley S.D., and Dietschy J.M. The metabolism and excretion of cholesterol by the liver. In: Arias I.M., Jakoby W.B., Popper H., et al. (Eds). The liver: biology and pathobiology (1988), Raven Press, New York 617-641
28. Oude Elferink R.P., Ottenhoff R., van Wijland M., et al. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest 95 (1995) 31-38
29. Van Nieuwkerk C.M., Elferink R.P., Groen A.K., et al. Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene. Gastroenterology 111 (1996) 165-171
30. Voshol P.J., Havinga R., Wolters H., et al. Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice. Gastroenterology 114 (1998) 1024-1034
31. 13C). Existence of an external secretion of cholesterol. Digestion 21 (1981) 232-243
32. Ehehalt R., Jochims C., Lehmann W.-D., et al. Evidence of luminal phosphatidylcholine secretion in rat ileum. Biochim Biophys Acta 1682 (2004) 63-71
33. Samuel P., and McNamara D.J. Differential absorption of exogenous and endogenous cholesterol in man. J Lipid Res 24 (1983) 265-276
34. Philips G.B. The lipid composition of human bile. Biochim Biophys Acta 41 (1960) 361-363
35. Turner D.A. Lipids of bile and intestinal synthesis of triglycerides. Fed Proc 21 (1962) 25-27
36. Hernell O., Staggers J.E., and Carey M.C. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings. Biochemistry 29 (1990) 2041-2056
37. Sedaghat A., Samuel P., Crouse J.R., and Ahrens Jr. E.H. Effects of neomycin on absorption, synthesis, and/or flux of cholesterol in man. J Clin Invest 55 (1975) 12-21
38. Gylling H., and Miettinen T.A. Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes. J Lipid Res 33 (1992) 1361-1371
39. Vuoristo M., and Miettinnen T.A. Increased biliary lipid secretion in celiac disease. Gastroenterology 88 (1985) 134-142