Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern

Endocrinology

Volumn 139, Issue 12, 1998, Pages 4991-4997

  Li, Hua ^a   Papadopoulos, Vassilios ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR; CHOLESTEROL; MEMBRANE PROTEIN; MUTANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STEROIDOGENESIS;

EID: 0031755752     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.12.6390     Document Type: Article

References (40)

1. Simpson ER, Waterman MR 1983 Regulation by ACTH of steroid hormone biosynthesis in the adrenal cortex. Can J Biochem Cell Biol 61:692-707
2. SCC in steroid hormone synthesis.
3. Papadopoulos V 1993 Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev 14:222-240
4. Costa E, Guidotti A 1979 Molecular mechanism in the recptor actions of benzodiazepines. Annu Rev Pharmacol Toxicol 19:531-545
5. Anholt RRH, Pedersen PL, DeSouza EB, Snyder SH 1986 The peripheral-type benzodiazepine receptor: localization to the mitochondrial outer membrane. J Biol Chem 261:576-583
6. Papadopoulos V 1998 Structure and function of the peripheral-type benzodiazepine receptor in steroidogenic cells. Proc Soc Exp Biol Med 217:130-142
7. Papadopoulos V, Mukhin AG, Costa E, Krueger KE 1990 The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biol Chem 265:3772-3779
8. Krueger KE, Papadopoulos V 1990 Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. J Biol Chem 265:15015-15022
9. Papadopoulos V, Amri H, Li H, Boujrad N, Vidic B, Gamier M 1997 Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line. J Biol Chem 272:32129-32135
10. Bernassau JM, Reversat JL, Ferrara P, Caput D, Lefur G 1993 A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport. J Mol Graph 11:236-245
11. Papadopoulos V 1996 Pharmacologic influence on androgen biosynthesis. In: Payne AH, Hardy MP, Russell LD (eds) The Leydig Cell. Cache River Press, Vienna, IL, pp 598-628
12. Leaver HA, Boyd GS 1981 Control of steroidogenesis in rat corpus luteum: the rate of access of cholesterol to the active site of the cholesterol side-chain cleavage enzyme. J Endocrinol 91:123-133
13. Amri H, Ogwuegbu SO, Boujrad N, Drieu K, Papadopoulos V 1996 In vivo regulation of the peripheral-type benzodiazepine receptor and glucocorticoid synthesis by the Ginkgo biloba extract EGb 761 and isolated ginkgolides. Endocrinology 137:5707-5718
14. Garnier M, Dimchev A, Boujrad N, Price MJ, Musto NA, Papadopoulos V 1994 In vitro reconstitution of a functional peripheral-type benzodiazepine receptor. Mol Pharm 45:201-211
15. Weiss R L 1978 Methods for protoplast formation in Escherichia coli. Meth Cell Biol 20:141-147
16. Munson PJ, Rodbard D 1980 LIGAND: a versatile computerized approach for charcterization of ligand binding systems. Anal Biochem 107:220-239
17. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 72:248-254
18. Moat AG, Foster JW 1995 Microbial Physiology. Wiley-Liss, New York
19. Tsankova V, Magistrelli A, Cantoni L, Tacconi MT 1995 Peripheral benzodiazepine receptor ligands in rat liver mitochondria: effect on cholesterol translocation. Eur J Pharm 294:601-607
20. Yeliseev AA, Kaplan S 1995 A sensory transducer homologous to the mammalian peripheral-type benzodiazepine receptor regulates photosynthetic membrane complex formation in Rhodobacter sphaeroides 2.4.1. J Biol Chem 270:21167-21175
21. DeGrella RF, Simoni RD 1982 Intracellular transport of cholesterol to the plasma membrane. J Biol Chem 257:14256-14262
