Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor Ezetimibe in the enterocyte brush border membrane

Journal of Biological Chemistry

Volumn 280, Issue 2, 2005, Pages 1306-1320

  Kramer, Werner ^a   Girbig, Frank ^a   Corsiero, Daniel ^a   Pfenninger, Anja ^a   Frick, Wendelin ^a   Jähne, Gerhard ^a   Rhein, Matthias ^a   Wendler, Wolfgang ^a   Lottspeich, Friedrich ^b   Hochleitner, Elisabeth O ^b   Orsó, Evelyn ^c   Schmitz, Gerd ^c  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; ANTIBODIES; BIOLOGICAL MEMBRANES; CHOLESTEROL; MICELLES;

AMINOPEPTIDASE; ENTEROCYTES; MICRODOMAINS; PLASMA MEMBRANES;

ENZYMES;

(5 (2 OXO HEXAHYDRO THIENO(3,4)IMIDAZOL 6 YL) PENTANOIC ACID [2 (4 AZIDO PHENYL) 1,1(4 {4 [3(3 HYDROXY 3 PHENYL PROPYL) 2 (4 METHOXY PHENYL) 4 OXO AZETIDIN 1 YL] PHENYLCARBOMYL} BUTYLCARBAMOYL) ETHYL] AMIDE; AZETIDINE DERIVATIVE; BINDING PROTEIN; CHOLESTEROL; EZETIMIBE; EZETIMIBE GLUCURONIDE; FLUORESCENT DYE; MEMBRANE PROTEIN; MICROSOMAL AMINOPEPTIDASE; MONOCLONAL ANTIBODY; S 6053; S 6054; S 6130; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CHOLESTEROL TRANSPORT; DRUG PROTEIN BINDING; ENDOCYTOSIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE BRUSH BORDER MEMBRANE; LIPID ABSORPTION; MALE; MICELLE; NONHUMAN; PHOTOAFFINITY LABELING; PHOTOREACTIVITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; PROTEIN TARGETING; RABBIT; SEQUENCE ANALYSIS; SMALL INTESTINE; VIRUS;

ABSORPTION; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIGENS, CD13; AZETIDINES; CACO-2 CELLS; CARRIER PROTEINS; CELL MEMBRANE; CHOLESTEROL; CHROMATOGRAPHY, AFFINITY; COLON; ENTEROCYTES; GLYCOSIDE HYDROLASES; GLYCOSYLATION; HUMANS; INTESTINE, SMALL; KIDNEY; MICELLES; MICROVILLI; MOLECULAR WEIGHT; PHOTOAFFINITY LABELS; PROTEIN BINDING; RABBITS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STOMACH;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 19944431827     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406309200     Document Type: Article

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