Expression of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma

Disease Markers

Volumn 25, Issue 3, 2008, Pages 141-148

  Tzao, Ching ^a   Lee, Shih Chun ^a   Tung, Ho Jui ^c   Hsu, Han Shui ^b   Hsu, Wen Hu ^b   Sun, Guang Huan ^a   Yu, Cheng Ping ^a   Jin, Jong Shiaw ^a   Cheng, Yeung Leung ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Esophageal squamous cell carcinoma; Hypoxia inducible factor (HIF) 1 ; Prognosis; Survival; Vascular endothelial growth factor (VEGF) D

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN D;

AGED; ANGIOGENESIS; ARTICLE; CANCER STAGING; CANCER SURVIVAL; DISEASE COURSE; ESOPHAGUS CARCINOMA; ESOPHAGUS RESECTION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TISSUE SECTION;

EID: 58149385538     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. D.M. Aebersold, P. Burri, K.T. Beer, J. Laissue, V. Djonov, R.H. Greiner and G.L. Semenza, Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer, Cancer Res 61 (2001), 2911-2916.
2. T. Amioka, Y. Kitadai, S. Tanaka, K. Haruma, M. Yoshihara, W. Yasui and K. Chayama, Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinoma invading the submucosa, Eur J Cancer 38 (2002), 1413-1419.
3. C. Blancher, J.W. Moore, K.L. Talks, S. Houlbrook and A.L. Harris, Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines, Cancer Res 60 (2000), 7106-7113.
4. P. Carmeliet, Y. Dor, J.M. Herbert, D. Fukumura, K. Brusselmans, M. Dewerchin, M. Neeman, F. Bono, R. Abramovitch, P. Maxwell, C.J. Koch, P. Ratcliffe, L. Moons, R.K. Jain, D. Collen and E. Keshert, Role of HIF-1α in hypoxiamediated apoptosis, cell proliferation and tumor angiogenesis, Nature 394 (1998), 435-439.
5. J.P. Dales, S. Garcia, S. Meunier-Carpentier, L. Andrac-Meyer, O. Haddad, M.N. Lavaut, C. Allasia, P. Bonnier and C. Charpin, Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients, Int J Cancer 116 (2005), 734-739.
6. J.A. Dibbens, D.L. Miller, A. Damert, W. Risau, M.A. Vadas and G.J. Goodall, Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements, Mol Biol Cell 10 (1999), 907-919.
7. L.M. Ellis, W. Liu, F. Fan, N. Reinmuth, R.M. Shaheen, Y.D. Jung and S. Ahmad, Role of angiogenesis inhibitors in cancer treatment, Oncology (Williston Park) 15 (2001), 9-46.
8. J. Folkman, How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes Memorial Award Lecture, Cancer Res 46 (1986), 467-473.
9. J. Folkman, What is the evidence that tumors are angiogenesis dependent, J Natl Cancer Inst 82 (1990), 4-6.
10. A. Furudoi, S. Tanaka, K. Haruma, Y. Kitadai, M. Yoshihara, K. Chayama and F Shimamoto, Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma, Oncology 62 (2002), 157-166.
11. M.L. George, M.G. Tutton, F. Janssen, A. Arnaout, A.M. Abulafi, S.A. Eccles and R.I. Swift, VEGF-A, VEGF-C, and VEGF-D in colorectal cancer progression, Neoplasia 3 (2001), 420-427.
12. F.L. Greene, American Joint Committee on Cancer, American Cancer Society. AJCC Cancer Staging Manual, (6th ed.), New York: Springer, 2002, 93-94.
13. J.E. Jung, H.G. Lee, I.H. Cho, D.H. Chung, S.H. Yoon, Y.M. Yang, J.W. Lee, S Choi, J.W. Park, S.K. Ye and M.H. Chung, STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells, FASEB J 19 (2005), 1296-1298.
14. E.L. Kaplan and P. Meier, Nonparametric estimation from incomplete observation, J Am Stat Assoc 53 (1958), 457-481.
15. T. Karpanen, M. Egeblad, M.J. Karkkainen, H. Kubo, S. Ylä-Herttuala, M. Jäättelä and K. Alitalo, Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth, Cancer Res 61 (2001), 1786-1790.
16. S. Kimura, Y. Kitadai, S. Tanaka, T. Kuwai, J. Hihara, K. Yoshida, T. Toge and K. Chayama, Expression of hypoxia-inducible factor (HIF)-1α is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma, Eur J Cancer 40 (2004), 1904-1912.
17. Y. Kitadai, K. Haruma, T. Tokutomi, S. Tanaka, K. Sumii, M. Carvalho, M. Kuwabara, K. Yoshida, T. Hirai, G. Kajiyama and E. Tahara, Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas, Clin Cancer Res 4 (1998), 2195-2200.
18. A.L. Kung, S. Wang, J.M. Klco, W.G. Kaelin and D.M. Livingston, Suppression of tumor growth through disruption of hypoxia inducible transcription, Nat Med 6 (2000), 1335-1340.
19. P.A. Kyzas, D. Stefanou, A. Batistatou and N.J. Agnantis, Hypoxia-induced tumor angiogenic pathway in head and neck cancer: an in vivo study, Cancer Lett 225 (2005), 297-304.
