In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 1, 1997, Pages 157-163

  Van Heek, Margaret ^a   France, Constance F ^a   Compton, Douglas S ^a   McLeod, Robbie L ^a   Yumibe, Nathan P ^a   Alton, Kevin B ^a   Sybertz, Edmund J ^a   Davis Jr , Harry R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS(4 METHOXYPHENYL) 3 (3 PHENYLPROPYL) 2 AZETIDINONE; EZETIMIBE; HYPOCHOLESTEROLEMIC AGENT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL INTAKE; CHOLESTEROL METABOLISM; DRUG METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RHESUS MONKEY;

ABSORPTION; ANIMALS; ANTICHOLESTEREMIC AGENTS; AZETIDINES; BILE; CHOLESTEROL; CHOLESTEROL, LDL; DOSE-RESPONSE RELATIONSHIP, DRUG; MACACA MULATTA; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030848734     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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