Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment

Genomics

Volumn 86, Issue 6, 2005, Pages 648-656

  Simon, Jason S ^a   Karnoub, Maha C ^a,b   Devlin, David J ^a   Arreaza, Maria G ^a   Qiu, Ping ^a   Monks, Stephanie A ^c   Severino, Michael E ^a,d   Deutsch, Paul ^a   Palmisano, Joanne ^a   Sachs, Alan B ^a,b   Bayne, Marvin L ^a   Plump, Andrew S ^a   Schadt, Eric E ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ROSETTA INPHARMATICS   (United States)

^c OKLAHOMA STATE UNIVERSITY   (United States)

^d AMGEN INC   (United States)

Author keywords

Cholesterol; Clinical trial; Drug response; Genetic association; NPC1L1; Target of ezetimibe

Indexed keywords

ATORVASTATIN; CARRIER PROTEIN; CHOLESTEROL; EZETIMIBE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NIEMANN PICK C1 LIKE 1 PROTEIN; SIMVASTATIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA SEQUENCE; DRUG ACTIVITY; DRUG RESPONSE; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN VARIANT; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN AMERICANS; ANTICHOLESTEREMIC AGENTS; AZETIDINES; CHOLESTEROL, LDL; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; HISPANIC AMERICANS; HUMANS; INTESTINAL ABSORPTION; MEMBRANE PROTEINS; PHYTOSTEROLS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; UNITED STATES; VARIATION (GENETICS);

EID: 28644452453     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2005.08.007     Document Type: Article

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