The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1580, Issue 1, 2002, Pages 77-93

  Altmann, Scott W ^a   Davis Jr , Harry R ^a   Yao, Xiaorui ^a   Laverty, Maureen ^a   Compton, Douglas S ^a   Zhu, Li Ji ^a   Crona, James H ^a   Caplen, Mary Ann ^a   Hoos, Lizbeth M ^a   Tetzloff, Glen ^a   Priestley, Tony ^a   Burnett, Duane A ^a   Strader, Catherine D ^a   Graziano, Michael P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Absorption; Cholesterol; Cloning; Enterocyte; Expression; Scavenger receptor class B; Type I

Indexed keywords

CHOLESTEROL; COMPLEMENTARY DNA; EZETIMIBE; NEW DRUG; RADIOISOTOPE; RECEPTOR SUBTYPE; SCAVENGER RECEPTOR; SCH 354909; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL CLONING; CELL ISOLATION; CELL SELECTION; CELL STRAIN; CHO CELL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG SYNTHESIS; FEMALE; FLUORESCENCE; IN SITU HYBRIDIZATION; INTESTINE CELL; ISOTOPE LABELING; KNOCKOUT MOUSE; MALE; MEMBRANE BINDING; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; SMALL INTESTINE ABSORPTION; TISSUE DISTRIBUTION; TISSUE SECTION; WILD TYPE;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIGENS, CD36; AZETIDINES; CHO CELLS; CHOLESTEROL; CLONING, MOLECULAR; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE LIBRARY; IN SITU HYBRIDIZATION; INTESTINAL ABSORPTION; INTESTINES; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS B;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0037196569     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(01)00190-1     Document Type: Article

References (47)

1. 2-Azetidinones as inhibitors of cholesterol absorption
2. Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH48461
3. The clinical development of a novel cholesterol absorption inhibitor
4. SCH48461, a novel inhibitor of cholesterol absorption
5. In vivo mechanism-based discovery of a potent cholesterol absorption inhibitor (SCH58235) through the identification of the active metabolites of SCH48461
6. The cholesterol inhibitor ezetimibe inhibits the development of atherosclerosis in apo E knockout (-/-) mice fed low fat and western diets
7. Ezetimibe (SCH58235) inhibits cholesterol absorption, reduces plasma cholesterol, and inhibits the development of atherosclerosis in Apo E knockout mice fed a cholesterol-free diet
8. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease
9. A comparative study of sterol absorption in different small-intestinal brush border membrane models
10. The absorption and metabolism of sterols
11. 2-Azetidinone cholesterol absorption inhibitors: Structure-activity relationships on the heterocyclic nucleus
12. Review of cholesterol absorption with emphasis on dietary and biliary cholesterol
13. Established and emerging strategies for inhibition of cholesterol absorption
14. Intestinal cholesterol absorption
15. Identification of a receptor mediating absorption of dietary cholesterol in the intestine
16. Discovery of SCH58235, a designed potent orally active inhibitor of cholesterol absorption
17. Characterization and chromosomal localization of rat scavenger receptor class B type I, a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting sequence
18. Efficient screening of retroviral cDNA expression libraries
19. New experimental approaches in retrovirus-mediated expression screening
20. Production of high-titer helper-free retroviruses by transient transfection
21. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types
22. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism
23. Some biochemical properties of suspensions of intestinal epithelial cells
24. Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation
25. Simplified mammalian DNA isolation procedure
26. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
27. Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family
28. Comparison of cholesterol and sitosterol uptake in different brush border membrane models
29. Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat
30. Effect of hydrophobic surfactant (Pluronic L-81) on lymphatic lipid transport in the rat
31. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
32. Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland
33. Expression cloning of SR-BI, a CD36-related class B scavenger receptor
34. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
35. Scavenger receptor, class B, type I-dependent stimulation of cholesterol esterification by high density lipoproteins, low density lipoproteins, and nonlipoprotein cholesterol
36. Molecular cloning and functional expression of human acyl-coenzyme A: Cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells
37. Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism
38. Formation and transport of chylomicrons by enterocytes to the lymphatics
39. Identification and characterization of rat intestinal trefoil factor: Tissue- and cell-specific member of the trefoil protein family
40. 3-Hydroxy-3-methylglutaryl coenzyme A reductase in isolated villous and crypt cells of the rat ileum
41. Parallel patterns of cell-specific gene expression during enterocyte differentiation and maturation in the small intestine of the rabbit
42. Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type 1-deficient mice
43. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1
44. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers