Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 25, 2002, Pages 16237-16242

  Yu, Liqing ^a,b   Hammer, Robert E ^a,b   Li Hawkins, Jia ^a,b   Von Bergmann, Klaus ^c   Lutjohann, Dieter ^c   Cohen, Jonathan C ^a,b   Hobbs, Helen H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

ATP binding cassette transporters; Bile; Knockout mice; Sitosterolemia

Indexed keywords

ABC TRANSPORTER; BILE ACID; CARBON 14; CHOLESTEROL; DNA FRAGMENT; GENOMIC DNA; STEROL; TAUROCHOLIC ACID;

ANIMAL CELL; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; BILE SECRETION; DIETARY INTAKE; EMBRYO; GENE MUTATION; ISOTOPE LABELING; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SITOSTEROLEMIA;

ANIMAL FEED; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; BIOLOGICAL TRANSPORT; CHIMERA; CHOLESTANOL; CHOLESTEROL; CHOLESTEROL, DIETARY; CROSSES, GENETIC; DIETARY FATS; FEMALE; GENE TARGETING; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LIPOPROTEINS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHYTOSTEROLS; SITOSTEROLS;

ANIMALIA;

EID: 0037058995     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.252582399     Document Type: Article

References (32)

1. Bhattacharyya, A. K. & Connor, W. E. (1974) J. Clin. Invest. 53, 1033-1043.
2. Bjorkhem, I., Boberg, K. & Leitersdorf, E. (2001) in The Metabolic and Molecular Bases of Inherited Disease, eds. Scriver, C., Beaudel, A., Sly, W. & Valle, D. (McGraw-Hill, New York), Vol. 11, pp. 2961-2988.
3. Miettinen, T. A. (1980) Eur. J. Clin. Invest. 10, 27-35.
4. Salen, G., Shore, V., Tint, G. S., Forte, T., Shefer, S. Horak, I., Horak, E., Dayal, B. Nguyen, L., Batta, A. K. et al. (1989) J. Lipid Res. 30, 1319-1330.
5. Morganroth, J., Levy, R. I., McMahon, A. E. & Gotlo, A. M., Jr. (1974) J. Pediatr. (Berlin) 85, 639-643.
6. Belamarich, P. F., Deckelbaum, R. J., Starc, T. J., Dobrin, B. E., Tint, G. S. & Salen, G. (1990) Pediatrics 86, 977-981.
7. Gregg, R. E., Connor, W. E., Lin, D. S. & Brewer, H. B., Jr. (1986) J. Clin. Invest. 77, 1864-1872.
8. Schoenheimer, R. (1931) Science 74, 579-584.
9. Gould, R. G., Jones, R. J., LeRoy, G, V., Wissler, R. W. & Taylor, C. B. (1969) Metabolism, 18, 652-662.
10. Salen, G., Ahrens, E. H., Jr., & Grundy, S. M. (1970) J. Clin. Invest. 49, 952-967.
11. Salen, G., Horak, L. Rothkopf, M., Cohen, J. L. Speck, J., Tint, G. S., Shore, V., Dayal, B., Chen, T. & Shefer, S. (1985) J. Lipid Res. 26, 1126-1133.
12. Berge, K. E., Tian, H., Graf, G. A., Yu, L., Grishin, N. V., Schultz, J. Kwiterovich, P., Shah, B., Barnes, R. & Hobbs, H. H. (2000) Science 290, 1771-1775.
13. Lee, M. H., Lu, K., Hazard, S., Yu, H., Shulenin, S., Hidaka, H., Kojima, H. Allikmets, R., Sakuma, N., Pegoraro, R., et al. (2001) Nat. Genet. 27, 79-83.
14. Repa, J. J., Berge, K. E., Pomajzl, C., Richardson, J. A., Hobbs, H. & Mangelsdorf, D. J. (2002) J. Biol. Chem. 277, 18793-18800.
15. Yu, L., Li-Hawkins, J., Hammer, R. E., Berge, K. E., Horton, J. D., Cohen, J. C. & Hobbs, H. H. (2002) J. Clin. Invest. 110, 671-680.
16. Graf, G. A., Li, W.-P., Gerard, R. D., Gelissen, I., White, A., Cohen, J. C. & Hobbs, H. H. (2002) J. Clin. Invest. 110, 659-669.
17. Dayal, B., Ertel, N. H., Rapole, K. R., Asgaonkar, A. & Salen, G. (1997) Steroids 62, 451-454.
18. Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E. & Herz, J. (1993) J. Clin. Invest, 92, 883-893.
19. Shimano, H., Shimonur, L., Hammer, R., Herz, J., Goldstein, J. L., Brown, M. S. & Horton, J. D. (1997) J. Clin. Invest. 100, 2115-2124.
20. Schwarz, M., Russell, D. W., Dietschy, J. M. & Turley, S. D. (1998) J. Lipid Res. 39, 1833-1843.
21. Turley, S. D., Herndon, M. W. & Dielschy, J. M. (1994) J. Lipid Res. 35, 328-339.
22. Lutjohann, D., Meese, C. O., Crouse, J. R., III, & von Bergmann, K. (1993) J. Lipid Res. 34, 1039-1046.
23. Lutjohann, D., Bjorkhem, I., Bell, U. F. & von Bergmann, K. (1995) J. Lipid Res. 36, 1763-1773.
24. Luljohann, D., Bjorkhem, I. & Ose, L. (1996) Scand. J. Clin. Lab. Invest. 56, 229-240.
25. Smit, J. J., Schinkel, A. H., Elferink, R. P. O., Groen, A. K., Wagenaar, E., van Deemter, L., Mol, C. A., Ottenhoff, R., van der Lugt, N. M. & van Room, M. A. (1993) Cell 75, 451-462.
26. Dietschy, J. M. & Turley, S. D. (2002) J. Biol. Chem. 277, 3801-3804.
27. Rudel, L. L., Kelley, K., Sawyer, J. K., Shah, R. & Wilson, M. D. (1998) Arterioscler. Thromb. Vasc. Biol. 18, 1818-1827.
28. Bhattacharyya, A. K., Connor, W. E., Lin, D. S., McMurry, M. M. & Shulman, R. S. (1991) Arterioscler. Thromb. 11, 1287-1294.
29. Carey, M. C. & Duane, W. C. (1994) in The Liver: Biology and Pathobiology, eds. Arias, I. M., Boyer, J. L., Fauslo, N., Jakoby, W. B., Schachler, D. A. & Shafritz, D. A. (Raven, New York), pp. 719-767.
30. Horton, J. D., Shimano, H., Hamilton, R. L., Brown, M. S. & Goldstein, J. L. (1999) J. Clin. Invest. 103, 1067-1076.
31. Yang, J., Goldstein, J. L., Hammer, R. E., Moon, Y. A., Brown, M. S. & Horton, J. D. (2001) Proc. Natl. Acad. Sci. USA 98, 13607-13612.
32. Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L. & Brown, M. S. (2002) J. Biol. Chem. 277, 9520-9528.