22. Farges R, Joseph-Liauzun E, Shire D, Caput D, Le Fur G, Ferrara P 1994 Site-directed mutagenesis of the peripheral benzodiazepine receptor: identification of amino acids implicated in the binding site of Ro5-4864. Mol Pharm 46:1160-1167
23. Pikuleva IA, Mackman RL, Kagawa N, Waterman MR, Ortiz de Montellano PR 1995 Active-site topology of bovine cholesterol side-chain cleavage cytochrome P450 (P450scc) and evidence for interaction of tyrosine 94 with the side chain of cholesterol. Arch Biochem Biophys 322:189-197
24. Boyle TP, Marotti KR 1992 Structure of the murine gene encoding apolipoprotein A-I. Gene 117:243-247
25. Murata M, Peranen J, Schreiner R, Wieland F, Kurzchalia T, Simons K 1995 VIP21/caveolin is a cholesterol-binding protein. Proc Natl Acad Sci USA 92:10339-10343
26. Stocco DM, Clark BJ 1996 Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17:221-244
27. Porter JA, Young KE, Beachy PA 1996 Cholesterol modification of hedgehog signaling proteins in animal development. Science 274:255-259
28. Su P, Rennert H, Shayiq RM, Yamamoto R, Zheng YM, Addya S, Stracuu JF III, Avadhani NG 1990 A cDNA encoding a rat mitochondrial cytochrome P450 catalyzing both the 26-hydroxylation of cholesterol and 25-hydroxylation of vitamin D3:gonadotropic regulation of the cognate mRNA in ovaries. DNA Cell Biol 9:657-667
29. Harder T, Kellner R, Parton RG, Gruenberg J 1997 Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol. Mol Biol Cell 8:533-545
30. Colles SM, Woodford JK, Moncecchi D, Myers-Payne SC, McLean LR, Billheimer JT, Schroeder F 1995 Cholesterol interaction with recombinant human sterol carrier protein-2. Lipids 30:795-803
31. Kai M, Eto T, Kondo K, Setogushi Y, Higashi S, Maeda Y, Setogushi T 1995 Synchronous circadian rhythms of mRNA levels and activities of cholesterol 7 alpha-hydroxylase in the rabbit and rat.J. Lipid Res 36:367-374
32. Ishizaki T, Hirayama N, Shinkawa H, Nimi O, Murooka Y 1989 Nucleotide sequence of the gene for cholesterol oxidase from a Streptomyces sp. J Bacteriol 171:596-601
33. Horinouchi S, Ishizuka H, Beppu T 1991 Cloning, nucleotide sequence, and transcriptional analysis of the NAD(P)-dependent cholesterol dehydrogenase gene from a Nocardia sp. and its hyperexpression in Streptomyces spp. Appl Environ Microbiol 57:1386-1393
34. Nilsson J, Blaeckberg L, Carlsson P, Enerbaeck S, Hernell O, Bjursell G 1990 cDNA cloning of human-milk bile-salt-stimulated lipase and evidence for its identity to pancreatic carboxylic ester hydrolase. Eur J Biochem 192:543-550
35. Pape ME, Schultz PA, Rea TJ, DeMattos RB, Kieft K, Bisgaier CL, Newton RS, Krause BR 1995 Tissue specific changes in acyl-CoA: cholesterol acyltransferase (ACAT) mRNA levels in rabbits. J Lipid Res 36:823-838
36. Knudsen J, Mansrup S, Rasmussen JT, Andreasen PH, Poulsen F, Kristiansen K 1993 The function of acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI). Mol Cell Biochem 123:129-138
37. Brown AS, Hall PF 1991 Stimulation by endozepine of the side-shain cleavage of cholesterol in a reconstituted enzyme system. Biochem Biophys Res Commun 180:609-614
38. Papadopoulos V, Berkovich A, Krueger KE, Costa E, Guidotti A 1991 Diazepam Binding Inhibitor (DBI) and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology 129:1481-1488
39. Clark BJ, Soo S-C, Caron KM, Ikeda Y, Parker KL, Stocco DM 1995 Hormonal and developmental regulation of the steroidogenic acute regulatory protein. Mol Endocr 9:1346-1355
40. Liscum L, Underwood KW 1995 Intracellular cholesterol transport and compartmentation. J Biol Chem 270:15433-15446