Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice

Molecular Pharmaceutics

Volumn 6, Issue 3, 2009, Pages 738-746

  Wang, Xu Li ^a   Xu, Rongzuo ^a   Wu, Xueming ^a   Gillespie, David ^b   Jensen, Randy ^b   Lu, Zheng Rong ^a,c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

HIF 1 ; Multifunctional carriers; RNAi; Systemic siRNA delivery; Targeted siRNA delivery

Indexed keywords

(1 AMINOETHYL)IMINO BIS[N (OLEICYLCYSTEINYLHISTINYL 1 AMINOETHYL)PROPIONAMIDE]; AMPHOPHILE; ARGINYLGLYCYLASPARTIC ACID; BOMBESIN; DRUG CARRIER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MACROGOL; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER INHIBITION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CHEMICAL MODIFICATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG RELEASE; DRUG UPTAKE; ENDOSOME; FEMALE; FLUORESCENCE IMAGING; GENE SILENCING; GLIOMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUDE MOUSE; PH; PRIORITY JOURNAL; RNA INTERFERENCE; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; CELL PROLIFERATION; FLOW CYTOMETRY; GENE SILENCING; GLIOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INJECTIONS, INTRAVENOUS; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; NANOPARTICLES; OLIGOPEPTIDES; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

EID: 67249148163     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp800192d     Document Type: Article

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