20. P.A. Kyzas, D. Stefanou and N.J. Agnantis, Immunohistochemical expression of vascular endothelial growth factor correlates with positive surgical margins and recurrence in T1 and T2 squamous cell carcinoma (SCC) of the lower lip, Oral Oncol 40 (2004), 941-947.
21. C. Leo, A.J. Giaccia and N.C. Denko, The hypoxic tumor microenvironment and gene expression, Semin Radiat Oncol 14 (2004), 207-214.
22. N. Matsutani, W. Yasui and K. Chayama, Clinicopathological significance of vascular endothelial growth factor (VEGF)-C in human esophageal squamous cell carcinoma, Int J Cancer 93 (2001), 662-666.
23. G. Melillo, Inhibiting hypoxia-inducible factor 1 for cancer therapy, Mol Cancer Res 4 (2006), 601-605.
24. C. Michiels, E. Minet, D. Mottet and M. Raes, Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes, Free Radic Biol Med 33 (2002), 1231-1242.
25. T. Niki, S. Iba, M. Tokunou, T. Yamada, Y. Matsuno and S. Hirohashi, Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma, Clin Cancer Res 6 (2000), 2431-2439.
26. P. O-charoenrat, P. Rhys-Evans and S.A. Eccles, Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis, Cancer 92 (2001), 556-568.
27. Y. Ogata, H. Fujita, H. Yamana, S. Sueyoshi and K. Shirouzu, Expression of vascular endothelial growth factor as a prognostic factor in node-positive squamous cell carcinoma in the thoracic esophagus: long-term follow-up study, World J Surg 27 (2003), 584-589.
28. B.Z. Olenyuk, G.J. Zhang, J.M. Klco, N.G. Nickols, W.G. Jr. Kaelin and P.B. Dervan, Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist, Proc Natl Acad Sci USA 101 (2004), 16768-16773.
29. S. Onogawa, Y. Kitadai, S. Tanaka, T. Kuwai, S. Kimura and K. Chayama, Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma, Cancer Sci 95 (2004), 32-39.
30. C.W. Pugh and P.J. Ratcliffe, Regulation of angiogenesis by hypoxia: role of the HIF system, Nat Med 9 (2003), 677-684.
31. N. Reinmuth, A.A. Parikh, S.A. Ahmad, W. Liu, O. Stoeltzing, F. Fan, A. Takeda, M. Akagi and L.M. Ellis, Biology of angiogenesis in tumors of the gastrointestinal tract, Microsci Res Tech 60 (2003), 199-207.
32. H.E. Ryan, M. Poloni, W. McNulty, D. Elson, M. Gassmann, J.M. Arbeit and R.S. Johnson, Hypoxia-inducible factor-1α is a positive factor in solid tumor growth, Cancer Res 60 (2000), 4010-4015.
33. A. Sandler, Bevacizumab in non small cell lung cancer, Clin Cancer Res 13 (2007), s4613-s4616.
34. G.L. Semenza, Signal transduction to hypoxia-inducible factor 1, Biochem Pharmacol 64 (2002), 993-998.
35. A. Shida, S. Fujioka, K. Kobayashi, Y. Ishibashi, H. Nimura, N. Mitsumori and K. Yanaga, Expression of vascular endothelial growth factor (VEGF)-C and -D in gastric carcinoma, Int J Clin Oncol 11 (2006), 38-43.
36. B.D. Smith, G.L. Smith, D. Carter, C.T. Sasaki and B.G. Hafty, Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma, J Clin Oncol 18 (2000), 2046-2052.
37. S.A. Stacker, C. Caesar, M.E. Baldwin, G.E. Thornton, R.A. Williams, R. Prevo, D.G. Jackson, S. Nishikawa, H. Kubo and M.G. Achen, VEGF-D promotes the metastatic spread of tumor cells via the lymphatics, Nat Med 7 (2001), 186-191.
38. C. Tan, R.G. de Noronha, A.J. Roecker, B. Pyrzynska, F. Khwaja, Z. Zhang, H. Zhang, Q. Teng, A.C. Nicholson, P. Giannakakou, W. Zhou, J.J. Olson, M.M. Pereira, K.C. Nicolaou and E.G. Van Meir, Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway, Cancer Res 65 (2005), 605-612.
39. The Lifetest Procedure, in: SAS Technical Report: P-179, Additional SAS/STAT Procedures, Release 6.03. Cary NC: SAS Institute, 1988, 49-90.
40. J.C. Tsai, C.K. Goldman and G.Y. Gillespie, Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF, J Neurosurg 82 (1995), 864-873.
41. T. Veikkola and K. Alitalo, VEGFs, receptors and angiogenesis, Semin CancerBiol 9 (1999), 211-220.
42. G.L. Wang, B.H. Jiang, E.A. Rue and G.L. Semenza, Hypoxia-inducible factor 1 is a basic helix-loop-helix-PAS heterodimer regulated by cellular O2 tension, Proc Natl Acad Sci USA 92 (1995), 5510-5514.
43. Y. Zeng, K. Opeskin, M.E. Baldwin, L.G. Horvath, M.G. Achen, S.A. Stacker, R.L. Sutherland and E.D. Williams, Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer, Clin Cancer Res 10 (2004), 5137-5144.
44. Q. Zhang, Z.F. Zhang, J.Y. Rao, J.D. Sato, J. Brown, D.V. Messadi and A.D. Le, Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas, Int J Cancer 111 (2004), 849-857.
45. H. Zhong, A.M. De Marzo, E. Laughner, M. Lim, D.A. Hilton, D. Zagzag, P. Buechler, W.B. Isaacs, G.L. Semenza and J.W. Simons, Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases, Cancer Res 59 (1999), 5830-5835.